3106-85-2,MFCD00076652
Catalog No.:AA0031YS

3106-85-2 | Spaglumic Acid

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10mg
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50mg
≥95%
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$238.00   $166.00
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100mg
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  • Technical Information
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Technical Information
Catalog Number:
AA0031YS
Chemical Name:
Spaglumic Acid
CAS Number:
3106-85-2
Molecular Formula:
C11H16N2O8
Molecular Weight:
304.2533
MDL Number:
MFCD00076652
SMILES:
OC(=O)CC[C@@H](C(=O)O)NC(=O)[C@@H](NC(=O)C)CC(=O)O
NSC Number:
758468
Properties
Computed Properties
 
Complexity:
448  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
9  
XLogP3:
-2.1  

Literature

Title: Altered development of the dorsolateral prefrontal cortex in chromosome 22q11.2 deletion syndrome: an in vivo proton spectroscopy study.

Journal: Biological psychiatry 20121015

Title: NAA and NAAG variation in neuronal activation during visual stimulation.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20121001

Title: Metabolite detection of pancreatic carcinoma by in vivo proton MR spectroscopy at 3T: initial results.

Journal: La Radiologia medica 20120801

Title: Three-dimensional arbitrary voxel shapes in spectroscopy with submillisecond TEs.

Journal: NMR in biomedicine 20120801

Title: NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia.

Journal: Translational psychiatry 20120701

Title: Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.

Journal: The Journal of biological chemistry 20120622

Title: Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T.

Journal: Magnetic resonance in medicine 20120501

Title: Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population.

Journal: Metabolic brain disease 20120301

Title: Proton magnetic resonance spectroscopy and its diagnostically important metabolites in the brain.

Journal: General physiology and biophysics 20120301

Title: Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla.

Journal: Biological psychiatry 20120201

Title: Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease.

Journal: Journal of magnetic resonance imaging : JMRI 20120201

Title: Effects of bee venom on glutamate-induced toxicity in neuronal and glial cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer.

Journal: Current medicinal chemistry 20120101

Title: Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 tesla proton MRS.

Journal: PloS one 20120101

Title: Tissue distribution of glutamate carboxypeptidase II (GCPII) with a focus on the central and peripheral nervous system.

Journal: Current medicinal chemistry 20120101

Title: NAAG, NMDA receptor and psychosis.

Journal: Current medicinal chemistry 20120101

Title: Structure-activity relationships of glutamate carboxypeptidase II (GCPII) inhibitors.

Journal: Current medicinal chemistry 20120101

Title: Altered neurochemical ingredient of hippocampus in patients with bipolar depression.

Journal: Depression research and treatment 20120101

Title: Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate.

Journal: International journal of inflammation 20120101

Title: Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.

Journal: Frontiers in behavioral neuroscience 20120101

Title: Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSI.

Journal: PloS one 20120101

Title: Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats.

Journal: PloS one 20120101

Title: N-acetylaspartylglutamate is an agonist at mGluR₃ in vivo and in vitro.

Journal: Journal of neurochemistry 20111201

Title: Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia.

Journal: Schizophrenia research 20111201

Title: N-acetylaspartylglutamate is not demonstrated to be a selective mGlu₃receptor agonist.

Journal: Journal of neurochemistry 20111201

Title: A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA).

Journal: Oncotarget 20111201

Title: Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.

Journal: The Journal of biological chemistry 20111104

Title: Whole-exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA).

Journal: American journal of medical genetics. Part A 20111101

Title: Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study.

Journal: AJNR. American journal of neuroradiology 20111001

Title: Who is resilient to depression? Multimodal imaging of the hippocampus in preclinical chronic mild stress model may provide clues.

Journal: Biological psychiatry 20110901

Title: Cerebral metabolic alterations and cognitive dysfunction in chronic kidney disease.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110801

Title: Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family.

Journal: Journal of neurochemistry 20110801

Title: Quantitative measurement of N-acetyl-aspartyl-glutamate at 3 T using TE-averaged PRESS spectroscopy and regularized lineshape deconvolution.

Journal: Magnetic resonance in medicine 20110801

Title: Transcranial direct current stimulation (tDCS) produces localized and specific alterations in neurochemistry: a ¹H magnetic resonance spectroscopy study.

Journal: Neuroscience letters 20110801

Title: Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.

Journal: Psychopharmacology 20110701

Title: Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.

Journal: PLoS genetics 20110701

Title: Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI.

Journal: Brain research 20110613

Title: Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0-T magnetic resonance spectroscopy study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20110601

Title: N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.

Journal: The Journal of biological chemistry 20110513

Title: Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.

Journal: Gut 20110301

Title: Anterior cingulate and frontal lobe white matter spectroscopy in early childhood of former very LBW premature infants.

Journal: Pediatric research 20110301

Title: Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus.

Journal: Nutritional neuroscience 20110301

Title: Correlation of findings in advanced MRI techniques with global severity scales in patients with Parkinson disease.

Journal: Academic radiology 20110201

Title: 1H-MRS in spinal cord injury: acute and chronic metabolite alterations in rat brain and lumbar spinal cord.

Journal: The European journal of neuroscience 20110201

Title: N-acetylaspartylglutamate in CNS hypomyelination.

Journal: Neuropediatrics 20110201

Title: Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice.

Journal: Brain research 20110131

Title: Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder.

Journal: Journal of psychiatric research 20110101

Title: Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.

Journal: Psychopharmacology 20110101

Title: Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder.

Journal: Depression research and treatment 20110101

Title: mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists.

Journal: Molecular pain 20110101

Title: Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies.

Journal: Journal of translational medicine 20110101

Title: Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model.

Journal: Molecular vision 20110101

Title: MR spectroscopy-based brain metabolite profiling in propionic acidaemia: metabolic changes in the basal ganglia during acute decompensation and effect of liver transplantation.

Journal: Orphanet journal of rare diseases 20110101

Title: Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.

Journal: PloS one 20110101

Title: Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer.

Journal: PloS one 20110101

Title: Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult.

Journal: PloS one 20110101

Title: The Vertebrate Brain, Evidence of Its Modular Organization and Operating System: Insights into the Brain's Basic Units of Structure, Function, and Operation and How They Influence Neuronal Signaling and Behavior.

Journal: Frontiers in behavioral neuroscience 20110101

Title: Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain's 'operating system': how NAA metabolism supports meaningful intercellular frequency-encoded communications.

Journal: Amino acids 20101101

Title: Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T.

Journal: Magnetic resonance in medicine 20101101

Title: Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101

Title: Elevated CSF N-acetylaspartylglutamate suggests specific molecular diagnostic abnormalities in patients with white matter diseases.

Journal: Biochimica et biophysica acta 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.

Journal: The Journal of biological chemistry 20100924

Title: Molecular characterization of N-acetylaspartylglutamate synthetase.

Journal: The Journal of biological chemistry 20100917

Title: Bioanalysis of N-acetyl-aspartyl-glutamate as a marker of glutamate carboxypeptidase II inhibition.

