Home Other Building Blocks 91940-87-3
91940-87-3,MFCD06798356
Catalog No.:AA006JAS

91940-87-3 | Zatebradine hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$152.00   $106.00
- +
10mg
≥95%
in stock  
$255.00   $178.00
- +
25mg
≥95%
in stock  
$555.00   $388.00
- +
50mg
99%
in stock  
$863.00   $604.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006JAS
Chemical Name:
Zatebradine hydrochloride
CAS Number:
91940-87-3
Molecular Formula:
C26H37ClN2O5
Molecular Weight:
493.0354
MDL Number:
MFCD06798356
SMILES:
COc1ccc(cc1OC)CCN(CCCN1CCc2c(CC1=O)cc(c(c2)OC)OC)C.Cl
Properties
Computed Properties
 
Complexity:
591  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
11  

Literature

Title: Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Journal: Journal of molecular and cellular cardiology 20120501

Title: Characterization of HCN and cardiac function in a colonial ascidian.

Journal: Journal of experimental zoology. Part A, Ecological genetics and physiology 20111001

Title: 8-OH-DPAT prevents cardiac arrhythmias and attenuates tachycardia during social stress in rats.

Journal: Physiology & behavior 20090216

Title: [Effects of zatebradine on the course of experimental myocardial infarction under long-term treatment conditions in rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20080101

Title: A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria.

Journal: European journal of pharmacology 20071208

Title: Three different bradycardic agents, zatebradine, diltiazem and propranolol, distinctly modify heart rate variability and QT-interval variability.

Journal: Pharmacology 20070101

Title: Bradycardic and proarrhythmic properties of sinus node inhibitors.

Journal: Molecular pharmacology 20060401

Title: [Selective I(f) channel inhibition: an alternative for treating coronary artery disease?].

Journal: Herz 20060201

Title: Characterization of the human HCN1 channel and its inhibition by capsazepine.

Journal: British journal of pharmacology 20041001

Title: Role of force--frequency relation during AV-block, sinus node block and beta-adrenoceptor block in conscious animals.

Journal: Basic research in cardiology 20040901

Title: Heart rate reduction by zatebradine reduces infarct size and mortality but promotes remodeling in rats with experimental myocardial infarction.

Journal: American journal of physiology. Heart and circulatory physiology 20040401

Title: The impact of organic inhibitors of the hyperpolarization activated current (Ih) on the electroretinogram (ERG) of rodents.

Journal: Archives italiennes de biologie 20040301

Title: Synthesis and pharmacological evaluation of 1-oxo-2-(3-piperidyl)-1,2,3,4- tetrahydroisoquinolines and related analogues as a new class of specific bradycardic agents possessing I(f) channel inhibitory activity.

Journal: Journal of medicinal chemistry 20031023

Title: A simulation analysis on mechanisms of damped oscillation in retinal rod photoreceptor cells.

Journal: Vision research 20030901

Title: Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?

Journal: Journal of cardiovascular pharmacology and therapeutics 20030601

Title: Effects of changing heart rate on electrophysiological and hemodynamic function in the dog.

Journal: Life sciences 20030314

Title: Multiple inhibitory effects of zatebradine (UL-FS 49) on the electrophysiological properties of retinal rod photoreceptors.

Journal: Pflugers Archiv : European journal of physiology 20020201

Title: Parallel solid-phase synthesis of zatebradine analogues as potential I(f) channel blockers.

Journal: Bioorganic & medicinal chemistry letters 20010903

Title: Intraretinal analysis of the a-wave of the electroretinogram (ERG) in dark-adapted intact cat retina.

Journal: Visual neuroscience 20010101

Title: Increases in inotropic state without change in heart rate: combined use of dobutamine and zatebradine in conscious dogs.

Journal: European journal of pharmacology 19961205

Title: Effects of zatebradine on ouabain-, two-stage coronary ligation- and epinephrine-induced ventricular tachyarrhythmias.

Journal: European journal of pharmacology 19960411

Title: Addition of zatebradine, a direct sinus node inhibitor, provides no greater exercise tolerance benefit in patients with angina taking extended-release nifedipine: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. The Zatebradine Study Group.

Journal: Journal of the American College of Cardiology 19950801

Title: Zatebradine attenuates cyclic AMP-related positive chronotropic but not inotropic responses in isolated, perfused right atria of the dog.

Journal: Clinical and experimental pharmacology & physiology 19950101

Title: Zatebradine, a specific bradycardic agent, enhances the positive inotropic actions of dobutamine in ischemic myocardium.

Journal: Journal of the American College of Cardiology 19940101

Title: Effect of zatebradine on contractility, relaxation and coronary blood flow.

Journal: Journal of the American College of Cardiology 19930201

Title: Specific bradycardic agents, a new therapeutic modality for anesthesiology: hemodynamic effects of UL-FS 49 and propranolol in conscious and isoflurane-anesthetized dogs.

Journal: Anesthesiology 19871101

Title: Cardiovascular characterization of UL-FS 49, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-][2-(3,4-dimethoxyphenyl)ethyl] methylimino]propyl]-2H-3-benzazepin-2-on hydrochloride, a new 'specific bradycardic agent'.

Journal: European journal of pharmacology 19840903

Title: Stieber J, et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol. 2006 Apr;69(4):1328-37. Epub 2005 Dec 30.

Title: Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:91940-87-3 Molecular Formula|91940-87-3 MDL|91940-87-3 SMILES|91940-87-3 Zatebradine hydrochloride