1596-67-4,MFCD00063070
Catalog No.:AA001R5E

1596-67-4 | L-Thyronine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
95%
in stock  
$78.00   $54.00
- +
100mg
≥ 98% (TLC)
in stock  
$165.00   $116.00
- +
250mg
≥ 98% (TLC)
in stock  
$296.00   $207.00
- +
1g
≥ 98% (TLC)
in stock  
$582.00   $408.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001R5E
Chemical Name:
L-Thyronine
CAS Number:
1596-67-4
Molecular Formula:
C15H15NO4
Molecular Weight:
273.2839
MDL Number:
MFCD00063070
SMILES:
OC(=O)[C@H](Cc1ccc(cc1)Oc1ccc(cc1)O)N
Properties
Computed Properties
 
Complexity:
307  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
-0.7  

Downstream Synthesis Route

[1]BiochemicalJournal,1934,vol.28,p.68,71

[2]AngewandteChemie-InternationalEdition,2015,vol.54,p.7674-7678    Angew.Chem.,2015,vol.127,p.7784-7788

3392-12-9    1596-67-4   
N-(t-butoxycarbonyl)-L-valyl-L-thyronine 

[1]Ganellin,C.Robin;Bishop,PaulB.;Bambal,RameshB.;Chan,SuzanneM.T.;Law,JamesK.;Marabout,Benoit;Luthra,PratibhaMehta;Moore,AndrewN.J.;Peschard,Olivier;Bourgeat,Pierre;Rose,Christiane;Vargas,Froylan;Schwartz,Jean-Charles[JournalofMedicinalChemistry,2000,vol.43,#4,p.664-674]

[1]Paik,Man-Jeong;Jeon,SoHee;Kang,JongSeong;Kim,KwanMook;Lee,Wonjae[BulletinoftheKoreanChemicalSociety,2014,vol.35,#7,p.2186-2188]

[2]Paik,Man-Jeong;Jeon,SoHee;Kang,JongSeong;Kim,KwanMook;Lee,Wonjae[BulletinoftheKoreanChemicalSociety,2014,vol.35,#7,p.2186-2188]

[1]AngewandteChemie-InternationalEdition,2015,vol.54,p.7674-7678    Angew.Chem.,2015,vol.127,p.7784-7788

Literature

Title: Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine.

Journal: International journal of environmental research and public health 20160601

Title: Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4.

Journal: Endocrinology 20121101

Title: Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20120921

Title: Mitochondrial F(0) F(1) -ATP synthase is a molecular target of 3-iodothyronamine, an endogenous metabolite of thyroid hormone.

Journal: British journal of pharmacology 20120801

Title: Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study.

Journal: Molecular bioSystems 20120706

Title: Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.

Journal: The Journal of endocrinology 20120601

Title: 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice.

Journal: British journal of pharmacology 20120501

Title: Tetrabromobisphenol-A disrupts thyroid hormone receptor alpha function in vitro: use of fluorescence polarization to assay corepressor and coactivator peptide binding.

Journal: Chemosphere 20120501

Title: Induction of torpor: mimicking natural metabolic suppression for biomedical applications.

Journal: Journal of cellular physiology 20120401

Title: Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis?

Journal: Molecular and cellular endocrinology 20120226

Title: ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation.

Journal: The Journal of biological chemistry 20120113

Title: Detection of 3-iodothyronamine in human patients: a preliminary study.

Journal: The Journal of clinical endocrinology and metabolism 20120101

Title: LTI models for 3-iodothyronamine time dynamics: a multiscale view.

Journal: IEEE transactions on bio-medical engineering 20111201

Title: 3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells.

Journal: Journal of molecular endocrinology 20110801

Title: Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion.

Journal: Cardiovascular drugs and therapy 20110801

Title: Selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite.

Journal: The Japanese journal of veterinary research 20110801

Title: Effects of the thyroid hormone derivatives 3-iodothyronamine and thyronamine on rat liver oxidative capacity.

Journal: Molecular and cellular endocrinology 20110720

Title: Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: Endogenous 3-iodothyronamine (T1AM): more than we bargained for.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: The changes of blood glucose control and lipid profiles after short-term smoking cessation in healthy males.

Journal: Psychiatry investigation 20110601

Title: Sustained torpidity following multi-dose administration of 3-iodothyronamine in mice.

