Name: Name:Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-
Brand: AABLOCKS
SKU: AA002V76
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA002V76

Chemical Name: Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-

CAS Number: 290315-45-6

Molecular Formula: C24H21ClF3NO4S

Molecular Weight: 511.9410

MDL Number: MFCD12963627

SMILES: OC(=O)CCCc1cc(F)ccc1[C@H](N(S(=O)(=O)c1ccc(cc1)Cl)c1cc(F)ccc1F)C

Properties

Complexity: 775

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Heavy Atom Count: 34

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 1

Rotatable Bond Count: 9

XLogP3: 5.6

Literature fold

Title: Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.

Journal: Journal of medicinal chemistry20111124

Title: Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Journal: Neuron20100909

Title: Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease.

Journal: Journal of medicinal chemistry20091022

Title: Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20090701

Title: The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.

Journal: The Journal of biological chemistry20080822

Title: Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay.

Journal: Journal of neuroscience methods20080315

Title: Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

Journal: The Journal of biological chemistry20071221

Title: Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20070411

Title: In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor.

Journal: Current drug metabolism20061201

Title: Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20060815

Title: Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

Journal: Biochemical pharmacology20050215

Title: Meunier J, et al. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl(2,5-difluorophenyl) aminoethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's d

Title: Weissmiller AM, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.

290315-45-6 | Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-