Title: Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes.
Journal: Toxicology and applied pharmacology 20180915
Title: Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells.
Journal: Toxicology letters 20180801
Title: Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20171001
Title: Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI-3 cells in vitro and promoting immune responses in WEHI-3 generated leukemia mice in vivo.
Journal: Environmental toxicology 20170201
Title: Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway.
Journal: Environmental toxicology 20161201
Title: Triptolide disrupts the actin-based Sertoli-germ cells adherens junctions by inhibiting Rho GTPases expression.
Journal: Toxicology and applied pharmacology 20161101
Title: Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells.
Journal: Chemico-biological interactions 20151005
Title: Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study.
Journal: Toxicology 20151002
Title: Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.
Journal: Scientific reports 20150101
Title: Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways.
Journal: Toxicology letters 20141104
Title: Interleukin-17 mediates triptolide-induced liver injury in mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140901
Title: Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.
Journal: Journal of applied toxicology : JAT 20140801
Title: Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer.
Journal: Oncology reports 20140701
Title: FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20140101
Title: Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolide in Wistar rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130801
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.
Journal: International journal of cancer 20121115
Title: Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20121101
Title: Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).
Journal: The Journal of biological chemistry 20121012
Title: Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression.
Journal: Pharmaceutical biology 20121001
Title: Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
Journal: Molecules (Basel, Switzerland) 20120917
Title: Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells.
Journal: Toxicology letters 20120903
Title: Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases.
Journal: British journal of clinical pharmacology 20120901
Title: Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression.
Journal: Journal of cancer research and clinical oncology 20120901
Title: Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120701
Title: In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles.
Journal: Arzneimittel-Forschung 20120701
Title: Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo.
Journal: Cancer letters 20120628
Title: Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon.
Journal: Cell biochemistry and function 20120601
Title: Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model.
Journal: International immunopharmacology 20120601
Title: Effect of triptolide on T-cell receptor beta variable gene mRNA expression in rats with collagen-induced arthritis.
Journal: Anatomical record (Hoboken, N.J. : 2007) 20120601
Title: Effect of triptolide on progesterone production from cultured rat granulosa cells.
Journal: Arzneimittel-Forschung 20120601
Title: Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.
Journal: Leukemia 20120401
Title: MKP-1: a negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells.
Journal: Cellular signalling 20120401
Title: Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.
Journal: Natural product reports 20120401
Title: [Effects of triptolide on bortezomib-induced apoptosis in multiple myeloma cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20120401
Title: Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells.
Journal: Phytotherapy research : PTR 20120301
Title: Triptolide attenuate the oxidative stress induced by LPS/D-GalN in mice.
Journal: Journal of cellular biochemistry 20120301
Title: Intrathecal administration of triptolide, a T lymphocyte inhibitor, attenuates chronic constriction injury-induced neuropathic pain in rats.
Journal: Brain research 20120203
Title: [Effect of triptolide on sensitivity of K562/A02 cell line to adriamycin].
Journal: Zhongguo shi yan xue ye xue za zhi 20120201
Title: [Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model].
Journal: Zhonghua nei ke za zhi 20120201
Title: Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model.
Journal: Cancer chemotherapy and pharmacology 20120101
Title: Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration.
Journal: Biomaterials 20120101
Title: Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.
Journal: Acta pharmacologica Sinica 20120101
Title: Effect of triptolide on estradiol release from cultured rat granulosa cells.
Journal: Endocrine journal 20120101
Title: Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.
Journal: PloS one 20120101
Title: Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression.
Journal: PloS one 20120101
Title: Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101
Title: Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum.
Journal: PloS one 20120101
Title: Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells.
Journal: Biochemical and biophysical research communications 20111209
Title: Complexation of triptolide and its succinate derivative with cyclodextrins: affinity capillary electrophoresis, isothermal titration calorimetry and 1H NMR studies.
Journal: Journal of chromatography. A 20111202
Title: Cytotoxicity of Triptolide and Triptolide loaded polymeric micelles in vitro.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111201
Title: Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury.
Journal: Fitoterapia 20111201
Title: Triptolide inhibits IFN-γ signaling via the Jak/STAT pathway in HaCaT keratinocytes.
Journal: Phytotherapy research : PTR 20111101
Title: Effect of triptolide on focal adhesion kinase and survival in MCF-7 breast cancer cells.
Journal: Oncology reports 20111101
Title: Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
Journal: Biochemical pharmacology 20111101
Title: Metabolite identification of triptolide by data-dependent accurate mass spectrometric analysis in combination with online hydrogen/deuterium exchange and multiple data-mining techniques.
Journal: Rapid communications in mass spectrometry : RCM 20111030
Title: Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production.
Journal: International immunopharmacology 20111001
Title: Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.
