51-35-4,MFCD00064320
Catalog No.:AA0035N5

51-35-4 | trans-4-Hydroxy-L-proline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100g
95%
in stock  
$18.00   $13.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0035N5
Chemical Name:
trans-4-Hydroxy-L-proline
CAS Number:
51-35-4
Molecular Formula:
C5H9NO3
Molecular Weight:
131.1299
MDL Number:
MFCD00064320
SMILES:
O[C@H]1CN[C@@H](C1)C(=O)O
NSC Number:
46704
Properties
Properties
 
BP:
355.2 °C at 760 mmHg  
Form:
Solid  
MP:
273 °C (dec.)(lit.)  
Refractive Index:
-75.5 ° (C=4, H2O)  
Solubility:
H2O: 50 mg/mL  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
125  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-3.3  

Upstream Synthesis Route

[1]JournalofOrganicChemistry,2006,vol.71,#13,p.5004-5007

[2]TetrahedronLetters,1994,vol.35,#3,p.451-454

[3]JournalofOrganicChemistry,1991,vol.56,#8,p.2787-2800

[4]CanadianJournalofBiochemistryandPhysiology,1959,vol.37,p.583,584

[5]JournalofMolecularCatalysisA:Chemical,2012,vol.363-364,p.404-410,7

[6]JournalofOrganicChemistry,2017,vol.82,#23,p.12366-12376

[7]ChemicalandPharmaceuticalBulletin,2018,vol.66,#5,p.575-580

[8]Patent:US2013/65935,2013,A1,

[1]ChemistryofMaterials,2011,vol.23,#5,p.1280-1287

[1]TetrahedronAsymmetry,2003,vol.14,#20,p.3141-3152

[2]TetrahedronAsymmetry,2002,vol.13,#2,p.197-201

[3]Tetrahedron,2009,vol.65,#4,p.862-876

[4]Patent:US2004/77879,2004,A1,.Locationinpatent:Page13

[5]Patent:WO2018/13867,2018,A1,.Locationinpatent:Paragraph339

[6]OrganicLetters,2000,vol.2,#56,p.4161-4164

[7]JournalofBiologicalChemistry,1952,vol.195,p.383,384

[8]ChemicalandPharmaceuticalBulletin,1999,vol.47,#11,p.1650-1654

[9]JournalofOrganicChemistry,2007,vol.72,#1,p.288-291

[10]TetrahedronAsymmetry,2002,vol.13,#2,p.197-201

[11]TetrahedronLetters,2010,vol.51,#41,p.5375-5377

[12]TetrahedronLetters,2016,vol.57,#44,p.4882-4884

[1]AdvancedSynthesisandCatalysis,2001,vol.343,#6-7,p.587-590

[1]NucleosidesandNucleotides,1999,vol.18,#3,p.493-508

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.1845-1847

[2]AngewandteChemie-InternationalEdition,2007,vol.46,p.9073-9077

[3]Patent:EP1193270,2002,A2.Locationinpatent:Page14,35-36,105

[4]TetrahedronLetters,2016,vol.57,p.4882-4884

[5]ChemicalandPharmaceuticalBulletin,2018,vol.66,p.575-580

[6]OrganicProcessResearchandDevelopment,2018,vol.22,p.1241-1256

[7]JournalofMedicinalChemistry,1991,vol.34,p.717-725

[8]Tetrahedron,2006,vol.62,p.2321-2330

[9]ChemicalCommunications,2003,p.2606-2607

[10]TetrahedronLetters,2020

[11]TetrahedronAsymmetry,2003,vol.14,p.139-143

[12]TetrahedronLetters,2011,vol.52,p.1493-1494

[13]TetrahedronAsymmetry,2006,vol.17,p.2479-2486

