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205391-01-1,MFCD05865100
Catalog No.:AA0029ZI

205391-01-1 | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5,6-diamino-3',6'-dihydroxy-

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1mg
≥95% (HPLC)
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$609.00   $427.00
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5mg
≥95% (HPLC)
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$2,027.00   $1,419.00
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0029ZI
Chemical Name:
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5,6-diamino-3',6'-dihydroxy-
CAS Number:
205391-01-1
Molecular Formula:
C20H14N2O5
Molecular Weight:
362.3356
MDL Number:
MFCD05865100
SMILES:
Oc1ccc2c(c1)Oc1c(C32OC(=O)c2c3cc(N)c(c2)N)ccc(c1)O
Properties
Computed Properties
 
Complexity:
589  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
XLogP3:
2.1  

Literature

Title: Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells.

Journal: American journal of physiology. Endocrinology and metabolism 20120601

Title: Pitfalls and limitations in using 4,5-diaminofluorescein for evaluating the influence of polyphenols on nitric oxide release from endothelial cells.

Journal: Free radical biology & medicine 20120601

Title: Spontaneous increases in the fluorescence of 4,5-diaminofluorescein and its analogs: their impact on the fluorometry of nitric oxide production in endothelial cells.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Quantitative 3D analysis of nitric oxide diffusion in a 3D artery model using sensor particles.

Journal: Angewandte Chemie (International ed. in English) 20110808

Title: Response to 'The use of diaminofluorescein for nitric oxide detection: conceptual and methodological distinction between NO and nitrosation'.

Journal: Free radical biology & medicine 20110301

Title: The use of diaminofluorescein for nitric oxide detection: Conceptual and methodological distinction between NO and nitrosation.

Journal: Free radical biology & medicine 20100915

Title: A Maillard reaction product enhances eNOS activity in human endothelial cells.

Journal: Molecular nutrition & food research 20100701

Title: Reactivity of glass-embedded met hemoglobin derivatives toward external NO: implications for nitrite-mediated production of bioactive NO.

Journal: Journal of the American Chemical Society 20090902

Title: Micro gas analyzer measurement of nitric oxide in breath by direct wet scrubbing and fluorescence detection.

Journal: Analytical chemistry 20090815

Title: Exogenous vs. endogenous gamma-glutamyltransferase activity: Implications for the specific determination of S-nitrosoglutathione in biological samples.

Journal: Archives of biochemistry and biophysics 20090715

Title: Direct evidence of nitric oxide release from neuronal nitric oxide synthase activation in the left ventricle as a result of cervical vagus nerve stimulation.

Journal: The Journal of physiology 20090615

Title: Use of diaminofluoresceins to detect and measure nitric oxide in low level generating human immune cells.

Journal: Journal of immunological methods 20090315

Title: A novel method of measuring nitric-oxide-dependent fluorescence using 4,5-diaminofluorescein (DAF-2) in the isolated Langendorff-perfused rabbit heart.

Journal: Pflugers Archiv : European journal of physiology 20080601

Title: Nitric oxide modulates sodium taste via a cGMP-independent pathway.

Journal: Developmental neurobiology 20070201

Title: Nitrosation of N-terminally blocked tryptophan and tryptophan-containing peptides by peroxynitrite.

Journal: Chembiochem : a European journal of chemical biology 20070122

Title: Design and characterization of a nano-encapsulated self-referenced fluorescent nitric oxide sensor for wide-field optical imaging.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20070101

Title: Synthesis of nitric oxide in human osteoblasts in response to physiologic stimulation of electrotherapy.

Journal: Annals of biomedical engineering 20061201

Title: Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium.

Journal: Canadian journal of physiology and pharmacology 20061001

Title: Thiocyanate cannot inhibit the formation of reactive nitrogen species in the human oral cavity in the presence of high concentrations of nitrite: detection of reactive nitrogen species with 4,5-diaminofluorescein.

Journal: Chemical research in toxicology 20060801

Title: Hypoxia induces production of nitric oxide and reactive oxygen species in glomus cells of rat carotid body.

Journal: Cell and tissue research 20060701

Title: Measuring nitric oxide in single neurons by capillary electrophoresis with laser-induced fluorescence: use of ascorbate oxidase in diaminofluorescein measurements.

Journal: Analytical chemistry 20060315

Title: Extracellular ATP stimulates NO production in rat thick ascending limb.

Journal: Hypertension (Dallas, Tex. : 1979) 20060301

Title: Detection of N-nitrosomelatonin and other N-nitrosotryptophan derivatives by transnitrosation of APF and DAF-2.

Journal: Journal of pineal research 20060101

Title: Nitric oxide (NO) detection by DAF fluorescence and chemiluminescence: a comparison using abiotic and biotic NO sources.

Journal: Journal of experimental botany 20060101

Title: Assessment of S-nitrosothiols on diaminofluorescein gels.

Journal: Analytical biochemistry 20051101

Title: Production of nitric oxide-derived reactive nitrogen species in human oral cavity and their scavenging by salivary redox components.