Journal: Journal of cellular physiology 20110401

Title: Thyronamines--past, present, and future.

Journal: Endocrine reviews 20110201

Title: Nongenomic signaling pathways triggered by thyroid hormones and their metabolite 3-iodothyronamine on the cardiovascular system.

Journal: Journal of cellular physiology 20110101

Title: 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements.

Journal: PloS one 20110101

Title: Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

Journal: PloS one 20110101

Title: Effects of competitive and noncompetitive showjumping on total and free iodothyronines, β-endorphin, ACTH and cortisol levels of horses.

Journal: Equine veterinary journal. Supplement 20101101

Title: Tissue distribution and cardiac metabolism of 3-iodothyronamine.

Journal: Endocrinology 20101001

Title: 3-Monoiodothyronamine: the rationale for its action as an endogenous adrenergic-blocking neuromodulator.

Journal: Brain research 20100910

Title: TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100901

Title: An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine.

Journal: The Journal of endocrinology 20100901

Title: Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.

Journal: Molecular bioSystems 20100801

Title: 3-Iodothyronamine (T(1)AM): a new chapter of thyroid hormone endocrinology?

Journal: Molecular bioSystems 20100801

Title: Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice.

Journal: Journal of neuroscience research 20100701

Title: Novel neural pathways for metabolic effects of thyroid hormone.

Journal: Trends in endocrinology and metabolism: TEM 20100401

Title: Cardiac effects of thyronamines.

Journal: Heart failure reviews 20100301

Title: Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.

Journal: Heart failure reviews 20100301

Title: Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system.

Journal: Molecular vision 20100101

Title: Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview.

Journal: Pharmacognosy reviews 20100101

Title: Tuning passive mechanics through differential splicing of titin during skeletal muscle development.

Journal: Biophysical journal 20091021

Title: Modulation of cardiac ionic homeostasis by 3-iodothyronamine.

Journal: Journal of cellular and molecular medicine 20090901

Title: Central effects of thyronamines on glucose metabolism in rats.

Journal: The Journal of endocrinology 20090601

Title: Identification and characterization of 3-iodothyronamine intracellular transport.

Journal: Endocrinology 20090401

Title: The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)).

Journal: ACS chemical biology 20090320

Title: The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents.

Journal: Diabetes, obesity & metabolism 20090301

Title: Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?

Journal: Endocrinology 20090301

Title: Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo.

Journal: Chembiochem : a European journal of chemical biology 20090126

Title: In silico identification of anthropogenic chemicals as ligands of zebrafish sex hormone binding globulin.

Journal: Toxicology and applied pharmacology 20090101

Title: Thyroid hormone analogs and metabolites: new applications for an old hormone?

Journal: Nature clinical practice. Endocrinology & metabolism 20090101

Title: Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.

Journal: PloS one 20090101

Title: Hydroxylated metabolites of polybrominated diphenyl ethers in human blood samples from the United States.

Journal: Environmental health perspectives 20090101

Title: Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum.

Journal: Journal of chromatography. A 20081107

Title: Hypophysectomy and hormonal therapy modulate mK1-immunoreactive duct cells in the mice sublingual glands.

Journal: Journal of molecular histology 20081001

Title: Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates.

Journal: Rapid communications in mass spectrometry : RCM 20081001

Title: Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients.

Journal: International journal of pharmaceutics 20080806

Title: Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors.

Journal: European journal of pharmacology 20080610

Title: Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats.

Journal: Neurochemical research 20080601

Title: Thyronamines are isozyme-specific substrates of deiodinases.

Journal: Endocrinology 20080601

Title: In-line coupling of a reversed-phase column to cope with limited chemoselectivity of a quinine carbamate-based anion-exchange type chiral stationary phase.

Journal: Journal of separation science 20080601

Title: Toward deciphering the code to aminergic G protein-coupled receptor drug design.

Journal: Chemistry & biology 20080401

Title: In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring.

Journal: Environmental health perspectives 20080301

Title: 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20080201

Title: 3'-monoiodothyronine sulfate and Triac sulfate are thyroid hormone metabolites in developing sheep.

Journal: Pediatric research 20080201

Title: Metabolic effects of thyroid hormone derivatives.

