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1619994-68-1,MFCD26142953
Catalog No.:AA001SIA

1619994-68-1 | GSK2801

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$12.00   $8.00
- +
5mg
98+%
in stock  
$27.00   $19.00
- +
10mg
98+%
in stock  
$41.00   $29.00
- +
50mg
98+%
in stock  
$117.00   $82.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001SIA
Chemical Name:
GSK2801
CAS Number:
1619994-68-1
Molecular Formula:
C20H21NO4S
Molecular Weight:
371.4500
MDL Number:
MFCD26142953
SMILES:
CCCOc1ccn2c(c1)c(cc2C(=O)C)c1ccccc1S(=O)(=O)C
Properties
Computed Properties
 
Complexity:
599  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
4.2  

Downstream Synthesis Route

[1]Chen,Peiling;Chaikuad,Apirat;Bamborough,Paul;Bantscheff,Marcus;Bountra,Chas;Chung,Chun-Wa;Fedorov,Oleg;Grandi,Paola;Jung,David;Lesniak,Robert;Lindon,Matthew;Müller,Susanne;Philpott,Martin;Prinjha,Rab;Rogers,Catherine;Selenski,Carolyn;Tallant,Cynthia;Werner,Thilo;Willson,TimothyM.;Knapp,Stefan;Drewry,DavidH.[JournalofMedicinalChemistry,2016,vol.59,#4,p.1410-1424]

[1]Chen,Peiling;Chaikuad,Apirat;Bamborough,Paul;Bantscheff,Marcus;Bountra,Chas;Chung,Chun-Wa;Fedorov,Oleg;Grandi,Paola;Jung,David;Lesniak,Robert;Lindon,Matthew;Müller,Susanne;Philpott,Martin;Prinjha,Rab;Rogers,Catherine;Selenski,Carolyn;Tallant,Cynthia;Werner,Thilo;Willson,TimothyM.;Knapp,Stefan;Drewry,DavidH.[JournalofMedicinalChemistry,2016,vol.59,#4,p.1410-1424]

[1]Chen,Peiling;Chaikuad,Apirat;Bamborough,Paul;Bantscheff,Marcus;Bountra,Chas;Chung,Chun-Wa;Fedorov,Oleg;Grandi,Paola;Jung,David;Lesniak,Robert;Lindon,Matthew;Müller,Susanne;Philpott,Martin;Prinjha,Rab;Rogers,Catherine;Selenski,Carolyn;Tallant,Cynthia;Werner,Thilo;Willson,TimothyM.;Knapp,Stefan;Drewry,DavidH.[JournalofMedicinalChemistry,2016,vol.59,#4,p.1410-1424]

[1]Chen,Peiling;Chaikuad,Apirat;Bamborough,Paul;Bantscheff,Marcus;Bountra,Chas;Chung,Chun-Wa;Fedorov,Oleg;Grandi,Paola;Jung,David;Lesniak,Robert;Lindon,Matthew;Müller,Susanne;Philpott,Martin;Prinjha,Rab;Rogers,Catherine;Selenski,Carolyn;Tallant,Cynthia;Werner,Thilo;Willson,TimothyM.;Knapp,Stefan;Drewry,DavidH.[JournalofMedicinalChemistry,2016,vol.59,#4,p.1410-1424]

[1]Chen,Peiling;Chaikuad,Apirat;Bamborough,Paul;Bantscheff,Marcus;Bountra,Chas;Chung,Chun-Wa;Fedorov,Oleg;Grandi,Paola;Jung,David;Lesniak,Robert;Lindon,Matthew;Müller,Susanne;Philpott,Martin;Prinjha,Rab;Rogers,Catherine;Selenski,Carolyn;Tallant,Cynthia;Werner,Thilo;Willson,TimothyM.;Knapp,Stefan;Drewry,DavidH.[JournalofMedicinalChemistry,2016,vol.59,#4,p.1410-1424]

Literature

Title: The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats.

Journal: The EMBO journal 20100707

Title: A novel family of bromodomain genes.

Journal: Genomics 20000101

Title: Chen P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016 Feb 25;59(4):1410-24.

Title: Bevill SM, et al. GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer. Mol Cancer Res. 2019 Jul;17(7):1503-1518.

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