Home Amines 148849-67-6
148849-67-6,MFCD00929899
Catalog No.:AA001L5U

148849-67-6 | 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)

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10mg
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50mg
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250mg
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1g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001L5U
Chemical Name:
2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)
CAS Number:
148849-67-6
Molecular Formula:
C27H37ClN2O5
Molecular Weight:
505.0461
MDL Number:
MFCD00929899
SMILES:
COc1cc2C[C@@H](c2cc1OC)CN(CCCN1CCc2c(CC1=O)cc(c(c2)OC)OC)C.Cl
Properties
Properties
 
BP:
626.9°C at 760mmHg  
Form:
Solid  
MP:
193-196?C  
Solubility:
H2O: ≥5mg/mL (warmed)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
663  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  

Literature

Title: Ivabradine: A Unique and Intriguing Medication for Treating Cardiovascular Disease.

Journal: Cardiology in review 20150101

Title: An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure.

Journal: Expert opinion on drug metabolism & toxicology 20140201

Title: Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.

Journal: Heart rhythm 20131101

Title: Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.

Journal: Journal of cardiovascular electrophysiology 20130801

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Ivabradine in systemic sclerosis related pulmonary arterial hypertension.

Journal: European journal of internal medicine 20121201

Title: Ivabradine: a ray of hope for inappropriate sinus tachycardia.

Journal: Journal of the American College of Cardiology 20121009

Title: Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation.

Journal: Journal of the American College of Cardiology 20121009

Title: Ivabradine for chronic heart failure?

Journal: Drug and therapeutics bulletin 20121001

Title: [New pharmacological approaches to ischemic heart disease].

Journal: Giornale italiano di cardiologia (2006) 20121001

Title: Ivabradine reduces total hospital burden in heart failure.

Journal: Cardiovascular journal of Africa 20121001

Title: Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat.

Journal: Human & experimental toxicology 20120901

Title: Beneficial effect of ivabradine in dilated cardiomyopathy from Becker muscular dystrophy.

Journal: Herz 20120901

Title: Lasting reduction of heart transplant tachycardia with ivabradine is effective and well tolerated: results of 48-month study.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20120801

Title: Pharmacokinetic interaction between ivabradine and phenytoin in healthy subjects.

Journal: Clinical drug investigation 20120801

Title: Safety and efficacy of oral ivabradine as a heart rate-reducing agent in patients undergoing CT coronary angiography.

Journal: The British journal of radiology 20120801

Title: Safe and well-tolerated treatment with ivabradine in systemic sclerosis affected by pulmonary hypertension.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20120701

Title: Treating stable angina - is there a NICE way towards an international consensus?

Journal: International journal of clinical practice 20120701

Title: The 2012 ESC Guidelines on Heart Failure.

Journal: European heart journal 20120701

Title: Anti-inflammatory effects of ivabradine in patients with acute coronary syndrome: a pilot study.

Journal: International journal of cardiology 20120628

Title: Role of heart rate as a marker and mediator of poor outcome for patients with heart failure.

Journal: Current heart failure reports 20120601

Title: Differential effects of ivabradine and ryanodine on pacemaker activity in canine sinus node and purkinje fibers.

Journal: Journal of cardiovascular electrophysiology 20120601

Title: Heart rate-lowering efficacy and respiratory safety of ivabradine in patients with obstructive airway disease: a randomized, double-blind, placebo-controlled, crossover study.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20120601

Title: [Ivabradine: heart rate reduction in coronary heart disease and chronic heart failure].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20120601

Title: Recent developments in the management of heart failure.

Journal: The Practitioner 20120601

Title: Effects on outcomes of heart rate reduction by ivabradine in patients with congestive heart failure: is there an influence of beta-blocker dose?: findings from the SHIFT (Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial) study.

Journal: Journal of the American College of Cardiology 20120529

Title: It is all about heart rate. Or is it?

Journal: Journal of the American College of Cardiology 20120529

Title: Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.

Journal: European heart journal 20120501

Title: Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20120501

Title: Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure.

Journal: European heart journal 20120501

Title: Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade.

Journal: Hypertension (Dallas, Tex. : 1979) 20120501

Title: Heart rate reduction: an old and novel candidate heart failure therapy.

Journal: Hypertension (Dallas, Tex. : 1979) 20120501

Title: The biological effects of ivabradine in cardiovascular disease.

Journal: Molecules (Basel, Switzerland) 20120430

Title: Incremental value and safety of oral ivabradine for heart rate reduction in computed tomography coronary angiography.

Journal: International journal of cardiology 20120405

Title: β-blockers in stage B: a precursor of heart failure.

Journal: Heart failure clinics 20120401

Title: Effect of ivabradine vs atenolol on heart rate and effort tolerance in patients with mild to moderate mitral stenosis and normal sinus rhythm.

Journal: Journal of cardiac failure 20120401

Title: [Update coronary artery disease: important progresses in acute and chronic therapy].

Journal: MMW Fortschritte der Medizin 20120322

Title: Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression.

Journal: British journal of pharmacology 20120301

Title: Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia.

Journal: Journal of cardiovascular pharmacology 20120301

Title: Effects of ivabradine on the pulmonary vein electrical activity and modulation of pacemaker currents and calcium homeostasis.

Journal: Journal of cardiovascular electrophysiology 20120201

Title: The funny current (If): is it a novel antiarrhythmic target to treat atrial fibrillation?

Journal: Journal of cardiovascular electrophysiology 20120201

Title: Increased time varying heart rate and cardiovascular risk in hypertension: benefit of selective I((f)) channel inhibitor?

Journal: Blood pressure 20120201

Title: Effects of ivabradine on heart rate and left ventricular function in healthy cats and cats with hypertrophic cardiomyopathy.