Journal: Analytical biochemistry 20100901

Title: Proton magnetic resonance spectroscopy of brain in obstructive sleep apnoea in north Indian Asian subjects.

Journal: The Indian journal of medical research 20100901

Title: Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.

Journal: Dialogues in clinical neuroscience 20100901

Title: Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status.

Journal: Movement disorders : official journal of the Movement Disorder Society 20100715

Title: Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.

Journal: Brain research 20100602

Title: Determination of kynurenic acid levels in rat brain microdialysis samples and changes in kynurenic acid levels induced by N-acetylaspartic acid.

Journal: Biomedical chromatography : BMC 20100601

Title: Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat.

Journal: Neurotoxicity research 20100501

Title: Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.

Journal: European journal of pharmacology 20100210

Title: Elevated CSF N-acetylaspartylglutamate in patients with free sialic acid storage diseases.

Journal: Neurology 20100126

Title: A novel key-lock mechanism for inactivating amino acid neurotransmitters during transit across extracellular space.

Journal: Amino acids 20100101

Title: N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats.

Journal: Neuropharmacology 20100101

Title: Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: a model of sporadic Alzheimer's disease.

Journal: Acta neurochirurgica. Supplement 20100101

Title: Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.

Journal: Journal of neurochemistry 20100101

Title: Pain perception in neurodevelopmental animal models of schizophrenia.

Journal: Physiological research 20100101

Title: Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS.

Journal: PloS one 20100101

Title: Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.

Journal: Arthritis research & therapy 20100101

Title: Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.

Journal: Molecular pain 20100101

Title: Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients.

Journal: Journal of affective disorders 20091201

Title: MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia.

Journal: NeuroImage 20091115

Title: Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter.

Journal: Neuroradiology 20091001

Title: Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease?

Journal: Neurochemical research 20090901

Title: GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity.

Journal: Journal of neurovirology 20090901

Title: The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20090701

Title: Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?

Journal: The American journal of psychiatry 20090701

Title: Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.

Journal: Metabolic brain disease 20090601

Title: The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.

Journal: Brain : a journal of neurology 20090601

Title: Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.

Journal: Biochemistry 20090519

Title: Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat--11 months follow-up.

Journal: Experimental neurology 20090101

Title: Role of retinal glial cells in neurotransmitter uptake and metabolism.

Journal: Neurochemistry international 20090101

Title: Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR.

Journal: Neuropharmacology 20090101

Title: In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment.

Journal: BMC neuroscience 20090101

Title: In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain.

Journal: BMC neuroscience 20090101

Title: Excitatory neurotransmitters in brain regions in interictal migraine patients.

Journal: Molecular pain 20090101

Title: Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae).

Journal: BMC genomics 20090101

Title: Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215

Title: [Intra-annual and seasonal allergic conjunctivitis treatment: comparison of two therapeutic protocols].

Journal: Journal francais d'ophtalmologie 20081201

Title: Simultaneous determination of N-acetylaspartylglutamate and N-acetylaspartate in rat brain homogenate using high-performance liquid chromatography with pre-column fluorescence derivatization.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081115

Title: Proton magnetic resonance spectroscopy reveals medial temporal metabolic abnormalities in adolescents with history of preterm birth.

Journal: Pediatric research 20081101

Title: The effect of epileptic seizures on proton MRS visible neurochemical concentrations.

Journal: Epilepsy research 20080901

Title: Modeling the impact of COPD on the brain.

Journal: International journal of chronic obstructive pulmonary disease 20080901

Title: Cognitive impairment in multiple sclerosis can be predicted by imaging early in the disease.

Journal: Journal of neurology, neurosurgery, and psychiatry 20080801

Title: Reduced parietooccipital white matter glutamine measured by proton magnetic resonance spectroscopy in treated graves' disease patients.

Journal: The Journal of clinical endocrinology and metabolism 20080801

Title: Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.

Journal: Journal of neurochemistry 20080801

Title: Increased level of N-acetylaspartylglutamate (NAAG) in the CSF of a patient with Pelizaeus-Merzbacher-like disease due to mutation in the GJA12 gene.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20080701

Title: The astrocyte surface NAAG receptor and NAAG peptidase signaling complex as a therapeutic target.

Journal: Drug news & perspectives 20080601

Title: Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.

Journal: Experimental eye research 20080501

Title: Cerebral impairment in chronic solvent-induced encephalopathy.

Journal: Annals of neurology 20080501

Title: N-acetylaspartate and N-acetylaspartylglutamate: neurobiology and clinical significance.

Journal: Neurology 20080415

Title: Small-molecule complement inhibitors cannot prevent the development of the platelet storage lesion.

Journal: Transfusion 20080401

Title: N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations.

Journal: Brain research bulletin 20080328

Title: Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.

Journal: Journal of molecular biology 20080307

Title: Oxidative stress and protein oxidation in the brain of water drinking and alcohol drinking rats administered the HIV envelope protein, gp120.

Journal: Journal of neurochemistry 20080301

Title: Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla.

Journal: Journal of magnetic resonance imaging : JMRI 20080301

Title: Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks.

Journal: European journal of pharmacology 20080128

Title: Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.

Journal: Biological psychiatry 20080101

Title: Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain.

Journal: Molecular pain 20080101

Title: Neurobiology of spirituality.

Journal: Mens sana monographs 20080101

Title: Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.

Journal: Journal of magnetic resonance imaging : JMRI 20071201

Title: Assessment of metabolite quantitation reproducibility in serial 3D-(1)H-MR spectroscopic imaging of human brain using stereotactic repositioning.

Journal: Magnetic resonance in medicine 20071001

Title: Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis.

Journal: The FEBS journal 20070901

Title: Using proton magnetic resonance imaging and spectroscopy to understand brain 'activation'.

Journal: Brain and language 20070801

Title: Low choline concentrations in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans.

Journal: AJNR. American journal of neuroradiology 20070801

Title: Temporal window of metabolic brain vulnerability to concussions: mitochondrial-related impairment--part I.

Journal: Neurosurgery 20070801

Title: Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

Journal: Journal of medicinal chemistry 20070712

Title: Quantitative proton MRS of cerebral metabolites in laminin alpha2 chain deficiency.

Journal: Brain & development 20070701

Title: Different transfer of nociceptive sensitivity from rats with postnatal hippocampal lesions to control rats.

Journal: The European journal of neuroscience 20070701

Title: In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla.

Journal: Magnetic resonance in medicine 20070601

Title: Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.

Journal: Neuroscience 20070525

Title: Selective vulnerability of hippocampal NAAGergic neurons in experimental temporal lobe epilepsy.

Journal: Brain research 20070504

Title: Biochemical characterization of human glutamate carboxypeptidase III.

Journal: Journal of neurochemistry 20070501

Title: The effect of sodium valproate on proton MRS visible neurochemical concentrations.

Journal: Epilepsy research 20070501

Title: Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1(mceph/mceph).

Journal: Neurobiology of disease 20070401

Title: Expression of glutamate carboxypeptidase II in human brain.

