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210344-95-9,MFCD23380217
Catalog No.:AA002KM9

210344-95-9 | L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester

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1mg
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$156.00   $109.00
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5mg
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$325.00   $228.00
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10mg
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25mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002KM9
Chemical Name:
L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester
CAS Number:
210344-95-9
Molecular Formula:
C30H41FN4O12
Molecular Weight:
668.6645
MDL Number:
MFCD23380217
SMILES:
COC(=O)CC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)CF)CC(=O)OC)C(C)C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(=O)OC
Properties
Computed Properties
 
Complexity:
1110  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
23  
XLogP3:
0.9  

Literature

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Title: Impairment of preimplantation and postimplantation embryonic development through intrinsic apoptotic processes by ginsenoside Rg1 in vitro and in vivo.

Journal: Environmental toxicology 20170701

Title: Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3β Pathway.

Journal: Neurotoxicity research 20160501

Title: Nilotinib reduced the viability of human ovarian cancer cells via mitochondria-dependent apoptosis, independent of JNK activation.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160301

Title: Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice.

Journal: Chinese medical journal 20151005

Title: Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways.

Journal: Toxicology letters 20141104

Title: Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells.

Journal: Apoptosis : an international journal on programmed cell death 20140301

Title: Purinergic P2X7 receptors mediate cell death in mouse cerebellar astrocytes in culture.

Journal: The Journal of pharmacology and experimental therapeutics 20131201

Title: PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells.

Journal: Toxicology letters 20130704

Title: Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling.

Journal: Toxicology and applied pharmacology 20130601

Title: Irinotecan induces senescence and apoptosis in colonic cells in vitro.

Journal: Toxicology letters 20121002

Title: Zebularine inhibits the growth of HeLa cervical cancer cells via cell cycle arrest and caspase-dependent apoptosis.

Journal: Molecular biology reports 20121001

Title: Emodin induces embryonic toxicity in mouse blastocysts through apoptosis.

Journal: Toxicology 20120904

Title: Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor.

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Title: Fluorescence-quenching-based homogeneous caspase-3 activity assay using photon upconversion.

Journal: Analytica chimica acta 20120506

Title: Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro.

Journal: Oncology reports 20120401

Title: Evaluation of differential representative values between Chinese hamster cells and human lymphocytes in mitomycin C-induced cytogenetic assays and caspase-3 activity.

Journal: Toxicology and industrial health 20120301

Title: Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells.

Journal: Toxicology letters 20120205

Title: 5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells.

Journal: Apoptosis : an international journal on programmed cell death 20120201

Title: The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells.

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Title: J7, a methyl jasmonate derivative, enhances TRAIL-mediated apoptosis through up-regulation of reactive oxygen species generation in human hepatoma HepG2 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120201

Title: Preparation and characterization of biocompatible chitosan nanoparticles for targeted brain delivery of peptides.

Journal: Methods in molecular biology (Clifton, N.J.) 20120101

Title: Thimerosal-induced apoptosis in mouse C2C12 myoblast cells occurs through suppression of the PI3K/Akt/survivin pathway.

Journal: PloS one 20120101

Title: Okadaic acid induces apoptosis through the PKR, NF-κB and caspase pathway in human osteoblastic osteosarcoma MG63 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111201

Title: Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes.

Journal: Free radical biology & medicine 20111201

Title: Cytotoxicity of synthetic cannabinoids found in 'Spice' products: the role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line.

Journal: Toxicology letters 20111110

Title: Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease.

Journal: Toxicology and applied pharmacology 20111101

Title: Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.

Journal: Toxicology and applied pharmacology 20111101

Title: α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling.

Journal: Journal of neurochemistry 20111101

Title: Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes.

Journal: Apoptosis : an international journal on programmed cell death 20110901

Title: Presence of cleaved caspase 3 in swine embryos of different developmental capacities produced by parthenogenetic activation.

Journal: Molecular reproduction and development 20110901

Title: Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway.

