178603-78-6,MFCD00237124
Catalog No.:AA002648

178603-78-6 | L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$67.00   $47.00
- +
5mg
98%
in stock  
$114.00   $80.00
- +
10mg
98%
in stock  
$193.00   $136.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA002648
Chemical Name:
L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
CAS Number:
178603-78-6
Molecular Formula:
C24H33ClN4O8
Molecular Weight:
540.9938
MDL Number:
MFCD00237124
SMILES:
ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)C)C)CC(=O)O
Properties
Computed Properties
 
Complexity:
845  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0  
Rotatable Bond Count:
14  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.9  

Literature

Title: NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.

Journal: Neuroscience 20170220

Title: Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats.

Journal: Journal of neuroinflammation 20170101

Title: Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice.

Journal: Chinese medical journal 20151005

Title: Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20121003

Title: Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.

Journal: The Journal of biological chemistry 20110930

Title: The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence.

Journal: Cell host & microbe 20110721

Title: Immunological response in early brain injury after SAH.

Journal: Acta neurochirurgica. Supplement 20110101

Title: Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice.

Journal: Stroke 20091201

Title: Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells.

Journal: Annals of the New York Academy of Sciences 20090801

Title: Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice.

Journal: Stroke 20090701

Title: Neuroprotective effects of Ac.YVAD.cmk on experimental spinal cord injury in rats.

Journal: Surgical neurology 20080601

Title: Blockade of caspase-1 increases neurogenesis in the aged hippocampus.

Journal: The European journal of neuroscience 20071101

Title: Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy.

Journal: Neurobiology of disease 20070801

Title: Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060701

Title: Effects of specific interleukin-1beta-converting enzyme inhibitor on ischemic acute renal failure in murine models.

Journal: Acta pharmacologica Sinica 20051101

Title: Improvement of memory for context by inhibition of caspase-1 in aged rats.

Journal: The European journal of neuroscience 20051001

Title: Neuroprotection by the caspase-1 inhibitor Ac-YVAD-(acyloxy)mk in experimental neuroAIDS is independent from IL-1beta generation.

Journal: Cell death and differentiation 20050801

Title: Caspase inhibition increases survival of neural stem cells in the gastrointestinal tract.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050801

Title: Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient.

Journal: Cell transplantation 20050101

Title: Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity.

Journal: The European journal of neuroscience 20041001

Title: Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation.

Journal: Clinical and diagnostic laboratory immunology 20040501

Title: Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.

Journal: Cytokine 20040107

Title: Reassessment of caspase inhibition to augment grafted dopamine neuron survival.

Journal: Cell transplantation 20040101

Title: Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.

Journal: Cell death and differentiation 20030801

Title: Inhibition of interleukin-1beta convertase is associated with decrease of neointimal hyperplasia after coronary artery stenting in pigs.

Journal: Molecular and cellular biochemistry 20030701

Title: Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells.

Journal: Toxicology letters 20030404

Title: Ultrastructural characterization of dissociated embryonic ventral mesencephalic tissue treated with neuroprotectants.

Journal: Cell transplantation 20030101

Title: A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury.

Journal: European journal of pharmacology 20021205

Title: Apoptosis induced by Pseudomonas aeruginosa in antigen presenting cells is diminished by genetic modification with CD40 ligand.

Journal: Pediatric research 20021101

Title: [Studies on evodiamine induced HeLa cell apoptosis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901

Title: Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells.

Journal: Acta pharmacologica Sinica 20020401

Title: Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020315

Title: Non-specific caspase inhibition reduces infarct size and improves post-ischaemic recovery in isolated ischaemic/reperfused rat hearts.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20011201

Title: HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death.

Journal: British journal of pharmacology 20011101

Title: Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone.

Journal: The Journal of biological chemistry 20010831

Title: Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.

Journal: Journal of neuroscience research 20010415

Title: Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4-induced hepatitis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010415

Title: Differential effects of caspase inhibitors on endotoxin-induced myocardial dysfunction and heart apoptosis.

Journal: American journal of physiology. Heart and circulatory physiology 20010401

Title: Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010315

Title: Proteolytic cleavage of epidermal growth factor receptor by caspases.

Journal: FEBS letters 20010223

Title: T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain.

Journal: Scandinavian journal of immunology 20010201

Title: Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis.

Journal: Oncogene 20010118

Title: Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea.

Journal: Reproduction, fertility, and development 20010101

Title: Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis.

Journal: Journal of cell science 20000901

Title: Detection of caspase-activation in intact lymphoid cells using standard caspase substrates and inhibitors.

Journal: Journal of immunological methods 20000731

Title: Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20000615

Title: The involvement of caspases in the CD95(Fas/Apo-1)- but not swelling-induced cellular taurine release from Jurkat T-lymphocytes.

Journal: Pflugers Archiv : European journal of physiology 20000501

Title: Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo.

Journal: Journal of molecular and cellular cardiology 19990901

Title: N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina.