Journal: Toxicology letters 20110810
Title: A high-sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos.
Journal: Biomedical chromatography : BMC 20110801
Title: Triptolide directly inhibits dCTP pyrophosphatase.
Journal: Chembiochem : a European journal of chemical biology 20110725
Title: Antifibrotic effects of triptolide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.
Journal: Phytotherapy research : PTR 20110701
Title: Clinical outcomes in children with Henoch-Schönlein purpura nephritis grade IIIa or IIIb.
Journal: Pediatric nephrology (Berlin, Germany) 20110701
Title: Does triptolide induce lysosomal-mediated apoptosis in human breast cancer cells?
Journal: Medical hypotheses 20110701
Title: The main anticancer bullets of the Chinese medicinal herb, thunder god vine.
Journal: Molecules (Basel, Switzerland) 20110623
Title: Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors.
Journal: The Journal of surgical research 20110615
Title: Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway.
Journal: Fitoterapia 20110601
Title: Role of reactive oxygen species in triptolide-induced apoptosis of renal tubular cells and renal injury in rats.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110601
Title: Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression.
Journal: Asian Pacific journal of tropical medicine 20110601
Title: [Modulatory effect of triptolide on differentiation of human Th17 cells].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601
Title: Semisynthesis of triptolide analogues: effect of γ-lactone and C-14 substituents on cytotoxic activities.
Journal: Bioorganic & medicinal chemistry letters 20110515
Title: CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110515
Title: Total synthesis of novel D-ring-modified triptolide analogues: structure-cytotoxic activity relationship studies on the D-ring of triptolide.
Journal: Organic & biomolecular chemistry 20110507
Title: Triptolide inhibits rat vascular smooth muscle cell proliferation and cell cycle progression via attenuation of ERK1/2 and Rb phosphorylation.
Journal: Experimental and molecular pathology 20110401
Title: Triptolide alleviates hepatic ischemia/reperfusion injury by attenuating oxidative stress and inhibiting NF-κB activity in mice.
Journal: The Journal of surgical research 20110401
Title: Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells.
Journal: Oncology reports 20110401
Title: Effectiveness of triptolide-coated stent on decreasing inflammation and attenuation of intimal hyperplasia in a pig after coronary angioplasty.
Journal: Angiology 20110401
Title: Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*.
Journal: Acta pharmacologica Sinica 20110401
Title: Derivatization of (5R)-hydroxytriptolide from benzylamine to enhance mass spectrometric detection: application to a Phase I pharmacokinetic study in humans.
Journal: Analytica chimica acta 20110309
Title: The effects of triptolide on airway remodelling and transforming growth factor-β₁/Smad signalling pathway in ovalbumin-sensitized mice.
Journal: Immunology 20110301
Title: Triptolide and its expanding multiple pharmacological functions.
Journal: International immunopharmacology 20110301
Title: XPB, a subunit of TFIIH, is a target of the natural product triptolide.
Journal: Nature chemical biology 20110301
Title: Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells.
Journal: Leukemia research 20110201
Title: Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway.
Journal: Oncology reports 20110201
Title: Triptolide attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction.
Journal: Nephrology (Carlton, Vic.) 20110201
Title: MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status.
Journal: Planta medica 20110101
Title: Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats.
Journal: Drug and chemical toxicology 20110101
Title: Therapeutic approach to multiple sclerosis by novel oral drug.
Journal: Recent patents on inflammation & allergy drug discovery 20110101
Title: In vitro synergistic cytotoxic effect of triptolide combined with hydroxycamptothecin on pancreatic cancer cells.
Journal: The American journal of Chinese medicine 20110101
Title: Inhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'.
Journal: Anticancer research 20110101
Title: Inhibition of poly(I:C)-induced matrix metalloproteinase expression in human corneal fibroblasts by triptolide.
Journal: Molecular vision 20110101
Title: Disappearance of sexual dimorphism in triptolide metabolism in monosodium glutamate treated neonatal rats.
Journal: Arzneimittel-Forschung 20110101
Title: [Pharmacokinetics of triptolide in Triptergium wilfordii microemulsion gel].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101
Title: Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).
Journal: PloS one 20110101
Title: Effect of triptolide on aromatase activity in human placental microsomes and human placental JEG-3 cells.
Journal: Arzneimittel-Forschung 20110101
Title: Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells.
Journal: Experimental & molecular medicine 20101231
Title: Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.
Journal: Journal of liposome research 20101201
Title: Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells.
Journal: Cancer letters 20101128
Title: Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.
Journal: European journal of pharmacology 20101110
Title: Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101101
Title: Transcription factor NF-κB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic malignancies.