Journal: Thyroid : official journal of the American Thyroid Association 20080201

Title: Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.

Journal: BMC structural biology 20080101

Title: Molecular characterization of senescence marker protein-30 gene promoter: identification of repressor elements and functional nuclear factor binding sites.

Journal: BMC molecular biology 20080101

Title: Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

Journal: The Journal of clinical investigation 20071203

Title: Thyroid hormones reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms.

Journal: Cellular and molecular neurobiology 20071101

Title: Comparative thyroidology: thyroid gland location and iodothyronine dynamics in Mozambique tilapia (Oreochromis mossambicus Peters) and common carp (Cyprinus carpio L.).

Journal: The Journal of experimental biology 20071101

Title: Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes.

Journal: Chemosphere 20071001

Title: Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.

Journal: Stroke 20070901

Title: Effect of early feed restriction on myofibre types and expression of growth-related genes in the gastrocnemius muscle of crossbred broiler chickens.

Journal: The British journal of nutrition 20070801

Title: Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070801

Title: Measurement of polybrominated diphenyl ethers and metabolites in mouse plasma after exposure to a commercial pentabromodiphenyl ether mixture.

Journal: Environmental health perspectives 20070701

Title: Thyronamines inhibit plasma membrane and vesicular monoamine transport.

Journal: ACS chemical biology 20070615

Title: Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1.

Journal: Journal of medicinal chemistry 20070614

Title: Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070501

Title: In vitro selection and characterization of RNA aptamers binding thyroxine hormone.

Journal: The Biochemical journal 20070401

Title: Thyronamines are substrates for human liver sulfotransferases.

Journal: Endocrinology 20070401

Title: Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8.

Journal: The Journal of clinical investigation 20070301

Title: Thyroid hormone treatments differentially affect the temperature kinetics properties of FoF1 ATPase and succinate oxidase as well as the lipid/phospholipid profiles of rat kidney mitochondria: a correlative study.

Journal: The Journal of membrane biology 20070201

Title: Responses to mild cold stress are predicted by different individual characteristics in young and older subjects.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20061201

Title: [Influences of excess iodine on thyroid hormone concentrations in cerebrum of filial mice and intervention of selenium].

Journal: Wei sheng yan jiu = Journal of hygiene research 20060301

Title: Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.

Journal: Journal of medicinal chemistry 20060209

Title: Clinical review: thyroid hormone replacement in children after cardiac surgery--is it worth a try?

Journal: Critical care (London, England) 20060101

Title: Thyroid hormone dysregulation in intrauterine growth retardation associated with maternal malnutrition and/or anemia.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20051001

Title: Alternate pathways of thyroid hormone metabolism.

Journal: Thyroid : official journal of the American Thyroid Association 20050801

Title: [Monoiodothyronine (T1), diiodothyronine (T2)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050801

Title: Optical quality changes of the ocular lens during induced parr-to-smolt metamorphosis in Rainbow Trout (Oncorhynchus mykiss). Ocular lens optical quality during induced salmonid metamorphosis.

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20050701

Title: Development of a validated HPLC method for the determination of iodotyrosines and iodothyronines in pharmaceuticals and biological samples using solid phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050105

Title: Sensitized photooxidation of thyroidal hormones. Evidence for heavy atom effect on singlet molecular oxygen [O2(1Deltag)]-mediated photoreactions.

Journal: Photochemistry and photobiology 20050101

Title: The role of thyroid hormone therapy in acutely ill cardiac patients.

Journal: Critical care (London, England) 20050101

Title: Role of sarco/endoplasmic reticulum Ca(2+)-ATPase in thermogenesis.

Journal: Bioscience reports 20050101

Title: 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.

Journal: Nature medicine 20040601

Title: Thyroxine-derivatives of lipopeptides: bifunctional dimerization inhibitors of human immunodeficiency virus-1 protease.

Journal: Biochemical pharmacology 20030401

Title: 5'-deiodinase activity and circulating thyronines in lactating cows.

Journal: Journal of dairy science 20030101

Title: Altered myosin isoform expression in rat skeletal muscles induced by a changed thyroid state.

Journal: Acta physiologica Scandinavica 20021101

Title: Thyronin treatment in adult and pediatric heart surgery: clinical experience and review of the literature.

Journal: European journal of heart failure 20021001

Title: Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.

