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Home Amines 1821428-35-6
1821428-35-6,MFCD30470661
Catalog No.:AA0023C1

1821428-35-6 | 2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$15.00   $11.00
- +
5mg
99%
in stock  
$37.00   $26.00
- +
10mg
99%
in stock  
$54.00   $38.00
- +
25mg
99%
in stock  
$91.00   $64.00
- +
50mg
99%
in stock  
$138.00   $96.00
- +
100mg
99%
in stock  
$220.00   $154.00
- +
250mg
98%
in stock  
$544.00   $381.00
- +
1g
98%
in stock  
$1,607.00   $1,125.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0023C1
Chemical Name:
2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-
CAS Number:
1821428-35-6
Molecular Formula:
C26H31N5O3
Molecular Weight:
461.5560
MDL Number:
MFCD30470661
SMILES:
CN(CCCOc1ccc(cn1)c1ccc2c(c1)c1c(cn2)n(c(=O)n1C1CCOCC1)C)C
Properties
Computed Properties
 
Complexity:
687  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
7  
XLogP3:
2.9  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[3]Pike,KurtG.;Barlaam,Bernard;Cadogan,Elaine;Campbell,Andrew;Chen,Yingxue;Colclough,Nicola;Davies,NicholaL.;De-Almeida,Camila;Degorce,SebastienL.;Didelot,Myriam;Dishington,Allan;Ducray,Richard;Durant,StephenT.;Hassall,LorraineA.;Holmes,Jane;Hughes,GarethD.;Macfaul,PhilipA.;Mulholland,KeithR.;McGuire,ThomasM.;Ouvry,Gilles;Pass,Martin;Robb,Graeme;Stratton,Natalie;Wang,Zhenhua;Wilson,Joanne;Zhai,Baochang;Zhao,Kang;Al-Huniti,Nidal[JournalofMedicinalChemistry,2018,vol.61,#9,p.3823-3841]

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[3]Pike,KurtG.;Barlaam,Bernard;Cadogan,Elaine;Campbell,Andrew;Chen,Yingxue;Colclough,Nicola;Davies,NicholaL.;De-Almeida,Camila;Degorce,SebastienL.;Didelot,Myriam;Dishington,Allan;Ducray,Richard;Durant,StephenT.;Hassall,LorraineA.;Holmes,Jane;Hughes,GarethD.;Macfaul,PhilipA.;Mulholland,KeithR.;McGuire,ThomasM.;Ouvry,Gilles;Pass,Martin;Robb,Graeme;Stratton,Natalie;Wang,Zhenhua;Wilson,Joanne;Zhai,Baochang;Zhao,Kang;Al-Huniti,Nidal[JournalofMedicinalChemistry,2018,vol.61,#9,p.3823-3841]

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[3]Pike,KurtG.;Barlaam,Bernard;Cadogan,Elaine;Campbell,Andrew;Chen,Yingxue;Colclough,Nicola;Davies,NicholaL.;De-Almeida,Camila;Degorce,SebastienL.;Didelot,Myriam;Dishington,Allan;Ducray,Richard;Durant,StephenT.;Hassall,LorraineA.;Holmes,Jane;Hughes,GarethD.;Macfaul,PhilipA.;Mulholland,KeithR.;McGuire,ThomasM.;Ouvry,Gilles;Pass,Martin;Robb,Graeme;Stratton,Natalie;Wang,Zhenhua;Wilson,Joanne;Zhai,Baochang;Zhao,Kang;Al-Huniti,Nidal[JournalofMedicinalChemistry,2018,vol.61,#9,p.3823-3841]

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[3]Pike,KurtG.;Barlaam,Bernard;Cadogan,Elaine;Campbell,Andrew;Chen,Yingxue;Colclough,Nicola;Davies,NicholaL.;De-Almeida,Camila;Degorce,SebastienL.;Didelot,Myriam;Dishington,Allan;Ducray,Richard;Durant,StephenT.;Hassall,LorraineA.;Holmes,Jane;Hughes,GarethD.;Macfaul,PhilipA.;Mulholland,KeithR.;McGuire,ThomasM.;Ouvry,Gilles;Pass,Martin;Robb,Graeme;Stratton,Natalie;Wang,Zhenhua;Wilson,Joanne;Zhai,Baochang;Zhao,Kang;Al-Huniti,Nidal[JournalofMedicinalChemistry,2018,vol.61,#9,p.3823-3841]

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[3]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

[4]CurrentPatentAssignee:ASTRAZENECAPLC-WO2015/170081,2015,A1

Literature

Title: The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).

Journal: Journal of medicinal chemistry 20180510

Title: Imidazo,5-cquinolin-2-one compounds and their use in treating cancer.?

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Tags:1821428-35-6 Molecular Formula|1821428-35-6 MDL|1821428-35-6 SMILES|1821428-35-6 2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-