Journal: World journal of gastroenterology 20110821

Title: The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells.

Journal: The Journal of biological chemistry 20110729

Title: Blocking caspase-3-dependent pathway preserves hair cells from salicylate-induced apoptosis in the guinea pig cochlea.

Journal: Molecular and cellular biochemistry 20110701

Title: Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation.

Journal: Neuro-oncology 20110301

Title: Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.

Journal: Chemical research in toxicology 20110114

Title: Atorvastatin acts synergistically with N-acetyl cysteine to provide therapeutic advantage against Fas-activated erythrocyte apoptosis during chronic arsenic exposure in rats.

Journal: Toxicology and applied pharmacology 20110101

Title: 17beta-estradiol attenuates programmed cell death in cortical pericontusional zone following traumatic brain injury via upregulation of ERalpha and inhibition of caspase-3 activation.

Journal: Neurochemistry international 20110101

Title: Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

Journal: Nature neuroscience 20110101

Title: Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells.

Journal: Toxicology letters 20101215

Title: Haplophytin-A induces caspase-8-mediated apoptosis via the formation of death-inducing signaling complex in human promyelocytic leukemia HL-60 cells.

Journal: Chemico-biological interactions 20101205

Title: Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2.

Journal: Apoptosis : an international journal on programmed cell death 20101201

Title: [Experimental study on treatment of rabbits optic nerve injury with Caspase-3 inhibitor z-DEVD-fmk].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20101201

Title: 1-(3',4',5'-Trimethoxyphenyl)-3-(3'',4''-dimethoxy-2''-hydroxyphenyl)-propane with microtubule-depolymerizing ability induces G2/M phase arrest and apoptosis in HepG2 cells.

Journal: Chemico-biological interactions 20101006

Title: 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.

Journal: World journal of gastroenterology 20100721

Title: Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.

Journal: Chemical research in toxicology 20100719

Title: Matrine induces apoptosis of human multiple myeloma cells via activation of the mitochondrial pathway.

Journal: Leukemia & lymphoma 20100701

Title: Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.

Journal: Toxicology and applied pharmacology 20100615

Title: Heat shock protein 70 and cellular disturbances in cochlear cisplatin ototoxicity model.

Journal: The Journal of laryngology and otology 20100601

Title: Sulfur mustard induces apoptosis in lung epithelial cells via a caspase amplification loop.

Journal: Toxicology 20100527

Title: Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway.

Journal: International journal of hematology 20100501

Title: Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells.

Journal: The FEBS journal 20100101

Title: Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta.

Journal: Endocrinology 20091201

Title: Feedback regulation of mitochondria by caspase-9 in the B cell receptor-mediated apoptosis.

Journal: Scandinavian journal of immunology 20091201

Title: Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.

Journal: Experimental cell research 20091115

Title: A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20091104

Title: The anti-apoptotic effects of caspase inhibitors on propyl gallate-treated HeLa cells in relation to reactive oxygen species and glutathione levels.

Journal: Archives of toxicology 20090901

Title: KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2).

Journal: Apoptosis : an international journal on programmed cell death 20090901

Title: Reactive oxygen species-induced cell death of rat primary astrocytes through mitochondria-mediated mechanism.

Journal: Journal of cellular biochemistry 20090801

Title: Involvement of both extrinsic and intrinsic apoptotic pathways in apoptosis induced by genistein in human cervical cancer cells.

Journal: Annals of the New York Academy of Sciences 20090801

Title: Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells.

Journal: Chemico-biological interactions 20090715

Title: Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt.

Journal: International journal of oncology 20090701

Title: PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells.

Journal: Biochemical and biophysical research communications 20090508

Title: Studies of learning and memory processes in adult rats in conditions of intracerebral administration of caspase inhibitors.

Journal: Neuroscience and behavioral physiology 20090501

Title: Erythropoietin protects retinal pigment epithelial cells from oxidative damage.