[14]ZeitschriftfurNaturforschung,B:ChemicalSciences,2008,vol.63,p.1300-1304

[15]Synlett,2010,p.1943-1946

[16]Patent:US2019/367488,2019,A1.Locationinpatent:Paragraph0865-0867

[17]Patent:WO2020/89687,2020,A2.Locationinpatent:Page/Pagecolumn107-108

[18]JournaloftheAmericanChemicalSociety,2003,vol.125,p.4702-4703

[19]JournalofOrganicChemistry,2017,vol.82,p.12366-12376

[20]Tetrahedron,2008,vol.64,p.2480-2488

[21]AdvancedSynthesisandCatalysis,2010,vol.352,p.108-112

[22]ChineseChemicalLetters,2014,vol.25,p.479-481

[23]HelveticaChimicaActa,1996,vol.79,p.2235-2248

[24]TetrahedronLetters,2015,vol.56,p.4036-4038

[25]TetrahedronLetters,1994,vol.35,p.451-454

[26]Tetrahedron,1998,vol.54,p.981-996

[27]Patent:JP5709101,2015,B2.Locationinpatent:Paragraph0054

[28]Tetrahedron,2009,vol.65,p.862-876

[29]JournalofMolecularCatalysisA:Chemical,2012,vol.363-364,p.404-410,7

[30]ChemicalandPharmaceuticalBulletin,1998,vol.46,p.697-703

[31]Patent:WO2005/40170,2005,A2.Locationinpatent:Page/Pagecolumn33

[32]JournalofOrganicChemistry,2016,vol.81,p.956-968

[33]Patent:WO2007/22638,2007,A1.Locationinpatent:Page/Pagecolumn100-101

[34]JournaloftheAmericanChemicalSociety,1957,vol.79,p.185,190

[35]CanadianJournalofBiochemistryandPhysiology,1959,vol.37,p.583,584

[36]JournalofFluorineChemistry,1991,vol.54,p.195

[37]JournalofOrganicChemistry,1991,vol.56,p.2787-2800

[38]JournalofOrganicChemistry,1994,vol.59,p.3616-3625

[39]Bioscience,BiotechnologyandBiochemistry,1995,vol.59,p.1161-1162

[40]JournalofOrganicChemistry,1997,vol.62,p.790-791

[41]CollectionofCzechoslovakChemicalCommunications,1996,vol.61,p.S234-S237

[42]JournalofOrganicChemistry,1997,vol.62,p.6773-6783

[43]CarbohydrateResearch,1996,vol.286,p.123-138

[44]Synlett,1999,p.1465-1467

[45]Nucleosides,nucleotidesandnucleicacids,2001,vol.20,p.1193-1196

[46]JournalofMedicinalChemistry,2004,vol.47,p.489-492

[47]Nucleosides,nucleotidesandnucleicacids,2003,vol.22,p.1285-1288

[48]JournalofOrganicChemistry,2006,vol.71,p.5004-5007

[49]TetrahedronAsymmetry,2006,vol.17,p.2479-2486

[50]TetrahedronLetters,2007,vol.48,p.841-844

[51]Patent:JP2005/112761,2005,A.Locationinpatent:Page/Pagecolumn8

[52]BioorganicandMedicinalChemistryLetters,2008,vol.18,p.1096-1101

[53]EuropeanJournalofOrganicChemistry,2010,p.927-936

[54]Synlett,2011,p.503-507

[55]Patent:WO2011/92671,2011,A1.Locationinpatent:Page/Pagecolumn33-34

[56]Macromolecules,2010,vol.43,p.6374-6380

[57]Chemistry-AEuropeanJournal,2011,vol.17,p.13433-13437

[58]MolecularBioSystems,2011,vol.7,p.1564-1575

[59]Patent:US2013/65935,2013,A1.Locationinpatent:Paragraph0096

[60]Tetrahedron,2013,vol.69,p.6866-6874