Journal: Journal of medicinal chemistry 20020718

Title: Should we reevaluate the variables for predicting the difficult airway in anesthesiology?

Journal: Anesthesia and analgesia 20020501

Title: Induction of pro-renin converting enzyme mk9 by thyroid hormone in the guinea-pig liver.

Journal: Biochemical and biophysical research communications 20020426

Title: A novel in vivo rabbit model of hypercatabolic critical illness reveals a biphasic neuroendocrine stress response.

Journal: Endocrinology 20020301

Title: Characterization of iodothyronine sulfatase activities in human and rat liver and placenta.

Journal: Endocrinology 20020301

Title: Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives.

Journal: Bioorganic & medicinal chemistry 20020201

Title: Reference intervals for thyroid hormones on the architect analyser.

Journal: Clinical chemistry and laboratory medicine 20020201

Title: Long-term effects of malnutrition during lactation on the thyroid function of offspring.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020101

Title: Effect of suckling and adrenergic stimulation on peripheral deiodination in lactating rats: differential expression of type 1 deiodinase mRNA forms.

Journal: The Journal of endocrinology 20011201

Title: Could a combined administration of dexamethasone and 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) be a more effective alternative to dexamethasone alone in the prevention of RDS?

Journal: European journal of obstetrics, gynecology, and reproductive biology 20011201

Title: Control of energy metabolism by iodothyronines.

Journal: Journal of endocrinological investigation 20011201

Title: Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury.

Journal: The Journal of clinical endocrinology and metabolism 20010601

Title: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.

Journal: Endocrinology 20010501

Title: Endocrine and chronobiological effects of fasting in women.

Journal: Fertility and sterility 20010501

Title: Response of rainbow trout gill Na+-ATPpase to T(3) and NaCl administration.

Journal: Physiological and biochemical zoology : PBZ 20010101

Title: Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20000606

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SDS
Tags:1596-67-4 Molecular Formula|1596-67-4 MDL|1596-67-4 SMILES|1596-67-4 L-Thyronine
Catalog No.: AA001R5E
1596-67-4,MFCD00063070
1596-67-4 | L-Thyronine
Pack Size: 10mg
Purity: 95%
in stock
$78.00 $54.00
Pack Size: 100mg
Purity: ≥ 98% (TLC)
in stock
$165.00 $116.00
Pack Size: 250mg
Purity: ≥ 98% (TLC)
in stock
$296.00 $207.00
Pack Size: 1g
Purity: ≥ 98% (TLC)
in stock
$582.00 $408.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001R5E
Chemical Name: L-Thyronine
CAS Number: 1596-67-4
Molecular Formula: C15H15NO4
Molecular Weight: 273.2839
MDL Number: MFCD00063070
SMILES: OC(=O)[C@H](Cc1ccc(cc1)Oc1ccc(cc1)O)N
Properties
Complexity: 307  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 5  
XLogP3: -0.7  
Downstream Synthesis Route
51-48-9    1596-67-4 

[1]BiochemicalJournal,1934,vol.28,p.68,71

[2]AngewandteChemie-InternationalEdition,2015,vol.54,p.7674-7678    Angew.Chem.,2015,vol.127,p.7784-7788

3392-12-9    1596-67-4   
N-(t-butoxycarbonyl)-L-valyl-L-thyronine 

[1]Ganellin,C.Robin;Bishop,PaulB.;Bambal,RameshB.;Chan,SuzanneM.T.;Law,JamesK.;Marabout,Benoit;Luthra,PratibhaMehta;Moore,AndrewN.J.;Peschard,Olivier;Bourgeat,Pierre;Rose,Christiane;Vargas,Froylan;Schwartz,Jean-Charles[JournalofMedicinalChemistry,2000,vol.43,#4,p.664-674]

1034-10-2    28105-38-6    1596-67-4 

[1]Paik,Man-Jeong;Jeon,SoHee;Kang,JongSeong;Kim,KwanMook;Lee,Wonjae[BulletinoftheKoreanChemicalSociety,2014,vol.35,#7,p.2186-2188]

[2]Paik,Man-Jeong;Jeon,SoHee;Kang,JongSeong;Kim,KwanMook;Lee,Wonjae[BulletinoftheKoreanChemicalSociety,2014,vol.35,#7,p.2186-2188]

51-48-9    4732-82-5    10468-90-3    70-40-6    4192-14-7    5817-39-0    1596-67-4 

[1]AngewandteChemie-InternationalEdition,2015,vol.54,p.7674-7678    Angew.Chem.,2015,vol.127,p.7784-7788

Literature fold

Title: Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine.