Journal: Free radical biology & medicine 20090415

Title: Resveratrol regulates the expression of NHE-1 by repressing its promoter activity: critical involvement of intracellular H2O2 and caspases 3 and 6 in the absence of cell death.

Journal: The international journal of biochemistry & cell biology 20090401

Title: Caspase-dependent molecular mechanisms of anti-human DR5 monoclonal antibody mDRA-6 inducing apoptosis of human leukemia Jurkat cells.

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20090201

Title: Natural activation of caspase-3 is required for the development of operant behavior in postnatal ontogenesis.

Journal: Neuroscience and behavioral physiology 20090101

Title: The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells.

Journal: Anticancer research 20090101

Title: Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.

Journal: BMC cancer 20090101

Title: Caspase inhibition attenuates accumulation of beta-amyloid by reducing beta-secretase production and activity in rat brains after stroke.

Journal: Neurobiology of disease 20081201

Title: Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 Cells.

Journal: Journal of microbiology and biotechnology 20081201

Title: Neuroprotective effects of caspase-3 inhibition on functional recovery and tissue sparing after acute spinal cord injury.

Journal: Spine 20081001

Title: Role of Bcl-2 family members in caspase-3/9-dependent apoptosis during Pseudomonas aeruginosa infection in U937 cells.

Journal: Apoptosis : an international journal on programmed cell death 20080601

Title: Arsenic trioxide decreases AKT protein in a caspase-dependent manner.

Journal: Molecular cancer therapeutics 20080601

Title: [Study of learning and memory processes in adult rats under conditions of intracerebral caspases inhibitors administration].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080401

Title: Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK.

Journal: Toxicology and applied pharmacology 20080301

Title: Adenosine receptor ligands protect against a combination of apoptotic and necrotic cell death in cerebellar granule neurons.

Journal: Experimental brain research 20080301

Title: Role of calpain and caspase in beta-amyloid-induced cell death in rat primary septal cultured neurons.

Journal: Neuropharmacology 20080301

Title: Doxorubicin induces biphasic neurotoxicity to rat cortical neurons.

Journal: Neurotoxicology 20080301

Title: The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery.

Journal: Journal of cellular biochemistry 20080201

Title: Exogenous Hsc70, but not thermal preconditioning, confers protection to motoneurons subjected to oxidative stress.

Journal: Developmental neurobiology 20080101

Title: Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway.

Journal: Journal of biomedicine & biotechnology 20080101

Title: Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin.

Journal: Apoptosis : an international journal on programmed cell death 20071001

Title: Organophosphorus pesticides induce apoptosis in human NK cells.

Journal: Toxicology 20070924

Title: Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.

Journal: International immunopharmacology 20070801

Title: An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070701

Title: Protective effects of myricetin and related flavonols against A2E and light mediated-cell death in bovine retinal primary cell culture.

Journal: Experimental eye research 20070701

Title: Apoptotic signaling induces hyperpermeability following hemorrhagic shock.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Central injection of caspase inhibitors facilitates the formation of freezing behavior in rats.

Journal: Bulletin of experimental biology and medicine 20070501

Title: GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals.

Journal: Biogerontology 20070401

Title: Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.

Journal: European journal of pharmacology 20070322

Title: Radio-responsive gene therapy for malignant glioma cells without the radiosensitive promoter: Caspase-3 gene therapy combined with radiation.

Journal: Cancer letters 20070208

Title: PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway.

Journal: International immunopharmacology 20070101

Title: Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: a role for caspase 3.

Journal: The international journal of biochemistry & cell biology 20070101

Title: Mountain grown ginseng induces apoptosis in HL-60 cells and its mechanism have little relation with TNF-alpha production.

Journal: The American journal of Chinese medicine 20070101

Title: Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro.

Journal: Annals of the New York Academy of Sciences 20070101

Title: [Developmental caspase-3 activation in the rat hippocampus is involved in the maturation of instrumental behavior].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20070101

Title: p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation.

Journal: Cancer research 20061201

Title: [The role of caspase-3 in rapamycin-induced apoptosis of hepatocellular carcinoma BEL-7402 cells].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20061201

Title: Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.