[61]EuropeanJournalofOrganicChemistry,2014,vol.2014,p.5351-5355

[62]Chemistry-AEuropeanJournal,2016,vol.22,p.6750-6754

[63]ChemicalCommunications,2018,vol.54,p.9202-9205

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.95-99

[2]Patent:WO2007/104219,2007,A1.Locationinpatent:Page/Pagecolumn15-16

[3]Patent:WO2007/104221,2007,A1.Locationinpatent:Page/Pagecolumn18

[4]JournaloftheChemicalSociety.PerkintransactionsI,1997,p.503-509

[5]OrganicProcessResearchandDevelopment,2003,vol.7,p.649-654

[6]ChemBioChem,2013,vol.14,p.499-509

[7]JournaloftheAmericanChemicalSociety,1952,vol.74,p.3818,3819

[8]ArchivderPharmazie,1999,vol.332,p.111-114

[9]Patent:WO2011/141847,2011,A1.Locationinpatent:Page/Pagecolumn7-9

[10]Patent:CN104130262,2017,B.Locationinpatent:Paragraph0123;0124;0125

[11]Patent:CN109134337,2019,A.Locationinpatent:Paragraph0048-0050;0055-0057

[1]JournalofOrganicChemistry,1984,vol.49,p.5164-5174

[1]Synthesis,1983,p.671-673

[1]JournalofOrganicChemistry,2009,vol.74,p.513-519

[2]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.2434-2437

[3]JournaloftheAmericanChemicalSociety,2013,vol.135,p.4333-4363

[4]Patent:US2009/163472,2009,A1.Locationinpatent:Page/Pagecolumn21

[5]JournalofHeterocyclicChemistry,2011,vol.48,p.1132-1139

[6]JournalofOrganicChemistry,2010,vol.75,p.1620-1629

[7]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.4099-4101

[8]Patent:WO2010/104721,2010,A1.Locationinpatent:Page/Pagecolumn21

[9]JournalofOrganicChemistry,1981,vol.46,p.2954-2960

[10]JournalofOrganicChemistry,1994,vol.59,p.3616-3625

[11]JournaloftheChemicalSociety.PerkintransactionsI,1997,p.539-546

[12]Patent:WO2014/32,2014,A1

Literature

Title: Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.

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SDS
Tags:51-35-4 Molecular Formula|51-35-4 MDL|51-35-4 SMILES|51-35-4 trans-4-Hydroxy-L-proline
Catalog No.: AA0035N5
51-35-4,MFCD00064320
51-35-4 | trans-4-Hydroxy-L-proline
Pack Size: 100g
Purity: 95%
in stock
$18.00 $13.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA0035N5
Chemical Name: trans-4-Hydroxy-L-proline
CAS Number: 51-35-4
Molecular Formula: C5H9NO3
Molecular Weight: 131.1299
MDL Number: MFCD00064320
SMILES: O[C@H]1CN[C@@H](C1)C(=O)O
NSC Number: 46704
Properties
BP: 355.2 °C at 760 mmHg  
Form: Solid  
MP: 273 °C (dec.)(lit.)  
Refractive Index: -75.5 ° (C=4, H2O)  
Solubility: H2O: 50 mg/mL  
Storage: Keep in dry area;Room Temperature;  
Complexity: 125  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 9  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -3.3  
Upstream Synthesis Route
51-35-4    13500-53-3 