Journal: American journal of veterinary research 20120201

Title: Ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography.

Journal: The American journal of cardiology 20120115

Title: Dose-dependent protective effect of ivabradine against ischemia-reperfusion-induced renal injury in rats.

Journal: Kidney & blood pressure research 20120101

Title: [Efficacy of ivabradine in patients with stable angina and comorbid chronic obstructive pulmonary disease].

Journal: Kardiologiia 20120101

Title: [The SHIFT study: a shift in a correct direction].

Journal: Kardiologiia 20120101

Title: Effects of treatment with ivabradine and atenolol on reproducibility of echocardiographic indices of left heart size and function in healthy cats.

Journal: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20120101

Title: Acquired haemophilia secondary to ivabradine presenting with acute respiratory distress syndrome.

Journal: BMJ case reports 20120101

Title: Concomitant administration of different doses of simvastatin with ivabradine influence on PAI-1 and heart rate in normo- and hypercholesterolaemic rats.

Journal: TheScientificWorldJournal 20120101

Title: Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice.

Journal: Journal of vascular research 20120101

Title: Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis.

Journal: PloS one 20120101

Title: [Pharmacological correction of heart rate in myocardial ischemia].

Journal: Terapevticheskii arkhiv 20120101

Title: The 'funny' current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.

Journal: Molecules (Basel, Switzerland) 20120101

Title: [Effect of ivabradine on pulmonary hypertension in chronic obstructive pulmonary disease].

Journal: Kardiologiia 20120101

Title: [Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and health related quality of life: results from the SHIFT substudies].

Journal: Vnitrni lekarstvi 20120101

Title: Ivabradine and nightmares: a previously unreported adverse reaction.

Journal: European journal of clinical pharmacology 20111201

Title: Efficacy of ivabradine in combination with Beta-blocker versus uptitration of Beta-blocker in patients with stable angina.

Journal: Cardiovascular drugs and therapy 20111201

Title: Limited role for ivabradine in the treatment of chronic heart failure.

Journal: Heart (British Cardiac Society) 20111201

Title: Beta-blocker dose up-titration or addition of ivabradine in stable angina: more is not necessarily better : editorial to: 'efficacy of ivabradine in combination with beta-blocker versus uptitration of beta-blocker in patients with stable angina' by E. Amosova et al.

Journal: Cardiovascular drugs and therapy 20111201

Title: Pharmacodynamic effects of ivabradine, a negative chronotropic agent, in healthy cats.

Journal: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20111201

Title: Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice.

Journal: American journal of physiology. Heart and circulatory physiology 20111101

Title: Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.

Journal: Basic research in cardiology 20111101

Title: Natural history of end-stage LV dysfunction: has it improved from the classic Franciosa and Cohn Graph?

Journal: Cardiology clinics 20111101

Title: [Ivabradine (pure heart-rate-lowering agent)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20111101

Title: Electrophysiological effects of ivabradine in dog and human cardiac preparations: potential antiarrhythmic actions.

Journal: European journal of pharmacology 20111015

Title: Pharmacokinetics of oral ivabradine in healthy cats.

Journal: Journal of veterinary pharmacology and therapeutics 20111001

Title: Reducing elevated heart rate in patients with multiple organ dysfunction syndrome by the I (f) (funny channel current) inhibitor ivabradine : MODI (f)Y trial.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20111001

Title: Left ventricular remodelling in systolic heart failure using ivabradine. Slower is smaller is better?

Journal: European heart journal 20111001

Title: Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy.

Journal: European heart journal 20111001

Title: Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study.

Journal: European heart journal 20111001

Title: The importance of reducing heart rate in cardiovascular diseases: effects of Ivabradine.

Journal: Minerva medica 20111001

Title: Effect of Carvedilol, Ivabradine or their combination on exercise capacity in patients with Heart Failure (the CARVIVA HF trial).

Journal: International journal of cardiology 20110901

Title: A pediatric case of cardiomyopathy induced by inappropriate sinus tachycardia: efficacy of ivabradine.

Journal: Pediatric cardiology 20110801

Title: Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: role of myocyte structure and myocardial perfusion.

Journal: Resuscitation 20110801

Title: Ivabradine, a novel heart rate slower: is it a sword of double blades in patients with idiopathic dilated cardiomyopathy?

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110801

Title: Medical therapy versus myocardial revascularization in chronic coronary syndrome and stable angina.

Journal: The American journal of medicine 20110801

Title: Selective and specific I(f) inhibition with ivabradine: new perspectives for the treatment of cardiovascular disease.

Journal: Expert review of cardiovascular therapy 20110801

Title: [New agents for the therapy of angina pectoris].

Journal: Der Internist 20110701

Title: [Angina pectoris: improving symptoms and prognosis. With ivabradine less angina pectoris and reduced need for nitrates].

Journal: MMW Fortschritte der Medizin 20110616

Title: [Reducing heart rate to treat angina pectoris].

Journal: Revue medicale suisse 20110608

Title: Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice.

Journal: Stroke 20110601

Title: Ivabradine added to guidelines-based therapy in systolic heart failure patients.

Journal: Internal and emergency medicine 20110601

Title: Heart rate: a forgotten link in coronary artery disease?

Journal: Nature reviews. Cardiology 20110426

Title: Pharmacokinetic interaction between ivabradine and carbamazepine in healthy volunteers.

Journal: Journal of clinical pharmacy and therapeutics 20110401

Title: [Heart failure].

Journal: Deutsche medizinische Wochenschrift (1946) 20110401

Title: [New therapeutic approaches in heart failure].

Journal: Deutsche medizinische Wochenschrift (1946) 20110401

Title: The use of ivabradine for inappropriate sinus tachycardia.