Journal: Neuroscience 20070223

Title: 1H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures, and epileptic discharges in EEG.

Journal: Epilepsia 20070201

Title: Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia.

Journal: Schizophrenia research 20070101

Title: Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus.

Journal: Journal of neurochemistry 20070101

Title: Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats.

Journal: The European journal of neuroscience 20070101

Title: Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients.

Journal: The British journal of ophthalmology 20070101

Title: 2-5A ligands--a new concept for the treatment of prostate cancer.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.

Journal: Neuropharmacology 20061201

Title: Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor.

Journal: The Journal of physiology 20061201

Title: Cerebral metabolic and structural alterations in hereditary spastic paraplegia with thin corpus callosum assessed by MRS and DTI.

Journal: Neuroradiology 20061201

Title: Effect of dipeptide N-acetylaspartylglutamate on denervation-induced changes in the volume of rat skeletal muscle fibers.

Journal: Bulletin of experimental biology and medicine 20061201

Title: Metabolic analysis of mouse brains that have compromised iron storage.

Journal: Metabolic brain disease 20060901

Title: [Alteration of the antinociceptive systems in chronic daily headaches].

Journal: Revista de neurologia 20060901

Title: Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators.

Journal: Journal of neurochemistry 20060901

Title: Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060901

Title: Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing?

Journal: Archives of neurology 20060801

Title: Detection of cerebral degeneration in amyotrophic lateral sclerosis using high-field magnetic resonance spectroscopy.

Journal: Archives of neurology 20060801

Title: Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI.

Journal: Neuropediatrics 20060801

Title: NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.

Journal: Journal of neurochemistry 20060501

Title: Identifying the affected hemisphere by (1)H-MR spectroscopy in patients with temporal lobe epilepsy and no pathological findings in high resolution MRI.

Journal: European journal of neurology 20060501

Title: ProFit: two-dimensional prior-knowledge fitting of J-resolved spectra.

Journal: NMR in biomedicine 20060401

Title: NAAG peptidase as a therapeutic target: Potential for regulating the link between glucose metabolism and cognition.

Journal: Drug news & perspectives 20060401

Title: Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

Journal: The EMBO journal 20060322

Title: Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study.

Journal: Journal of neurology 20060201

Title: Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes.

Journal: Journal of neurochemistry 20060201

Title: Neuroprotective effects of selective group II mGluR activation in brain trauma and traumatic neuronal injury.

Journal: Journal of neurotrauma 20060201

Title: Magnetic resonance imaging and proton magnetic resonance spectroscopy of megalencephaly and dilated Virchow-Robin spaces.

Journal: Pediatric neurology 20060101

Title: Neurotransmitters of the suprachiasmatic nuclei.

Journal: Journal of circadian rhythms 20060101

Title: Neonatal administration of N-acetyl-L-aspartyl-L-glutamate induces early neurodegeneration in hippocampus and alters behaviour in young adult rats.

Journal: Neurochemistry international 20060101

Title: Preface: a brief review of N-acetylaspartate.

Journal: Advances in experimental medicine and biology 20060101

Title: A brief overview of N-acetylaspartate and N-acetylaspartylglutamate.

Journal: Advances in experimental medicine and biology 20060101

Title: Expression of N-acetylaspartate and N-acetylaspartylglutamate in the nervous system.

Journal: Advances in experimental medicine and biology 20060101

Title: Canavan disease: studies on the knockout mouse.

Journal: Advances in experimental medicine and biology 20060101

Title: Functions of N-acetylaspartate and N-acetylaspartylglutamate in brain: evidence of a role in maintenance of higher brain integrative activities of information processing and cognition.

Journal: Advances in experimental medicine and biology 20060101

Title: Hypoacetylaspartia: clinical and biochemical follow-up of a patient.

Journal: Advances in experimental medicine and biology 20060101

Title: Synthesis of N-acetylaspartyl-glutamate (NAAG) and N-acetylaspartate (NAA) in axons and glia of the crayfish medial giant nerve fiber.

Journal: Advances in experimental medicine and biology 20060101

Title: Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.

Journal: Advances in experimental medicine and biology 20060101

Title: N-acetylaspartylglutamate (NAAG) in spinal cord injury and disease.

Journal: Advances in experimental medicine and biology 20060101

Title: N-acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher disease.

Journal: Advances in experimental medicine and biology 20060101

Title: Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia.

Journal: Journal of neurochemistry 20051201

Title: Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system.

Journal: NMR in biomedicine 20051201

Title: NAAG peptidase inhibitors and their potential for diagnosis and therapy.

Journal: Nature reviews. Drug discovery 20051201

Title: Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

Journal: Clinical biochemistry 20051101

Title: Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography.

Journal: Neuroscience letters 20051028

Title: Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury.

Journal: Journal of neurochemistry 20051001

Title: A phase rotation scheme for achieving very short echo times with localized stimulated echo spectroscopy.

Journal: Magnetic resonance imaging 20051001

Title: Quantitative proton MRS of Pelizaeus-Merzbacher disease: evidence of dys- and hypomyelination.

Journal: Neurology 20050913

Title: The metabotropic glutamate receptor mGluR3 is critically required for hippocampal long-term depression and modulates long-term potentiation in the dentate gyrus of freely moving rats.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20050901

Title: The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia.

Journal: Trends in pharmacological sciences 20050901

Title: Central N-acetyl aspartylglutamate deficit: a possible pathogenesis of schizophrenia.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20050901

Title: Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2.

Journal: Pharmaceutical research 20050801

Title: Strategies to increase central N-acetyl aspartylglutamate: a potential treatment for schizophrenia and bipolar disorders.

Journal: Schizophrenia research 20050715

Title: Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat.

Journal: Journal of neurochemistry 20050701

Title: Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors.

Journal: Journal of neurochemistry 20050501

Title: Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy.

Journal: Magnetic resonance in medicine 20050501

Title: Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050316

Title: Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.

Journal: Schizophrenia research 20050301

Title: In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.

Journal: Journal of neurochemistry 20050301

Title: NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050101

Title: Group II mGluR-induced long term depression in the dentate gyrus in vivo is NMDA receptor-independent and does not require protein synthesis.

Journal: Neuropharmacology 20050101

Title: High-field localized 1H NMR spectroscopy in the anesthetized and in the awake monkey.

Journal: Magnetic resonance imaging 20041201

Title: In vivo quantitative 1H MRS of cerebellum and evaluation of quantitation reproducibility by simulation of different levels of noise and spectral resolution.

Journal: Magnetic resonance imaging 20041201

Title: Serotonin1B receptors: from protein to physiological function and behavior.

Journal: Neuroscience and biobehavioral reviews 20041001

Title: Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: metabolite concentrations, quantification precision, and reproducibility.

Journal: Journal of magnetic resonance imaging : JMRI 20040901

Title: Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.

Journal: Neurology 20040824

Title: Aspartoacylase deficiency does not affect N-acetylaspartylglutamate level or glutamate carboxypeptidase II activity in the knockout mouse brain.

