Name: Name:HATU
Brand: AABLOCKS
SKU: AA001L6G
Rating: 90 (10 reviews)

HATU (148893-10-1) is a versatile reagent widely used in organic synthesis, particularly in the preparation of peptides and small molecules with biological activity. It serves as an efficient coupling agent in amide bond formation reactions, facilitating the synthesis of peptide chains and complex organic compounds. HATU is also employed as a catalyst for selective acylation reactions, enabling the precise modification of functional groups within molecules. Furthermore, it plays a crucial role in the synthesis of Aurora A kinase inhibitors, where its reactivity is leveraged to create compounds with potential therapeutic applications in cancer treatment. Additionally, HATU is utilized in HPLC assays to determine the enantiomeric composition of D- and L-acids in human plasma, demonstrating its analytical utility in pharmaceutical research. Its application extends to the preparation of N-arylsulfonamide-linked peptides via solid-phase synthesis, highlighting its compatibility with diverse synthetic strategies. Moreover, HATU facilitates selective cyclization-oxidation-deselenation sequences, further expanding its synthetic versatility in the development of novel organic molecules.

Catalog No.: AA001L6G

148893-10-1 | HATU

Pack Size： 1g

Purity： 99%

in stock

$6.00 $4.00

Pack Size： 5g

Purity： 95%

in stock

$7.00 $5.00

Pack Size： 10g

Purity： 99%

in stock

$9.00 $6.00

Pack Size： 25g

Purity： 99%

in stock

$18.00 $12.00

Pack Size： 100g

Purity： 99%

in stock

$62.00 $43.00

Pack Size： 500g

Purity： 99%

in stock

$259.00 $181.00

Pack Size： 1kg

Purity： 99%

in stock

$509.00 $356.00

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Technical Information

Catalog Number: AA001L6G

Chemical Name: HATU

CAS Number: 148893-10-1

Molecular Formula: C10H15F6N6OP++

Molecular Weight: 380.2299

MDL Number: MFCD00274639

SMILES: F[P+](F)(F)(F)(F)F.CN(C(=[O+]n1nnc2c1nccc2)N(C)C)C

Properties

Form: Solid

MP: 183-188 °C (dec.)

Storage: Inert atmosphere;2-8℃;

Complexity: 351

Covalently-Bonded Unit Count: 2

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 24

Hydrogen Bond Acceptor Count: 11

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Downstream Synthesis Route

302964-23-4

148893-10-1

mixedanhydrideintermediate

[1]Patent:US2004/54186,2004,A1.Locationinpatent:Page86-87;91

(6S,8R)-N-{(1R)-1-(3AS,4S,6S7AR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-ylpropyl-8-amino-8-methyl-4-oxo-3-3-(trifluoromethyl)benzylamino}-4,6,7,8-tetrahydropyrrolo1,2-apyrimidine-6-carboxamide

132-60-5

148893-10-1

437758-43-5

[1]Patent:US2003/64962,2003,A1

201740-78-5

148893-10-1

C12(13)CH17N5O4

[1]Chemistry-AEuropeanJournal,2012,vol.18,p.9024-9031

148893-10-1

100-51-6

1420476-91-0

[1]OrganicLetters,2013,vol.15,p.642-645

Literature fold

Title: Occupational contact urticaria from the solid-phase peptide synthesis coupling agents HATU and HBTU.

Journal: Contact dermatitis20030801

Title: The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts.

Journal: Angewandte Chemie (International ed. in English)20020201

Application fold

HATU (148893-10-1) is a versatile reagent widely used in organic synthesis, particularly in the preparation of peptides and small molecules with biological activity. It serves as an efficient coupling agent in amide bond formation reactions, facilitating the synthesis of peptide chains and complex organic compounds. HATU is also employed as a catalyst for selective acylation reactions, enabling the precise modification of functional groups within molecules. Furthermore, it plays a crucial role in the synthesis of Aurora A kinase inhibitors, where its reactivity is leveraged to create compounds with potential therapeutic applications in cancer treatment. Additionally, HATU is utilized in HPLC assays to determine the enantiomeric composition of D- and L-acids in human plasma, demonstrating its analytical utility in pharmaceutical research. Its application extends to the preparation of N-arylsulfonamide-linked peptides via solid-phase synthesis, highlighting its compatibility with diverse synthetic strategies. Moreover, HATU facilitates selective cyclization-oxidation-deselenation sequences, further expanding its synthetic versatility in the development of novel organic molecules.

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