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22990-19-8,MFCD02179241
Catalog No.:AA002LP9

22990-19-8 | 1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
97%
in stock  
$6.00   $4.00
- +
5g
97%
in stock  
$11.00   $8.00
- +
10g
97%
in stock  
$20.00   $14.00
- +
100g
98%
in stock  
$126.00   $88.00
- +
500g
98%
in stock  
$583.00 $408.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA002LP9
Chemical Name:
1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS Number:
22990-19-8
Molecular Formula:
C15H15N
Molecular Weight:
209.2863
MDL Number:
MFCD02179241
SMILES:
c1ccc(cc1)C1NCCc2c1cccc2
NSC Number:
338399
Properties
Properties
 
BP:
338.4°C at 760 mmHg  
Form:
Solid  
MP:
96-98 °C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
220  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3  

Downstream Synthesis Route
3230-65-7   
phenylmagnesiumbromide 
  22990-19-8 

[1]ChemischeBerichte,1958,vol.91,p.1133,1138

[1]ChemCatChem,2014,vol.6,p.1010-1014

[2]Patent:CN103159677,2016,B.Locationinpatent:Paragraph0065;0068

[3]Patent:CN109438348,2019,A.Locationinpatent:Paragraph0025

[4]Patent:WO2008/128028,2008,A2.Locationinpatent:Page/Pagecolumn28

[5]Patent:CN108329309,2018,A.Locationinpatent:Paragraph0029;103-0104

[6]Patent:CN105541712,2016,A.Locationinpatent:Paragraph0055;0064

[7]AsianJournalofChemistry,2017,vol.29,p.1035-1038

[8]TetrahedronLetters,2016,vol.57,p.747-749

[9]ChemCatChem,2013,vol.5,p.2939-2945

[10]MonatsheftefurChemie,1929,vol.53,p.54961

[11]TetrahedronLetters,1985,vol.26,p.3693-3696

[12]JournalofMedicinalChemistry,1989,vol.32,p.1242-1248

[13]TetrahedronLetters,2006,vol.47,p.4585-4589

[14]EuropeanJournalofOrganicChemistry,2007,p.6106-6117

[15]Patent:WO2006/35280,2006,A1.Locationinpatent:Page/Pagecolumn21

[16]OrganicProcessResearchandDevelopment,2013,vol.17,p.432-437

[17]ACSMedicinalChemistryLetters,2017,vol.8,p.824-829

[18]Patent:CN106699657,2017,A.Locationinpatent:Paragraph0047;0048;0049

[19]Patent:KR2015/111825,2015,A.Locationinpatent:Paragraph0786;0788

[20]ChemicalScience,2017,vol.8,p.4093-4099

[21]AngewandteChemie-InternationalEdition,2018,vol.57,p.1863-1868    Angew.Chem.,2018,vol.130,p.1881-1886,6

[22]Chimia,2018,vol.72,p.189-192

[23]DaltonTransactions,2018,vol.47,p.10837-10841

[24]JournaloftheAmericanChemicalSociety,2018,vol.140,p.13171-13175

[25]Patent:CN110041255,2019,A.Locationinpatent:Paragraph0016

[26]JournaloftheAmericanChemicalSociety,2019,vol.141,p.15869-15878

[1]JournaloftheChemicalSociety,1949,p.2587

[2]JournaloftheChemicalSociety,1949,p.2587

[1]JournalofOrganicChemistry,1984,vol.49,p.130-133

[1]Heterocycles,1982,vol.19,p.653-656

Literature

Title: Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors.

Journal: Archiv der Pharmazie 20120601

Title: Ortho-rhom-bic polymorph of (6,7-dimeth-oxy-1,2,3,4-tetra-hydro-isoquinolin-1-yl)methanol.

Journal: Acta crystallographica. Section E, Structure reports online 20110701

Title: Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives.

Journal: European journal of medicinal chemistry 20060201

Title: In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.

Journal: Journal of the American Chemical Society 20050511

Title: Design, synthesis, and inhibition of platelet aggregation for some 1-o-chlorophenyl-1,2,3,4-tetrahydroisoquinoline derivatives.

Journal: Bioorganic & medicinal chemistry 20041215

Title: Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats.

