Home Other Building Blocks 1492952-76-7
1492952-76-7,MFCD31560488
Catalog No.:AA001LGE

1492952-76-7 | Asciminib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$89.00   $62.00
- +
5mg
98%
in stock  
$359.00   $252.00
- +
10mg
98%
in stock  
$534.00   $374.00
- +
25mg
98%
in stock  
$831.00   $582.00
- +
50mg
98%
in stock  
$1,125.00   $788.00
- +
100mg
98%
in stock  
$1,904.00   $1,333.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001LGE
Chemical Name:
Asciminib
CAS Number:
1492952-76-7
Molecular Formula:
C20H18ClF2N5O3
Molecular Weight:
449.8384
MDL Number:
MFCD31560488
SMILES:
O[C@@H]1CCN(C1)c1ncc(cc1c1n[nH]cc1)C(=O)Nc1ccc(cc1)OC(Cl)(F)F
Properties
Computed Properties
 
Complexity:
626  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2013/310395,2013,A1Locationinpatent:Paragraph0545-0546

[1]Schoepfer,Joseph;Jahnke,Wolfgang;Berellini,Giuliano;Buonamici,Silvia;Cotesta,Simona;Cowan-Jacob,SandraW.;Dodd,Stephanie;Drueckes,Peter;Fabbro,Doriano;Gabriel,Tobias;Groell,Jean-Marc;Grotzfeld,RobertM.;Hassan,A.Quamrul;Henry,Chrystèle;Iyer,Varsha;Jones,Darryl;Lombardo,Franco;Loo,Alice;Manley,PaulW.;Pellé,Xavier;Rummel,Gabriele;Salem,Bahaa;Warmuth,Markus;Wylie,AndrewA.;Zoller,Thomas;Marzinzik,AndreasL.;Furet,Pascal[JournalofMedicinalChemistry,2018,vol.61,#18,p.8120-8135]

[2]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2013/310395,2013,A1Locationinpatent:Paragraph0392

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2013/310395,2013,A1Locationinpatent:Paragraph0390-0391

1492952-76-7   
CASUnavailable 

[1]Tran,Phi;Hanna,Imad;Eggimann,FabianKurt;Schoepfer,Joseph;Ray,Tapan;Zhu,Bing;Wang,Lai;Priess,Petra;Tian,Xianbin;Hourcade-Potelleret,Florence;Einolf,HeidiJ.[Xenobiotica,2020,vol.50,#2,p.150-169]

1492952-76-7   
CASUnavailable 
 
CASUnavailable 

[1]Tran,Phi;Hanna,Imad;Eggimann,FabianKurt;Schoepfer,Joseph;Ray,Tapan;Zhu,Bing;Wang,Lai;Priess,Petra;Tian,Xianbin;Hourcade-Potelleret,Florence;Einolf,HeidiJ.[Xenobiotica,2020,vol.50,#2,p.150-169]

Literature

Title: Wylie AA, et al. The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. Nature. 2017 Mar 30;543(7647):733-737.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1492952-76-7
Tags:1492952-76-7 Molecular Formula|1492952-76-7 MDL|1492952-76-7 SMILES|1492952-76-7 Asciminib