Journal: Acta cardiologica 20110401

Title: Safety of ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter Substudy).

Journal: The American journal of cardiology 20110315

Title: Reversal of tachycardiomyopathy due to left atrial tachycardia by ivabradine.

Journal: Journal of cardiovascular electrophysiology 20110301

Title: Single centre experience of ivabradine in postural orthostatic tachycardia syndrome.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110301

Title: Ivabradine improves coronary flow reserve in patients with stable coronary artery disease.

Journal: Atherosclerosis 20110301

Title: Ivabradine: an hypothesis generating study--an important link between bench and bedside.

Journal: Atherosclerosis 20110301

Title: Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20110301

Title: Ivabradine in the treatment of orthostatic intolerance.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110301

Title: Innovation in coronary artery disease and heart failure: clinical benefits of pure heart rate reduction with ivabradine.

Journal: Annals of the New York Academy of Sciences 20110301

Title: Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL.

Journal: International journal of cardiology 20110203

Title: Ivabradine for the treatment of stable angina pectoris in octogenarians.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20110201

Title: [Postural orthostatic tachycardia syndrome: current concepts in pathophysiology, diagnosis and therapeutic options].

Journal: Fortschritte der Neurologie-Psychiatrie 20110201

Title: Ivabradine: recent and potential applications in clinical practice.

Journal: Expert opinion on pharmacotherapy 20110201

Title: Heart rate decrease: a new paradigm in the treatment of heart failure. Insights from the SHIFT study.

Journal: Archives of cardiovascular diseases 20110201

Title: Reversal of cardiomyopathy with ivabradine.

Journal: Internal medicine journal 20110201

Title: Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling.

Journal: American journal of physiology. Heart and circulatory physiology 20110101

Title: Heart rate and heart failure. Not a simple relationship.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20110101

Title: Rate control with ivabradine: angina pectoris and beyond.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20110101

Title: [Ivabradine].

Journal: Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec 20110101

Title: Comparison of the effects of ivabradine and atenolol on heart rate and echocardiographic variables of left heart function in healthy cats.

Journal: Journal of veterinary internal medicine 20110101

Title: [The SHIFT study].

Journal: Giornale italiano di cardiologia (2006) 20110101

Title: Spironolactone diminishes spontaneous ventricular premature beats by reducing HCN4 protein expression in rats with myocardial infarction.

Journal: Molecular medicine reports 20110101

Title: [From results of BEAUTIFUL trial to results of SHIFT trial: BEAUTIFUL possibility to make a SHIFT in current guidelines].

Journal: Kardiologiia 20110101

Title: Heart failure: ivabradine is no better than optimised beta-blocker therapy.

Journal: Prescrire international 20110101

Title: Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets.

Journal: Current medicinal chemistry 20110101

Title: Cardioprotection by ivabradine through heart rate reduction and beyond.

Journal: Journal of cardiovascular pharmacology and therapeutics 20110101

Title: New data support ivabradine use in chronic heart failure.

Journal: Cardiovascular journal of Africa 20110101

Title: [Alternative therapy with ivabradine in patients with functional class III chronic heart failure].

Journal: Kardiologiia 20110101

Title: [Efficacy of ivabradin in combined treatment of patients with postinfarction systolic chronic cardiac failure].

Journal: Terapevticheskii arkhiv 20110101

Title: Ivabradine and outcomes in chronic heart failure.

Journal: Lancet (London, England) 20101218

Title: Ivabradine and outcomes in chronic heart failure.

Journal: Lancet (London, England) 20101218

Title: Use of ivabradine in catecholamine-induced tachycardia after high-risk cardiac surgery.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20101201

Title: Ivabradine in patients with inappropriate sinus tachycardia.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20101201

Title: Benefit of heart rate reduction in heart failure.

Journal: Current heart failure reports 20101201

Title: Impact of ''off-label'' use of ivabradine on exercise capacity, gas exchange, functional class, quality of life, and neurohormonal modulation in patients with ischemic chronic heart failure.

Journal: Journal of cardiovascular pharmacology and therapeutics 20101201

Title: Heart failure: A SHIFT from ion channels to clinical practice.

Journal: Nature reviews. Cardiology 20101201

Title: Ivabradine in combination with a beta-blocker. Stable angina: do not use instead, of or, with a beta-blocker.

Journal: Prescrire international 20101201

Title: Clinical trials update from the European Society of Cardiology Meeting 2010: SHIFT, PEARL-HF, STAR-heart, and HEBE-III.

Journal: European journal of heart failure 20101101

Title: [Clinical study SHIFT-- ivabradine--a new therapeutic options.].

Journal: Kardiologia polska 20101101

Title: Stable angina: role of ivabradine unchanged between 2006 and 2010.

Journal: Prescrire international 20101101

Title: [Patients with cardiovascular risk. SH/fT study: mortality rate reduced by a fourth].

Journal: MMW Fortschritte der Medizin 20101007

Title: Ivabradine in combination with beta-blocker therapy for the treatment of stable angina pectoris in every day clinical practice.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20101001

Title: Safety and effectiveness of ivabradine after cardiac transplantation.

Journal: Transplantation proceedings 20101001

Title: [Clinical-hemodynamic and anti-ischemic effects ivabradine and nebivolol ischemic heart disease with left ventricular dysfunction].

Journal: Georgian medical news 20101001

Title: [Ivabradine as treatment of inappropriate sinus tachycardia].

Journal: Medicina clinica 20100918

Title: [Heart failure. Heart rate control prevents clinical complications].

Journal: MMW Fortschritte der Medizin 20100916

Title: Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial.

Journal: Lancet (London, England) 20100911

Title: Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.

Journal: Lancet (London, England) 20100911

Title: Ivabradine in heart failure--no paradigm SHIFT…yet.