Journal: Current molecular pharmacology 20101101
Title: Synthesis and biological evaluation of novel triptolide analogues for anticancer activity.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.
Journal: International journal of oncology 20101101
Title: Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101001
Title: Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20101001
Title: Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma.
Journal: The Journal of surgical research 20101001
Title: Autophagy in pancreatic cancer: an emerging mechanism of cell death.
Journal: Autophagy 20101001
Title: Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.
Journal: Molecular immunology 20100901
Title: Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma.
Journal: The Journal of surgical research 20100901
Title: Diastereoselective formal total synthesis of (+/-)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane.
Journal: Chemical communications (Cambridge, England) 20100821
Title: Triptolide T10 enhances AAV-mediated gene transfer in mice striatum.
Journal: Neuroscience letters 20100802
Title: Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways.
Journal: Gastroenterology 20100801
Title: [Effect of triptolide on reversing hypermethylation of apc gene in Jurkat cells and its possible mechanisms].
Journal: Zhongguo shi yan xue ye xue za zhi 20100801
Title: [Effects of triptolide on hypothalamic-pituitary-adrenal axis of rats].
Journal: Fa yi xue za zhi 20100801
Title: Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100701
Title: RNA polymerase - an important molecular target of triptolide in cancer cells.
Journal: Cancer letters 20100628
Title: Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells.
Journal: Anti-cancer drugs 20100601
Title: Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation.
Journal: Glia 20100601
Title: Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation.
Journal: American journal of physiology. Lung cellular and molecular physiology 20100601
Title: Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.
Journal: Kidney international 20100601
Title: Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.
Journal: Acta pharmacologica Sinica 20100601
Title: Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function.
Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20100601
Title: [Effects of triptolide-medicated serum on secretion function of adrenocortical cells isolated from rats].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20100601
Title: Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines.
Journal: Cancer letters 20100528
Title: Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.
Journal: Cancer letters 20100528
Title: Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats.
Journal: Toxicology 20100430
Title: Novel anti-inflammatory and neuroprotective agents for Parkinson's disease.
Journal: CNS & neurological disorders drug targets 20100401
Title: Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20100401
Title: [Effects of triptolide on cell proliferation and regulation of Ras-MAPKs pathway in synoviocytes induced by tumor necrosis factor].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401
Title: Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.
Journal: Bioorganic & medicinal chemistry 20100301
Title: Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.
Journal: Current drug discovery technologies 20100301
Title: Targeting tumor proteasome with traditional Chinese medicine.
Journal: Current drug discovery technologies 20100301
Title: Induction of dual specificity phosphatase 1 (DUSP1) by gonadotropin-releasing hormone (GnRH) and the role for gonadotropin subunit gene expression in mouse pituitary gonadotroph L beta T2 cells.
Journal: Biology of reproduction 20100201
Title: Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.
Journal: Toxicology letters 20100201
Title: TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells.
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20100201
Title: [Research progress on immunosuppressive activity of monomers extracted from Chinese medicine].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201
Title: Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro.
Journal: Toxicology 20100112
Title: A facile construction strategy of stable lipid nanoparticles for drug delivery using a hydrogel-thickened microemulsion system.
Journal: Nanotechnology 20100108
Title: Triptolide functions as a potent angiogenesis inhibitor.
Journal: International journal of cancer 20100101
Title: Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells.
Journal: Vascular pharmacology 20100101
Title: Programmed cell death 5 factor enhances triptolide-induced fibroblast-like synoviocyte apoptosis of rheumatoid arthritis.
Journal: Artificial cells, blood substitutes, and immobilization biotechnology 20100101
Title: Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide.
Journal: Molecular cancer 20100101
Title: Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.
Journal: Journal of neuroimmunology 20091210
Title: Protective and therapeutic effect of triptolide in EAE explained by induction of major stress protein HSP70.
Journal: Journal of neuroimmunology 20091210
Title: Identification of inhibitors of HSF1 functional activity by high-content target-based screening.
Journal: Journal of biomolecular screening 20091201
Title: Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism.
Journal: Oncology reports 20091201
Title: Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20091101
Title: Triptolide abrogates oncogene FIP1L1-PDGFRalpha addiction and induces apoptosis in hypereosinophilic syndrome.
Journal: Cancer science 20091101
Title: Ancient drugs, modern targets.
Journal: Cancer biology & therapy 20091101
Title: Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.
Journal: Cancer biology & therapy 20091101
Title: Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression.
Journal: Experimental & molecular medicine 20091031
Title: Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.
Journal: Molecular cancer therapeutics 20091001
Title: Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells.
Journal: Experimental & molecular medicine 20090930
Title: Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.
Journal: Molecular cancer therapeutics 20090901
Title: Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents.
