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17692-31-8,MFCD00079124
Catalog No.:AA0024WW

17692-31-8 | 3-(4-phenylpiperazin-1-yl)propane-1,2-diol

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25mg
98% NMR
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$6.00   $4.00
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100mg
98% NMR
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$7.00   $5.00
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1g
98% NMR
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$11.00   $8.00
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5g
98% NMR
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$18.00   $13.00
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25g
98% NMR
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$28.00   $20.00
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100g
98% NMR
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$99.00   $69.00
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500g
98% NMR
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0024WW
Chemical Name:
3-(4-phenylpiperazin-1-yl)propane-1,2-diol
CAS Number:
17692-31-8
Molecular Formula:
C13H20N2O2
Molecular Weight:
236.3101
MDL Number:
MFCD00079124
SMILES:
OCC(CN1CCN(CC1)c1ccccc1)O
NSC Number:
757820
Properties
Properties
 
BP:
412.7°C at 760 mmHg  
Form:
Solid  
MP:
105° (Morren); mp 108° (Bourdais)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
212  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.6  

Downstream Synthesis Route

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

[2]TetrahedronLetters,1992,vol.33,p.3231-3234

[1]ArchivderPharmazie,1984,vol.317,p.323-329

17692-31-8    125599-27-1   
4-(3,4-Dimethoxy-phenyl)-2,6-dimethyl-1-(3-phenyl-propyl)-1,4-dihydro-pyridine-3,5-dicarboxylicacid3-2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propylester5-methylester 

[1]ChemicalandPharmaceuticalBulletin,1995,vol.43,p.818-828

Literature

Title: Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20131201

Title: Efficacy of levodropropizine in pediatric cough.

Journal: Pulmonary pharmacology & therapeutics 20121001

Title: Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review.

Journal: Journal of pain & palliative care pharmacotherapy 20110101

Title: Cough management: a practical approach.

Journal: Cough (London, England) 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: An anaphylactic reaction caused by levodropropizine.

Journal: Allergy 20100301

Title: Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.

Journal: International journal of analytical chemistry 20100101

Title: The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.

Journal: Bratislavske lekarske listy 20090101

Title: HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.

Journal: Archives of pharmacal research 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

Title: [Determination of levodropropizine and its pharmacokinetics in human plasma using LC/MS/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041201

Title: Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Journal: Therapeutic drug monitoring 20040801

Title: Antitussive effect of diltiazem in experimental conditions.

Journal: Bratislavske lekarske listy 20040101

Title: Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

Journal: Drugs under experimental and clinical research 20040101

Title: Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

Title: Chemo-enzymatic synthesis of levodropropizine.

Journal: Farmaco (Societa chimica italiana : 1989) 20031001

Title: Levodropropizine does not affect P0.1 and breathing pattern in healthy volunteers and patients with chronic respiratory impairment.

Journal: Pulmonary pharmacology & therapeutics 20030101

Title: Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101

Title: Machado AKMS, et, al. Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review. Crit Rev Anal Chem. 2019 Dec 9;1-9.

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