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1446144-04-2,MFCD27997886
Catalog No.:AA001JRT

1446144-04-2 | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-

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Purity
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Price(USD)
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1mg
99+%
in stock  
$12.00   $8.00
- +
2mg
99+%
in stock  
$17.00   $12.00
- +
5mg
99+%
in stock  
$25.00   $18.00
- +
10mg
99+%
in stock  
$35.00   $25.00
- +
25mg
99+%
in stock  
$50.00   $35.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001JRT
Chemical Name:
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-
CAS Number:
1446144-04-2
Molecular Formula:
C19H18ClN5OS
Molecular Weight:
399.8971
MDL Number:
MFCD27997886
SMILES:
NC(=O)C[C@@H]1N=C(c2ccc(cc2)Cl)c2c(n3c1nnc3C)sc(c2C)C
Properties
Computed Properties
 
Complexity:
611  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.9  

Downstream Synthesis Route

[1]CurrentPatentAssignee:HINOVAPHARMACEUTICALS-CN109503618,2019,A

1446144-04-2   
CASUnavailable 
 
CASUnavailable 

[1]CurrentPatentAssignee:HINOVAPHARMACEUTICALS-CN109503618,2019,ALocationinpatent:Paragraph0175;0176;0177;0178

1446144-04-2    534-07-6   
CASUnavailable 

[1]CurrentPatentAssignee:HINOVAPHARMACEUTICALS-CN109503618,2019,ALocationinpatent:Paragraph0180-0183

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2020/86858,2020,A1Locationinpatent:Page/Pagecolumn506

[2]Dragovich,PeterS.;Pillow,ThomasH.;Blake,RobertA.;Sadowsky,JackD.;Adaligil,Emel;Adhikari,Pragya;Bhakta,Sunil;Blaquiere,Nicole;Chen,Jinhua;DelaCruz-Chuh,Josefa;Gascoigne,KarenE.;Hartman,StevenJ.;He,Mingtao;Kaufman,Susan;Kleinheinz,Tracy;Kozak,KatherineR.;Liu,Liang;Liu,Liling;Liu,Qi;Lu,Ying;Meng,Fanwei;Mulvihill,MelindaM.;O'Donohue,Aimee;Rowntree,RebeccaK.;Staben,LeannaR.;Staben,StevenT.;Wai,John;Wang,Jian;Wei,Binqing;Wilson,Catherine;Xin,Jianfeng;Xu,Zijin;Yao,Hui;Zhang,Donglu;Zhang,Hongyan;Zhou,Hao;Zhu,Xiaoyu[JournalofMedicinalChemistry,2021,vol.64,#5,p.2534-2575]

1446144-04-2   
CASUnavailable 

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2020/86858,2020,A1

[2]Dragovich,PeterS.;Pillow,ThomasH.;Blake,RobertA.;Sadowsky,JackD.;Adaligil,Emel;Adhikari,Pragya;Bhakta,Sunil;Blaquiere,Nicole;Chen,Jinhua;DelaCruz-Chuh,Josefa;Gascoigne,KarenE.;Hartman,StevenJ.;He,Mingtao;Kaufman,Susan;Kleinheinz,Tracy;Kozak,KatherineR.;Liu,Liang;Liu,Liling;Liu,Qi;Lu,Ying;Meng,Fanwei;Mulvihill,MelindaM.;O'Donohue,Aimee;Rowntree,RebeccaK.;Staben,LeannaR.;Staben,StevenT.;Wai,John;Wang,Jian;Wei,Binqing;Wilson,Catherine;Xin,Jianfeng;Xu,Zijin;Yao,Hui;Zhang,Donglu;Zhang,Hongyan;Zhou,Hao;Zhu,Xiaoyu[JournalofMedicinalChemistry,2021,vol.64,#5,p.2534-2575]

Literature

Title: Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma.

Journal: Leukemia 20141001

Title: The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors.

Journal: Cell death & disease 20141001

Title: Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20140805

Title: BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20120501

Title: Devaiah BN, et al. BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6927-32.

Title: Moros A, et al. Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma. Leukemia. 2014 Oct;28(10):2049-59

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Tags:1446144-04-2 Molecular Formula|1446144-04-2 MDL|1446144-04-2 SMILES|1446144-04-2 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-