Journal: Journal of medicinal chemistry 20090827
Title: Triptolide promotes generation of FoxP3+ T regulatory cells in rats.
Journal: Journal of ethnopharmacology 20090817
Title: Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo.
Journal: Surgery 20090801
Title: [Advance in the anti-tumor mechanism of triptolide].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801
Title: Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo.
Journal: Oral oncology 20090701
Title: Activity of triptolide against human mast cells harboring the kinase domain mutant KIT.
Journal: Cancer science 20090701
Title: [Effect of triptolide on the proliferation and apoptosis of human epidermal squamous cell carcinoma cell line A431 in vitro].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090701
Title: [Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts].
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090701
Title: Caspase 3 is involved in the apoptosis induced by triptolide in HK-2 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601
Title: Possible involvement of mitogen-activated protein kinase phosphatase-1 (MKP-1) in thyrotropin-releasing hormone (TRH)-induced prolactin gene expression.
Journal: Biochemical and biophysical research communications 20090515
Title: Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicine.
Journal: Journal of chromatography. A 20090508
Title: Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms.
Journal: Gastroenterology 20090501
Title: Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma.
Journal: Leukemia & lymphoma 20090501
Title: Overcoming glucocorticoid resistance: a new pathway from an ancient Chinese medicine?
Journal: Leukemia & lymphoma 20090501
Title: Clinical applications of the immunomodulatory properties of triptolide besides in arthritis.
Journal: Scandinavian journal of immunology 20090501
Title: A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.
Journal: Molecular pharmacology 20090401
Title: Inhibiting the transcription factor HSF1 as an anticancer strategy.
Journal: Expert opinion on therapeutic targets 20090401
Title: Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry.
Journal: Biomedical chromatography : BMC 20090301
Title: The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells.
Journal: Biomaterials 20090301
Title: Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090301
Title: [Suppression of murine EAE by triptolide is related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes].
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090301
Title: [Cordyceps sinensis polysaccharide enhances apoptosis of HL-60 cells induced by triptolide].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20090301
Title: [Triptolide evaluates DNA methylation level of matrix metalloproteinase 9 gene in human fibrosarcoma HT-1080 cells].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301
Title: Triptolide and management of systemic malignancies besides pancreatic carcinomas.
Journal: World journal of gastroenterology 20090227
Title: Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.
Journal: Journal of ethnopharmacology 20090112
Title: Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway.
Journal: International journal of toxicology 20090101
Title: The effect of triptolide on CD4+ and CD8+ cells in the Peyer's patch of DA rats with collagen induced arthritis.
Journal: Natural product research 20090101
Title: Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis.
Journal: International immunopharmacology 20081220
Title: [Overexpression of programmed cell death 5 factor enhances triptolides-induced fibroblast-like synoviocytes apoptosis in rheumatoid arthritis].
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20081218
Title: Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia.
Journal: Journal of neuroimmunology 20081215
Title: Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography. Comparison of various elution and operating strategies.
Journal: Journal of chromatography. A 20081212
Title: Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells.
Journal: Experimental hematology 20081201
Title: In vivo evaluation of the safety of triptolide-loaded hydrogel-thickened microemulsion.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201
Title: Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20081201
Title: Prolongation of rat intestinal allograft survival by administration of triptolide-modified donor bone marrow-derived dendritic cells.
Journal: Transplantation proceedings 20081201
Title: [Advances in the study of immunopharmacological effects and mechanisms of extracts of Tripterygium wilfordii Hook. f. in neuroimmunologic disorders].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081201
Title: Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells.
Journal: Cancer letters 20081108
Title: The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice.
Journal: Clinical immunology (Orlando, Fla.) 20081101
Title: Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101
Title: Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia.
Journal: Journal of neurochemistry 20081101
Title: Therapeutic strategies for Parkinson's disease: the ancient meets the future--traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells.
Journal: Neurochemical research 20081001
Title: Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis.
Journal: Scandinavian journal of immunology 20081001
Title: Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-kappaB pathways in human multiple myeloma cells.
Journal: International journal of molecular medicine 20081001
Title: Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro.
Journal: Kidney international 20080901
Title: Triptolide reduces cystogenesis in a model of ADPKD.
Journal: Journal of the American Society of Nephrology : JASN 20080901
Title: Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.
Journal: Journal of neuroscience research 20080815
Title: Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53.
Journal: Oncogene 20080731
Title: Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.
Journal: European journal of pharmacology 20080728
Title: Mycophenolate mofetil and triptolide alleviating airway inflammation in asthmatic model mice partly by inhibiting bone marrow eosinophilopoiesis.
Journal: International immunopharmacology 20080701
Title: Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure.
