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28808-62-0,MFCD11101451
Catalog No.:AA002WIJ

28808-62-0 | Fraxinellone

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5mg
≥98%
in stock  
$75.00   $52.00
- +
10mg
≥98%
in stock  
$142.00   $99.00
- +
25mg
≥98%
in stock  
$279.00   $195.00
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50mg
≥98%
in stock  
$446.00   $312.00
- +
500mg
98% by HPLC
in stock  
$4,218.00   $2,952.00
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1000mg
98% by HPLC
in stock  
$6,710.00   $4,697.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002WIJ
Chemical Name:
Fraxinellone
CAS Number:
28808-62-0
Molecular Formula:
C14H16O3
Molecular Weight:
232.2750
MDL Number:
MFCD11101451
SMILES:
CC1=C2C(=O)O[C@H]([C@@]2(CCC1)C)c1cocc1
NSC Number:
638730
Properties
Properties
 
BP:
372.9°C at 760 mmHg  
Form:
Solid  
MP:
106-116ºC  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
385  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
2.5  

Downstream Synthesis Route

[1]JournaloftheChemicalSocietyB:PhysicalOrganic,1970,p.1521,1522

28808-62-0    108-24-7   
2'-acetylfraxinellone 

[1]ArchivderPharmazie,1930,vol.268,p.39,40,46

[1]JournaloftheChemicalSocietyB:PhysicalOrganic,1970,p.1521,1522

28808-62-0   
3-(2-bromo-3furyl)-3a,7-dimethyl-3a,4,5,6-tetrahydro-3<i>H</i>-isobenzofuran-1-one 

[1]ArchivderPharmazie,1930,vol.268,p.39,40,46

(+)-isofraxinellone 
  28808-62-0 

[1]Phytochemistry,1985,vol.24,p.2379-2382

Literature

Title: Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone.

Journal: Toxicology and applied pharmacology 20141115

Title: Synthesis and insecticidal activity of some novel fraxinellone-based esters.

Journal: Journal of agricultural and food chemistry 20120718

Title: [Dermatopharmacokinetic studies of liangfu cream in mice skin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

Title: [Effects of penetration enhancers on in vitro percutaneous absorption and amount retained in skin of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in Liangfu cream].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

Title: Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells.

Journal: Biological & pharmaceutical bulletin 20090601

Title: Neuroprotective limonoids of root bark of Dictamnus dasycarpus.

Journal: Journal of natural products 20080201

Title: [Improving the solubility of fraxinellone to increase its oral bioavailability and hepatoprotective action against acute liver injury in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070601

Title: Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.

Journal: Journal of agricultural and food chemistry 20020313

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SDS
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