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205391-02-2,MFCD05865101
Catalog No.:AA0029ZH

205391-02-2 | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-bis(acetyloxy)-5,6-diamino-

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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0029ZH
Chemical Name:
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-bis(acetyloxy)-5,6-diamino-
CAS Number:
205391-02-2
Molecular Formula:
C24H18N2O7
Molecular Weight:
446.4089
MDL Number:
MFCD05865101
SMILES:
CC(=O)Oc1ccc2c(c1)Oc1c(C32OC(=O)c2c3cc(N)c(c2)N)ccc(c1)OC(=O)C
Properties
Computed Properties
 
Complexity:
779  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.3  

Literature

Title: Effects of moderate electrical stimulation on reactive species production by primary rat skeletal muscle cells: cross talk between superoxide and nitric oxide production.

Journal: Journal of cellular physiology 20120601

Title: [Influence of environmental factors on the generation of nitric oxide in the roots of etiolated pea seedlings].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20120101

Title: Endogenous presynaptic nitric oxide supports an anterograde signaling in the central nervous system.

Journal: Journal of neurochemistry 20110801

Title: Flux of nitric oxide between the necrotrophic pathogen Botrytis cinerea and the host plant.

Journal: Molecular plant pathology 20110801

Title: Improved measurements of intracellular nitric oxide in intact microvessels using 4,5-diaminofluorescein diacetate.

Journal: American journal of physiology. Heart and circulatory physiology 20110701

Title: Monitoring of intracellular nitric oxide in leishmaniasis: its applicability in patients with visceral leishmaniasis.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20110101

Title: Interaction of purinergic and nitrergic mechanisms in the caudal nucleus tractus solitarii of rats.

Journal: Autonomic neuroscience : basic & clinical 20091203

Title: Nitric oxide, induced by wounding, mediates redox regulation in pelargonium leaves.

Journal: Plant biology (Stuttgart, Germany) 20090901

Title: Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament.

Journal: Hearing research 20090801

Title: Immunoreactivity for neuronal NOS and fluorescent indication of NO formation in the NTS of juvenile rats submitted to chronic intermittent hypoxia.

Journal: Autonomic neuroscience : basic & clinical 20090615

Title: Intracellular nitric oxide assessment in whole blood leukocytes by flow cytometry: optimization and applicability to monitor patients with chronic graft nephropathy.

Journal: Journal of immunological methods 20090415

Title: Use of diaminofluoresceins to detect and measure nitric oxide in low level generating human immune cells.

Journal: Journal of immunological methods 20090315

Title: Increased NO bioavailability in aging male rats by genistein and exercise training: using 4, 5-diaminofluorescein diacetate.

Journal: Reproductive biology and endocrinology : RB&E 20090101

Title: The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits.

Journal: Anesthesia and analgesia 20080901

Title: A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis.

Journal: Nature chemical biology 20080701

Title: Floral transition and nitric oxide emission during flower development in Arabidopsis thaliana is affected in nitrate reductase-deficient plants.

Journal: Plant & cell physiology 20080701

Title: Nitric oxide detection by DAF (diaminofluorescein) fluorescence in human myometrial tissue.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080601

Title: Developmental changes in endothelium-dependent relaxation of the chicken ductus arteriosus.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080301

Title: Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes.

Journal: American journal of physiology. Cell physiology 20080201

Title: Imaging of nitric oxide in a living vertebrate using a diamino-fluorescein probe.

Journal: Free radical biology & medicine 20070815

Title: Nitric oxide decreases ammonium release in tadpoles of the clawed frog, Xenopus laevis, Daudin.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20070501

Title: Effect of high-salt diet on vascular relaxation and oxidative stress in mesenteric resistance arteries.

Journal: Journal of vascular research 20070101

Title: Abscisic acid (ABA) inhibits light-induced stomatal opening through calcium- and nitric oxide-mediated signaling pathways.

Journal: Nitric oxide : biology and chemistry 20070101

Title: Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope.

Journal: Arthritis and rheumatism 20061101

Title: Direct nitric oxide measurement in human spermatozoa: flow cytometric analysis using the fluorescent probe, diaminofluorescein.

Journal: International journal of andrology 20061001

Title: Nitric oxide is formed in Medicago truncatula-Sinorhizobium meliloti functional nodules.

Journal: Molecular plant-microbe interactions : MPMI 20060901

Title: Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells.

Journal: Clinical and experimental pharmacology & physiology 20060801

Title: Schistosoma mansoni: use of a fluorescent indicator to detect nitric oxide and related species in living parasites.

Journal: Experimental parasitology 20060601

Title: Inhibitory effects of saponins from Anemarrhena asphodeloides Bunge on the growth of vascular smooth muscle cells.

Journal: Biomedical and environmental sciences : BES 20060601

Title: The free-radical scavenger, edaravone, augments NO release from vascular cells and platelets after laser-induced, acute endothelial injury in vivo.

Journal: Platelets 20060501

Title: Nitric oxide synthase localization in the rat neutrophils: immunocytochemical, molecular, and biochemical studies.

Journal: Journal of leukocyte biology 20060301

Title: Solving an enigma: arterial pole development in the zebrafish heart.

Journal: Developmental biology 20060215

Title: Neural tube closure depends on nitric oxide synthase activity.

Journal: Journal of neurochemistry 20060101

Title: Rapid and reactive nitric oxide production by astrocytes in mouse neocortical slices.

Journal: Glia 20051115

Title: Performance of diamino fluorophores for the localization of sources and targets of nitric oxide.

Journal: Free radical biology & medicine 20050201

Title: Effect of bradykinin on nitric oxide production, urea synthesis and viability of rat hepatocyte cultures.

