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178419-45-9,MFCD21266569
Catalog No.:AA0025XW

178419-45-9 | Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one

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50mg
95%
3 weeks  
$524.00   $367.00
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100mg
95%
3 weeks  
$725.00   $508.00
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250mg
95%
3 weeks  
$984.00   $689.00
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500mg
95%
3 weeks  
$1,486.00   $1,040.00
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1g
95%
3 weeks  
$1,875.00   $1,313.00
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2.5g
95%
3 weeks  
$3,563.00   $2,494.00
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5g
95%
3 weeks  
$5,218.00   $3,653.00
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10g
95%
3 weeks  
$7,679.00   $5,375.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0025XW
Chemical Name:
Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
CAS Number:
178419-45-9
Molecular Formula:
C9H14N2O2
Molecular Weight:
182.2197
MDL Number:
MFCD21266569
SMILES:
O=C1NCC2(O1)CN1CCC2CC1
Properties
Computed Properties
 
Complexity:
248  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.2  

Literature

Title: In vitro binding characteristics of [3H]AZ11637326, a novel alpha7-selective neuronal nicotinic receptor agonist radioligand.

Journal: European journal of pharmacology 20101025

Title: Young and older good learners have higher levels of brain nicotinic receptor binding.

Journal: Neurobiology of aging 20100601

Title: Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis.

Journal: British journal of pharmacology 20100501

Title: Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.

Journal: British journal of pharmacology 20100201

Title: Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.

Journal: Arthritis and rheumatism 20090101

Title: Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20081101

Title: [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice.

Journal: Gastroenterology 20071001

Title: The cholinergic anti-inflammatory pathway and the gastrointestinal tract.

Journal: Gastroenterology 20071001

Title: Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Journal: Journal of medicinal chemistry 20050728

Title: A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist.

Journal: The Journal of organic chemistry 20040917

Title: Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.

Journal: Bioorganic & medicinal chemistry letters 20040419

Title: AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors.

Journal: Psychopharmacology 20040401

Title: Attentional effects of nicotinic agonists in rats.

Journal: Neuropharmacology 20030601

Title: Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.

Journal: European journal of pharmacology 20030124

Title: Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus.

Journal: The Journal of physiology 20011001

Title: The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?

Journal: Psychopharmacology 20010701

Title: Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

Journal: The Journal of pharmacology and experimental therapeutics 20000901

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Tags:178419-45-9 Molecular Formula|178419-45-9 MDL|178419-45-9 SMILES|178419-45-9 Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one