Journal: Free radical research 20050701

Title: Increased intracellular pH at the macula densa activates nNOS during tubuloglomerular feedback.

Journal: Kidney international 20050501

Title: Nitric oxide release is induced by dopamine during illumination of the carp retina: serial neurochemical control of light adaptation.

Journal: The European journal of neuroscience 20050401

Title: Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs.

Journal: Journal of the American Chemical Society 20050323

Title: Nitric oxide mediates inhibitory effect of leptin on insulin-like growth factor I augmentation of 17beta-estradiol production in human granulosa cells.

Journal: Biology of reproduction 20050101

Title: Measurement of nitric oxide by 4,5-diaminofluorescein without interferences.

Journal: The Analyst 20041201

Title: High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism.

Journal: American journal of physiology. Renal physiology 20040901

Title: Direct evidence that induced nitric oxide production in hepatocytes prevents liver damage during lipopolysaccharide tolerance in rats.

Journal: The Journal of surgical research 20040515

Title: Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bioimaging system.

Journal: The Journal of surgical research 20040401

Title: Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe.

Journal: Journal of the American Chemical Society 20040317

Title: Distinct glutamate receptors govern differential levels of nitric oxide production in a layer-specific manner in the rat cerebellar cortex.

Journal: Neuroscience 20040101

Title: Nitric oxide imaging in neurons using confocal microscopy.

Journal: Methods in molecular biology (Clifton, N.J.) 20040101

Title: A nonradioactive assay for nitric oxide synthase activity in tissue extracts.

Journal: Methods in molecular biology (Clifton, N.J.) 20040101

Title: Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells.

Journal: Nitric oxide : biology and chemistry 20030901

Title: Cooperation between insulin and leptin in the modulation of vascular tone.

Journal: Hypertension (Dallas, Tex. : 1979) 20030801

Title: Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030401

Title: Nitric oxide mediated photo-induced cell death in human malignant cells.

Journal: International journal of oncology 20030401

Title: Nitric oxide inhibits adenosine 5'-triphosphate-induced Ca2+ response in inner hair cells of the guinea pig cochlea.

Journal: Neuroscience letters 20030213

Title: Interfering with nitric oxide measurements. 4,5-diaminofluorescein reacts with dehydroascorbic acid and ascorbic acid.

Journal: The Journal of biological chemistry 20021213

Title: Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography.

Journal: Circulation research 20021213

Title: 4,5-diaminofluoroscein imaging of nitric oxide synthesis in crayfish terminal ganglia.

Journal: Journal of neurobiology 20021115

Title: Hyperglycemic switch from mitochondrial nitric oxide to superoxide production in endothelial cells.

Journal: American journal of physiology. Heart and circulatory physiology 20021101

Title: Changes of cell volume and nitric oxide concentration in macula densa cells caused by changes in luminal NaCl concentration.

Journal: Journal of the American Society of Nephrology : JASN 20021101

Title: The demonstration of nitric oxide in cochlear blood vessels in vivo and in vitro: the role of endothelial nitric oxide in venular permeability.

Journal: Hearing research 20021001

Title: Increased nitric oxide-dependent nitrosylation of 4,5-diaminofluorescein by oxidants: implications for the measurement of intracellular nitric oxide.

Journal: Free radical biology & medicine 20020901

Title: Increased basal nitric oxide release despite enhanced free radical production in hypertension.

Journal: Journal of hypertension 20020601

Title: Sensory neurons respond to hypoxia with NO production associated with mitochondria.

Journal: Molecular and cellular neurosciences 20020601

Title: Nitric oxide-induced signalling in rat lacrimal acinar cells.

Journal: Acta physiologica Scandinavica 20020201

Title: Orthogonality of calcium concentration and ability of 4,5-diaminofluorescein to detect NO.

Journal: The Journal of biological chemistry 20020104

Title: Quantitation of S-nitrosothiols in cells and biological fluids.

Journal: Methods in enzymology 20020101

Title: Nitric oxide production in living neurons is modulated by sphingosine: a fluorescence microscopy study.

Journal: FEBS letters 20011012

Title: Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein.

Journal: FEBS letters 20011005

Title: Determinants of shear stress-stimulated endothelial nitric oxide production assessed in real-time by 4,5-diaminofluorescein fluorescence.

Journal: Biochemical and biophysical research communications 20010817

Title: Distinction between nitrosating mechanisms within human cells and aqueous solution.

Journal: The Journal of biological chemistry 20010810

Title: Nitric oxide generation by isolated descending vasa recta.

Journal: American journal of physiology. Heart and circulatory physiology 20010701

Title: Effect of red wine and ethanol on production of nitric oxide in healthy subjects.

Journal: The American journal of cardiology 20010415

Title: Photoactivation and calcium sensitivity of the fluorescent NO indicator 4,5-diaminofluorescein (DAF-2): implications for cellular NO imaging.

Journal: FEBS letters 20010302

Title: A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.

Journal: Nitric oxide : biology and chemistry 20010101

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Tags:205391-01-1 Molecular Formula|205391-01-1 MDL|205391-01-1 SMILES|205391-01-1 Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5,6-diamino-3',6'-dihydroxy-