Home Oxazoles 300816-15-3
300816-15-3,MFCD09038564
Catalog No.:AA0035HU

300816-15-3 | 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$58.00   $40.00
- +
5mg
95%
in stock  
$155.00   $108.00
- +
10mg
95%
in stock  
$255.00   $178.00
- +
50mg
95%
in stock  
$366.00   $257.00
- +
100mg
95%
in stock  
$525.00   $368.00
- +
250mg
95%
in stock  
$998.00   $699.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0035HU
Chemical Name:
6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
CAS Number:
300816-15-3
Molecular Formula:
C25H27N3O3
Molecular Weight:
417.5002
MDL Number:
MFCD09038564
SMILES:
O=C1Nc2ccc(cc2C2(O1)CCN(CC2)CCc1nc(oc1C)c1ccccc1)C
Properties
Properties
 
Form:
Solid  
Solubility:
DMSO: soluble1mg/mL, clear (warmed)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
630  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
4.3  

Literature

Title: CCR2 signaling contributes to ischemia-reperfusion injury in kidney.

Journal: Journal of the American Society of Nephrology : JASN 20031001

Title: CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

Journal: Journal of medicinal chemistry 20030911

Title: Baamonde, Ana., et al. Involvement of glutamate NMDA and AMPA receptors, glial cells and IL-1β in the spinal hyperalgesia evoked by the chemokine CCL2 in mice. Neuroscience Letters (2011), 502(3), 178-181.

Title: Yang, Dong., et al. Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury. Respiratory Physiology & Neurobiology (2010), 170(3), 253-259.

Title: Kitagawa, Kiyoki., et al. Blockade of CCR2 ameliorates progressive fibrosis in kidney. American Journal of Pathology (2004), 165(1), 237-246.

Title: Tominaga T, et al. Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5181-8.

Title: Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.

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Tags:300816-15-3 Molecular Formula|300816-15-3 MDL|300816-15-3 SMILES|300816-15-3 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one