Journal: Lancet (London, England) 20100911

Title: Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice.

Journal: Atherosclerosis 20100901

Title: Ivabradine: appropriate treatment for inappropriate sinus tachycardia.

Journal: Heart rhythm 20100901

Title: Efficacy of ivabradine administration in patients affected by inappropriate sinus tachycardia.

Journal: Heart rhythm 20100901

Title: [Antianginal efficacy of ivabradine in a very old patient with aortic stenosis: effects on cardiac output and transvalvular aortic gradients].

Journal: Giornale italiano di cardiologia (2006) 20100901

Title: Conventional and novel drug therapeutics to relief myocardial ischemia.

Journal: Cardiovascular drugs and therapy 20100801

Title: Inappropriate sinus tachycardia - successful treatment with ivabradine.

Journal: Kardiologia polska 20100801

Title: A case of inappropriate sinus tachycardia after atrio-ventricular nodal reentrant tachycardia cryoablation successfully treated by ivabradine.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20100701

Title: Efficacy of ivabradine in a case of inappropriate sinus tachycardia and ventricular dysfunction.

Journal: Journal of cardiovascular electrophysiology 20100701

Title: Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.

Journal: European heart journal 20100601

Title: Ivabradine as a heart rate-lowering agent in a patient with end-stage renal failure after heart transplantation.

Journal: Kardiologia polska 20100601

Title: Successful use of ivabradine in a case of exaggerated autonomic dysfunction.

Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20100601

Title: [Stable angina pectoris. Effective symptom control and cardioprotection with ivabradine].

Journal: MMW Fortschritte der Medizin 20100527

Title: Chronic heart rate reduction facilitates cardiomyocyte survival after myocardial infarction.

Journal: Anatomical record (Hoboken, N.J. : 2007) 20100501

Title: Ivabradine versus bisoprolol.

Journal: Minerva cardioangiologica 20100401

Title: Heart rate in ischemic heart disease. The innovation of ivabradine: more than pure heart rate reduction.

Journal: Advances in therapy 20100401

Title: Comparison of ivabradine plus beta-blockers versus beta -blocker therapy only.

Journal: Cardiovascular journal of Africa 20100401

Title: Ivabradine to treat inappropriate sinus tachycardia after the fast pathway ablation in a patient with severe pectus excavatum.

Journal: Pacing and clinical electrophysiology : PACE 20100301

Title: Ivabradine: from molecular basis to clinical effectiveness.

Journal: Advances in therapy 20100301

Title: [Heart rate: a risk factor or an epiphenomenon?].

Journal: Giornale italiano di cardiologia (2006) 20100301

Title: The role of the funny current in pacemaker activity.

Journal: Circulation research 20100219

Title: Effect of HCN channel inhibition on retinal morphology and function in normal and dystrophic rodents.

Journal: Investigative ophthalmology & visual science 20100201

Title: Specific inhibition of HCN channels slows rhythm differently in atria, ventricle and outflow tract and stabilizes conduction in the anoxic-reoxygenated embryonic heart model.

Journal: Pharmacological research 20100101

Title: Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT).

Journal: European journal of heart failure 20100101

Title: Funny channel-based pacemaking.

Journal: Heart rhythm 20100101

Title: Efficacy of ivabradine, a selective I(f) inhibitor, in patients with chronic stable angina pectoris and diabetes mellitus.

Journal: The American journal of cardiology 20100101

Title: [Ivabradine in the treatment of patients with angina pectoris: lessons of the BEAUTIFUL trial].

Journal: Kardiologiia 20100101

Title: [Efficacy of ivabradine in combination therapy for complicated acute coronary syndrome in patients with type 2 diabetes mellitus].

Journal: Terapevticheskii arkhiv 20100101

Title: Efficacy of ivabradine in four patients with inappropriate sinus tachycardia: a three month-long experience based on electrocardiographic, Holter monitoring, exercise tolerance and quality of life assessments.

Journal: Cardiology journal 20100101

Title: [Effect of the I(f) channel blocker ivabradine on the parameters of external respiration function in patients with chronic obstructive pulmonary disease in its stable course period].

Journal: Terapevticheskii arkhiv 20100101

Title: [Study evaluating the impact of a combination of inotropic support and heart rate control on prognosis and stabilization rate in patients with decompensated chronic heart failure (LEGION)].

Journal: Terapevticheskii arkhiv 20100101

Title: [Investigation of pacemaker shift in the rabbit sinoatrial node using the optical mapping technique].

Journal: Biofizika 20100101

Title: Cardiogenic shock due to tachycardiomyopathy after heart transplantation: successful treatment with ivabradine.

Journal: Cardiology 20100101

Title: [Application of cardiac resynchronization therapy and ivabradine in a patient with chronic heart failure].

Journal: Kardiologiia 20100101

Title: [Possibilities of if channels inhibitor ivabradine in complex treatment of survivors of myocardial infarction with stable angina].

Journal: Kardiologiia 20100101

Title: I(f) inhibition in cardiovascular diseases.

Journal: Advances in pharmacology (San Diego, Calif.) 20100101

Title: Inotropic effects of ivabradine in the mammalian heart.

Journal: Pharmacology 20100101

Title: SHIFTING the burden of heart failure.

Journal: Cardiovascular journal of Africa 20100101

Title: [Dynamics of structural functional parameters of cardiovascular system in patients with Stable Angina and Congestive Heart Failure treated with Ivabradine for six months].

Journal: Kardiologiia 20100101

Title: [The efficacy and safety of the combination of β-blocker bisoprolol and if inhibitor I(f) ivabradine in patients with stable angina and chronic obstructive pulmonary disease].

Journal: Kardiologiia 20100101

Title: [Ivabradine in coronary heart disease: experimental and clinical pharmacology].

