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65277-42-1,MFCD00058579
Catalog No.:AA0034ZV

65277-42-1 | 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%
in stock  
$8.00   $6.00
- +
5g
98%
in stock  
$11.00   $8.00
- +
10g
98%
in stock  
$13.00   $9.00
- +
25g
98%
in stock  
$23.00   $16.00
- +
500g
98%
in stock  
$411.00   $288.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0034ZV
Chemical Name:
1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
CAS Number:
65277-42-1
Molecular Formula:
C26H28Cl2N4O4
Molecular Weight:
531.4309
MDL Number:
MFCD00058579
SMILES:
Clc1ccc(c(c1)Cl)[C@@]1(OC[C@H](O1)COc1ccc(cc1)N1CCN(CC1)C(=O)C)Cn1cncc1
UN Number:
2811
Properties
Properties
 
BP:
753.4 °C at 760 mmHg  
Form:
Solid  
MP:
146 °C  
Refractive Index:
-10.5 ° (C=0.4, CHCl3)  
Solubility:
methanol: soluble50mg/mL  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
735  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
7  
XLogP3:
4.3  

Literature

Title: Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75.

Title: Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70.

Title: Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151(9):4301-12.

Title: Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.

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SDS
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Tags:65277-42-1 Molecular Formula|65277-42-1 MDL|65277-42-1 SMILES|65277-42-1 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one