Journal: Cancer research 20080701
Title: Effect of poly(D, L-lactic acid) nanoparticles as triptolide carrier on abating rats renal toxicity by NMR-based metabolic analysis.
Journal: Journal of nanoscience and nanotechnology 20080701
Title: Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: implication for immunosuppressive therapy in Parkinson's disease.
Journal: Neuroscience bulletin 20080601
Title: Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.
Journal: Arthritis and rheumatism 20080601
Title: Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080601
Title: [Effects of triptolide on proliferation and apoptosis of Jurkat cell line in acute T lymphocytic leukemia].
Journal: Zhongguo shi yan xue ye xue za zhi 20080601
Title: Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20080501
Title: Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.
Journal: Blood 20080401
Title: Fluorination of triptolide and its analogues and their cytotoxicity.
Journal: Bioorganic & medicinal chemistry letters 20080401
Title: Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells.
Journal: Biological & pharmaceutical bulletin 20080401
Title: Formal total synthesis of triptolide.
Journal: Chemical communications (Cambridge, England) 20080314
Title: Apoptosis of human pancreatic cancer cells induced by Triptolide.
Journal: World journal of gastroenterology 20080314
Title: [The cornea: stasis and dynamics].
Journal: Nippon Ganka Gakkai zasshi 20080301
Title: Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis.
Journal: Respiratory medicine 20080201
Title: Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property.
Journal: Clinical and experimental pharmacology & physiology 20080101
Title: Role of triptolide as an adjunct chemotherapy for ovarian cancer.
Journal: Chemotherapy 20080101
Title: [Male antifertility drugs and cell apoptosis].
Journal: Zhonghua nan ke xue = National journal of andrology 20080101
Title: Development and validation of a liquid chromatography coupled with atmospheric-pressure chemical ionization ion trap mass spectrometric method for the simultaneous determination of triptolide, tripdiolide, and tripterine in human serum.
Journal: Journal of analytical toxicology 20080101
Title: Male reproductive toxicity and toxicokinetics of triptolide in rats.
Journal: Arzneimittel-Forschung 20080101
Title: Triptolide, a component of Chinese herbal medicine, modulates the functional phenotype of dendritic cells.
Journal: Transplantation 20071215
Title: Triptolide inhibits NF-kappaB activation and reduces injury of donor lung induced by ischemia/reperfusion.
Journal: Acta pharmacologica Sinica 20071201
Title: Honeybee (Apis cerana) foraging responses to the toxic honey of Tripterygium hypoglaucum (Celastraceae): changing threshold of nectar acceptability.
Journal: Journal of chemical ecology 20071201
Title: Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.
Journal: Cancer research 20071001
Title: [Effect of triptolide on the expression of matrix metalloproteinases 2 and 9 in lungs of experimental pulmonary hypertension].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20071001
Title: Molecular understanding and modern application of traditional medicines: triumphs and trials.
Journal: Cell 20070907
Title: Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression.
Journal: American journal of respiratory cell and molecular biology 20070901
Title: Experimental AA amyloidosis in mice is inhibited by treatment with triptolide, a purified traditional Chinese medicine.
Journal: International immunopharmacology 20070901
Title: [Effect of triptolide on the development of monocrotaline-induced pulmonary hypertension in pneumonectomized rat].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901
Title: Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration.
Journal: International journal of pharmaceutics 20070816
Title: Enhanced antitumor effect of combined triptolide and ionizing radiation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070815
Title: Involvement of PDCD5 in the regulation of apoptosis in fibroblast-like synoviocytes of rheumatoid arthritis.
Journal: Apoptosis : an international journal on programmed cell death 20070801
Title: [Effect of triptolide on airway remodeling and the expression of phosphoinositide 3-kinases in asthmatic rats].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801
Title: Gene expression profile analyses of mice livers injured by Leigongteng.
Journal: World journal of gastroenterology 20070714
Title: Kinetic release of triptolide after injection of renal-targeting 14-succinyl triptolide-lysozyme in a rat kidney study by liquid chromatography/mass spectrometry.
Journal: Biomedical chromatography : BMC 20070701
Title: Triptolide upregulates NGF synthesis in rat astrocyte cultures.
Journal: Neurochemical research 20070701
Title: Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines.
Journal: Biochimica et biophysica acta 20070701
Title: Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells.
Journal: International journal of molecular medicine 20070501
Title: Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma.
Journal: Postgraduate medical journal 20070501
Title: [Triptolide-eluting stent prevents porcine coronary artery in-stent restenosis by affecting PCNA and P27(kip1) expression].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070501
Title: Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-kappaB pathways.
Journal: Molecular immunology 20070401
Title: Therapeutic effect of combined triptolide and glycyrrhizin treatment on rats with collagen induced arthritis.