Journal: Investigative ophthalmology & visual science 19990901

Title: The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19990302

Title: Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas.

Journal: Diabetes 19990301

Title: Caspase-1 is not involved in CD95/Fas-induced apoptosis in Jurkat T cells.

Journal: Experimental cell research 19990201

Title: Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation.

Journal: Free radical research 19990101

Title: Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade.

Journal: Neuroscience 19990101

Title: Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2.

Journal: Experimental cell research 19981125

Title: Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19981015

Title: Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways.

Journal: The Journal of experimental medicine 19980907

Title: NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria.

Journal: The European journal of neuroscience 19980501

Title: Preparation and imaging of nuclear spreads from cells of the zebrafish embryo. Evidence for large degradation intermediates in apoptosis.

Journal: Chromosoma 19980301

Title: The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases.

Journal: Cell death and differentiation 19980301

Title: The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages.

Journal: Infection and immunity 19971201

Title: Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.

Journal: The Journal of biological chemistry 19971121

Title: Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species.

Journal: Journal of neurochemistry 19971101

Title: B cell receptor cross-linking prevents Fas-induced cell death by inactivating the IL-1 beta-converting enzyme protease and regulating Bcl-2/Bcl-x expression.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19971001

Title: Need for caspases in apoptosis of trophic factor-deprived PC12 cells.

Journal: Journal of neuroscience research 19971001

Title: Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture.

Journal: Journal of neurochemistry 19970401

Title: Antiapoptotic effect of benzyloxycarbonyl-aspartyl-(beta-tertier-butyl ester)-bromomethylketone (Z-D(OtBu)-Bmk), an intermediate of interleukin-1 beta converting enzyme inhibitors.

Journal: International journal of immunopharmacology 19970401

Title: Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19970304

Title: Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis.

Journal: Biochemical and biophysical research communications 19970103

Title: Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease.

Journal: The Journal of biological chemistry 19961206

Title: Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19961101

Title: Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells.

Journal: Cancer research 19961015

Title: Apoptosis by a cytosolic extract from Fas-activated cells.

Journal: The EMBO journal 19951101

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SDS
Tags:178603-78-6 Molecular Formula|178603-78-6 MDL|178603-78-6 SMILES|178603-78-6 L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
Catalog No.: AA002648
178603-78-6,MFCD00237124
178603-78-6 | L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
Pack Size: 1mg
Purity: 98%
in stock
$67.00 $47.00
Pack Size: 5mg
Purity: 98%
in stock
$114.00 $80.00
Pack Size: 10mg
Purity: 98%
in stock
$193.00 $136.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA002648
Chemical Name: L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
CAS Number: 178603-78-6
Molecular Formula: C24H33ClN4O8
Molecular Weight: 540.9938
MDL Number: MFCD00237124
SMILES: ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)C)C)CC(=O)O
Properties
Complexity: 845  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 37  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 6  
Isotope Atom Count: 0  
Rotatable Bond Count: 14  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.9  
Literature fold

Title: NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.

Journal: Neuroscience20170220

Title: Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats.

Journal: Journal of neuroinflammation20170101

Title: Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice.

Journal: Chinese medical journal20151005

Title: Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20121003

Title: Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.

Journal: The Journal of biological chemistry20110930

Title: The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence.

Journal: Cell host & microbe20110721

Title: Immunological response in early brain injury after SAH.

Journal: Acta neurochirurgica. Supplement20110101

Title: Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice.

Journal: Stroke20091201

Title: Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells.

Journal: Annals of the New York Academy of Sciences20090801

Title: Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice.

Journal: Stroke20090701

Title: Neuroprotective effects of Ac.YVAD.cmk on experimental spinal cord injury in rats.

Journal: Surgical neurology20080601

Title: Blockade of caspase-1 increases neurogenesis in the aged hippocampus.

Journal: The European journal of neuroscience20071101

Title: Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy.

Journal: Neurobiology of disease20070801

Title: Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20060701

Title: Effects of specific interleukin-1beta-converting enzyme inhibitor on ischemic acute renal failure in murine models.

Journal: Acta pharmacologica Sinica20051101

Title: Improvement of memory for context by inhibition of caspase-1 in aged rats.

Journal: The European journal of neuroscience20051001

Title: Neuroprotection by the caspase-1 inhibitor Ac-YVAD-(acyloxy)mk in experimental neuroAIDS is independent from IL-1beta generation.

Journal: Cell death and differentiation20050801

Title: Caspase inhibition increases survival of neural stem cells in the gastrointestinal tract.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20050801

Title: Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient.

Journal: Cell transplantation20050101

Title: Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity.

Journal: The European journal of neuroscience20041001

Title: Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation.

Journal: Clinical and diagnostic laboratory immunology20040501

Title: Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.

Journal: Cytokine20040107

Title: Reassessment of caspase inhibition to augment grafted dopamine neuron survival.