Journal: Kidney international 20061001

Title: Long-term potentiation in the hippocampus in conditions of inhibition of caspase-3: analysis of facilitation in paired-pulse stimulation.

Journal: Neuroscience and behavioral physiology 20061001

Title: Effect of delta-elemene on Hela cell lines by apoptosis induction.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061001

Title: Advanced glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes.

Journal: Life sciences 20060808

Title: Correlation of apoptotic potential of simple oxiranes with cytotoxicity.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20060801

Title: Chlorpyrifos induces apoptosis in human monocyte cell line U937.

Journal: Toxicology 20060725

Title: Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress.

Journal: Biochemical and biophysical research communications 20060714

Title: Initiation of apoptosis and autophagy by photodynamic therapy.

Journal: Lasers in surgery and medicine 20060601

Title: Cadmium-induced apoptosis in murine macrophages is antagonized by antioxidants and caspase inhibitors.

Journal: Journal of toxicology and environmental health. Part A 20060601

Title: Inhibition of calpain and caspase-3 prevented apoptosis and preserved electrophysiological properties of voltage-gated and ligand-gated ion channels in rat primary cortical neurons exposed to glutamate.

Journal: Neuroscience 20060512

Title: Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.

Journal: Journal of hepatology 20060501

Title: Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060501

Title: E-cadherin and its downstream catenins are proteolytically cleaved in human HaCaT keratinocytes exposed to UVB.

Journal: Experimental dermatology 20060401

Title: [Effects of caspase-3 inhibitor on the neuronal apoptosis in rat cerebral cortex after ischemia-reperfusion injury].

Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology 20060301

Title: Role of apoptotic signaling pathway in metabolic disturbances occurring in liver tissue after cryopreservation: Study on rat precision-cut liver slices.

Journal: Life sciences 20060227

Title: Apoptosis induced by atRA in MEPM cells is mediated through activation of caspase and RAR.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060201

Title: Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts.

Journal: The FEBS journal 20060101

Title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20060101

Title: Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix.

Journal: The European journal of neuroscience 20060101

Title: Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells.

Journal: Basic & clinical pharmacology & toxicology 20060101

Title: [Effects of intracerebroventricular administration of a caspase-3 inhibitor Z-DEVD-FMK on behavior of rats].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20060101

Title: Molecular mechanism of matrine-induced apoptosis in leukemia K562 cells.

Journal: The American journal of Chinese medicine 20060101

Title: Molecular mechanisms of hexavalent chromium-induced apoptosis in human bronchoalveolar cells.

Journal: American journal of respiratory cell and molecular biology 20051201

Title: Contribution of reactive oxygen species and caspase-3 to apoptosis and attenuated ICAM-1 expression by paclitaxel-treated MDA-MB-435 breast carcinoma cells.

Journal: International journal of oncology 20051201

Title: [Inducement effect of Meisoindigo on apoptosis of leukemia cell line HL-60 and its mechanism].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20051201

Title: Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20051122

Title: Caspase-3 is required in the apoptotic disintegration of the nuclear matrix.

Journal: Experimental cell research 20051115

Title: The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats.

Journal: Surgical neurology 20050901

Title: Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.

Journal: European journal of pharmacology 20050822

Title: Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and -independent apoptotic pathways.

Journal: Biology of reproduction 20050801

Title: Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms.

Journal: International journal of oncology 20050801

Title: [Effects of caspase-3 inhibition on long-term potentiation in the hippocampus: analysis of paired pulse facilitation].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20050801

Title: Preparation and in vitro evaluation of chitosan nanoparticles containing a caspase inhibitor.

Journal: International journal of pharmaceutics 20050725

Title: Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium.

Journal: The Biochemical journal 20050715

Title: Phosphatase-1 and -2A inhibition modulates apoptosis in human osteoarthritis chondrocytes independently of nitric oxide production.