Journal: Therapie 20100101

Title: Ivabradine reduces chemokine-induced CD4-positive lymphocyte migration.

Journal: Mediators of inflammation 20100101

Title: Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis.

Journal: Cardiology 20100101

Title: [Antianginal efficacy and tolerability of ivabradine in the therapy of patients with stable angina: results of the CONTROL study].

Journal: Kardiologiia 20100101

Title: Comparison of ivabradine versus metoprolol in early phases of reperfused anterior myocardial infarction with impaired left ventricular function: preliminary findings.

Journal: Journal of cardiac failure 20091201

Title: Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart.

Journal: Cardiovascular research 20091001

Title: Vascular endothelial ageing, heartbeat after heartbeat.

Journal: Cardiovascular research 20091001

Title: 'Funny' current: if heart rate slowing is not the best answer, what might be?

Journal: Cardiovascular research 20091001

Title: Effects of selective I f-channel inhibition with ivabradine on hemodynamics in a patient with restrictive cardiomyopathy.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20091001

Title: Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial.

Journal: European heart journal 20091001

Title: A BEAUTIFUL lesson--ivabradine protects from ischaemia, but not from heart failure: through heart rate reduction or more?

Journal: European heart journal 20091001

Title: Treatment of stable angina pectoris by ivabradine in every day practice: the REDUCTION study.

Journal: American heart journal 20091001

Title: Arrhythmic effects of ivabradine in patients with coronary artery disease.

Journal: Clinical and investigative medicine. Medecine clinique et experimentale 20091001

Title: New pharmacological agents for arrhythmias.

Journal: Circulation. Arrhythmia and electrophysiology 20091001

Title: Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients.

Journal: Transplantation 20090927

Title: Effect of ivabradine in dobutamine induced sinus tachycardia in a case of acute heart failure.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20090801

Title: Postmyocardial infarction remodeling and coronary reserve: effects of ivabradine and beta blockade therapy.

Journal: American journal of physiology. Heart and circulatory physiology 20090701

Title: A case of cardiomyopathy induced by inappropriate sinus tachycardia and cured by ivabradine.

Journal: Pacing and clinical electrophysiology : PACE 20090701

Title: Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction.

Journal: Trends in cardiovascular medicine 20090701

Title: Randomised, double-blind, placebo-controlled trial of ivabradine in patients with acute coronary syndrome: effects of the If current inhibitor ivabradine on reduction of inflammation markers in patients with acute coronary syndrome--RIVIERA trial study design and rationale.

Journal: Cardiovascular drugs and therapy 20090601

Title: [Ivabradine, an I(f) current inhibitor--new treatment options in coronary heart disease].

Journal: Revue medicale suisse 20090527

Title: Angina: Ivabradine for treatment of stable angina pectoris.

Journal: Nature reviews. Cardiology 20090501

Title: Ivabradine as a treatment option for inappropriate sinus tachycardia.

Journal: Revista espanola de cardiologia 20090501

Title: [Ivabradine - a new therapeutic option for cardiogenic shock?].

Journal: Herz 20090501

Title: [Ivabradine in patients with stable ischemic heart disease and left ventricular systolic dysfunction: the results of the BEAUTIFUL study].

Journal: Vnitrni lekarstvi 20090501

Title: Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors.

Journal: Investigative ophthalmology & visual science 20090401

Title: Interpreting clinical trials: the 'beautiful' case.

Journal: Fundamental & clinical pharmacology 20090401

Title: Ivabradine - the beauty of a slow heart rate.

Journal: International journal of clinical practice 20090401

Title: [The BEAUTIFUL study].

Journal: Giornale italiano di cardiologia (2006) 20090401

Title: Multiple coronary to left ventricular fistulae.

Journal: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20090301

Title: Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

Journal: Journal of molecular and cellular cardiology 20090301

Title: Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial.

Journal: European heart journal 20090301

Title: A new combination therapy in stable angina pectoris.

Journal: European heart journal 20090301

Title: Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20090201

Title: Focus on ivabradine: a new heart rate-controlling drug.

Journal: Expert review of cardiovascular therapy 20090201

Title: Review of the If selective channel inhibitor ivabradine in the treatment of chronic stable angina.

Journal: Advances in therapy 20090201

Title: Ca2+: is there something new for the cardiovascular anesthesiologist?

Journal: Current opinion in anaesthesiology 20090201

Title: Influence of heart rate reduction on Doppler myocardial imaging parameters in a small animal model.

Journal: Ultrasound in medicine & biology 20090101

Title: Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure.

Journal: Journal of cardiovascular pharmacology 20090101

Title: Treatment of inappropriate sinus tachycardia with ivabradine in a patient with postural orthostatic tachycardia syndrome and a dual chamber pacemaker.

Journal: Pacing and clinical electrophysiology : PACE 20090101

Title: Ivabradine: cardiovascular effects.

Journal: Recent patents on cardiovascular drug discovery 20090101

Title: Ivabradine: beyond heart rate control.

Journal: Advances in therapy 20090101

Title: [Antianginal effect of long-term use of ivabradine in patients with ischemic heart disease and diabetes in ambulatory conditions].

Journal: Kardiologiia 20090101

Title: Ivabradine - a first-in-its-class treatment for lowering heart rate.

Journal: Cardiovascular journal of Africa 20090101

Title: Effect of ivabradine, a novel antianginal agent, on driving performance: A randomized, double-blind, placebo-controlled trial in healthy volunteers.

Journal: Clinical drug investigation 20090101

Title: [Heart rate control: f-channel blockers].

Journal: Fiziologiia cheloveka 20090101

Title: Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris.

Journal: Cardiology 20090101

Title: Heart rate as a treatable cardiovascular risk factor.

