17692-31-8,MFCD00079124
Catalog No.:AA0024WW

17692-31-8 | 3-(4-phenylpiperazin-1-yl)propane-1,2-diol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98% NMR
in stock  
$6.00   $4.00
- +
100mg
98% NMR
in stock  
$7.00   $5.00
- +
1g
98% NMR
in stock  
$11.00   $8.00
- +
5g
98% NMR
in stock  
$19.00   $13.00
- +
25g
98% NMR
in stock  
$29.00   $20.00
- +
100g
98% NMR
in stock  
$100.00   $70.00
- +
500g
98% NMR
in stock  
$362.00   $253.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0024WW
Chemical Name:
3-(4-phenylpiperazin-1-yl)propane-1,2-diol
CAS Number:
17692-31-8
Molecular Formula:
C13H20N2O2
Molecular Weight:
236.3101
MDL Number:
MFCD00079124
SMILES:
OCC(CN1CCN(CC1)c1ccccc1)O
NSC Number:
757820
Properties
Properties
 
BP:
412.7°C at 760 mmHg  
Form:
Solid  
MP:
105° (Morren); mp 108° (Bourdais)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
212  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.6  

Downstream Synthesis Route

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

[2]TetrahedronLetters,1992,vol.33,p.3231-3234

[1]ArchivderPharmazie,1984,vol.317,p.323-329

17692-31-8    125599-27-1   
4-(3,4-Dimethoxy-phenyl)-2,6-dimethyl-1-(3-phenyl-propyl)-1,4-dihydro-pyridine-3,5-dicarboxylicacid3-2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propylester5-methylester 

[1]ChemicalandPharmaceuticalBulletin,1995,vol.43,p.818-828

Literature

Title: Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20131201

Title: Efficacy of levodropropizine in pediatric cough.

Journal: Pulmonary pharmacology & therapeutics 20121001

Title: Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review.

Journal: Journal of pain & palliative care pharmacotherapy 20110101

Title: Cough management: a practical approach.

Journal: Cough (London, England) 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: An anaphylactic reaction caused by levodropropizine.

Journal: Allergy 20100301

Title: Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.

Journal: International journal of analytical chemistry 20100101

Title: The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.

Journal: Bratislavske lekarske listy 20090101

Title: HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.

Journal: Archives of pharmacal research 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

Title: [Determination of levodropropizine and its pharmacokinetics in human plasma using LC/MS/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041201

Title: Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Journal: Therapeutic drug monitoring 20040801

Title: Antitussive effect of diltiazem in experimental conditions.

Journal: Bratislavske lekarske listy 20040101

Title: Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

Journal: Drugs under experimental and clinical research 20040101

Title: Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

Title: Chemo-enzymatic synthesis of levodropropizine.

Journal: Farmaco (Societa chimica italiana : 1989) 20031001

Title: Levodropropizine does not affect P0.1 and breathing pattern in healthy volunteers and patients with chronic respiratory impairment.

Journal: Pulmonary pharmacology & therapeutics 20030101

Title: Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101

Title: Machado AKMS, et, al. Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review. Crit Rev Anal Chem. 2019 Dec 9;1-9.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 17692-31-8
Tags:17692-31-8 Molecular Formula|17692-31-8 MDL|17692-31-8 SMILES|17692-31-8 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Catalog No.: AA0024WW
17692-31-8,MFCD00079124
17692-31-8 | 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Pack Size: 25mg
Purity: 98% NMR
in stock
$6.00 $4.00
Pack Size: 100mg
Purity: 98% NMR
in stock
$7.00 $5.00
Pack Size: 1g
Purity: 98% NMR
in stock
$11.00 $8.00
Pack Size: 5g
Purity: 98% NMR
in stock
$19.00 $13.00
Pack Size: 25g
Purity: 98% NMR
in stock
$29.00 $20.00
Pack Size: 100g
Purity: 98% NMR
in stock
$100.00 $70.00
Pack Size: 500g
Purity: 98% NMR
in stock
$362.00 $253.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0024WW
Chemical Name: 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
CAS Number: 17692-31-8
Molecular Formula: C13H20N2O2
Molecular Weight: 236.3101
MDL Number: MFCD00079124
SMILES: OCC(CN1CCN(CC1)c1ccccc1)O
NSC Number: 757820
Properties
BP: 412.7°C at 760 mmHg  
Form: Solid  
MP: 105° (Morren); mp 108° (Bourdais)  
Storage: Keep in dry area;Room Temperature;  
Complexity: 212  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.6  
Downstream Synthesis Route
108-24-7    17692-31-8    142794-17-0 