Journal: Annals of the rheumatic diseases 20050701

Title: The phospholipid scramblase PLSCR1 increases UV induced apoptosis primarily through the augmentation of the intrinsic apoptotic pathway and independent of direct phosphorylation by protein kinase C delta.

Journal: Biochimica et biophysica acta 20050415

Title: Resveratrol-induced apoptotic death in human U251 glioma cells.

Journal: Molecular cancer therapeutics 20050401

Title: Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.

Journal: Molecular cancer therapeutics 20050401

Title: E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation.

Journal: Molecular cancer research : MCR 20050401

Title: PRAM-1 potentiates arsenic trioxide-induced JNK activation.

Journal: The Journal of biological chemistry 20050311

Title: Inhibition of caspases alleviates gentamicin-induced cochlear damage in guinea pigs.

Journal: Auris, nasus, larynx 20050301

Title: [Mechanism of apoptosis induced by specific COX-2 inhibitor SC236 in gastric cancer cells].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20050301

Title: Central administration of a caspase inhibitor impairs shuttle-box performance in rats.

Journal: Neuroscience 20050101

Title: Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.

Journal: Bioconjugate chemistry 20050101

Title: Incorporation of branched-chain fatty acid into cellular lipids and caspase-independent apoptosis in human breast cancer cell line, SKBR-3.

Journal: Lipids in health and disease 20050101

Title: Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells.

Journal: Experimental & molecular medicine 20041231

Title: Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway.

Journal: Oncogene 20041216

Title: Involvement of apoptosis in disruption of developmental competence of bovine oocytes by heat shock during maturation.

Journal: Biology of reproduction 20041201

Title: Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.

Journal: Annals of the New York Academy of Sciences 20041201

Title: Caspase 3 inhibition improves survival and reduces early graft injury after ischemia and reperfusion in rat liver transplantation.

Journal: Transplantation 20041115

Title: Inhibition of caspase-3 blocks long-term potentiation in hippocampal slices.

Journal: Neuroscience and behavioral physiology 20041101

Title: Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway.

Journal: European journal of pharmacology 20041019

Title: Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism.

Journal: Carcinogenesis 20041001

Title: Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20041001

Title: Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways.

Journal: Cell death and differentiation 20040901

Title: 6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression.

Journal: Journal of neuroscience research 20040901

Title: Involvement of caspase-10 in advanced glycation end-product-induced apoptosis of bovine retinal pericytes in culture.

Journal: Biochimica et biophysica acta 20040804

Title: Caspase-3 inhibitor prevents apoptosis of human islets immediately after isolation and improves islet graft function.

Journal: Pancreas 20040801

Title: Role of glutathione in dimethylarsinic acid-induced apoptosis.

Journal: Toxicology and applied pharmacology 20040801

Title: Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway.

Journal: Acta pharmacologica Sinica 20040801

Title: Increased platelet phosphatidylserine exposure and caspase activation in chronic uremia.

Journal: Journal of thrombosis and haemostasis : JTH 20040801

Title: Ca influx shutdown in neutrophils induced by Fas (CD95) cross-linking.

Journal: Immunology 20040701

Title: Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells.

Journal: Oncogene 20040603

Title: Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway.

Journal: Cardiovascular research 20040601

Title: Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2.

Journal: Neurotoxicology 20040601

Title: Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20040601

Title: Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury.

Journal: American journal of physiology. Heart and circulatory physiology 20040501

Title: Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation.

Journal: International journal of molecular medicine 20040501

Title: Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis.

Journal: Oncogene 20040401

Title: The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells.

Journal: Molecular cancer therapeutics 20040401

Title: LIGHT sensitizes IFN-gamma-mediated apoptosis of HT-29 human carcinoma cells through both death receptor and mitochondria pathways.

Journal: Cell research 20040401

Title: Caspase-3: its potential involvement in Cr(III)-induced apoptosis of lymphocytes.

Journal: Molecular and cellular biochemistry 20040401

Title: Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase.