Journal: British medical bulletin 20090101

Title: Heart rate in coronary syndromes and heart failure.

Journal: Progress in cardiovascular diseases 20090101

Title: Elevated heart rate in cardiovascular diseases: a target for treatment?

Journal: Progress in cardiovascular diseases 20090101

Title: [Efficacy of therapy with bisoprolol and ivabradine in patients with ischemic heart disease combined with chronic obstructive pulmonary disease assessment of parameters of 24-hour ECG monitoring].

Journal: Kardiologiia 20090101

Title: [Heart rate reduction: beneficial effects in heart failure and post-infarcted myocardium].

Journal: Therapie 20090101

Title: Impact of a pure reduction in heart rate for the treatment of left ventricular dysfunction: clinical benefits of ivabradine in the BEAUTIFUL trial.

Journal: Therapie 20090101

Title: Lessons from the BEAUTIfUL trial.

Journal: Cardiovascular journal of Africa 20090101

Title: Ivabradine use in refractory unstable angina: a case report.

Journal: International journal of immunopathology and pharmacology 20090101

Title: Ivabradine reduces cardiovascular events in angina patients.

Journal: Cardiovascular journal of Africa 20090101

Title: Treatment of inappropriate sinus tachycardia with ivabradine.

Journal: Wiener klinische Wochenschrift 20090101

Title: Role of heart rate in cardiovascular diseases: how the results of the BEAUTIFUL study change clinical practice.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

Title: Ivabradine in heart failure: what about digoxin?

Journal: Lancet (London, England) 20081220

Title: Pleiotropic action(s) of the bradycardic agent ivabradine: cardiovascular protection beyond heart rate reduction.

Journal: British journal of pharmacology 20081201

Title: Clinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HF.

Journal: European journal of heart failure 20081201

Title: Ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study.

Journal: Journal of cardiovascular pharmacology 20081201

Title: Effects of ivabradine on allograft function and exercise performance in heart transplant recipients with permanent sinus tachycardia.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20081101

Title: Ivabradine for stable angina?

Journal: Drug and therapeutics bulletin 20081101

Title: Ivabradine: pharmacodynamic aspects of its clinical use.

Journal: Methods and findings in experimental and clinical pharmacology 20081001

Title: [Coronary heart disease. Rapid heart rate has an unfavorable prognosis].

Journal: MMW Fortschritte der Medizin 20080918

Title: Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial.

Journal: Lancet (London, England) 20080906

Title: Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial.

Journal: Lancet (London, England) 20080906

Title: BEAUTIFUL results--the slower, the better?

Journal: Lancet (London, England) 20080906

Title: Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction.

Journal: European heart journal 20080901

Title: Chronic stable angina pectoris.

Journal: Disease-a-month : DM 20080901

Title: [What are the alternatives to betablockers in 2009?].

Journal: Revue medicale de Bruxelles 20080901

Title: Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart.

Journal: Cardiovascular research 20080701

Title: Absence of respiratory effects with ivabradine in patients with asthma.

Journal: British journal of clinical pharmacology 20080701

Title: Direct evidence for calcium conductance of hyperpolarization-activated cyclic nucleotide-gated channels and human native If at physiological calcium concentrations.

Journal: Cardiovascular research 20080601

Title: Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice.

Journal: British journal of pharmacology 20080601

Title: Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function.

Journal: British journal of pharmacology 20080601

Title: Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure.

Journal: European journal of heart failure 20080601

Title: [Is resting heart rate a cardiovascular risk factor?].

Journal: Praxis 20080528

Title: [Resting heart rate as prognostic parameter--a slow rate indicates strength].

Journal: MMW Fortschritte der Medizin 20080522

Title: Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice.

Journal: Circulation 20080506

Title: Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents.

Journal: British journal of pharmacology 20080401

Title: The role of heart rate reduction in angina management and beyond.

Journal: British journal of hospital medicine (London, England : 2005) 20080401

Title: [Ivabradine (Procoralan)].

Journal: Revue medicale de Liege 20080401

Title: Ivabradine: I(f) inhibition in the management of stable angina pectoris and other cardiovascular diseases.

Journal: Drugs of today (Barcelona, Spain : 1998) 20080301

Title: HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade.

Journal: Heart rhythm 20080201

Title: [Effect of ivabradin on mechanism of inter-ventricle interaction and respiratory function in conditions of cardio-respiratory pathology (results of Russian pilot study)].

Journal: Voenno-meditsinskii zhurnal 20080201

Title: Effect of long-term heart rate reduction by If current inhibition on pressure overload-induced heart failure in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: Ivabradine as an alternative therapeutic trial in the therapy of inappropriate sinus tachycardia: a case report.

Journal: Cardiology 20080101

Title: I f inhibition with ivabradine : electrophysiological effects and safety.

Journal: Drug safety 20080101

Title: Does ivabradine exhibit a role in the reduction of bladder overactivity?

Journal: International urology and nephrology 20080101

Title: [Clinical efficacy of ivabradine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].

Journal: Kardiologiia 20080101

Title: [The program ALTERNATIVA--investigation of antianginal efficacy and tolerability of coraxan (ivabradine) and assessment of quality of life of patients with stable angina: results of an epidemiological stage].

Journal: Kardiologiia 20080101

Title: [The role of beta-adrenoblockers and If-inhibitor ivabradine in lowering of rate of development of cardiac complications after carotid endarterectomy].

Journal: Kardiologiia 20080101

Title: [Comparative efficacy of ivabradine and atenolol in correction of clinical and functional parameters in patients with stable effort angina].

Journal: Kardiologiia 20080101

Title: [Clinical efficiency of ivabradine in patients with cardiorespiratory pathology].