[1]JournalofOrganicChemistry,2006,vol.71,#13,p.5004-5007

[2]TetrahedronLetters,1994,vol.35,#3,p.451-454

[3]JournalofOrganicChemistry,1991,vol.56,#8,p.2787-2800

[4]CanadianJournalofBiochemistryandPhysiology,1959,vol.37,p.583,584

[5]JournalofMolecularCatalysisA:Chemical,2012,vol.363-364,p.404-410,7

[6]JournalofOrganicChemistry,2017,vol.82,#23,p.12366-12376

[7]ChemicalandPharmaceuticalBulletin,2018,vol.66,#5,p.575-580

[8]Patent:US2013/65935,2013,A1,

618-28-0    3398-22-9    51-35-4 

[1]ChemistryofMaterials,2011,vol.23,#5,p.1280-1287

51-35-4    2584-71-6 

[1]TetrahedronAsymmetry,2003,vol.14,#20,p.3141-3152

[2]TetrahedronAsymmetry,2002,vol.13,#2,p.197-201

[3]Tetrahedron,2009,vol.65,#4,p.862-876

[4]Patent:US2004/77879,2004,A1,.Locationinpatent:Page13

[5]Patent:WO2018/13867,2018,A1,.Locationinpatent:Paragraph339

[6]OrganicLetters,2000,vol.2,#56,p.4161-4164

[7]JournalofBiologicalChemistry,1952,vol.195,p.383,384

[8]ChemicalandPharmaceuticalBulletin,1999,vol.47,#11,p.1650-1654

[9]JournalofOrganicChemistry,2007,vol.72,#1,p.288-291

[10]TetrahedronAsymmetry,2002,vol.13,#2,p.197-201

[11]TetrahedronLetters,2010,vol.51,#41,p.5375-5377

[12]TetrahedronLetters,2016,vol.57,#44,p.4882-4884

232262-93-0    2584-71-6    51-35-4 

[1]AdvancedSynthesisandCatalysis,2001,vol.343,#6-7,p.587-590

46122-47-8    2584-71-6    51-35-4 

[1]NucleosidesandNucleotides,1999,vol.18,#3,p.493-508

Downstream Synthesis Route
501-53-1    51-35-4    13504-85-3 

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.1845-1847

[2]AngewandteChemie-InternationalEdition,2007,vol.46,p.9073-9077

[3]Patent:EP1193270,2002,A2.Locationinpatent:Page14,35-36,105

[4]TetrahedronLetters,2016,vol.57,p.4882-4884

[5]ChemicalandPharmaceuticalBulletin,2018,vol.66,p.575-580

[6]OrganicProcessResearchandDevelopment,2018,vol.22,p.1241-1256

[7]JournalofMedicinalChemistry,1991,vol.34,p.717-725

[8]Tetrahedron,2006,vol.62,p.2321-2330

[9]ChemicalCommunications,2003,p.2606-2607

[10]TetrahedronLetters,2020

[11]TetrahedronAsymmetry,2003,vol.14,p.139-143

[12]TetrahedronLetters,2011,vol.52,p.1493-1494

[13]TetrahedronAsymmetry,2006,vol.17,p.2479-2486

[14]ZeitschriftfurNaturforschung,B:ChemicalSciences,2008,vol.63,p.1300-1304

[15]Synlett,2010,p.1943-1946

[16]Patent:US2019/367488,2019,A1.Locationinpatent:Paragraph0865-0867

[17]Patent:WO2020/89687,2020,A2.Locationinpatent:Page/Pagecolumn107-108

[18]JournaloftheAmericanChemicalSociety,2003,vol.125,p.4702-4703

[19]JournalofOrganicChemistry,2017,vol.82,p.12366-12376

[20]Tetrahedron,2008,vol.64,p.2480-2488

[21]AdvancedSynthesisandCatalysis,2010,vol.352,p.108-112

[22]ChineseChemicalLetters,2014,vol.25,p.479-481

[23]HelveticaChimicaActa,1996,vol.79,p.2235-2248

[24]TetrahedronLetters,2015,vol.56,p.4036-4038

[25]TetrahedronLetters,1994,vol.35,p.451-454

[26]Tetrahedron,1998,vol.54,p.981-996

[27]Patent:JP5709101,2015,B2.Locationinpatent:Paragraph0054

[28]Tetrahedron,2009,vol.65,p.862-876

[29]JournalofMolecularCatalysisA:Chemical,2012,vol.363-364,p.404-410,7

[30]ChemicalandPharmaceuticalBulletin,1998,vol.46,p.697-703

[31]Patent:WO2005/40170,2005,A2.Locationinpatent:Page/Pagecolumn33

[32]JournalofOrganicChemistry,2016,vol.81,p.956-968

[33]Patent:WO2007/22638,2007,A1.Locationinpatent:Page/Pagecolumn100-101

[34]JournaloftheAmericanChemicalSociety,1957,vol.79,p.185,190