Journal: BMC physiology 20050101

Title: Rodent and human mast cells produce functionally significant intracellular reactive oxygen species but not nitric oxide.

Journal: The Journal of biological chemistry 20041119

Title: Impact of cirrhosis on the development of experimental hepatic metastases by B16F1 melanoma cells in C57BL/6 mice.

Journal: Hepatology (Baltimore, Md.) 20041101

Title: Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20041101

Title: Direct intracellular nitric oxide detection in isolated adult cardiomyocytes: flow cytometric analysis using the fluorescent probe, diaminofluorescein.

Journal: Journal of molecular and cellular cardiology 20041001

Title: Cellular and subcellular localization of endogenous nitric oxide in young and senescent pea plants.

Journal: Plant physiology 20040901

Title: Nitric oxide is involved in growth regulation and re-orientation of pollen tubes.

Journal: Development (Cambridge, England) 20040601

Title: Nicotinic receptor mediated stimulation of NO-generation in neurons of rat thoracic dorsal root ganglia.

Journal: Neuroscience letters 20040506

Title: Angiotensin II stimulates calcium and nitric oxide release from Macula densa cells through AT1 receptors.

Journal: Hypertension (Dallas, Tex. : 1979) 20040301

Title: Adiponectin stimulates production of nitric oxide in vascular endothelial cells.

Journal: The Journal of biological chemistry 20031107

Title: Visualization of nitric oxide production and intracellular calcium in juxtamedullary afferent arteriolar endothelial cells.

Journal: Acta physiologica Scandinavica 20031101

Title: Leukocyte behavior in angiogenic vessels is affected by tumor-derived nitric oxide.

Journal: The Japanese journal of physiology 20031001

Title: Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contractions.

Journal: Free radical biology & medicine 20030901

Title: Mislocalization of eNOS and upregulation of cerebral vascular Ca2+ channel activity in angiotensin-hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20030501

Title: Reactive oxygen species-mediated regulation of eNOS and iNOS expression in multicellular prostate tumor spheroids.

Journal: International journal of cancer 20030410

Title: Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.

Journal: The European journal of neuroscience 20030401

Title: Activation of the cGMP/nitric oxide signal transduction system by nicotine in the retina.

Journal: Visual neuroscience 20030101

Title: Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography.

Journal: Circulation research 20021213

Title: In situ localization of nitric oxide synthase and direct evidence of NO production in rat retinal ganglion cells.

Journal: Brain research 20020419

Title: Oxidative stress in glial cultures: detection by DAF-2 fluorescence used as a tool to measure peroxynitrite rather than nitric oxide.

Journal: Glia 20020415

Title: Hydrogen peroxide induces a rapid production of nitric oxide in mung bean (Phaseolus aureus).

Journal: Nitric oxide : biology and chemistry 20020301

Title: Nitric oxide and abscisic acid cross talk in guard cells.

Journal: Plant physiology 20020301

Title: Nitric oxide production mediated by nitrate reductase in the green alga Chlamydomonas reinhardtii: an alternative NO production pathway in photosynthetic organisms.

Journal: Plant & cell physiology 20020301

Title: Mitochondrial nitric oxide localization in H9c2 cells revealed by confocal microscopy.

Journal: Biochemical and biophysical research communications 20020125

Title: Simultaneous detection of both nitric oxide and reactive oxygen species in guinea pig vestibular sensory cells.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20020101

Title: Neuronal nitric oxide synthase immunohistochemistry and 4,5-diaminofluorescein diacetate: tools for nitric oxide research.

Journal: Journal of neuroscience methods 20011115

Title: Signaling pathway for nitric oxide generation with simulated ischemia in flow-adapted endothelial cells.

Journal: American journal of physiology. Heart and circulatory physiology 20011101

Title: Serotonin-induced nitric oxide production in the ventral nerve cord of the earthworm, Eisenia fetida.

Journal: Neuroscience research 20011001

Title: Characterization of basal nitric oxide production in living cells.

Journal: Biochimica et biophysica acta 20010926

Title: Visualization of nitric oxide production in the earthworm ventral nerve cord.

Journal: Neuroscience research 20010601

Title: Increased nitric oxide production in nasal epithelial cells from allergic patients--RT-PCR analysis and direct imaging by a fluorescence indicator: DAF-2 DA.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010601

Title: Detection of nitric oxide in the guinea pig inner ear, using a combination of aldehyde fixative and 4,5-diaminofluorescein diacetate.

Journal: Acta oto-laryngologica 20010601

Title: Nitric oxide production by human peripheral blood mononuclear cells.

Journal: Annals of the Academy of Medicine, Singapore 20010501

Title: Direct evidence of nitric oxide production in the guinea pig organ of Corti.

Journal: Acta oto-laryngologica 20010401

Title: Nitric oxide in guinea pig vestibular sensory cells following gentamicin exposure in vitro.

Journal: Acta oto-laryngologica 20010401

Title: Photoactivation and calcium sensitivity of the fluorescent NO indicator 4,5-diaminofluorescein (DAF-2): implications for cellular NO imaging.

Journal: FEBS letters 20010302

Title: Nitric oxide distribution and production in the guinea pig cochlea.

Journal: Hearing research 20010301

Title: Nitrosative stress by cyclosporin A in the endothelium: studies with the NO-sensitive probe diaminofluorescein-2/diacetate using flow cytometry.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010101

Title: Wany A, et al. Localization of Nitric Oxide in Wheat Roots by DAF Fluorescence. Methods Mol Biol. 2016;1424:39-47.

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Tags:205391-02-2 Molecular Formula|205391-02-2 MDL|205391-02-2 SMILES|205391-02-2 Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-bis(acetyloxy)-5,6-diamino-