Journal: Planta medica 20070401
Title: Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii.
Journal: Phytochemistry 20070401
Title: Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats.
Journal: Biological & pharmaceutical bulletin 20070401
Title: [Effects of triptolide on the production of interferon-gamma in human peripheral blood mononuclear cell and phosphorylation of signal transducer and activator of transcription-1 and production of interleukin-8].
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20070401
Title: [Microstructure of novel solid lipid nanoparticle loaded triptolide].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070401
Title: Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene.
Journal: European journal of pharmacology 20070315
Title: Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).
Journal: Phytochemistry 20070301
Title: [Effects of triptolide on prostate carcinoma in mouse RM-1 cells].
Journal: Zhonghua nan ke xue = National journal of andrology 20070301
Title: [Effect of combination glycyrrhiizin and triptolide on TNF-alpha and IL-10 in serum of collagen induced arthritis rats].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301
Title: Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells.
Journal: Acta biochimica et biophysica Sinica 20070201
Title: Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice.
Journal: Biochemical pharmacology 20070101
Title: The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages.
Journal: Journal of molecular medicine (Berlin, Germany) 20070101
Title: Triptolide suppresses IL-1beta-induced chemokine and stromelysin-1 gene expression in human colonic subepithelial myofibroblasts.
Journal: Acta pharmacologica Sinica 20070101
Title: [Pharmacokinetics of triptolide in Beagle dogs].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070101
Title: Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity.
Journal: Immunobiology 20070101
Title: Inhibitory effect of triptolide on glioblastoma multiforme in vitro.
Journal: The Journal of international medical research 20070101
Title: Triptolide alters mitochondrial functions.
Journal: Advances in experimental medicine and biology 20070101
Title: The effect of triptolide on apoptosis of glioblastoma multiforme (GBM) cells.
Journal: The Journal of international medical research 20070101
Title: Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-kappaB signaling in human gastric AGS cells.
Journal: Anticancer research 20070101
Title: Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis.
Journal: Pharmacological reports : PR 20070101
Title: Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis.
Journal: International immunopharmacology 20061205
Title: Synthesis, characterization and in vitro evaluation of triptolide-lysozyme conjugate for renal targeting delivery of triptolide.
Journal: Archives of pharmacal research 20061201
Title: [Study on content variation of triptolide in medicinal material of Tripterygium].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201
Title: Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro.
Journal: Acta pharmacologica Sinica 20061101
Title: Effects of triptolide and TNF-alpha on the expression of VEGF in Raji cells and on angiogenesis in ECV304 cells.
Journal: Zhongguo shi yan xue ye xue za zhi 20061001
Title: [Correlations between diagnostic information and therapeutic efficacy in rheumatoid arthritis analyzed with decision tree model].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20061001
Title: [Progress in research on mechanisms of anti-rheumatoid arthritis of triptolide].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001
Title: Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells.
Journal: Cancer letters 20060908
Title: Inhibition by triptolide of chemokine, proinflammatory cytokine, and adhesion molecule expression induced by lipopolysaccharide in corneal fibroblasts.
Journal: Investigative ophthalmology & visual science 20060901
Title: [Protective effects of triptolide on the lipopolysaccharide-mediated degeneration of dopaminergic neurons in substantia nigra].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060801
Title: Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells.
Journal: European journal of pharmacology 20060717
Title: Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.
Journal: Blood 20060715
Title: Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
Journal: Biochemical and biophysical research communications 20060707
Title: Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes.
Journal: Neuroscience research 20060601
Title: (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.
Journal: Journal of neuroimmunology 20060601
Title: Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study.
Journal: Journal of pharmaceutical and biomedical analysis 20060503
Title: Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.
Journal: Journal of molecular medicine (Berlin, Germany) 20060501
Title: Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death.
Journal: The Journal of biological chemistry 20060407
Title: Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities.
Journal: Bioorganic & medicinal chemistry letters 20060401
Title: Inhibitory effects of Triptolide on interferon-gamma-induced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retro-ocular fibroblasts derived from patients with Graves' ophthalmopathy.
Journal: Clinical & experimental ophthalmology 20060401
Title: Triptolide inhibits B7-H1 expression on proinflammatory factor activated renal tubular epithelial cells by decreasing NF-kappaB transcription.
Journal: Molecular immunology 20060301
Title: The effect of triptolide on CD4+ and CD8+ cells in Peyer's patch of SD rats with collagen induced arthritis.
Journal: International immunopharmacology 20060201
Title: Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage.
Journal: International journal of molecular medicine 20060101
Title: Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.
Journal: Anticancer research 20060101
Title: A novel method to convert triptolide into tripchlorolide in Tripterygium wilfordii.
