[1]CurrentPatentAssignee:JILINYATAI(GROUP)CO.,LTD.-CN106146386,2016,A
[1]CurrentPatentAssignee:JILINYATAI(GROUP)CO.,LTD.-CN106146386,2016,A
[1]Patent:CN106146386,2016,A
[1]Patent:CN106146386,2016,A.Locationinpatent:Paragraph0068;0069;0070;0071
[2]Patent:WO2017/137910,2017,A1.Locationinpatent:Page/Pagecolumn29
[1]CurrentPatentAssignee:JILINYATAI(GROUP)CO.,LTD.-CN106146386,2016,A
Title: Pharmacokinetics of single and repeated oral doses prucalopride in healthy Chinese volunteers.
Journal: International journal of clinical pharmacology and therapeutics 20121101
Title: Prucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipation.
Journal: Expert opinion on drug metabolism & toxicology 20121001
Title: The use of Resolor (prucalopride) for chronic constipation in women.
Journal: British journal of nursing (Mark Allen Publishing) 20120901
Title: The successful treatment of acute refractory pseudo-obstruction with prucalopride.
Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20120801
Title: Recent advances in the management of difficult constipation.
Journal: Current gastroenterology reports 20120801
Title: The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations.
Journal: The Journal of pharmacology and experimental therapeutics 20120601
Title: Study of the regulation of the inotropic response to 5-HT4 receptor activation via phosphodiesterases and its cross-talk with C-type natriuretic peptide in porcine left atrium.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120601
Title: Inotropic effects of prokinetic agents with 5-HT(4) receptor agonist actions on human isolated myocardial trabeculae.
Journal: Life sciences 20120409
Title: The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4.
Journal: Neuropharmacology 20120401
Title: Prucalopride in a case of severe opioid induced constipation.
Journal: Minerva anestesiologica 20120401
Title: Assessment of the cardiac safety of prucalopride in healthy volunteers: a randomized, double-blind, placebo- and positive-controlled thorough QT study.
Journal: British journal of clinical pharmacology 20120201
Title: Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study.
Journal: Alimentary pharmacology & therapeutics 20120101
Title: In-vitro acetylcholine release is not a straightforward model to study hippocampal 5-HT₄ receptors.
Journal: Neuroreport 20111207
Title: Chronic constipation: current treatment options.
Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20111001
Title: Investigation of neurogenic excitatory and inhibitory motor responses and their control by 5-HT(4) receptors in circular smooth muscle of pig descending colon.
Journal: European journal of pharmacology 20110930
Title: Estimating the relationship between preference-based generic utility instruments and disease-specific quality-of-life measures in severe chronic constipation: challenges in practice.
Journal: PharmacoEconomics 20110801
Title: [Treatment of severe chronic constipation: differential roles of conventional laxatives and the prucalopride prokinetic].
Journal: Zeitschrift fur Gastroenterologie 20110801
Title: What role for prucalopride in constipation?
Journal: Drug and therapeutics bulletin 20110801
Title: Development and validation of a sample stabilization strategy and a UPLC-MS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF).
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110715
Title: Prucalopride for the treatment of women with chronic constipation in whom standard laxative regimens have failed to provide adequate relief.
Journal: Health technology assessment (Winchester, England) 20110501
Title: Prucalopride. In chronic constipation: poorly documented risks.
Journal: Prescrire international 20110501
Title: Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis.
Journal: Gut 20110201
Title: [New treatment option for women with chronic constipation - prucalopride stimulates the disturbed gut motility again].
Journal: Zeitschrift fur Gastroenterologie 20110101
Title: [Prucalopride - oral (Resolor)].
Journal: Journal de pharmacie de Belgique 20101201
Title: Clinical trial: the efficacy of open-label prucalopride treatment in patients with chronic constipation - follow-up of patients from the pivotal studies.
Journal: Alimentary pharmacology & therapeutics 20101101
Title: Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation.
Journal: Digestive diseases and sciences 20101001
Title: A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100901
Title: [New drugs for the treatment of constipation].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20100701
Title: Influence of 5-HT4 receptor activation on acetylcholine release in human large intestine with endometriosis.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100501
Title: Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201
Title: Prucalopride for constipation.
Journal: Expert opinion on pharmacotherapy 20100201
Title: Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat.
Journal: PloS one 20100101
Title: Investigations into the binding affinities of different human 5-HT4 receptor splice variants.