Journal: International journal of environmental research and public health20160601

Title: Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4.

Journal: Endocrinology20121101

Title: Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A20120921

Title: Mitochondrial F(0) F(1) -ATP synthase is a molecular target of 3-iodothyronamine, an endogenous metabolite of thyroid hormone.

Journal: British journal of pharmacology20120801

Title: Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study.

Journal: Molecular bioSystems20120706

Title: Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.

Journal: The Journal of endocrinology20120601

Title: 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice.

Journal: British journal of pharmacology20120501

Title: Tetrabromobisphenol-A disrupts thyroid hormone receptor alpha function in vitro: use of fluorescence polarization to assay corepressor and coactivator peptide binding.

Journal: Chemosphere20120501

Title: Induction of torpor: mimicking natural metabolic suppression for biomedical applications.

Journal: Journal of cellular physiology20120401

Title: Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis?

Journal: Molecular and cellular endocrinology20120226

Title: ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation.

Journal: The Journal of biological chemistry20120113

Title: Detection of 3-iodothyronamine in human patients: a preliminary study.

Journal: The Journal of clinical endocrinology and metabolism20120101

Title: LTI models for 3-iodothyronamine time dynamics: a multiscale view.

Journal: IEEE transactions on bio-medical engineering20111201

Title: 3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells.

Journal: Journal of molecular endocrinology20110801

Title: Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion.

Journal: Cardiovascular drugs and therapy20110801

Title: Selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite.

Journal: The Japanese journal of veterinary research20110801

Title: Effects of the thyroid hormone derivatives 3-iodothyronamine and thyronamine on rat liver oxidative capacity.

Journal: Molecular and cellular endocrinology20110720

Title: Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay.

Journal: The Journal of clinical endocrinology and metabolism20110601

Title: Endogenous 3-iodothyronamine (T1AM): more than we bargained for.

Journal: The Journal of clinical endocrinology and metabolism20110601

Title: The changes of blood glucose control and lipid profiles after short-term smoking cessation in healthy males.

Journal: Psychiatry investigation20110601

Title: Sustained torpidity following multi-dose administration of 3-iodothyronamine in mice.

Journal: Journal of cellular physiology20110401

Title: Thyronamines--past, present, and future.

Journal: Endocrine reviews20110201

Title: Nongenomic signaling pathways triggered by thyroid hormones and their metabolite 3-iodothyronamine on the cardiovascular system.

Journal: Journal of cellular physiology20110101

Title: 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements.

Journal: PloS one20110101

Title: Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

Journal: PloS one20110101

Title: Effects of competitive and noncompetitive showjumping on total and free iodothyronines, β-endorphin, ACTH and cortisol levels of horses.

Journal: Equine veterinary journal. Supplement20101101

Title: Tissue distribution and cardiac metabolism of 3-iodothyronamine.

Journal: Endocrinology20101001

Title: 3-Monoiodothyronamine: the rationale for its action as an endogenous adrenergic-blocking neuromodulator.

Journal: Brain research20100910

Title: TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20100901

Title: An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine.

Journal: The Journal of endocrinology20100901

Title: Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.

Journal: Molecular bioSystems20100801

Title: 3-Iodothyronamine (T(1)AM): a new chapter of thyroid hormone endocrinology?

Journal: Molecular bioSystems20100801

Title: Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice.

Journal: Journal of neuroscience research20100701

Title: Novel neural pathways for metabolic effects of thyroid hormone.

Journal: Trends in endocrinology and metabolism: TEM20100401

Title: Cardiac effects of thyronamines.

Journal: Heart failure reviews20100301

Title: Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.

Journal: Heart failure reviews20100301

Title: Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system.

Journal: Molecular vision20100101

Title: Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview.

Journal: Pharmacognosy reviews20100101

Title: Tuning passive mechanics through differential splicing of titin during skeletal muscle development.

Journal: Biophysical journal20091021

Title: Modulation of cardiac ionic homeostasis by 3-iodothyronamine.