Journal: Phytochemical analysis : PCA 20060101
Title: Effect of triptolide on expression of receptor activator of nuclear factor-kappaB ligand in rat adjuvant induced arthritis.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101
Title: Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101
Title: Monitoring of the conversion from triptolide to tripchlorolide in Triptergium wilfordii by micellar electrokinetic caillary chromatography.
Journal: Journal of chromatography. A 20051202
Title: Studies on calcium dependence reveal multiple modes of action for triptolide.
Journal: Chemistry & biology 20051201
Title: Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells.
Journal: Biochemical and biophysical research communications 20051104
Title: Protection effect of triptolide to liver injury in rats with severe acute pancreatitis.
Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20051101
Title: [Inhibitory effect of triptolide on proliferation of PC12 cells].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101
Title: Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.
Journal: Blood 20051001
Title: Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition.
Journal: Biological & pharmaceutical bulletin 20050901
Title: Triptolide affects the differentiation, maturation and function of human dendritic cells.
Journal: International immunopharmacology 20050801
Title: [Effects of triptolide on anti-angiogenesis by reducing expression of urokinase plasminogen activator].
Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20050801
Title: Inhibitory effect of triptolide on chemokine expression induced by proinflammatory cytokines in human corneal fibroblasts.
Journal: Investigative ophthalmology & visual science 20050701
Title: [Effect of triptolide on expression of urokinase-type plasminogen activators in vascular endothelial cells].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20050701
Title: [Study of triptolide-induced apoptosis in MUTZ-1 cells and its allied mechanism].
Journal: Zhongguo shi yan xue ye xue za zhi 20050601
Title: Clinical observation on effect of triptolide tablet in treating patients with psoriasis vulgaris.
Journal: Chinese journal of integrative medicine 20050601
Title: [The effects of triptolide inhibition of mouse lymphocytes activated in vitro].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050601
Title: [Effects of triptolide on migration of vascular endothelial cells].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050501
Title: [Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050501
Title: [Isopropyl myristate molecular gels and drug-loaded transdermal capability].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050501
Title: Determination of triptolide in root extracts of Tripterygium wilfordii by solid-phase extraction and reverse-phase high-performance liquid chromatography.
Journal: Journal of chromatography. A 20050408
Title: The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle.
Journal: Pharmacological research 20050401
Title: Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection.
Journal: Neurobiology of disease 20050401
Title: FK506 enhances triptolide-induced down-regulation of cyclooxygenase-2, inducible nitric oxide synthase as well as their products PGE2 and NO in TNF-alpha-stimulated synovial fibroblasts from rheumatoid arthritic patients.
Journal: European journal of medical research 20050329
Title: Anti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats.
Journal: Journal of ethnopharmacology 20050227
Title: Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes.
Journal: Biochemical and biophysical research communications 20050204
Title: Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells.
Journal: Acta pharmacologica Sinica 20050201
Title: [Progress in research on triptolide].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201
Title: [Determination of triptolide in Tripterygium total terpenoids tablets by HPLC].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201
Title: Stent-based delivery of triptolide reduces neointimal formation in rabbit iliac arteries.
Journal: Chinese medical journal 20050120
Title: Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.
Journal: Biomedical chromatography : BMC 20050101
Title: Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells.
Journal: Leukemia research 20050101
Title: Triptolide loaded solid lipid nanoparticle hydrogel for topical application.
Journal: Drug development and industrial pharmacy 20050101
Title: Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.
Journal: Immunopharmacology and immunotoxicology 20050101
Title: Effects of triptolide on the expression and activity of NF-kappaB in synovium of collagen-induced arthritis rats.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101
Title: The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.
Journal: The Journal of biological chemistry 20041224
Title: [Influence of triptolide on neuronal apoptosis in rat with cerebral injury after focal ischemia reperfusion].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101
Title: Recent pharmacological studies on natural products in China.
Journal: European journal of pharmacology 20041001
Title: [Progress in structure modification of triptolide].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041001
Title: Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription.
Journal: Arthritis and rheumatism 20040901
Title: A study of microemulsion systems for transdermal delivery of triptolide.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20040827
Title: Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.
Journal: Biochemical and biophysical research communications 20040702
Title: Synergistic effect of triptolide and tacrolimus on rat cardiac allotransplantation.
Journal: Japanese heart journal 20040701
Title: [Preparation and toxicity of triptolide-loaded poly (D,L-lactic acid) nanoparticles].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040701
Title: Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase.
Journal: European journal of pharmacology 20040621
Title: Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus.
Journal: Journal of Asian natural products research 20040601
Title: New drugs to improve transplant outcomes.
Journal: Transplantation 20040515
Title: [Regulatory function of nuclear factor kappa B on lymphocyte proliferation and apoptosis in bronchial asthmatic rats and effect of triptolide on the regulation].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040501
Title: Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats.