Journal: Cell transplantation20040101

Title: Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.

Journal: Cell death and differentiation20030801

Title: Inhibition of interleukin-1beta convertase is associated with decrease of neointimal hyperplasia after coronary artery stenting in pigs.

Journal: Molecular and cellular biochemistry20030701

Title: Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells.

Journal: Toxicology letters20030404

Title: Ultrastructural characterization of dissociated embryonic ventral mesencephalic tissue treated with neuroprotectants.

Journal: Cell transplantation20030101

Title: A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury.

Journal: European journal of pharmacology20021205

Title: Apoptosis induced by Pseudomonas aeruginosa in antigen presenting cells is diminished by genetic modification with CD40 ligand.

Journal: Pediatric research20021101

Title: [Studies on evodiamine induced HeLa cell apoptosis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20020901

Title: Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells.

Journal: Acta pharmacologica Sinica20020401

Title: Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity.

Journal: Journal of immunology (Baltimore, Md. : 1950)20020315

Title: Non-specific caspase inhibition reduces infarct size and improves post-ischaemic recovery in isolated ischaemic/reperfused rat hearts.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20011201

Title: HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death.

Journal: British journal of pharmacology20011101

Title: Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone.

Journal: The Journal of biological chemistry20010831

Title: Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.

Journal: Journal of neuroscience research20010415

Title: Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4-induced hepatitis.

Journal: Journal of immunology (Baltimore, Md. : 1950)20010415

Title: Differential effects of caspase inhibitors on endotoxin-induced myocardial dysfunction and heart apoptosis.

Journal: American journal of physiology. Heart and circulatory physiology20010401

Title: Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice.

Journal: Journal of immunology (Baltimore, Md. : 1950)20010315

Title: Proteolytic cleavage of epidermal growth factor receptor by caspases.

Journal: FEBS letters20010223

Title: T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain.

Journal: Scandinavian journal of immunology20010201

Title: Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis.

Journal: Oncogene20010118

Title: Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea.

Journal: Reproduction, fertility, and development20010101

Title: Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis.

Journal: Journal of cell science20000901

Title: Detection of caspase-activation in intact lymphoid cells using standard caspase substrates and inhibitors.

Journal: Journal of immunological methods20000731

Title: Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20000615

Title: The involvement of caspases in the CD95(Fas/Apo-1)- but not swelling-induced cellular taurine release from Jurkat T-lymphocytes.

Journal: Pflugers Archiv : European journal of physiology20000501

Title: Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo.

Journal: Journal of molecular and cellular cardiology19990901

Title: N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina.

Journal: Investigative ophthalmology & visual science19990901

Title: The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1.

Journal: Proceedings of the National Academy of Sciences of the United States of America19990302

Title: Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas.

Journal: Diabetes19990301

Title: Caspase-1 is not involved in CD95/Fas-induced apoptosis in Jurkat T cells.

Journal: Experimental cell research19990201

Title: Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation.

Journal: Free radical research19990101

Title: Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade.

Journal: Neuroscience19990101

Title: Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2.

Journal: Experimental cell research19981125

Title: Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience19981015

Title: Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways.

Journal: The Journal of experimental medicine19980907

Title: NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria.

Journal: The European journal of neuroscience19980501

Title: Preparation and imaging of nuclear spreads from cells of the zebrafish embryo. Evidence for large degradation intermediates in apoptosis.

Journal: Chromosoma19980301

Title: The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases.

Journal: Cell death and differentiation19980301

Title: The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages.

Journal: Infection and immunity19971201

Title: Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.

Journal: The Journal of biological chemistry19971121

Title: Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species.

Journal: Journal of neurochemistry19971101

Title: B cell receptor cross-linking prevents Fas-induced cell death by inactivating the IL-1 beta-converting enzyme protease and regulating Bcl-2/Bcl-x expression.

Journal: Journal of immunology (Baltimore, Md. : 1950)19971001

Title: Need for caspases in apoptosis of trophic factor-deprived PC12 cells.

Journal: Journal of neuroscience research19971001

Title: Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture.

Journal: Journal of neurochemistry19970401

Title: Antiapoptotic effect of benzyloxycarbonyl-aspartyl-(beta-tertier-butyl ester)-bromomethylketone (Z-D(OtBu)-Bmk), an intermediate of interleukin-1 beta converting enzyme inhibitors.

Journal: International journal of immunopharmacology19970401

Title: Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.

Journal: Proceedings of the National Academy of Sciences of the United States of America19970304

Title: Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis.

Journal: Biochemical and biophysical research communications19970103

Title: Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease.

Journal: The Journal of biological chemistry19961206

Title: Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis.

Journal: Journal of immunology (Baltimore, Md. : 1950)19961101

Title: Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells.

Journal: Cancer research19961015

Title: Apoptosis by a cytosolic extract from Fas-activated cells.

Journal: The EMBO journal19951101

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