Journal: Brain research 20040806

Title: Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia.

Journal: Journal of neurochemistry 20040801

Title: Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model.

Journal: The European journal of neuroscience 20040701

Title: Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

Journal: Protein science : a publication of the Protein Society 20040601

Title: SH-SY5Y neuroblastoma cells: a model system for studying biosynthesis of NAAG.

Journal: Neuroreport 20040519

Title: Severe hypomyelination associated with increased levels of N-acetylaspartylglutamate in CSF.

Journal: Neurology 20040511

Title: The cloning and characterization of a second brain enzyme with NAAG peptidase activity.

Journal: Journal of neurochemistry 20040501

Title: A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brain.

Journal: Magnetic resonance imaging 20040501

Title: NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR.

Journal: Journal of neurochemistry 20040501

Title: Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3.

Journal: Journal of neurochemistry 20040401

Title: Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.

Journal: Journal of medicinal chemistry 20040325

Title: NAAG fails to antagonize synaptic and extrasynaptic NMDA receptors in cerebellar granule neurons.

Journal: Neuropharmacology 20040301

Title: Measurement of brain glutamate using TE-averaged PRESS at 3T.

Journal: Magnetic resonance in medicine 20040301

Title: Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer.

Journal: Journal of cellular biochemistry 20040215

Title: Reduced isolation-induced aggressiveness in mice following NAALADase inhibition.

Journal: Psychopharmacology 20040201

Title: GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism.

Journal: Journal of neurophysiology 20040101

Title: Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040101

Title: Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants.

Journal: Synapse (New York, N.Y.) 20031215

Title: N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures.

Journal: Brain research 20031121

Title: Magnetization transfer imaging and magnetic resonance spectroscopy of normal-appearing white matter in late-life major depression.

Journal: Journal of magnetic resonance imaging : JMRI 20031101

Title: Metabotropic glutamate receptor regulation of neuronal cell death.

Journal: Experimental neurology 20031101

Title: High-field proton MRS of human brain.

Journal: European journal of radiology 20031101

Title: Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.

Journal: Neurology 20031014

Title: Effect of carbohydrate moieties on the folate hydrolysis activity of the prostate specific membrane antigen.

Journal: The Prostate 20031001

Title: Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat.

Journal: Neuropeptides 20031001

Title: Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease.

Journal: Brain research bulletin 20030830

Title: Brain metabolism in Alzheimer disease and vascular dementia assessed by in vivo proton magnetic resonance spectroscopy.

Journal: Psychiatry research 20030730

Title: Prostate targeting ligands based on N-acetylated alpha-linked acidic dipeptidase.

Journal: Biochemical and biophysical research communications 20030718

Title: Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701

Title: N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: a postmortem study.

Journal: Biological psychiatry 20030615

Title: Reductions in N-acetylaspartylglutamate and the 67 kDa form of glutamic acid decarboxylase immunoreactivities in the visual system of albino and pigmented rats after optic nerve transections.

Journal: The Journal of comparative neurology 20030407

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie 20030401

Title: Proton MRS profile of cerebral metabolic abnormalities in Krabbe disease.

Journal: Neurology 20030311

Title: Characterisation of the 1H and 13C NMR spectra of N-acetylaspartylglutamate and its detection in urine from patients with Canavan disease.

Journal: Journal of pharmaceutical and biomedical analysis 20030310

Title: Modulation of epileptiform burst frequency by the metabotropic glutamate receptor subtype mGluR3.

Journal: Epilepsy research 20030301

Title: Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging.

Journal: NMR in biomedicine 20030201

Title: Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy.

Journal: Brain & development 20030101

Title: Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate.

Journal: Neuroscience 20030101

Title: Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro.

Journal: Neuroscience 20030101

Title: Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy.

Journal: Magnetic resonance in medicine 20021201

Title: [N acetyl-aspartyl glutamic acid (NAAGA) inhibits the adhesion of leukocytes to activated endothelial cells and down-modulates the cytokine-induced expression of adhesion molecules].

Journal: Journal francais d'ophtalmologie 20021201

Title: Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assay.

Journal: Analytical biochemistry 20021101

Title: High-performance liquid chromatography method for detecting prostate-specific membrane antigen activity.

Journal: Analytical biochemistry 20021101

Title: Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis.

Journal: Brain : a journal of neurology 20021001

Title: Maturation of the human fetal brain as observed by 1H MR spectroscopy.

Journal: Magnetic resonance in medicine 20021001

Title: Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.

Journal: Journal of neurochemistry 20021001

Title: Glutamine uptake and metabolism to N-acetylaspartylglutamate (NAAG) by crayfish axons and glia.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20021001

Title: Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors.

Journal: Journal of medicinal chemistry 20020912

Title: A short-echo-time proton magnetic resonance spectroscopic imaging study of temporal lobe epilepsy.

Journal: Epilepsia 20020901

Title: NAALADase (GCP II) inhibition prevents cocaine-kindled seizures.

Journal: Neuropharmacology 20020901

Title: Mechanism of NMDA receptor contribution to axon-to-glia signaling in the crayfish medial giant nerve fiber.

Journal: Glia 20020401

Title: Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.

Journal: European journal of pharmacology 20020222

Title: Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Reproducibility of in vivo metabolite quantification with proton magnetic resonance spectroscopic imaging.

Journal: Journal of magnetic resonance imaging : JMRI 20020201

Title: Measurement of glutamate carboxypeptidase II (NAALADase) enzyme activity by the hydrolysis of [³H]-N-acetylaspartylglutamate (NAAG).

Journal: Current protocols in pharmacology 20020201

Title: N-Acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier.

Journal: Neuroscience letters 20020111

Title: Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens.

Journal: The Journal of pharmacology and experimental therapeutics 20020101

Title: N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve.

Journal: Annals of neurology 20020101

Title: Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells.

Journal: Journal of molecular neuroscience : MN 20011201

Title: Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta.

Journal: European journal of pharmacology 20011026

Title: Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation.

Journal: European journal of pharmacology 20010824

Title: Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.

Journal: Brain research 20010803

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Journal: NeuroImage 20010801

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Journal: Current medicinal chemistry 20010701

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Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010401

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Journal: Brain : a journal of neurology 20010201

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Journal: The European journal of neuroscience 20010101

Title: N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber.

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SDS
Tags:3106-85-2 Molecular Formula|3106-85-2 MDL|3106-85-2 SMILES|3106-85-2 Spaglumic Acid
Catalog No.: AA0031YS
3106-85-2,MFCD00076652
3106-85-2 | Spaglumic Acid
Pack Size: 10mg
Purity: ≥95%
in stock
$89.00 $62.00
Pack Size: 50mg
Purity: ≥95%
in stock
$238.00 $166.00
Pack Size: 100mg
Purity: ≥95%
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$428.00 $299.00
Pack Size: 250mg
Purity: ≥95%
in stock
$958.00 $670.00
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Technical Information
Catalog Number: AA0031YS
Chemical Name: Spaglumic Acid
CAS Number: 3106-85-2
Molecular Formula: C11H16N2O8
Molecular Weight: 304.2533
MDL Number: MFCD00076652
SMILES: OC(=O)CC[C@@H](C(=O)O)NC(=O)[C@@H](NC(=O)C)CC(=O)O
NSC Number: 758468
Properties
Complexity: 448  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Heavy Atom Count: 21  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 5  
Rotatable Bond Count: 9  
XLogP3: -2.1  
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Journal: La Radiologia medica20120801

Title: Three-dimensional arbitrary voxel shapes in spectroscopy with submillisecond TEs.