Journal: Physiological genomics 20040413
Title: TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20040301
Title: Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.
Journal: Journal of neuroimmunology 20040301
Title: [Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040301
Title: [Effect of Chinese herb Tripterygium wilfordii Hook F monomer triptolide on apoptosis of PC12 cells induced by Abeta1-42].
Journal: Sheng li xue bao : [Acta physiologica Sinica] 20040225
Title: [Progress in biotransformation of triptolides and bufadienolides].
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20040201
Title: Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells.
Journal: Leukemia & lymphoma 20040201
Title: Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.
Journal: BMC pharmacology 20040101
Title: Inhibition by triptolide of IL-1-induced collagen degradation by corneal fibroblasts.
Journal: Investigative ophthalmology & visual science 20031201
Title: The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response.
Journal: International immunopharmacology 20031001
Title: Analysis of triptolide-regulated gene expression in Jurkat cells by complementary DNA microarray.
Journal: Acta pharmacologica Sinica 20030901
Title: Solid lipid nanoparticle and microemulsion for topical delivery of triptolide.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030901
Title: PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy.
Journal: Molecular cancer therapeutics 20030901
Title: PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2.
Journal: Oncogene 20030821
Title: Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells.
Journal: Biochemical pharmacology 20030715
Title: [Neuroprotective effects of Tripterygium Wilforddi Hook F monomer T10 on glutamate induced PC12 cell line damage and its mechanism].
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20030618
Title: Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures.
Journal: Neuroreport 20030523
Title: [Enhancement by FK506 of triptolide-induced inhibition of expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts].
Journal: Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20030301
Title: Triptolide inhibits the growth and metastasis of solid tumors.
Journal: Molecular cancer therapeutics 20030101
Title: Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.
Journal: Drugs in R&D 20030101
Title: Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation.
Journal: Experimental & molecular medicine 20021231
Title: Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20021201
Title: [Effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats].
Journal: Zhonghua nan ke xue = National journal of andrology 20021201
Title: Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells.
Journal: Kidney international 20021001
Title: [Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20021001
Title: Triptolide inhibits proinflammatory factor-induced over-expression of class II MHC and B7 molecules in renal tubular epithelial cells.
Journal: Acta pharmacologica Sinica 20020901
Title: Synergistic cytotoxicity and apoptosis induced in human cholangiocarcinoma cell lines by a combined treatment with tumor necrosis factor-alpha (TNF-alpha) and triptolide.
Journal: Asian Pacific journal of allergy and immunology 20020901
Title: Liver fluke-associated cholangiocarcinoma.
Journal: The British journal of surgery 20020801
Title: Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020801
Title: [The effect of triptolide on the proliferation of airway smooth muscle and the expression of c-fos and c-jun in asthmatic rats].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20020501
Title: Inhibition of vascular endothelial growth factor expression and production by triptolide.
Journal: Planta medica 20020401
Title: Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells.
Journal: Oncogene 20011129
Title: [Triptolide inhibits vascular endothelial growth factor expression and production by endothelial cells].
Journal: Zhonghua yi xue za zhi 20010925
Title: Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts.
Journal: Arthritis and rheumatism 20010901
Title: Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.
Journal: Leukemia & lymphoma 20010701
Title: Triptolide inhibits vascular endothelial growth factor expression and production in endothelial cells.
Journal: Acta pharmacologica Sinica 20010701
Title: Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines.
Journal: Toxicology letters 20010531
Title: PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.
Journal: The American journal of pathology 20010301
Title: Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway.
Journal: The Journal of biological chemistry 20010119
Title: Chiral auxiliaries for asymmetric radical cyclization reactions: application to the enantioselective synthesis of (+)-triptocallol.
Journal: Organic letters 20010111
Title: [Determination of triptolide in human plasma by gas chromatography-electron capture detection].
Journal: Se pu = Chinese journal of chromatography 20010101
Title: [Effect of Tripterygium wilfordii on Th1, Th2 cytokines production in asthma patients].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101
Title: [Effect of tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101
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Title: Huang M, et al. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Mol Cancer Ther. 2013 Feb;12(2):184-94.
Title: Xu P, et al. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25-35 via the Autophagy Pathway.PLoS One. 2015 Nov 10;10(11):e0142719.
Title: Kong LL, et al. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.Sci Rep. 2015 Jul 2;5:11747.
Title: Zhang W, et al. Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism. Int J Mol Sci. 2016 Dec 19;17(12). pii: E2139.
Title: Cai J, et al. Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ. J Exp Clin Cancer Res. 2021;40(1):190. Published 2021 Jun 9.