Journal: Biochemical and biophysical research communications 20040312

Title: Diepoxybutane induces caspase and p53-mediated apoptosis in human lymphoblasts.

Journal: Toxicology and applied pharmacology 20040301

Title: Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration.

Journal: Molecular and cellular neurosciences 20040301

Title: Caspase-3 activation in systemic anaplastic large-cell lymphoma.

Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20040101

Title: Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.

Journal: Cardiovascular research 20040101

Title: Inhibitors directed towards caspase-1 and -3 are less effective than pan caspase inhibition in preventing renal proximal tubular cell apoptosis.

Journal: Nephron. Experimental nephrology 20040101

Title: Caspase 3-mediated proteolysis of the N-terminal cytoplasmic domain of the human erythroid anion exchanger 1 (band 3).

Journal: The Journal of biological chemistry 20031226

Title: Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes.

Journal: The Journal of biological chemistry 20031205

Title: 15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20031201

Title: Apoptosis of lymphocytes induced by chromium(VI/V) is through ROS-mediated activation of Src-family kinases and caspase-3.

Journal: Free radical biology & medicine 20031101

Title: Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis.

Journal: Cell death and differentiation 20031001

Title: Caspase-3-dependent apoptosis in vascular smooth muscle cell by proteasome inhibition.

Journal: Journal of cardiovascular pharmacology 20031001

Title: Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone.

Journal: Journal of dental research 20031001

Title: Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20031001

Title: [Effects of caspases on cerebromicrovascular endothelial cell apoptosis induced by hypoxia].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20031001

Title: Caspase activity is essential for long-term potentiation.

Journal: Journal of neuroscience research 20030915

Title: Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.

Journal: Blood 20030801

Title: Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.

Journal: Cell death and differentiation 20030801

Title: RU486-inducible retrovirus-mediated caspase-3 overexpression is cytotoxic to bcl-xL-expressing myeloma cells in vitro and in vivo.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20030801

Title: Activated monocytes induce human retinal pigment epithelial cell apoptosis through caspase-3 activation.

Journal: Laboratory investigation; a journal of technical methods and pathology 20030801

Title: Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells.

Journal: The Journal of antibiotics 20030801

Title: The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic plaque.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030701

Title: Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation.

Journal: Surgery 20030701

Title: Triggering of apoptosis is not sufficient to induce human immunodeficiency virus gene expression.

Journal: IUBMB life 20030701

Title: LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members.

Journal: Cancer letters 20030610

Title: Caspase 3 activation is essential for efficient influenza virus propagation.

Journal: The EMBO journal 20030602

Title: Activation of a caspase-dependent oxidative damage response mediates TGFbeta1 apoptosis in rat hepatocytes.

Journal: Experimental and molecular pathology 20030601

Title: The binding of protein S and the protein S-C4BP complex to neutrophils is apoptosis dependent.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030601

Title: Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity.

Journal: Acta oto-laryngologica 20030501

Title: Caspase-3 inhibitor reduces apototic photoreceptor cell death during inherited retinal degeneration in tubby mice.

Journal: Molecular vision 20030429

Title: Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop.

Journal: Oncogene 20030417

Title: Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.

Journal: Molecular carcinogenesis 20030401

Title: Expression of Bcl-x(S) in Xenopus oocytes induces BH3-dependent and caspase-dependent cytochrome c release and apoptosis.

Journal: Molecular cancer research : MCR 20030101

Title: Caspase inhibition does not protect against liver damage in hemorrhagic shock.

Journal: Shock (Augusta, Ga.) 20030101

Title: Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.

Journal: Cancer science 20030101

Title: Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration.

Journal: Neuroscience 20030101

Title: [Caspase-3 inhibition blocks long-term potentiation in hippocampal slices].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20030101

Title: Implication of caspases during maedi-visna virus-induced apoptosis.

Journal: The Journal of general virology 20021201

Title: Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-X(L).

Journal: Experimental & molecular medicine 20021130

Title: Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.