Journal: NMR in biomedicine20120801

Title: NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia.

Journal: Translational psychiatry20120701

Title: Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.

Journal: The Journal of biological chemistry20120622

Title: Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T.

Journal: Magnetic resonance in medicine20120501

Title: Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population.

Journal: Metabolic brain disease20120301

Title: Proton magnetic resonance spectroscopy and its diagnostically important metabolites in the brain.

Journal: General physiology and biophysics20120301

Title: Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla.

Journal: Biological psychiatry20120201

Title: Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease.

Journal: Journal of magnetic resonance imaging : JMRI20120201

Title: Effects of bee venom on glutamate-induced toxicity in neuronal and glial cells.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer.

Journal: Current medicinal chemistry20120101

Title: Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 tesla proton MRS.

Journal: PloS one20120101

Title: Tissue distribution of glutamate carboxypeptidase II (GCPII) with a focus on the central and peripheral nervous system.

Journal: Current medicinal chemistry20120101

Title: NAAG, NMDA receptor and psychosis.

Journal: Current medicinal chemistry20120101

Title: Structure-activity relationships of glutamate carboxypeptidase II (GCPII) inhibitors.

Journal: Current medicinal chemistry20120101

Title: Altered neurochemical ingredient of hippocampus in patients with bipolar depression.

Journal: Depression research and treatment20120101

Title: Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate.

Journal: International journal of inflammation20120101

Title: Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.

Journal: Frontiers in behavioral neuroscience20120101

Title: Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSI.

Journal: PloS one20120101

Title: Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats.

Journal: PloS one20120101

Title: N-acetylaspartylglutamate is an agonist at mGluR₃ in vivo and in vitro.

Journal: Journal of neurochemistry20111201

Title: Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia.

Journal: Schizophrenia research20111201

Title: N-acetylaspartylglutamate is not demonstrated to be a selective mGlu₃receptor agonist.

Journal: Journal of neurochemistry20111201

Title: A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA).

Journal: Oncotarget20111201

Title: Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.

Journal: The Journal of biological chemistry20111104

Title: Whole-exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA).

Journal: American journal of medical genetics. Part A20111101

Title: Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study.

Journal: AJNR. American journal of neuroradiology20111001

Title: Who is resilient to depression? Multimodal imaging of the hippocampus in preclinical chronic mild stress model may provide clues.

Journal: Biological psychiatry20110901

Title: Cerebral metabolic alterations and cognitive dysfunction in chronic kidney disease.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20110801

Title: Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family.

Journal: Journal of neurochemistry20110801

Title: Quantitative measurement of N-acetyl-aspartyl-glutamate at 3 T using TE-averaged PRESS spectroscopy and regularized lineshape deconvolution.

Journal: Magnetic resonance in medicine20110801

Title: Transcranial direct current stimulation (tDCS) produces localized and specific alterations in neurochemistry: a ¹H magnetic resonance spectroscopy study.

Journal: Neuroscience letters20110801

Title: Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.

Journal: Psychopharmacology20110701

Title: Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.

Journal: PLoS genetics20110701

Title: Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI.

Journal: Brain research20110613

Title: Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0-T magnetic resonance spectroscopy study.

Journal: Movement disorders : official journal of the Movement Disorder Society20110601

Title: N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.

Journal: The Journal of biological chemistry20110513

Title: Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.

Journal: Gut20110301

Title: Anterior cingulate and frontal lobe white matter spectroscopy in early childhood of former very LBW premature infants.

Journal: Pediatric research20110301

Title: Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus.

Journal: Nutritional neuroscience20110301

Title: Correlation of findings in advanced MRI techniques with global severity scales in patients with Parkinson disease.

Journal: Academic radiology20110201

Title: 1H-MRS in spinal cord injury: acute and chronic metabolite alterations in rat brain and lumbar spinal cord.

Journal: The European journal of neuroscience20110201

Title: N-acetylaspartylglutamate in CNS hypomyelination.

Journal: Neuropediatrics20110201

Title: Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice.

Journal: Brain research20110131

Title: Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder.

Journal: Journal of psychiatric research20110101

Title: Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.

Journal: Psychopharmacology20110101

Title: Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder.

Journal: Depression research and treatment20110101

Title: mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists.

Journal: Molecular pain20110101

Title: Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies.

Journal: Journal of translational medicine20110101

Title: Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model.

Journal: Molecular vision20110101

Title: MR spectroscopy-based brain metabolite profiling in propionic acidaemia: metabolic changes in the basal ganglia during acute decompensation and effect of liver transplantation.

Journal: Orphanet journal of rare diseases20110101

Title: Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.

Journal: PloS one20110101

Title: Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer.

Journal: PloS one20110101

Title: Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult.

Journal: PloS one20110101

Title: The Vertebrate Brain, Evidence of Its Modular Organization and Operating System: Insights into the Brain's Basic Units of Structure, Function, and Operation and How They Influence Neuronal Signaling and Behavior.

Journal: Frontiers in behavioral neuroscience20110101

Title: Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain's 'operating system': how NAA metabolism supports meaningful intercellular frequency-encoded communications.

Journal: Amino acids20101101

Title: Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T.

Journal: Magnetic resonance in medicine20101101

Title: Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20101101

Title: Elevated CSF N-acetylaspartylglutamate suggests specific molecular diagnostic abnormalities in patients with white matter diseases.

Journal: Biochimica et biophysica acta20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.

Journal: The Journal of biological chemistry20100924

Title: Molecular characterization of N-acetylaspartylglutamate synthetase.

Journal: The Journal of biological chemistry20100917

Title: Bioanalysis of N-acetyl-aspartyl-glutamate as a marker of glutamate carboxypeptidase II inhibition.

Journal: Analytical biochemistry20100901

Title: Proton magnetic resonance spectroscopy of brain in obstructive sleep apnoea in north Indian Asian subjects.

Journal: The Indian journal of medical research20100901

Title: Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.

Journal: Dialogues in clinical neuroscience20100901

Title: Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status.

Journal: Movement disorders : official journal of the Movement Disorder Society20100715

Title: Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.

Journal: Brain research20100602

Title: Determination of kynurenic acid levels in rat brain microdialysis samples and changes in kynurenic acid levels induced by N-acetylaspartic acid.

Journal: Biomedical chromatography : BMC20100601

Title: Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat.

Journal: Neurotoxicity research20100501

Title: Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.

Journal: European journal of pharmacology20100210

Title: Elevated CSF N-acetylaspartylglutamate in patients with free sialic acid storage diseases.

Journal: Neurology20100126

Title: A novel key-lock mechanism for inactivating amino acid neurotransmitters during transit across extracellular space.

Journal: Amino acids20100101

Title: N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats.

Journal: Neuropharmacology20100101

Title: Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: a model of sporadic Alzheimer's disease.

Journal: Acta neurochirurgica. Supplement20100101

Title: Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.

Journal: Journal of neurochemistry20100101

Title: Pain perception in neurodevelopmental animal models of schizophrenia.

Journal: Physiological research20100101

Title: Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS.

Journal: PloS one20100101

Title: Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.

Journal: Arthritis research & therapy20100101

Title: Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.

Journal: Molecular pain20100101

Title: Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients.

Journal: Journal of affective disorders20091201

Title: MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia.

Journal: NeuroImage20091115

Title: Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter.

Journal: Neuroradiology20091001

Title: Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease?

Journal: Neurochemical research20090901

Title: GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity.

Journal: Journal of neurovirology20090901

Title: The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor.

Journal: The Journal of pharmacology and experimental therapeutics20090701

Title: Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?

Journal: The American journal of psychiatry20090701

Title: Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.

Journal: Metabolic brain disease20090601

Title: The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.

Journal: Brain : a journal of neurology20090601

Title: Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.

Journal: Biochemistry20090519

Title: Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat--11 months follow-up.

Journal: Experimental neurology20090101

Title: Role of retinal glial cells in neurotransmitter uptake and metabolism.

Journal: Neurochemistry international20090101

Title: Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR.

Journal: Neuropharmacology20090101

Title: In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment.

Journal: BMC neuroscience20090101

Title: In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain.

Journal: BMC neuroscience20090101

Title: Excitatory neurotransmitters in brain regions in interictal migraine patients.

Journal: Molecular pain20090101

Title: Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae).

Journal: BMC genomics20090101

Title: Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20081215

Title: [Intra-annual and seasonal allergic conjunctivitis treatment: comparison of two therapeutic protocols].

Journal: Journal francais d'ophtalmologie20081201

Title: Simultaneous determination of N-acetylaspartylglutamate and N-acetylaspartate in rat brain homogenate using high-performance liquid chromatography with pre-column fluorescence derivatization.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20081115

Title: Proton magnetic resonance spectroscopy reveals medial temporal metabolic abnormalities in adolescents with history of preterm birth.

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Title: The effect of epileptic seizures on proton MRS visible neurochemical concentrations.

Journal: Epilepsy research20080901

Title: Modeling the impact of COPD on the brain.

Journal: International journal of chronic obstructive pulmonary disease20080901

Title: Cognitive impairment in multiple sclerosis can be predicted by imaging early in the disease.

Journal: Journal of neurology, neurosurgery, and psychiatry20080801

Title: Reduced parietooccipital white matter glutamine measured by proton magnetic resonance spectroscopy in treated graves' disease patients.

Journal: The Journal of clinical endocrinology and metabolism20080801

Title: Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.

Journal: Journal of neurochemistry20080801

Title: Increased level of N-acetylaspartylglutamate (NAAG) in the CSF of a patient with Pelizaeus-Merzbacher-like disease due to mutation in the GJA12 gene.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society20080701

Title: The astrocyte surface NAAG receptor and NAAG peptidase signaling complex as a therapeutic target.

Journal: Drug news & perspectives20080601

Title: Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.

Journal: Experimental eye research20080501

Title: Cerebral impairment in chronic solvent-induced encephalopathy.

Journal: Annals of neurology20080501

Title: N-acetylaspartate and N-acetylaspartylglutamate: neurobiology and clinical significance.

Journal: Neurology20080415

Title: Small-molecule complement inhibitors cannot prevent the development of the platelet storage lesion.

Journal: Transfusion20080401

Title: N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations.

Journal: Brain research bulletin20080328

Title: Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.

Journal: Journal of molecular biology20080307

Title: Oxidative stress and protein oxidation in the brain of water drinking and alcohol drinking rats administered the HIV envelope protein, gp120.

Journal: Journal of neurochemistry20080301

Title: Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla.

Journal: Journal of magnetic resonance imaging : JMRI20080301

Title: Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks.

Journal: European journal of pharmacology20080128

Title: Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.

Journal: Biological psychiatry20080101

Title: Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain.

Journal: Molecular pain20080101

Title: Neurobiology of spirituality.

Journal: Mens sana monographs20080101

Title: Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.

Journal: Journal of magnetic resonance imaging : JMRI20071201

Title: Assessment of metabolite quantitation reproducibility in serial 3D-(1)H-MR spectroscopic imaging of human brain using stereotactic repositioning.

Journal: Magnetic resonance in medicine20071001

Title: Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis.

Journal: The FEBS journal20070901

Title: Using proton magnetic resonance imaging and spectroscopy to understand brain 'activation'.

Journal: Brain and language20070801

Title: Low choline concentrations in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans.

Journal: AJNR. American journal of neuroradiology20070801

Title: Temporal window of metabolic brain vulnerability to concussions: mitochondrial-related impairment--part I.

Journal: Neurosurgery20070801

Title: Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

Journal: Journal of medicinal chemistry20070712

Title: Quantitative proton MRS of cerebral metabolites in laminin alpha2 chain deficiency.

Journal: Brain & development20070701

Title: Different transfer of nociceptive sensitivity from rats with postnatal hippocampal lesions to control rats.

Journal: The European journal of neuroscience20070701

Title: In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla.

Journal: Magnetic resonance in medicine20070601

Title: Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.

Journal: Neuroscience20070525

Title: Selective vulnerability of hippocampal NAAGergic neurons in experimental temporal lobe epilepsy.

Journal: Brain research20070504

Title: Biochemical characterization of human glutamate carboxypeptidase III.

Journal: Journal of neurochemistry20070501

Title: The effect of sodium valproate on proton MRS visible neurochemical concentrations.

Journal: Epilepsy research20070501

Title: Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1(mceph/mceph).

Journal: Neurobiology of disease20070401

Title: Expression of glutamate carboxypeptidase II in human brain.

Journal: Neuroscience20070223

Title: 1H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures, and epileptic discharges in EEG.

Journal: Epilepsia20070201

Title: Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia.

Journal: Schizophrenia research20070101

Title: Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus.

Journal: Journal of neurochemistry20070101

Title: Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats.

Journal: The European journal of neuroscience20070101

Title: Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients.

Journal: The British journal of ophthalmology20070101

Title: 2-5A ligands--a new concept for the treatment of prostate cancer.

Journal: Nucleosides, nucleotides & nucleic acids20070101

Title: Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.

Journal: Neuropharmacology20061201

Title: Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor.

Journal: The Journal of physiology20061201

Title: Cerebral metabolic and structural alterations in hereditary spastic paraplegia with thin corpus callosum assessed by MRS and DTI.