[35]CanadianJournalofBiochemistryandPhysiology,1959,vol.37,p.583,584

[36]JournalofFluorineChemistry,1991,vol.54,p.195

[37]JournalofOrganicChemistry,1991,vol.56,p.2787-2800

[38]JournalofOrganicChemistry,1994,vol.59,p.3616-3625

[39]Bioscience,BiotechnologyandBiochemistry,1995,vol.59,p.1161-1162

[40]JournalofOrganicChemistry,1997,vol.62,p.790-791

[41]CollectionofCzechoslovakChemicalCommunications,1996,vol.61,p.S234-S237

[42]JournalofOrganicChemistry,1997,vol.62,p.6773-6783

[43]CarbohydrateResearch,1996,vol.286,p.123-138

[44]Synlett,1999,p.1465-1467

[45]Nucleosides,nucleotidesandnucleicacids,2001,vol.20,p.1193-1196

[46]JournalofMedicinalChemistry,2004,vol.47,p.489-492

[47]Nucleosides,nucleotidesandnucleicacids,2003,vol.22,p.1285-1288

[48]JournalofOrganicChemistry,2006,vol.71,p.5004-5007

[49]TetrahedronAsymmetry,2006,vol.17,p.2479-2486

[50]TetrahedronLetters,2007,vol.48,p.841-844

[51]Patent:JP2005/112761,2005,A.Locationinpatent:Page/Pagecolumn8

[52]BioorganicandMedicinalChemistryLetters,2008,vol.18,p.1096-1101

[53]EuropeanJournalofOrganicChemistry,2010,p.927-936

[54]Synlett,2011,p.503-507

[55]Patent:WO2011/92671,2011,A1.Locationinpatent:Page/Pagecolumn33-34

[56]Macromolecules,2010,vol.43,p.6374-6380

[57]Chemistry-AEuropeanJournal,2011,vol.17,p.13433-13437

[58]MolecularBioSystems,2011,vol.7,p.1564-1575

[59]Patent:US2013/65935,2013,A1.Locationinpatent:Paragraph0096

[60]Tetrahedron,2013,vol.69,p.6866-6874

[61]EuropeanJournalofOrganicChemistry,2014,vol.2014,p.5351-5355

[62]Chemistry-AEuropeanJournal,2016,vol.22,p.6750-6754

[63]ChemicalCommunications,2018,vol.54,p.9202-9205

51-35-4    4457-32-3    96034-57-0 

[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.95-99

[2]Patent:WO2007/104219,2007,A1.Locationinpatent:Page/Pagecolumn15-16

[3]Patent:WO2007/104221,2007,A1.Locationinpatent:Page/Pagecolumn18

[4]JournaloftheChemicalSociety.PerkintransactionsI,1997,p.503-509

[5]OrganicProcessResearchandDevelopment,2003,vol.7,p.649-654

[6]ChemBioChem,2013,vol.14,p.499-509

[7]JournaloftheAmericanChemicalSociety,1952,vol.74,p.3818,3819

[8]ArchivderPharmazie,1999,vol.332,p.111-114

[9]Patent:WO2011/141847,2011,A1.Locationinpatent:Page/Pagecolumn7-9

[10]Patent:CN104130262,2017,B.Locationinpatent:Paragraph0123;0124;0125

[11]Patent:CN109134337,2019,A.Locationinpatent:Paragraph0048-0050;0055-0057

27151-65-1    108-24-7    51-35-4    79562-55-3 

[1]JournalofOrganicChemistry,1984,vol.49,p.5164-5174

66065-85-8    51-35-4    83235-10-3 

[1]Synthesis,1983,p.671-673

51-35-4    77449-94-6 

[1]JournalofOrganicChemistry,2009,vol.74,p.513-519

[2]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.2434-2437

[3]JournaloftheAmericanChemicalSociety,2013,vol.135,p.4333-4363

[4]Patent:US2009/163472,2009,A1.Locationinpatent:Page/Pagecolumn21

[5]JournalofHeterocyclicChemistry,2011,vol.48,p.1132-1139

[6]JournalofOrganicChemistry,2010,vol.75,p.1620-1629

[7]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.4099-4101

[8]Patent:WO2010/104721,2010,A1.Locationinpatent:Page/Pagecolumn21

[9]JournalofOrganicChemistry,1981,vol.46,p.2954-2960

[10]JournalofOrganicChemistry,1994,vol.59,p.3616-3625

[11]JournaloftheChemicalSociety.PerkintransactionsI,1997,p.539-546

[12]Patent:WO2014/32,2014,A1

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