Journal: Cancer letters 20021128

Title: Therapeutic effect of caspase inhibitors in the prevention of apoptosis and reversal of chronic cerebral vasospasm.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20021101

Title: F-actin cleavage in apoptotic outer hair cells in chinchilla cochleas exposed to intense noise.

Journal: Hearing research 20021001

Title: Induction of apoptosis dependent on caspase activities and growth arrest in HL-60 cells by PGA2.

Journal: Prostaglandins & other lipid mediators 20020901

Title: Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes.

Journal: Journal of molecular and cellular cardiology 20020801

Title: Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

Journal: The Journal of biological chemistry 20020726

Title: Apoptosis is an adaptive response in bovine preimplantation embryos that facilitates survival after heat shock.

Journal: Biochemical and biophysical research communications 20020705

Title: Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines.

Journal: The Journal of nutrition 20020701

Title: Manumycin inhibits farnesyltransferase and induces apoptosis of drug-resistant interleukin 6-producing myeloma cells.

Journal: British journal of haematology 20020701

Title: Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells.

Journal: Oncogene 20020606

Title: Preliminary study of the effects of caspase inhibitors on vasospasm in dog penetrating arteries.

Journal: Life sciences 20020510

Title: Critical role of mitochondria, but not caspases, during glucocorticosteroid-induced human eosinophil apoptosis.

Journal: American journal of respiratory cell and molecular biology 20020501

Title: Activation of caspase-like proteases and induction of apoptosis by isopentenyladenosine in tobacco BY-2 cells.

Journal: Planta 20020501

Title: Morphine induces apoptosis of human microglia and neurons.

Journal: Neuropharmacology 20020501

Title: Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation.

Journal: Diabetes 20020401

Title: Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells.

Journal: Acta pharmacologica Sinica 20020401

Title: Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

Title: Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes.

Journal: FEBS letters 20020227

Title: The 3C protease activity of enterovirus 71 induces human neural cell apoptosis.

Journal: Virology 20020215

Title: p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells.

Journal: Neurobiology of disease 20020201

Title: Thromboxane receptor signalling in human myometrial cells.

Journal: Prostaglandins & other lipid mediators 20020101

Title: Induction of caspase-activated deoxyribonuclease activity after focal cerebral ischemia and reperfusion.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020101

Title: Biochemical and morphological events during okadaic acid-induced apoptosis of Tsc2-null ERC-18 cell line.

Journal: Toxicologic pathology 20020101

Title: Caspase-3-like proteases are activated by infection but are not required for replication of vesicular stomatitis virus.

Journal: Virus research 20011128

Title: Involvement of caspases and of mitochondria in Fas ligation-induced eosinophil apoptosis: modulation by interleukin-5 and interferon-gamma.

Journal: Journal of leukocyte biology 20011101

Title: Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.

Journal: Molecular pharmacology 20011001

Title: Different orders for acquisition of apoptotic characteristics by leukocytes.

Journal: Journal of leukocyte biology 20010901

Title: Enhancement of hyperthermia-induced apoptosis by a free radical initiator, 2,2'-azobis (2-amidinopropane) dihydrochloride, in human histiocytic lymphoma U937 cells.

Journal: Free radical research 20010901

Title: Role of transcription factor Ets-1 in the apoptosis of human vascular endothelial cells.

Journal: Journal of cellular physiology 20010801

Title: Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis.

Journal: Journal of neurobiology 20010801

Title: Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis.

Journal: Journal of neuroscience research 20010701

Title: Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway.

Journal: The American journal of pathology 20010701

Title: Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes.

Journal: Arthritis and rheumatism 20010701

Title: Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons.

Journal: Neuroscience letters 20010629

Title: Caspase-3 inhibition partially protects oxidant production in apoptotic human neutrophils.

Journal: The Journal of surgical research 20010601

Title: Synergistic protective effect of caspase inhibitors and bFGF against brain injury induced by transient focal ischaemia.

Journal: British journal of pharmacology 20010601

Title: Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.

Journal: Leukemia 20010601

Title: Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis.