Journal: Neuroradiology20061201

Title: Effect of dipeptide N-acetylaspartylglutamate on denervation-induced changes in the volume of rat skeletal muscle fibers.

Journal: Bulletin of experimental biology and medicine20061201

Title: Metabolic analysis of mouse brains that have compromised iron storage.

Journal: Metabolic brain disease20060901

Title: [Alteration of the antinociceptive systems in chronic daily headaches].

Journal: Revista de neurologia20060901

Title: Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators.

Journal: Journal of neurochemistry20060901

Title: Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie20060901

Title: Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing?

Journal: Archives of neurology20060801

Title: Detection of cerebral degeneration in amyotrophic lateral sclerosis using high-field magnetic resonance spectroscopy.

Journal: Archives of neurology20060801

Title: Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI.

Journal: Neuropediatrics20060801

Title: NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.

Journal: Journal of neurochemistry20060501

Title: Identifying the affected hemisphere by (1)H-MR spectroscopy in patients with temporal lobe epilepsy and no pathological findings in high resolution MRI.

Journal: European journal of neurology20060501

Title: ProFit: two-dimensional prior-knowledge fitting of J-resolved spectra.

Journal: NMR in biomedicine20060401

Title: NAAG peptidase as a therapeutic target: Potential for regulating the link between glucose metabolism and cognition.

Journal: Drug news & perspectives20060401

Title: Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

Journal: The EMBO journal20060322

Title: Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study.

Journal: Journal of neurology20060201

Title: Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes.

Journal: Journal of neurochemistry20060201

Title: Neuroprotective effects of selective group II mGluR activation in brain trauma and traumatic neuronal injury.

Journal: Journal of neurotrauma20060201

Title: Magnetic resonance imaging and proton magnetic resonance spectroscopy of megalencephaly and dilated Virchow-Robin spaces.

Journal: Pediatric neurology20060101

Title: Neurotransmitters of the suprachiasmatic nuclei.

Journal: Journal of circadian rhythms20060101

Title: Neonatal administration of N-acetyl-L-aspartyl-L-glutamate induces early neurodegeneration in hippocampus and alters behaviour in young adult rats.

Journal: Neurochemistry international20060101

Title: Preface: a brief review of N-acetylaspartate.

Journal: Advances in experimental medicine and biology20060101

Title: A brief overview of N-acetylaspartate and N-acetylaspartylglutamate.

Journal: Advances in experimental medicine and biology20060101

Title: Expression of N-acetylaspartate and N-acetylaspartylglutamate in the nervous system.

Journal: Advances in experimental medicine and biology20060101

Title: Canavan disease: studies on the knockout mouse.

Journal: Advances in experimental medicine and biology20060101

Title: Functions of N-acetylaspartate and N-acetylaspartylglutamate in brain: evidence of a role in maintenance of higher brain integrative activities of information processing and cognition.

Journal: Advances in experimental medicine and biology20060101

Title: Hypoacetylaspartia: clinical and biochemical follow-up of a patient.

Journal: Advances in experimental medicine and biology20060101

Title: Synthesis of N-acetylaspartyl-glutamate (NAAG) and N-acetylaspartate (NAA) in axons and glia of the crayfish medial giant nerve fiber.

Journal: Advances in experimental medicine and biology20060101

Title: Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.

Journal: Advances in experimental medicine and biology20060101

Title: N-acetylaspartylglutamate (NAAG) in spinal cord injury and disease.

Journal: Advances in experimental medicine and biology20060101

Title: N-acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher disease.

Journal: Advances in experimental medicine and biology20060101

Title: Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia.

Journal: Journal of neurochemistry20051201

Title: Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system.

Journal: NMR in biomedicine20051201

Title: NAAG peptidase inhibitors and their potential for diagnosis and therapy.

Journal: Nature reviews. Drug discovery20051201

Title: Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

Journal: Clinical biochemistry20051101

Title: Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography.

Journal: Neuroscience letters20051028

Title: Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury.

Journal: Journal of neurochemistry20051001

Title: A phase rotation scheme for achieving very short echo times with localized stimulated echo spectroscopy.

Journal: Magnetic resonance imaging20051001

Title: Quantitative proton MRS of Pelizaeus-Merzbacher disease: evidence of dys- and hypomyelination.

Journal: Neurology20050913

Title: The metabotropic glutamate receptor mGluR3 is critically required for hippocampal long-term depression and modulates long-term potentiation in the dentate gyrus of freely moving rats.

Journal: Cerebral cortex (New York, N.Y. : 1991)20050901

Title: The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia.

Journal: Trends in pharmacological sciences20050901

Title: Central N-acetyl aspartylglutamate deficit: a possible pathogenesis of schizophrenia.

Journal: Medical science monitor : international medical journal of experimental and clinical research20050901

Title: Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2.

Journal: Pharmaceutical research20050801

Title: Strategies to increase central N-acetyl aspartylglutamate: a potential treatment for schizophrenia and bipolar disorders.

Journal: Schizophrenia research20050715

Title: Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat.

Journal: Journal of neurochemistry20050701

Title: Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors.

Journal: Journal of neurochemistry20050501

Title: Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy.

Journal: Magnetic resonance in medicine20050501

Title: Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050316

Title: Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.

Journal: Schizophrenia research20050301

Title: In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.

Journal: Journal of neurochemistry20050301

Title: NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20050101

Title: Group II mGluR-induced long term depression in the dentate gyrus in vivo is NMDA receptor-independent and does not require protein synthesis.

Journal: Neuropharmacology20050101

Title: High-field localized 1H NMR spectroscopy in the anesthetized and in the awake monkey.

Journal: Magnetic resonance imaging20041201

Title: In vivo quantitative 1H MRS of cerebellum and evaluation of quantitation reproducibility by simulation of different levels of noise and spectral resolution.

Journal: Magnetic resonance imaging20041201

Title: Serotonin1B receptors: from protein to physiological function and behavior.

Journal: Neuroscience and biobehavioral reviews20041001

Title: Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: metabolite concentrations, quantification precision, and reproducibility.

Journal: Journal of magnetic resonance imaging : JMRI20040901

Title: Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.

Journal: Neurology20040824

Title: Aspartoacylase deficiency does not affect N-acetylaspartylglutamate level or glutamate carboxypeptidase II activity in the knockout mouse brain.

Journal: Brain research20040806

Title: Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia.

Journal: Journal of neurochemistry20040801

Title: Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model.

Journal: The European journal of neuroscience20040701

Title: Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

Journal: Protein science : a publication of the Protein Society20040601

Title: SH-SY5Y neuroblastoma cells: a model system for studying biosynthesis of NAAG.

Journal: Neuroreport20040519

Title: Severe hypomyelination associated with increased levels of N-acetylaspartylglutamate in CSF.

Journal: Neurology20040511

Title: The cloning and characterization of a second brain enzyme with NAAG peptidase activity.

Journal: Journal of neurochemistry20040501

Title: A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brain.

Journal: Magnetic resonance imaging20040501

Title: NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR.

