Home Amines 183322-45-4
183322-45-4,MFCD01074805
Catalog No.:AA0027FW

183322-45-4 | N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

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5mg
≥98%
in stock  
$90.00   $63.00
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10mg
≥98%
in stock  
$152.00   $106.00
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25mg
≥98%
in stock  
$348.00   $243.00
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50mg
≥98%
in stock  
$566.00   $396.00
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100mg
98% by HPLC
in stock  
$949.00   $664.00
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500mg
98% by HPLC
in stock  
$2,920.00   $2,044.00
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1000mg
98% by HPLC
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0027FW
Chemical Name:
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
CAS Number:
183322-45-4
Molecular Formula:
C16H15BrClN3O2
Molecular Weight:
396.6662
MDL Number:
MFCD01074805
SMILES:
COc1cc2c(ncnc2cc1OC)Nc1cccc(c1)Br.Cl
Properties
Computed Properties
 
Complexity:
360  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Downstream Synthesis Route
CASUnavailable 
  13790-39-1    183322-45-4 

[1]Rocco,SilvanaA.;Barbarini,JoseEduardo;Rittner,Roberto[Synthesis,2004,#3,p.429-435]

[2]Bridges;Zhou;Cody;Rewcastle;McMichael;Showalter;Fry;Kraker;Denny[JournalofMedicinalChemistry,1996,vol.39,#1,p.267-276]

[3]Lim,JohnK.;Negash,Kitaw;Hanrahan,StephenM.;Vanbrocklin,HenryF.[Journaloflabelledcompoundsandradiopharmaceuticals,2000,vol.43,#12,p.1183-1191]

[4]VanBrocklin,HenryF.;Lim,JohnK.;Coffing,StephanieL.;Hom,DarrenL.;Negash,Kitaw;Ono,MicheleY.;Gilmore,JenniferL.;Bryant,Ianthe;RieseII,DavidJ.[JournalofMedicinalChemistry,2005,vol.48,#23,p.7445-7456]

[5]Rewcastle;Denny;Bridges;Zhou;Cody;McMichael;Fry[JournalofMedicinalChemistry,1995,vol.38,#18,p.3482-3487]

Literature

Title: Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.

Journal: Journal of medicinal chemistry 20051117

Title: Bridges AJ, et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39(1):267-76.

Title: Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265(5175):1093-5.

Title: Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3(11):2099-106.

Title: Kunkel MW, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13(4):295-302.

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SDS
Tags:183322-45-4 Molecular Formula|183322-45-4 MDL|183322-45-4 SMILES|183322-45-4 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride