Title: Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.
Journal: Journal of medicinal chemistry 20060824
Title: The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism.
Journal: Molecular pharmacology 20060801
Title: Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-dependent kinase 2 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20030602
Title: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.
Journal: Biochemical pharmacology 20021001
Title: A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.
Journal: Cancer research 20010815