Journal: Journal of cellular and molecular medicine20090901

Title: Central effects of thyronamines on glucose metabolism in rats.

Journal: The Journal of endocrinology20090601

Title: Identification and characterization of 3-iodothyronamine intracellular transport.

Journal: Endocrinology20090401

Title: The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)).

Journal: ACS chemical biology20090320

Title: The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents.

Journal: Diabetes, obesity & metabolism20090301

Title: Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?

Journal: Endocrinology20090301

Title: Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo.

Journal: Chembiochem : a European journal of chemical biology20090126

Title: In silico identification of anthropogenic chemicals as ligands of zebrafish sex hormone binding globulin.

Journal: Toxicology and applied pharmacology20090101

Title: Thyroid hormone analogs and metabolites: new applications for an old hormone?

Journal: Nature clinical practice. Endocrinology & metabolism20090101

Title: Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.

Journal: PloS one20090101

Title: Hydroxylated metabolites of polybrominated diphenyl ethers in human blood samples from the United States.

Journal: Environmental health perspectives20090101

Title: Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum.

Journal: Journal of chromatography. A20081107

Title: Hypophysectomy and hormonal therapy modulate mK1-immunoreactive duct cells in the mice sublingual glands.

Journal: Journal of molecular histology20081001

Title: Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates.

Journal: Rapid communications in mass spectrometry : RCM20081001

Title: Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients.

Journal: International journal of pharmaceutics20080806

Title: Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors.

Journal: European journal of pharmacology20080610

Title: Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats.

Journal: Neurochemical research20080601

Title: Thyronamines are isozyme-specific substrates of deiodinases.

Journal: Endocrinology20080601

Title: In-line coupling of a reversed-phase column to cope with limited chemoselectivity of a quinine carbamate-based anion-exchange type chiral stationary phase.

Journal: Journal of separation science20080601

Title: Toward deciphering the code to aminergic G protein-coupled receptor drug design.

Journal: Chemistry & biology20080401

Title: In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring.

Journal: Environmental health perspectives20080301

Title: 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology20080201

Title: 3'-monoiodothyronine sulfate and Triac sulfate are thyroid hormone metabolites in developing sheep.

Journal: Pediatric research20080201

Title: Metabolic effects of thyroid hormone derivatives.

Journal: Thyroid : official journal of the American Thyroid Association20080201

Title: Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.

Journal: BMC structural biology20080101

Title: Molecular characterization of senescence marker protein-30 gene promoter: identification of repressor elements and functional nuclear factor binding sites.

Journal: BMC molecular biology20080101

Title: Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

Journal: The Journal of clinical investigation20071203

Title: Thyroid hormones reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms.

Journal: Cellular and molecular neurobiology20071101

Title: Comparative thyroidology: thyroid gland location and iodothyronine dynamics in Mozambique tilapia (Oreochromis mossambicus Peters) and common carp (Cyprinus carpio L.).

Journal: The Journal of experimental biology20071101

Title: Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes.

Journal: Chemosphere20071001

Title: Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.

Journal: Stroke20070901

Title: Effect of early feed restriction on myofibre types and expression of growth-related genes in the gastrocnemius muscle of crossbred broiler chickens.

Journal: The British journal of nutrition20070801

Title: Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20070801

Title: Measurement of polybrominated diphenyl ethers and metabolites in mouse plasma after exposure to a commercial pentabromodiphenyl ether mixture.

Journal: Environmental health perspectives20070701

Title: Thyronamines inhibit plasma membrane and vesicular monoamine transport.

Journal: ACS chemical biology20070615

Title: Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1.

Journal: Journal of medicinal chemistry20070614

Title: Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20070501

Title: In vitro selection and characterization of RNA aptamers binding thyroxine hormone.

Journal: The Biochemical journal20070401

Title: Thyronamines are substrates for human liver sulfotransferases.

Journal: Endocrinology20070401

Title: Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8.

Journal: The Journal of clinical investigation20070301

Title: Thyroid hormone treatments differentially affect the temperature kinetics properties of FoF1 ATPase and succinate oxidase as well as the lipid/phospholipid profiles of rat kidney mitochondria: a correlative study.

Journal: The Journal of membrane biology20070201

Title: Responses to mild cold stress are predicted by different individual characteristics in young and older subjects.

