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Home Other Building Blocks 2487-40-3
2487-40-3,MFCD00031505
Catalog No.:AA002PN3

2487-40-3 | 2-Mercapto-1,9-dihydro-6h-purin-6-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$66.00   $47.00
- +
1g
>80.0%(HPLC)
in stock  
$92.00   $64.00
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5g
>80.0%(HPLC)
in stock  
$293.00   $205.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002PN3
Chemical Name:
2-Mercapto-1,9-dihydro-6h-purin-6-one
CAS Number:
2487-40-3
Molecular Formula:
C5H4N4OS
Molecular Weight:
168.1765
MDL Number:
MFCD00031505
SMILES:
S=c1[nH]c(=O)c2c([nH]1)[nH]cn2
Properties
Properties
 
Form:
Solid  
MP:
>300°C  
Refractive Index:
1.6390 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
219  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
XLogP3:
-0.1  

Downstream Synthesis Route

[1]Beaman[JournaloftheAmericanChemicalSociety,1954,vol.76,p.5633,5635,5636]Robinsetal.[JournaloftheAmericanChemicalSociety,1953,vol.75,p.263,264]

[1]Elionetal.[JournaloftheAmericanChemicalSociety,1956,vol.78,p.217,219]

[1]Elionetal.[JournaloftheAmericanChemicalSociety,1956,vol.78,p.217,219]

[2]CurrentPatentAssignee:PALACKYUNIVERSITYOLOMOUC;BIOPATTERNS;BIOPATTERNSSRO-WO2010/130233,2010,A1Locationinpatent:Page/Pagecolumn35

[1]Bredereck;Edenhofer[ChemischeBerichte,1955,vol.88,p.1306,1309]Murawitsch-Aleksandr;Meshonowa[ZhurnalOrganicheskoiKhimii,1977,vol.13,p.2013;engl.Ausg.S.1873]

Literature

Title: Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).

Journal: Biochemistry 20120313

Title: Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease.

Journal: American journal of respiratory and critical care medicine 20120101

Title: An ab initio and AIM investigation into the hydration of 2-thioxanthine.

Journal: Chemistry Central journal 20100101

Title: Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important.

Journal: The Journal of biological chemistry 20080516

Title: Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase--enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different.

Journal: Biochemistry. Biokhimiia 20070201

Title: Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.

Journal: Journal of medicinal chemistry 20061214

Title: Inhibition of DNA repair glycosylases by base analogs and tryptophan pyrolysate, Trp-P-1.

Journal: Acta biochimica Polonica 20050101

Title: Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems.

Journal: European journal of biochemistry 20020801

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19951109

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SDS
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Tags:2487-40-3 Molecular Formula|2487-40-3 MDL|2487-40-3 SMILES|2487-40-3 2-Mercapto-1,9-dihydro-6h-purin-6-one