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28585-51-5,MFCD03788706
Catalog No.:AA002VO6

28585-51-5 | Thymidine, 2-thio-

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10mg
2 weeks  
$206.00   $144.00
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25mg
2 weeks  
$295.00   $207.00
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50mg
2 weeks  
$474.00   $332.00
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100mg
2 weeks  
$697.00   $488.00
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250mg
2 weeks  
$1,411.00   $988.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002VO6
Chemical Name:
Thymidine, 2-thio-
CAS Number:
28585-51-5
Molecular Formula:
C10H14N2O4S
Molecular Weight:
258.2942
MDL Number:
MFCD03788706
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C)c(=O)[nH]c1=S
Properties
Computed Properties
 
Complexity:
385  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-0.6  

Downstream Synthesis Route

[1]Hassan,AbdallaE.A.;Sheng,Jia;Zhang,Wen;Huang,Zhen[JournaloftheAmericanChemicalSociety,2010,vol.132,p.2120-2121]

[2]Wang,Rui;Ranganathan,SrivathsanV.;Basanta-Sanchez,Maria;Shen,Fusheng;Chen,Alan;Sheng,Jia[ChemicalCommunications,2015,vol.51,#91,p.16369-16372]

[3]Haruehanroengra,Phensinee;Vangaveti,Sweta;Ranganathan,SrivathsanV.;Wang,Rui;Chen,Alan;Sheng,Jia[ACSChemicalBiology,2017,vol.12,#6,p.1504-1513]

[4]Yu,Ping;Zhou,Honglin;Li,Yuanyuan;Du,Zhifeng;Wang,Rui[Nucleosides,nucleotidesandnucleicacids,2021,vol.40,#7,p.754-766]

[5]Kuimelis;Nambiar[TetrahedronLetters,1993,vol.34,#24,p.3813-3816]

[6]Rajur;McLaughlin[TetrahedronLetters,1992,vol.33,#41,p.6081-6084]

4,4-dimethoxytritylchloride 
  28585-51-5    125258-60-8 

[1]CurrentPatentAssignee:UNIVERSITYSYSTEMOFGEORGIA;SENARESEARCHINC-WO2010/135564,2010,A2Locationinpatent:Page/Pagecolumn52-53

[1]CurrentPatentAssignee:NIUAOWEITECHENGDUBIOTECHNOLOGY;XIRUIENTEBIOTECHCHENGDU-CN113004358,2021,ALocationinpatent:Paragraph0098;0100;0103-0104

Literature

Title: Self-Avoiding Molecular Recognition Systems (SAMRS).

Journal: Nucleic acids symposium series (2004) 20080101

Title: Stability and mismatch discrimination of DNA duplexes containing 2,6-diaminopurine and 2-thiothymidine locked nucleic acid bases.

Journal: Nucleic acids symposium series (2004) 20080101

Title: Triplex forming ability of oligonucleotides containing 2'-O-methyl-2-thiouridine or 2-thiothymidine.

Journal: Bioorganic & medicinal chemistry letters 20060615

Title: Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine.

Journal: Journal of the American Chemical Society 20060118

Title: Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

Journal: Biochemistry 20040120

Title: Synthesis and antiherpesvirus activities of 5-alkyl-2-thiopyrimidine nucleoside analogues.

Journal: Antiviral chemistry & chemotherapy 20020301

Title: Anti-herpesvirus activities and cytotoxicities of 2-thiopyrimidine nucleoside analogues in vitro.

Journal: Antiviral chemistry & chemotherapy 19990701

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