Journal: Klinicheskaia meditsina 20080101

Title: The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction - baseline characteristics of the study population.

Journal: Cardiology 20080101

Title: [Experience of the use of ivabradine in clinical practice].

Journal: Kardiologiia 20080101

Title: [Possibilities of the use of ivabradine in complex therapy acute coronary syndrome].

Journal: Kardiologiia 20080101

Title: Characterization of the heart rate-lowering action of ivabradine, a selective I(f) current inhibitor.

Journal: American journal of therapeutics 20080101

Title: Elevated heart rate proven to increase coronary events.

Journal: Cardiovascular journal of Africa 20080101

Title: Going for gold, from Beijing to Munich, highlights from the ESC 2008 Congress: BEAUTIFUL, GISSI-HF, and potential new therapies for acute decompensated heart failure.

Journal: Cardiovascular therapeutics 20080101

Title: Letters to the editor: comments on the BEAUTIfUL study.

Journal: Cardiovascular journal of Africa 20080101

Title: [Effect of ivabradin and clopidogrel on platelet hemostasis indices in patients with acute coronary syndrome without ST-segment elevation and with concurrent cardiac insufficiency].

Journal: Likars'ka sprava 20080101

Title: [Clinical efficacy of ivabradin and nebivolol addition in combined treatment of ischemic heart disease patients with left ventricular dysfunction].

Journal: Terapevticheskii arkhiv 20080101

Title: Symptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradine.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20071201

Title: The heart rate-lowering agent ivabradine inhibits the pacemaker current I(f) in human atrial myocytes.

Journal: Journal of cardiovascular electrophysiology 20071101

Title: Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradine.

Journal: Transplantation 20071027

Title: Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen.

Journal: American journal of physiology. Heart and circulatory physiology 20070701

Title: Ivabradine: a new strategy for management of stable angina.

Journal: British journal of hospital medicine (London, England : 2005) 20070601

Title: [Heart rate as a cardiovascular risk factor: potential clinical benefit with ivabradine].

Journal: Revue medicale suisse 20070530

Title: Heart rate reduction via selective 'funny' channel blockers.

Journal: Current opinion in pharmacology 20070401

Title: Selective inhibition of the pacemaker channel I(f) improves symptoms in severe dilated cardiomyopathy.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20070401

Title: Conversion of post-systolic wall thickening into ejectional thickening by selective heart rate reduction during myocardial stunning.

Journal: European heart journal 20070401

Title: I(f) current and heart rate control.

Journal: Arquivos brasileiros de cardiologia 20070401

Title: Heart rate reduction by inhibition of If or by beta-blockade has different effects on postsystolic wall thickening.

Journal: British journal of pharmacology 20070201

Title: Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.

Journal: Clinical cardiology 20070201

Title: Heart failure management. Interview with Karl Swedberg.

Journal: Timely topics in medicine. Cardiovascular diseases 20070109

Title: Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity.

Journal: British journal of pharmacology 20070101

Title: Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial.

Journal: Drugs 20070101

Title: Long-term safety and efficacy of ivabradine in patients with chronic stable angina.

Journal: Cardiology 20070101

Title: If inhibition by Ivabradine. Foreword.

Journal: Drugs 20070101

Title: The funny current: cellular basis for the control of heart rate.

Journal: Drugs 20070101

Title: Preclinical results with I(f) current inhibition by ivabradine.

Journal: Drugs 20070101

Title: Clinical results of I(f) current inhibition by ivabradine.

Journal: Drugs 20070101

Title: Perspectives of I(f) inhibition by ivabradine in cardiology.

Journal: Drugs 20070101

Title: [Selective and specific reduction in the heart rate: a promising direction in the creation of new cardiovascular drugs].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20070101

Title: [New drugs; ivabradine].

Journal: Nederlands tijdschrift voor geneeskunde 20061202

Title: Comparison of a beta-blocker and an If current inhibitor in rabbits with myocardial infarction.

Journal: The Journal of cardiovascular surgery 20061201

Title: [Heart rate reduction as a therapeutic strategy: novel options].

Journal: Der Internist 20061201

Title: [Ivabradine--a medical alternative for patients with chronic stable angina pectoris].

Journal: Ugeskrift for laeger 20061113

Title: Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction: the morBidity-mortality EvAlUaTion of the I(f) inhibitor ivabradine in patients with coronary disease and left ventricULar dysfunction (BEAUTIFUL) study.

Journal: American heart journal 20061101

Title: Ivabradine: a selective If current inhibitor in the treatment of stable angina.

Journal: Recent patents on cardiovascular drug discovery 20061101

Title: Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial.

Journal: Journal of clinical pharmacology 20061001

Title: Lack of pharmacokinetic interaction between omeprazole or lansoprazole and ivabradine in healthy volunteers: an open-label, randomized, crossover, pharmacokinetic interaction clinical trial.

Journal: Journal of clinical pharmacology 20061001

Title: Heart rate lowering by inhibition of the pacemaker current: a new therapeutic perspective in cardiovascular disease.

Journal: Cardiovascular & hematological agents in medicinal chemistry 20061001

Title: Selective and specific I(f) inhibition: new perspectives for the treatment of stable angina.

Journal: Expert opinion on pharmacotherapy 20060601

Title: Therapeutic effects of I(f) blockade: evidence and perspective.

Journal: Pharmacological research 20060501

Title: The discovery of the selective I(f) current inhibitor ivabradine. A new therapeutic approach to ischemic heart disease.

Journal: Pharmacological research 20060501

Title: Funny channels in the control of cardiac rhythm and mode of action of selective blockers.

Journal: Pharmacological research 20060501

Title: Anti-ischaemic effect of ivabradine.

Journal: Pharmacological research 20060501

Title: Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.