Journal: Oncogene 20010524

Title: Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry.

Journal: Cytometry 20010501

Title: Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2.

Journal: Investigative ophthalmology & visual science 20010501

Title: Both caspase-dependent and caspase-independent pathways may be involved in hippocampal CA1 neuronal death because of loss of cytochrome c From mitochondria in a rat forebrain ischemia model.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010501

Title: The incidence of cytoplasmic fragmentation in mouse embryos in vitro is not affected by inhibition of caspase activity.

Journal: Fertility and sterility 20010501

Title: Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8.

Journal: FEBS letters 20010323

Title: Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells.

Journal: Journal of leukocyte biology 20010301

Title: Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells.

Journal: Journal of agricultural and food chemistry 20010301

Title: Involvement of caspase-3 in apoptosis induced by Viscum album var. coloratum agglutinin in HL-60 cells.

Journal: Bioscience, biotechnology, and biochemistry 20010301

Title: FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.

Journal: Biochemical and biophysical research communications 20010223

Title: Hamster Bcl-2 protein is cleaved in vitro and in cells by caspase-9 and caspase-3.

Journal: Biochemical and biophysical research communications 20010223

Title: Proteolytic cleavage of epidermal growth factor receptor by caspases.

Journal: FEBS letters 20010223

Title: Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells.

Journal: Stroke 20010201

Title: Involvement of caspases in apoptotic cell death of murine macrophages infected with Actinobacillus actinomycetemcomitans.

Journal: Journal of periodontal research 20010201

Title: Caspase-3 activity and carbonyl cyanide m-chlorophenylhydrazone-induced apoptosis in HL-60.

Journal: Alternatives to laboratory animals : ATLA 20010101

Title: Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor.

Journal: Neuroscience 20010101

Title: Caspase inhibition and N6-benzyladenosine-induced apoptosis in HL-60 cells.

Journal: Journal of cellular biochemistry 20010101

Title: Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity.

Journal: Experimental & molecular medicine 20001231

Title: Degradation of the type I inositol 1,4,5-trisphosphate receptor by caspase-3 in SH-SY5Y neuroblastoma cells undergoing apoptosis.

Journal: Journal of neurochemistry 20001101

Title: Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner in human gastric adenocarcinoma cells.

Journal: Cancer letters 20001001

Title: The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20000915

Title: Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis.

Journal: Journal of cell science 20000901

Title: Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition.

Journal: The American journal of pathology 20000601

Title: Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.

Journal: Journal of neurochemistry 20000301

Title: Caspase-3 mediated neuronal death after traumatic brain injury in rats.

Journal: Journal of neurochemistry 20000201

Title: Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis.

Journal: The Journal of biological chemistry 19990827

Title: Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas.

Journal: Diabetes 19990301

Title: Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia.

Journal: Neuroscience 19990101

Title: Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.

Journal: FEBS letters 19981127

Title: Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2.

Journal: Experimental cell research 19981125

Title: Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.

Journal: The Journal of biological chemistry 19981023

Title: Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 19981001

Title: Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways.

Journal: The Journal of experimental medicine 19980907

Title: Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

Journal: The Journal of biological chemistry 19980814

Title: Caspases (interleukin-1beta-converting enzyme family proteases) are involved in the regulation of the survival of osteoclasts.

Journal: Bone 19980701

Title: Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis.

Journal: The Journal of biological chemistry 19980522

Title: Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 19980301

Title: p53-induced apoptosis in the human T-ALL cell line CCRF-CEM.

Journal: Oncogene 19971113

Title: Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation.

Journal: Molecular and cellular biology 19971101

Title: Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med. 2006 Nov 15;41(10):1578-89.

Title: Knoblach SM, et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct;24(10):1119-32.

Title: Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17(19), 7415-7424.

Title: Huang MY, et al. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. Apoptosis. 2016 Feb;21(2):130-42.

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Tags:210344-95-9 Molecular Formula|210344-95-9 MDL|210344-95-9 SMILES|210344-95-9 L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester