Title: 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.
Journal: Journal of medicinal chemistry 20121011
Title: 4-Methyl-N-p-tolyl-piperidine-1-carbox-amide.
Journal: Acta crystallographica. Section E, Structure reports online 20120501
Title: (2,6-Difluoro-phen-yl)(4-methyl-piperidin-1-yl)methanone.
Journal: Acta crystallographica. Section E, Structure reports online 20110901
Title: Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.
Journal: Biochemistry 20110712
Title: N-(4-Chloro-phen-yl)-4-methyl-piperidine-1-carboxamide.
Journal: Acta crystallographica. Section E, Structure reports online 20110701
Title: 3-Bromo-5-meth-oxy-4-(4-methyl-piperidin-1-yl)furan-2(5H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20110401
Title: (5S)-3-Chloro-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]-4-(4-methyl-piperidin-1-yl)furan-2(5H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20110301
Title: Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines.
Journal: European journal of medicinal chemistry 20100301
Title: Density functional analysis of the trigonal uranyl equatorial coordination in hexahomotrioxacalix[3]arene-based macrocyclic complexes.
Journal: Inorganic chemistry 20100215
Title: Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin.
Journal: PloS one 20100101
Title: 2,2'-[(Biphenyl-4,4'-di-yl)di(ethene-1,2-di-yl)]dibenzene-sulfonic acid-4-methyl-piperidine-water (1/2/2).
Journal: Acta crystallographica. Section E, Structure reports online 20090801
Title: Bis(4-methyl-piperidinium) hexa-chlorido-stannate(IV).
Journal: Acta crystallographica. Section E, Structure reports online 20080401
Title: Solution structure of the Legionella pneumophila Mip-rapamycin complex.
Journal: BMC structural biology 20080101
Title: DFT and ab initio calculations of the vibrational frequencies and visible spectra of triazenes derived from cyclic amines.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070601
Title: Combined experimental and computational study of the thermochemistry of methylpiperidines.
Journal: The Journal of organic chemistry 20060512
Title: Letter: electron ionization-induced fragmentation of new thiochalcone derivatives.
Journal: European journal of mass spectrometry (Chichester, England) 20060101
Title: Mechanism of hydrodenitrogenation on phosphides and sulfides.
Journal: The journal of physical chemistry. B 20050217
Title: Exocellular peptides from Antarctic psychrophile Pseudoalteromonas Haloplanktis.
Journal: Marine biotechnology (New York, N.Y.) 20050101
Title: Five- to six-coordination in (nitrosyl)iron(II) porphyrinates: effects of binding the sixth ligand.
Journal: Inorganic chemistry 20030908
Title: [Fe(TPP)(4-MePip)(2)]: an axially compressed bis(secondary amine) complex of an iron(II) porphyrin.
Journal: Acta crystallographica. Section C, Crystal structure communications 20030601
Title: Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects.
Journal: Journal of medicinal chemistry 20020801
Title: Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides.
Journal: Bioorganic & medicinal chemistry letters 20020520
Title: A short synthesis of argatroban. a potent selective thrombin inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20010806
4-Methylpiperidine serves as a versatile building block in organic synthesis, particularly in the creation of bioactive compounds with diverse applications. Through its incorporation into chemical reactions, it facilitates the synthesis of various biologically significant molecules. Among its synthetic uses, 4-Methylpiperidine is instrumental in the preparation of dimethyl bis(4-methylpiperidine-dithiocarbamato-S,S′)-tin(IV), which may exhibit potential pharmacological properties. Additionally, it is employed in the synthesis of (E)-4-(4′-methylpiperidino-N-alkoxy) stilbenes and 4-methylpiperidinoalkylthio and 4-methylpiperidinoalkoxy derivatives of (E)-chalcone, compounds that could possess biological activity relevant to medicinal chemistry. Furthermore, 4-Methylpiperidine serves as a valuable deprotecting reagent in solid-phase peptide synthesis, enabling the removal of Fmoc (fluorenylmethyloxycarbonyl) protecting groups from amino acids. Its versatility and utility make it a valuable asset in synthetic organic chemistry, contributing to the development of bioactive molecules with potential therapeutic applications.