Journal: Pharmacology 20100101
Title: Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20091201
Title: Translating 5-HT receptor pharmacology.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20091201
Title: Prucalopride for chronic constipation.
Journal: Drugs of today (Barcelona, Spain : 1998) 20091201
Title: Prucalopride: a new drug for the treatment of chronic constipation.
Journal: Expert review of gastroenterology & hepatology 20090801
Title: Motility: prucalopride for chronic constipation.
Journal: Nature reviews. Gastroenterology & hepatology 20090601
Title: The use of novel promotility and prosecretory agents for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation.
Journal: Advances in therapy 20090501
Title: Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives.
Journal: Gut 20090301
Title: Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study.
Journal: Alimentary pharmacology & therapeutics 20090201
Title: Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in stomach.
Journal: British journal of pharmacology 20090101
Title: Prucalopride.
Journal: Drugs 20090101
Title: New treatments for irritable bowel syndrome in women.
Journal: Women's health (London, England) 20081101
Title: Management of constipation in the elderly: emerging therapeutic strategies.
Journal: World journal of gastroenterology 20080907
Title: Alternative splicing and exon duplication generates 10 unique porcine 5-HT 4 receptor splice variants including a functional homofusion variant.
Journal: Physiological genomics 20080612
Title: A placebo-controlled trial of prucalopride for severe chronic constipation.
Journal: The New England journal of medicine 20080529
Title: The long and short of a constipation-reducing medication.
Journal: The New England journal of medicine 20080529
Title: Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice.
Journal: Behavioural brain research 20080305
Title: 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice.
Journal: British journal of pharmacology 20070401
Title: The action of the novel gastrointestinal prokinetic prucalopride on the HERG K+ channel and the common T897 polymorph.
Journal: European journal of pharmacology 20070112
Title: 5HT4 agonists inhibit interferon-gamma-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes.
Journal: Journal of neuroimmunology 20061001
Title: 5-HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20060901
Title: Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development.
Journal: British journal of pharmacology 20060101
Title: 5-HT4 receptors located on cholinergic nerves in human colon circular muscle.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050601
Title: Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050601
Title: Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists.
Journal: Biological psychiatry 20050415
Title: Electrophysiological effects of prucalopride, a novel enterokinetic agent, on isolated atrial myocytes from patients treated with beta-adrenoceptor antagonists.
Journal: The Journal of pharmacology and experimental therapeutics 20050401
Title: Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease.
Journal: Neuroscience 20040101
Title: Effect of enterokinetic prucalopride on intestinal motility in fast rats.
Journal: World journal of gastroenterology 20030915
Title: Gastrointestinal motility disorders and gastrointestinal prokinetic therapy.
Journal: The Veterinary clinics of North America. Small animal practice 20030901
Title: Irritable bowel syndrome: an overview of diagnosis and pharmacologic treatment.
Journal: Cleveland Clinic journal of medicine 20030601
Title: Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial.
Journal: Digestion 20030101
Title: 5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity.
Journal: The European journal of neuroscience 20020901
Title: Prucalopride, a systemic enterokinetic, for the treatment of constipation.
Journal: Alimentary pharmacology & therapeutics 20020701
Title: Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation.
Journal: Alimentary pharmacology & therapeutics 20020401
Title: Efficacy and tolerability of prucalopride in patients with constipation due to spinal cord injury.
Journal: Scandinavian journal of gastroenterology 20020401
Title: The effects of the specific 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers.
Journal: Alimentary pharmacology & therapeutics 20020301
Title: Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach.
Journal: British journal of pharmacology 20020101
Title: Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride.
Journal: The American journal of gastroenterology 20020101
Title: Pharmacological treatment of irritable bowel syndrome--from concept to sales.
Journal: The European journal of surgery. Supplement. : = Acta chirurgica. Supplement 20020101
Title: Serotoninergic neuroenteric modulators.
Journal: Lancet (London, England) 20011215
Title: Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel.
Journal: The Journal of pharmacology and experimental therapeutics 20011201
Title: The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein.
Journal: The Journal of biological chemistry 20011130
Title: Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20011001
Title: Drug therapy options for patients with irritable bowel syndrome.
Journal: The American journal of managed care 20010701
Title: The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.
Journal: European journal of pharmacology 20010629
Title: 5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study.
Journal: British journal of pharmacology 20010401
Title: Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder.
Journal: Gastroenterology 20010201
Title: Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
Title: Johnson DE, et al. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3):681-91.