Journal: Journal of neurochemistry20040501

Title: Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3.

Journal: Journal of neurochemistry20040401

Title: Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.

Journal: Journal of medicinal chemistry20040325

Title: NAAG fails to antagonize synaptic and extrasynaptic NMDA receptors in cerebellar granule neurons.

Journal: Neuropharmacology20040301

Title: Measurement of brain glutamate using TE-averaged PRESS at 3T.

Journal: Magnetic resonance in medicine20040301

Title: Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer.

Journal: Journal of cellular biochemistry20040215

Title: Reduced isolation-induced aggressiveness in mice following NAALADase inhibition.

Journal: Psychopharmacology20040201

Title: GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism.

Journal: Journal of neurophysiology20040101

Title: Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20040101

Title: Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants.

Journal: Synapse (New York, N.Y.)20031215

Title: N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures.

Journal: Brain research20031121

Title: Magnetization transfer imaging and magnetic resonance spectroscopy of normal-appearing white matter in late-life major depression.

Journal: Journal of magnetic resonance imaging : JMRI20031101

Title: Metabotropic glutamate receptor regulation of neuronal cell death.

Journal: Experimental neurology20031101

Title: High-field proton MRS of human brain.

Journal: European journal of radiology20031101

Title: Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.

Journal: Neurology20031014

Title: Effect of carbohydrate moieties on the folate hydrolysis activity of the prostate specific membrane antigen.

Journal: The Prostate20031001

Title: Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat.

Journal: Neuropeptides20031001

Title: Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease.

Journal: Brain research bulletin20030830

Title: Brain metabolism in Alzheimer disease and vascular dementia assessed by in vivo proton magnetic resonance spectroscopy.

Journal: Psychiatry research20030730

Title: Prostate targeting ligands based on N-acetylated alpha-linked acidic dipeptidase.

Journal: Biochemical and biophysical research communications20030718

Title: Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20030701

Title: N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: a postmortem study.

Journal: Biological psychiatry20030615

Title: Reductions in N-acetylaspartylglutamate and the 67 kDa form of glutamic acid decarboxylase immunoreactivities in the visual system of albino and pigmented rats after optic nerve transections.

Journal: The Journal of comparative neurology20030407

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie20030401

Title: Proton MRS profile of cerebral metabolic abnormalities in Krabbe disease.

Journal: Neurology20030311

Title: Characterisation of the 1H and 13C NMR spectra of N-acetylaspartylglutamate and its detection in urine from patients with Canavan disease.

Journal: Journal of pharmaceutical and biomedical analysis20030310

Title: Modulation of epileptiform burst frequency by the metabotropic glutamate receptor subtype mGluR3.

Journal: Epilepsy research20030301

Title: Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging.

Journal: NMR in biomedicine20030201

Title: Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy.

Journal: Brain & development20030101

Title: Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate.

Journal: Neuroscience20030101

Title: Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro.

Journal: Neuroscience20030101

Title: Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy.

Journal: Magnetic resonance in medicine20021201

Title: [N acetyl-aspartyl glutamic acid (NAAGA) inhibits the adhesion of leukocytes to activated endothelial cells and down-modulates the cytokine-induced expression of adhesion molecules].

Journal: Journal francais d'ophtalmologie20021201

Title: Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assay.

Journal: Analytical biochemistry20021101

Title: High-performance liquid chromatography method for detecting prostate-specific membrane antigen activity.

Journal: Analytical biochemistry20021101

Title: Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis.

Journal: Brain : a journal of neurology20021001

Title: Maturation of the human fetal brain as observed by 1H MR spectroscopy.

Journal: Magnetic resonance in medicine20021001

Title: Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.

Journal: Journal of neurochemistry20021001

Title: Glutamine uptake and metabolism to N-acetylaspartylglutamate (NAAG) by crayfish axons and glia.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology20021001

Title: Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors.

Journal: Journal of medicinal chemistry20020912

Title: A short-echo-time proton magnetic resonance spectroscopic imaging study of temporal lobe epilepsy.

Journal: Epilepsia20020901

Title: NAALADase (GCP II) inhibition prevents cocaine-kindled seizures.

Journal: Neuropharmacology20020901

Title: Mechanism of NMDA receptor contribution to axon-to-glia signaling in the crayfish medial giant nerve fiber.

Journal: Glia20020401

Title: Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.

Journal: European journal of pharmacology20020222

Title: Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain.

Journal: The Journal of pharmacology and experimental therapeutics20020201

Title: Reproducibility of in vivo metabolite quantification with proton magnetic resonance spectroscopic imaging.

Journal: Journal of magnetic resonance imaging : JMRI20020201

Title: Measurement of glutamate carboxypeptidase II (NAALADase) enzyme activity by the hydrolysis of [³H]-N-acetylaspartylglutamate (NAAG).

Journal: Current protocols in pharmacology20020201

Title: N-Acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier.

Journal: Neuroscience letters20020111

Title: Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens.

Journal: The Journal of pharmacology and experimental therapeutics20020101

Title: N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve.

Journal: Annals of neurology20020101

Title: Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells.

Journal: Journal of molecular neuroscience : MN20011201

Title: Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta.

Journal: European journal of pharmacology20011026

Title: Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation.

Journal: European journal of pharmacology20010824

Title: Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.

Journal: Brain research20010803

Title: In vivo short echo time 1H-magnetic resonance spectroscopic imaging (MRSI) of the temporal lobes.

Journal: NeuroImage20010801

Title: Design of NAALADase inhibitors: a novel neuroprotective strategy.

Journal: Current medicinal chemistry20010701

Title: Group II mGlu receptor agonists fail to protect against various neurotoxic insults induced in murine cortical, striatal and cerebellar granular pure neuronal cultures.

Journal: Neuropharmacology20010701

Title: Postmortem degradation of N-acetyl aspartate and N-acetyl aspartylglutamate: an HPLC analysis of different rat CNS regions.

Journal: Neurochemical research20010601

Title: Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy?

Journal: Annals of neurology20010401

Title: [Synthesis and release of N-acetylaspartyl glutamate (NAAG) in medial giant axons in crayfish].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova20010401

Title: beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor.

Journal: Journal of neurophysiology20010301

Title: Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy.

Journal: Brain : a journal of neurology20010201

Title: [Antioxidant effects of mast cell inhibitors in a human conjunctival cell line].

Journal: Journal francais d'ophtalmologie20010201

Title: Amino acids are still as exciting as ever.

Journal: Current opinion in pharmacology20010201

Title: Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.

Journal: Neurochemistry international20010101

Title: Inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test.

Journal: Neuroscience20010101

Title: NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance.

Journal: The European journal of neuroscience20010101

Title: N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber.

Journal: Neuroscience20010101

Title: Synthesis and release of N-acetylaspartylglutamate (NAAG) by crayfish nerve fibers: implications for axon-glia signaling.

Journal: Neuroscience20010101

Title: Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: implications for axon-glia signaling.

Journal: Neuroscience20010101

Title: Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors.

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