Journal: The Journal of physiology 20060415

Title: Bradycardic and proarrhythmic properties of sinus node inhibitors.

Journal: Molecular pharmacology 20060401

Title: [Possibilities of reducing heart rate by I(f)-channel inhibitors].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20060322

Title: Comparative effects of ivabradine, a selective heart rate-lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise.

Journal: British journal of clinical pharmacology 20060201

Title: Evolving treatment strategies for chronic refractory angina.

Journal: Expert opinion on pharmacotherapy 20060201

Title: Ivabradine -- the first selective sinus node I(f) channel inhibitor in the treatment of stable angina.

Journal: International journal of clinical practice 20060201

Title: [Selective I(f) channel inhibition: an alternative for treating coronary artery disease?].

Journal: Herz 20060201

Title: Serious workings of the funny current.

Journal: Progress in biophysics and molecular biology 20060101

Title: [The discovery of the selective If current inhibitor ivabradine (Procoralan): a new therapeutic approach to ischemic heart disease].

Journal: Medecine sciences : M/S 20060101

Title: [A new medicine for treatment of stable angina pectoris].

Journal: Terapevticheskii arkhiv 20060101

Title: If current inhibition: cellular basis and physiology.

Journal: Advances in cardiology 20060101

Title: Heart rate reduction by pharmacological If current inhibition.

Journal: Advances in cardiology 20060101

Title: Clinical perspectives of heart rate slowing for coronary event reduction and heart failure.

Journal: Advances in cardiology 20060101

Title: Clinical effect of 'pure' heart rate slowing with a prototype If current inhibitor: placebo-controlled experience with ivabradine.

Journal: Advances in cardiology 20060101

Title: Heart rate slowing versus other pharmacological antianginal strategies.

Journal: Advances in cardiology 20060101

Title: Novel If current inhibitor ivabradine: safety considerations.

Journal: Advances in cardiology 20060101

Title: Heart rate slowing for myocardial dysfunction/heart failure.

Journal: Advances in cardiology 20060101

Title: Future directions: what data do we need?

Journal: Advances in cardiology 20060101

Title: [Ivabradine--the first selective and specific I(f) inhibitor, novel preparation for treatment of stable angina].

Journal: Kardiologiia 20060101

Title: [Ivabradin (coraxan). One more new approach to fighting myocardial ischemia in patients with ischemic heart disease].

Journal: Terapevticheskii arkhiv 20060101

Title: Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle.

Journal: Physiological genomics 20051214

Title: Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina.

Journal: European heart journal 20051201

Title: If at first you don't succeed try ... a new target in the treatment of angina.

Journal: European heart journal 20051201

Title: Physiology and pharmacology of the cardiac pacemaker ('funny') current.

Journal: Pharmacology & therapeutics 20050701

Title: Cardiac pacemaker I(f) current and its inhibition by heart rate-reducing agents.

Journal: Current medical research and opinion 20050701

Title: [Ivabradine -- a novel approach for heart rate lowering].

Journal: Deutsche medizinische Wochenschrift (1946) 20050617

Title: New agent ivabradine (Procoralan) for treatment of chronic stable angina.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20050101

Title: Drug insight: If inhibitors as specific heart-rate-reducing agents.

Journal: Nature clinical practice. Cardiovascular medicine 20041201

Title: Selective reduction of heart rate by ivabradine: effect on the visco-elastic arterial properties in rats.

Journal: Journal of hypertension 20040901

Title: I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities.

Journal: British journal of pharmacology 20040501

Title: Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure.

Journal: Circulation 20040406

Title: Heart rate reduction during exercise-induced myocardial ischaemia and stunning.

Journal: European heart journal 20040401

Title: Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs.

Journal: The Journal of pharmacology and experimental therapeutics 20040101

Title: Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.

Journal: Drugs 20040101

Title: Pharmacokinetics-pharmacodynamics during drug development--an example from Servier: ivabradine.

Journal: Therapie 20040101

Title: [Selection and pharmacological characterisation of Procoralan, a selective inhibitor of the pacemaker If current].

Journal: Therapie 20040101

Title: Heart rate reduction: a potential target for the treatment of myocardial ischaemia.

Journal: Therapie 20040101

Title: Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs.

Journal: Journal of cardiovascular pharmacology 20031101

Title: Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?

Journal: Journal of cardiovascular pharmacology and therapeutics 20030601

Title: Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial.

Journal: Circulation 20030218

Title: Contributions of heart rate and contractility to myocardial oxygen balance during exercise.

Journal: American journal of physiology. Heart and circulatory physiology 20030201

Title: Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology.

Journal: Drugs in R&D 20030101

Title: Effect of chronic heart rate reduction with ivabradine on carotid and aortic structure and function in normotensive and hypertensive rats.

Journal: Journal of vascular research 20030101

Title: A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction.

Journal: Cardiology 20030101

Title: Clinical trial simulation using therapeutic effect modeling: application to ivabradine efficacy in patients with angina pectoris.

Journal: Journal of pharmacokinetics and pharmacodynamics 20020801

Title: Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise.

Journal: American journal of physiology. Heart and circulatory physiology 20020201

Title: Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning.

Journal: The Journal of pharmacology and experimental therapeutics 20011201

Title: An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine.

Journal: Journal of pharmacokinetics and pharmacodynamics 20010201

Title: Optimal design of a population pharmacodynamic experiment for ivabradine.

Journal: Pharmaceutical research 20010101

Title: Tardif JC, et al. Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26(23):2529-36.

Title: Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105.

Title: Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512.

Title: Du XJ, et al. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142(1):107-12.

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Tags:148849-67-6 Molecular Formula|148849-67-6 MDL|148849-67-6 SMILES|148849-67-6 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)