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3-Indolepropionic acid is a crucial building block in organic synthesis, serving as a precursor for various bioactive compounds with pharmaceutical significance. It is utilized in the preparation of fluorescent analogues of strigolactones, anti-tumor agents, melanocortin receptor ligands, and immunosuppressive agents. Additionally, it is involved in the synthesis of inhibitors targeting hepatitis C virus, histamine H4 receptor agonists, NR2B/NMDA receptor antagonists, CB1 antagonists for obesity treatment, antibacterial agents, and inhibitors of TGF-β receptor binding. This compound's versatility and reactivity make it a valuable tool in medicinal chemistry, offering potential therapeutic applications across a range of diseases and disorders.