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627-03-2,MFCD00004310
Catalog No.:AA00337O

627-03-2 | Ethoxyacetic acid

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1g
98%
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$6.00   $4.00
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10g
98%
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$9.00   $7.00
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25g
98%
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$22.00   $15.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00337O
Chemical Name:
Ethoxyacetic acid
CAS Number:
627-03-2
Molecular Formula:
C4H8O3
Molecular Weight:
104.1045
MDL Number:
MFCD00004310
SMILES:
CCOCC(=O)O
NSC Number:
6750
UN Number:
3265
Properties
Properties
 
BP:
206.5°C  
Form:
Liquid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
60  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  

Downstream Synthesis Route

[1]Patent:TW2016/2107,2016,A.Locationinpatent:Paragraph0106;0107

[2]Tetrahedron,2016,vol.72,p.7249-7255

[3]OrganicSyntheses,1933,vol.13,p.42

[4]JournaloftheAmericanChemicalSociety,1944,vol.66,p.2092

[1]OrganicLetters,2018,vol.20,p.8052-8056

[2]Patent:WO2018/196823,2018,A1.Locationinpatent:Paragraph0174;0199-0200

[3]Tetrahedron,2018,vol.74,p.3663-3670

[4]EuropeanJournalofOrganicChemistry,2017,vol.2017,p.5789-5794

[5]Patent:WO2020/23680,2020,A1.Locationinpatent:Page/Pagecolumn13;80

[6]GreenChemistry,2017,vol.19,p.3927-3937

[7]ChemischeBerichte,1937,vol.70,p.1042

[8]JournaloftheChemicalSociety,1923,vol.123,p.751    JournaloftheChemicalSociety,1925,vol.127,p.169

[9]AnnalesdeChimie(Cachan,France),1906,vol.<8>9,p.491    BulletindelaSocieteChimiquedeFrance,1907,vol.<4>1,p.368

[10]BulletindelaSocieteChimiquedeFrance,1932,vol.<4>51,p.838,842

[11]JournaloftheChemicalSocietyB:PhysicalOrganic,1971,p.565-566

[12]TetrahedronLetters,1994,vol.35,p.7269-7272

[13]JournalofBiochemicalandMolecularToxicology,2003,vol.17,p.76-85

[14]JournalofMedicinalChemistry,2004,vol.47,p.5923-5936

[15]Patent:US2003/69271,2003,A1

[16]Patent:US4766222,1988,A

[17]Patent:US4551477,1985,A

[18]BioorganicandMedicinalChemistryLetters,2010,vol.20,p.1019-1022

[19]Patent:WO2010/51177,2010,A1.Locationinpatent:Page/Pagecolumn39

[20]Patent:WO2010/120854,2010,A1.Locationinpatent:Page/Pagecolumn138

[21]Patent:WO2011/6935,2011,A2.Locationinpatent:Page/Pagecolumn93-94

[22]Tetrahedron,2011,vol.67,p.9690-9699

[23]OrganicandBiomolecularChemistry,2012,vol.10,p.1598-1601

[24]Patent:WO2012/80728,2012,A1.Locationinpatent:Page/Pagecolumn32

[25]Patent:EP2540728,2013,A1.Locationinpatent:Page/Pagecolumn60

[26]Patent:WO2013/52550,2013,A2.Locationinpatent:Paragraph0225

[27]Patent:WO2014/145512,2014,A2.Locationinpatent:Page/Pagecolumn120

[28]Patent:US9873694,2018,B2.Locationinpatent:Page/Pagecolumn104

[29]Patent:US6686343,2004,B1.Locationinpatent:Pagecolumn12

[1]CombinatorialChemistryandHighThroughputScreening,2013,vol.16,p.484-493

[2]OrganicSyntheses,1933,vol.13,p.42

[1]Tetrahedron,2016,vol.72,p.7249-7255

[2]JournaloftheAmericanChemicalSociety,1949,vol.71,p.770,772

[1]CombinatorialChemistryandHighThroughputScreening,2013,vol.16,p.484-493

[2]HelveticaChimicaActa,1983,vol.66,p.1691-1703

Literature

Title: Comparison of osteoblast and cardiomyocyte differentiation in the embryonic stem cell test for predicting embryotoxicity in vivo.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20140901

Title: Urinary biomarkers of exposure to glycol ethers and chlorinated solvents during pregnancy: determinants of exposure and comparison with indirect methods of exposure assessment.

Journal: Occupational and environmental medicine 20120101

Title: Hematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats.

Journal: Pharmacological reports : PR 20120101

Title: Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20110901

Title: Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110401

Title: Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite.

Journal: PloS one 20110101

Title: Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites.

Journal: Toxicology and applied pharmacology 20100601

Title: Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090701

Title: Simultaneous UV Spectrophotometric Estimation of Ambroxol Hydrochloride and Levocetirizine Dihydrochloride.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice.

Journal: Industrial health 20070801

Title: Inhibitory effect of ethylene glycol monoethyl ether on rat sperm motion.

Journal: Industrial health 20061001

Title: Gas chromatography analysis of urinary alkoxyacetic acids as biomarkers of exposure to aliphatic alkyl ethers.

Journal: Journal of analytical toxicology 20060501

Title: The alkoxyacetic acids as calcium and magnesium chelating agents in vitro.

Journal: Acta poloniae pharmaceutica 20060101

Title: Health effects of exposure to ethylene glycol monoethyl ether in female workers.

Journal: Industrial health 20041001

Title: Determination of urinary metabolites of alkyl cellosolves by solid phase extraction and GC/FID.

Journal: Journal of occupational health 20040701

Title: Percutaneous penetration and metabolism of 2-ethoxyethanol.

Journal: Toxicology and applied pharmacology 20020415

Title: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate.

Journal: International journal of toxicology 20020101

Title: Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administration with toluene and xylene.

Journal: Toxicology letters 19990111

Title: Studies on the toxicity of some glycol ethers and alkoxyacetic acids in primary testicular cell cultures.

Journal: Toxicology and applied pharmacology 19850701

Title: Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat.

Journal: Environmental health perspectives 19840801

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Tags:627-03-2 Molecular Formula|627-03-2 MDL|627-03-2 SMILES|627-03-2 Ethoxyacetic acid