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Home Other Building Blocks 51-35-4
51-35-4,MFCD00064320
Catalog No.:AA0035N5

51-35-4 | trans-4-Hydroxy-L-proline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
97%
in stock  
$11.00   $8.00
- +
25g
97%
in stock  
$13.00   $9.00
- +
100g
97%
in stock  
$36.00   $25.00
- +
500g
97%
in stock  
$44.00   $31.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0035N5
Chemical Name:
trans-4-Hydroxy-L-proline
CAS Number:
51-35-4
Molecular Formula:
C5H9NO3
Molecular Weight:
131.1299
MDL Number:
MFCD00064320
SMILES:
O[C@H]1CN[C@@H](C1)C(=O)O
NSC Number:
46704
Properties
Properties
 
BP:
355.2 °C at 760 mmHg  
Form:
Solid  
MP:
273 °C (dec.)(lit.)  
Refractive Index:
-75.5 ° (C=4, H2O)  
Solubility:
H2O: 50 mg/mL  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
125  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
-3.3  

Upstream Synthesis Route

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[1]ChemistryofMaterials,2011,vol.23,#5,p.1280-1287

[1]TetrahedronAsymmetry,2003,vol.14,#20,p.3141-3152

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Downstream Synthesis Route

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[14]ZeitschriftfurNaturforschung,B:ChemicalSciences,2008,vol.63,p.1300-1304

[15]Synlett,2010,p.1943-1946

[16]Patent:US2019/367488,2019,A1.Locationinpatent:Paragraph0865-0867

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[18]JournaloftheAmericanChemicalSociety,2003,vol.125,p.4702-4703

[19]JournalofOrganicChemistry,2017,vol.82,p.12366-12376

[20]Tetrahedron,2008,vol.64,p.2480-2488

[21]AdvancedSynthesisandCatalysis,2010,vol.352,p.108-112

[22]ChineseChemicalLetters,2014,vol.25,p.479-481

[23]HelveticaChimicaActa,1996,vol.79,p.2235-2248

[24]TetrahedronLetters,2015,vol.56,p.4036-4038

[25]TetrahedronLetters,1994,vol.35,p.451-454

[26]Tetrahedron,1998,vol.54,p.981-996

[27]Patent:JP5709101,2015,B2.Locationinpatent:Paragraph0054

[28]Tetrahedron,2009,vol.65,p.862-876

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[34]JournaloftheAmericanChemicalSociety,1957,vol.79,p.185,190

[35]CanadianJournalofBiochemistryandPhysiology,1959,vol.37,p.583,584

[36]JournalofFluorineChemistry,1991,vol.54,p.195

[37]JournalofOrganicChemistry,1991,vol.56,p.2787-2800

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[46]JournalofMedicinalChemistry,2004,vol.47,p.489-492

[47]Nucleosides,nucleotidesandnucleicacids,2003,vol.22,p.1285-1288

[48]JournalofOrganicChemistry,2006,vol.71,p.5004-5007

[49]TetrahedronAsymmetry,2006,vol.17,p.2479-2486

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[51]Patent:JP2005/112761,2005,A.Locationinpatent:Page/Pagecolumn8

[52]BioorganicandMedicinalChemistryLetters,2008,vol.18,p.1096-1101

[53]EuropeanJournalofOrganicChemistry,2010,p.927-936

[54]Synlett,2011,p.503-507

[55]Patent:WO2011/92671,2011,A1.Locationinpatent:Page/Pagecolumn33-34

[56]Macromolecules,2010,vol.43,p.6374-6380

[57]Chemistry-AEuropeanJournal,2011,vol.17,p.13433-13437

[58]MolecularBioSystems,2011,vol.7,p.1564-1575

[59]Patent:US2013/65935,2013,A1.Locationinpatent:Paragraph0096

[60]Tetrahedron,2013,vol.69,p.6866-6874

[61]EuropeanJournalofOrganicChemistry,2014,vol.2014,p.5351-5355

[62]Chemistry-AEuropeanJournal,2016,vol.22,p.6750-6754

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[1]BioorganicandMedicinalChemistryLetters,2000,vol.10,p.95-99

[2]Patent:WO2007/104219,2007,A1.Locationinpatent:Page/Pagecolumn15-16

[3]Patent:WO2007/104221,2007,A1.Locationinpatent:Page/Pagecolumn18

[4]JournaloftheChemicalSociety.PerkintransactionsI,1997,p.503-509

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[11]Patent:CN109134337,2019,A.Locationinpatent:Paragraph0048-0050;0055-0057

[1]JournalofOrganicChemistry,1984,vol.49,p.5164-5174

[1]Synthesis,1983,p.671-673

[1]JournalofOrganicChemistry,2009,vol.74,p.513-519

[2]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.2434-2437

[3]JournaloftheAmericanChemicalSociety,2013,vol.135,p.4333-4363

[4]Patent:US2009/163472,2009,A1.Locationinpatent:Page/Pagecolumn21

[5]JournalofHeterocyclicChemistry,2011,vol.48,p.1132-1139

[6]JournalofOrganicChemistry,2010,vol.75,p.1620-1629

[7]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.4099-4101

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[12]Patent:WO2014/32,2014,A1

Literature

Title: Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.

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