Journal: Psychopharmacology 20031101

Quotation Request
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SDS
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Tags:22990-19-8 Molecular Formula|22990-19-8 MDL|22990-19-8 SMILES|22990-19-8 1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Catalog No.: AA002LP9
22990-19-8,MFCD02179241
22990-19-8 | 1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Pack Size： 1g
Purity： 97%
in stock
$6.00 $4.00
Pack Size： 5g
Purity： 97%
in stock
$11.00 $8.00
Pack Size： 10g
Purity： 97%
in stock
$20.00 $14.00
Pack Size： 100g
Purity： 98%
in stock
$126.00 $88.00
Pack Size： 500g
Purity： 98%
in stock
$583.00 $408.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA002LP9
Chemical Name: 1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS Number: 22990-19-8
Molecular Formula: C15H15N
Molecular Weight: 209.2863
MDL Number: MFCD02179241
SMILES: c1ccc(cc1)C1NCCc2c1cccc2
NSC Number: 338399
Properties
BP: 338.4°C at 760 mmHg  
Form: Solid  
MP: 96-98 °C  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 220  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 16  
Hydrogen Bond Acceptor Count: 1  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3  
Downstream Synthesis Route
3230-65-7   
phenylmagnesiumbromide 
  22990-19-8 

[1]ChemischeBerichte,1958,vol.91,p.1133,1138

52250-50-7    22990-19-8 

[1]ChemCatChem,2014,vol.6,p.1010-1014

[2]Patent:CN103159677,2016,B.Locationinpatent:Paragraph0065;0068

[3]Patent:CN109438348,2019,A.Locationinpatent:Paragraph0025

[4]Patent:WO2008/128028,2008,A2.Locationinpatent:Page/Pagecolumn28

[5]Patent:CN108329309,2018,A.Locationinpatent:Paragraph0029;103-0104

[6]Patent:CN105541712,2016,A.Locationinpatent:Paragraph0055;0064

[7]AsianJournalofChemistry,2017,vol.29,p.1035-1038

[8]TetrahedronLetters,2016,vol.57,p.747-749

[9]ChemCatChem,2013,vol.5,p.2939-2945

[10]MonatsheftefurChemie,1929,vol.53,p.54961

[11]TetrahedronLetters,1985,vol.26,p.3693-3696

[12]JournalofMedicinalChemistry,1989,vol.32,p.1242-1248

[13]TetrahedronLetters,2006,vol.47,p.4585-4589

[14]EuropeanJournalofOrganicChemistry,2007,p.6106-6117

[15]Patent:WO2006/35280,2006,A1.Locationinpatent:Page/Pagecolumn21

[16]OrganicProcessResearchandDevelopment,2013,vol.17,p.432-437

[17]ACSMedicinalChemistryLetters,2017,vol.8,p.824-829

[18]Patent:CN106699657,2017,A.Locationinpatent:Paragraph0047;0048;0049

[19]Patent:KR2015/111825,2015,A.Locationinpatent:Paragraph0786;0788

[20]ChemicalScience,2017,vol.8,p.4093-4099

[21]AngewandteChemie-InternationalEdition,2018,vol.57,p.1863-1868    Angew.Chem.,2018,vol.130,p.1881-1886,6

[22]Chimia,2018,vol.72,p.189-192

[23]DaltonTransactions,2018,vol.47,p.10837-10841

[24]JournaloftheAmericanChemicalSociety,2018,vol.140,p.13171-13175

[25]Patent:CN110041255,2019,A.Locationinpatent:Paragraph0016

[26]JournaloftheAmericanChemicalSociety,2019,vol.141,p.15869-15878

52250-50-7    3297-72-1    22990-19-8 

[1]JournaloftheChemicalSociety,1949,p.2587

[2]JournaloftheChemicalSociety,1949,p.2587

119-65-3    758-11-2    591-51-5    22990-19-8 

[1]JournalofOrganicChemistry,1984,vol.49,p.130-133

3230-65-7    591-51-5    22990-19-8 

[1]Heterocycles,1982,vol.19,p.653-656

Literature fold

Title: Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors.

Journal: Archiv der Pharmazie20120601

Title: Ortho-rhom-bic polymorph of (6,7-dimeth-oxy-1,2,3,4-tetra-hydro-isoquinolin-1-yl)methanol.

Journal: Acta crystallographica. Section E, Structure reports online20110701

Title: Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives.

Journal: European journal of medicinal chemistry20060201

Title: In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.

Journal: Journal of the American Chemical Society20050511

Title: Design, synthesis, and inhibition of platelet aggregation for some 1-o-chlorophenyl-1,2,3,4-tetrahydroisoquinoline derivatives.

Journal: Bioorganic & medicinal chemistry20041215

Title: Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats.

Journal: Psychopharmacology20031101

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