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

141-78-6    17692-31-8    142730-59-4 

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

142730-57-2    142730-59-4    142730-58-3    17692-31-8 

[1]TetrahedronLetters,1992,vol.33,p.3231-3234

[2]TetrahedronLetters,1992,vol.33,p.3231-3234

17692-31-8    74-88-4    90331-38-7 

[1]ArchivderPharmazie,1984,vol.317,p.323-329

17692-31-8    125599-27-1   
4-(3,4-Dimethoxy-phenyl)-2,6-dimethyl-1-(3-phenyl-propyl)-1,4-dihydro-pyridine-3,5-dicarboxylicacid3-2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propylester5-methylester 

[1]ChemicalandPharmaceuticalBulletin,1995,vol.43,p.818-828

Literature fold

Title: Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20131201

Title: Efficacy of levodropropizine in pediatric cough.

Journal: Pulmonary pharmacology & therapeutics20121001

Title: Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review.

Journal: Journal of pain & palliative care pharmacotherapy20110101

Title: Cough management: a practical approach.

Journal: Cough (London, England)20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: An anaphylactic reaction caused by levodropropizine.

Journal: Allergy20100301

Title: Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.

Journal: International journal of analytical chemistry20100101

Title: The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.

Journal: Bratislavske lekarske listy20090101

Title: HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.

Journal: Archives of pharmacal research20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20050505

Title: [Determination of levodropropizine and its pharmacokinetics in human plasma using LC/MS/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20041201

Title: Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Journal: Therapeutic drug monitoring20040801

Title: Antitussive effect of diltiazem in experimental conditions.

Journal: Bratislavske lekarske listy20040101

Title: Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

Journal: Drugs under experimental and clinical research20040101

Title: Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20031225

Title: Chemo-enzymatic synthesis of levodropropizine.

Journal: Farmaco (Societa chimica italiana : 1989)20031001

Title: Levodropropizine does not affect P0.1 and breathing pattern in healthy volunteers and patients with chronic respiratory impairment.

Journal: Pulmonary pharmacology & therapeutics20030101

Title: Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20030101

Title: Machado AKMS, et, al. Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review. Crit Rev Anal Chem. 2019 Dec 9;1-9.

Building Blocks More >
17734-21-3
17734-21-3
Benzenepentanamine
AA00256O | MFCD00870521
177785-41-0
177785-41-0
4-Amino-N-cyclopropylbenzenesulfonamide
AA0025GN | MFCD04035197
178119-93-2
178119-93-2
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid
AA0025OU | MFCD02682475
17846-15-0
17846-15-0
Adamantane-1-carbohydrazide
AA0025ZQ | MFCD00154679
17887-80-8
17887-80-8
1,3-Bis(trimethylsilyloxy)propane
AA0026CH | MFCD00161340
179104-32-6
179104-32-6
3-Chloro-2-(isopropylthio)aniline
AA0026Q3 | MFCD00831111
1795-31-9
1795-31-9
Tris(trimethylsilyl)phosphite
AA0026Z5 | MFCD00015588
179873-45-1
179873-45-1
N-[4-(1H-Imidazol-1-yl)benzyl]-n-methylamine
AA002789 | MFCD07772795
18343-45-8
18343-45-8
1,2,3-Benzotriazin-4(3H)-one, 8-chloro-
AA0027IB | MFCD25960294
20196-21-8
20196-21-8
Thiomorpholin-3-one
AA0027V5 | MFCD00152870
Submit
© 2017 AA BLOCKS, INC. All rights reserved.