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143313-51-3,MFCD00237123
Catalog No.:AA007YVG

143313-51-3 | Caspase-1 Inhibitor I

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1mg
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5mg
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10mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007YVG
Chemical Name:
Caspase-1 Inhibitor I
CAS Number:
143313-51-3
Molecular Formula:
C23H32N4O8
Molecular Weight:
492.5222
MDL Number:
MFCD00237123
SMILES:
O=C[C@@H](N[C@H](C(=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)C)C)CC(=O)O
Properties
Computed Properties
 
Complexity:
780  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
13  
XLogP3:
-0.8  

Literature

Title: Release of apical dominance in potato tuber is accompanied by programmed cell death in the apical bud meristem.

Journal: Plant physiology 20120401

Title: Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.

Journal: Bioorganic & medicinal chemistry letters 20110415

Title: Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).

Journal: Bioorganic & medicinal chemistry letters 20100901

Title: Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.

Journal: Journal of medicinal chemistry 20090423

Title: Type III secretion system 1 of Vibrio parahaemolyticus induces oncosis in both epithelial and monocytic cell lines.

Journal: Microbiology (Reading, England) 20090301

Title: Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia.

Journal: Intensive care medicine 20070501

Title: Small molecular anti-cytokine agents.

Journal: Medicinal research reviews 20060101

Title: Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injury.

Journal: Journal of leukocyte biology 20050501

Title: Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum.

Journal: Acta pharmacologica Sinica 20050201

Title: Maturation and release of interleukin-1beta by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors.

Journal: The Journal of biological chemistry 20030815

Title: Caspase-mediated cleavage of JNK during stress-induced apoptosis.

Journal: Biochemical and biophysical research communications 20030711

Title: Caspase inhibition attenuates transection-induced oligodendrocyte apoptosis in the developing chick spinal cord.

Journal: Molecular and cellular neurosciences 20030701

Title: Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.

Journal: International journal of cancer 20030210

Title: A common pathway for chemotherapy-induced apoptosis in human squamous cell carcinoma lines distinct from that of receptor-mediated cell death.

Journal: Anticancer research 20030101

Title: Time sequence analysis of caspase-3-independent programmed cell death and apoptosis in X-irradiated human leukemic MOLT-4 cells.

Journal: Cell and tissue research 20021201

Title: Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2).

Journal: Experimental & molecular medicine 20020731

Title: Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18.

Journal: Clinical immunology (Orlando, Fla.) 20020501

Title: Metal-catalyzed oxidation of extracellular matrix proteins promotes human mesangial cell apoptosis and is associated with enhanced expression of Bax and caspase activation.

Journal: Biochemical and biophysical research communications 20020405

Title: Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells.

Journal: Journal of neuroscience research 20020315

Title: Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells.

Journal: The Journal of biological chemistry 20011214

Title: Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.

Journal: British journal of cancer 20011101

Title: Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes.

Journal: Arthritis and rheumatism 20010701

Title: Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation.

Journal: European journal of immunology 20010301

Title: Purpurin-18 in combination with light leads to apoptosis or necrosis in HL60 leukemia cells.

Journal: Photochemistry and photobiology 20010301

Title: Analysis of nuclear apoptotic process in a cell-free system.

Journal: Cellular and molecular life sciences : CMLS 20010201

Title: Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19990815

Title: Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.

Journal: Oncogene 19990708

Title: Caspase-3 activation during apoptosis caused by glutathione-doxorubicin conjugate.

Journal: British journal of cancer 19990501

Title: Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death.

Journal: The Journal of biological chemistry 19990226

Title: Caspase-1 is not involved in CD95/Fas-induced apoptosis in Jurkat T cells.

Journal: Experimental cell research 19990201

Title: Comparison of the apoptotic pathways induced by L-amino acid oxidase and hydrogen peroxide.

Journal: Journal of biochemistry 19990201

Title: Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3.

Journal: Cell proliferation 19990201

Title: Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.

Journal: Chemical & pharmaceutical bulletin 19990101

Title: Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.

Journal: Cell death and differentiation 19981201

Title: Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2.

Journal: Experimental cell research 19981125

Title: Partial purification and characterization of two distinct types of caspases from human epidermis.

Journal: The Journal of investigative dermatology 19980901

Title: Activation of interleukin-1beta-converting enzyme by nigericin is independent of apoptosis.

Journal: Cytokine 19980901

Title: Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19980515

Title: Proteolytic cleavage of HsRad51 during apoptosis.

Journal: FEBS letters 19980508

Title: Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease.

Journal: The American journal of physiology 19980401

Title: Preparation and imaging of nuclear spreads from cells of the zebrafish embryo. Evidence for large degradation intermediates in apoptosis.

Journal: Chromosoma 19980301

Title: Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease.

Journal: Gut 19980201

Title: Guanine nucleotides protect Rho proteins from endogenous proteolytic degradation in renal membranes.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 19980101

Title: The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages.

Journal: Infection and immunity 19971201

Title: Need for caspases in apoptosis of trophic factor-deprived PC12 cells.

Journal: Journal of neuroscience research 19971001

Title: Involvement of caspases in sympathetic neuron apoptosis.

Journal: Journal of cell science 19970901

Title: Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A.

Journal: Kidney international 19970801

Title: Antiapoptotic effect of benzyloxycarbonyl-aspartyl-(beta-tertier-butyl ester)-bromomethylketone (Z-D(OtBu)-Bmk), an intermediate of interleukin-1 beta converting enzyme inhibitors.

Journal: International journal of immunopharmacology 19970401

Title: Involvement of CPP32/Yama-like protease in CPT-11-induced death signal transduction pathway.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 19961201

Title: Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin-1 beta converting enzyme (ICE).

Journal: International journal of peptide and protein research 19940801

Title: Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248.

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Tags:143313-51-3 Molecular Formula|143313-51-3 MDL|143313-51-3 SMILES|143313-51-3 Caspase-1 Inhibitor I