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189279-58-1,MFCD09955301
Catalog No.:AA002I3C

189279-58-1 | Delafloxacin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
5mg
98%
in stock  
$11.00   $8.00
- +
10mg
98%
in stock  
$15.00   $11.00
- +
25mg
98%
in stock  
$23.00   $16.00
- +
50mg
98%
in stock  
$32.00   $22.00
- +
250mg
98%
in stock  
$65.00   $46.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002I3C
Chemical Name:
Delafloxacin
CAS Number:
189279-58-1
Molecular Formula:
C18H12ClF3N4O4
Molecular Weight:
440.7605
MDL Number:
MFCD09955301
SMILES:
OC1CN(C1)c1c(F)cc2c(c1Cl)n(cc(c2=O)C(=O)O)c1nc(N)c(cc1F)F
Properties
Computed Properties
 
Complexity:
755  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
2.7  

Downstream Synthesis Route

[1]Patent:US5998436,1999,A

[1]Patent:CN108084161,2018,A.Locationinpatent:Paragraph0018;0069-0071

[2]Patent:CN110467600,2019,A.Locationinpatent:Paragraph0031-0037;0072;0073;0076;0077

[3]Patent:CN105017223,2017,B.Locationinpatent:Paragraph0037-0038;0040;0041;0043;0045;0048

[4]Patent:CN106256824,2016,A.Locationinpatent:Paragraph0034

[5]Patent:US2006/228411,2006,A1.Locationinpatent:Page/Pagecolumn2

[6]Patent:CN105693695,2016,A.Locationinpatent:Paragraph0028

6284-40-8    189279-58-1   
1-deoxy-1-(methylamino)-D-glucitol1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylatetrihydrate 

[1]Patent:US2007/43019,2007,A1.Locationinpatent:Page/Pagecolumn4-5

[2]Patent:US2007/43019,2007,A1.Locationinpatent:Page/Pagecolumn5

[1]Patent:CN106256824,2016,A.Locationinpatent:Paragraph0030

[2]Patent:WO2006/15194,2006,A2.Locationinpatent:Page/Pagecolumn17

[3]OrganicProcessResearchandDevelopment,2009,vol.13,p.54-59

[4]Patent:WO2010/36329,2010,A2.Locationinpatent:Page/Pagecolumn14-15;20-21

[5]OrganicProcessResearchandDevelopment,2006,vol.10,p.803-807

1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid 
  189279-58-1 

[1]OrganicProcessResearchandDevelopment,2006,vol.10,p.803-807

[2]Patent:CN108033948,2018,A

Literature

Title: Managing community acquired pneumonia in the elderly - the next generation of pharmacotherapy on the horizon.

Journal: Expert opinion on pharmacotherapy 20170801

Title: The 2009 Nobel Prize in Chemistry: Thomas A. Steitz and the structure of the ribosome.

Journal: The Yale journal of biology and medicine 20110601

Title: Methicillin-resistant Staphylococcus aureus: a pervasive pathogen highlights the need for new antimicrobial development.

Journal: The Yale journal of biology and medicine 20101201

Title: New antibiotics for antibiotic-resistant bacteria.

Journal: F1000 biology reports 20090101

Title: Comparative pharmacodynamics of the new fluoroquinolone ABT492 and levofloxacin with Streptococcus pneumoniae in an in vitro dynamic model.

Journal: International journal of antimicrobial agents 20050501

Title: Comparative pharmacodynamics of the new fluoroquinolone ABT492 and ciprofloxacin with Escherichia coli and Pseudomonas aeruginosa in an in vitro dynamic model.

Journal: International journal of antimicrobial agents 20040801

Title: The in vitro activity of a new fluoroquinolone, ABT-492, against recent clinical isolates of Chlamydia pneumoniae.

Journal: The Journal of antimicrobial chemotherapy 20040701

Title: ABT492 and levofloxacin: comparison of their pharmacodynamics and their abilities to prevent the selection of resistant Staphylococcus aureus in an in vitro dynamic model.

Journal: The Journal of antimicrobial chemotherapy 20040701

Title: In vitro activity of ABT-492 against anaerobic bacteria.

Journal: Journal of chemotherapy (Florence, Italy) 20040601

Title: Comparative study of the in vitro activity of a new fluoroquinolone, ABT-492.

Journal: The Journal of antimicrobial chemotherapy 20040501

Title: Comparative antimicrobial activities of the newly synthesized quinolone WQ-3034, levofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex.

Journal: Antimicrobial agents and chemotherapy 20000201

Title: Lepak AJ, et al. In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4764-9.

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