Journal: Journal of applied physiology (Bethesda, Md. : 1985)20061201

Title: [Influences of excess iodine on thyroid hormone concentrations in cerebrum of filial mice and intervention of selenium].

Journal: Wei sheng yan jiu = Journal of hygiene research20060301

Title: Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.

Journal: Journal of medicinal chemistry20060209

Title: Clinical review: thyroid hormone replacement in children after cardiac surgery--is it worth a try?

Journal: Critical care (London, England)20060101

Title: Thyroid hormone dysregulation in intrauterine growth retardation associated with maternal malnutrition and/or anemia.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20051001

Title: Alternate pathways of thyroid hormone metabolism.

Journal: Thyroid : official journal of the American Thyroid Association20050801

Title: [Monoiodothyronine (T1), diiodothyronine (T2)].

Journal: Nihon rinsho. Japanese journal of clinical medicine20050801

Title: Optical quality changes of the ocular lens during induced parr-to-smolt metamorphosis in Rainbow Trout (Oncorhynchus mykiss). Ocular lens optical quality during induced salmonid metamorphosis.

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology20050701

Title: Development of a validated HPLC method for the determination of iodotyrosines and iodothyronines in pharmaceuticals and biological samples using solid phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20050105

Title: Sensitized photooxidation of thyroidal hormones. Evidence for heavy atom effect on singlet molecular oxygen [O2(1Deltag)]-mediated photoreactions.

Journal: Photochemistry and photobiology20050101

Title: The role of thyroid hormone therapy in acutely ill cardiac patients.

Journal: Critical care (London, England)20050101

Title: Role of sarco/endoplasmic reticulum Ca(2+)-ATPase in thermogenesis.

Journal: Bioscience reports20050101

Title: 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.

Journal: Nature medicine20040601

Title: Thyroxine-derivatives of lipopeptides: bifunctional dimerization inhibitors of human immunodeficiency virus-1 protease.

Journal: Biochemical pharmacology20030401

Title: 5'-deiodinase activity and circulating thyronines in lactating cows.

Journal: Journal of dairy science20030101

Title: Altered myosin isoform expression in rat skeletal muscles induced by a changed thyroid state.

Journal: Acta physiologica Scandinavica20021101

Title: Thyronin treatment in adult and pediatric heart surgery: clinical experience and review of the literature.

Journal: European journal of heart failure20021001

Title: Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.

Journal: Journal of medicinal chemistry20020718

Title: Should we reevaluate the variables for predicting the difficult airway in anesthesiology?

Journal: Anesthesia and analgesia20020501

Title: Induction of pro-renin converting enzyme mk9 by thyroid hormone in the guinea-pig liver.

Journal: Biochemical and biophysical research communications20020426

Title: A novel in vivo rabbit model of hypercatabolic critical illness reveals a biphasic neuroendocrine stress response.

Journal: Endocrinology20020301

Title: Characterization of iodothyronine sulfatase activities in human and rat liver and placenta.

Journal: Endocrinology20020301

Title: Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives.

Journal: Bioorganic & medicinal chemistry20020201

Title: Reference intervals for thyroid hormones on the architect analyser.

Journal: Clinical chemistry and laboratory medicine20020201

Title: Long-term effects of malnutrition during lactation on the thyroid function of offspring.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20020101

Title: Effect of suckling and adrenergic stimulation on peripheral deiodination in lactating rats: differential expression of type 1 deiodinase mRNA forms.

Journal: The Journal of endocrinology20011201

Title: Could a combined administration of dexamethasone and 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) be a more effective alternative to dexamethasone alone in the prevention of RDS?

Journal: European journal of obstetrics, gynecology, and reproductive biology20011201

Title: Control of energy metabolism by iodothyronines.

Journal: Journal of endocrinological investigation20011201

Title: Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury.

Journal: The Journal of clinical endocrinology and metabolism20010601

Title: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.

Journal: Endocrinology20010501

Title: Endocrine and chronobiological effects of fasting in women.

Journal: Fertility and sterility20010501

Title: Response of rainbow trout gill Na+-ATPpase to T(3) and NaCl administration.

Journal: Physiological and biochemical zoology : PBZ20010101

Title: Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR.

Journal: Proceedings of the National Academy of Sciences of the United States of America20000606

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