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Title: Reduced adenosine release from the aged mammalian heart.
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Title: Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
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Title: Site-directed spin labeling of DNA reveals mismatch-induced nanometer distance changes between flanking nucleotides.
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Title: First total synthesis of a naturally occurring iodinated 5'-deoxyxylofuranosyl marine nucleoside.
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Title: A genome-wide over-expression screen identifies genes involved in phagocytosis in the human protozoan parasite, Entamoeba histolytica.
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Title: Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice.
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Title: 1,N6-etheno-2'-deoxytubercidin hemihydrate.
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Title: PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.
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Title: Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses.
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Title: Reversibly photoswitchable nucleosides: synthesis and photochromic properties of diarylethene-functionalized 7-deazaadenosine derivatives.
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Title: Adenosine A1 receptor blockage mediates theophylline-associated seizures.
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Title: Design and synthesis of novel SATE derivatives of acyclic isocytosine and 9-deazaadenine C-nucleosides.
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Title: Deciphering ligand dependent degree of binding site closure and its implication in inhibitor design: A modeling study on human adenosine kinase.
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Title: Predominance of adenosine excitatory over inhibitory effects on transmission at the neuromuscular junction of infant rats.
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Title: Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
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Title: Excited state processes in 1-deazariboflavin studied by ultrafast fluorescence kinetics.
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Title: Relationship of impairment induced by intracellular S-adenosylhomocysteine accumulation with DNA methylation in human umbilical vein endothelial cells treated with 3-deazaadenosine.
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Title: Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site.
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Title: Preclinical assessment of the treatment of second-stage African trypanosomiasis with cordycepin and deoxycoformycin.
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Title: Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
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Title: Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells.
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Title: 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling.
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Title: TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.
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Title: Genome-scale reconstruction of Escherichia coli's transcriptional and translational machinery: a knowledge base, its mathematical formulation, and its functional characterization.
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Title: A small molecule inhibitor of alpha4 integrin-dependent cell migration.
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Title: Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.
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Title: The nucleotide analogue 3-deazaadenosine prevents neointima-formation after balloon injury.
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Title: 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice.
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Title: Efficacy of the tubercidin antileishmania action associated with an inhibitor of the nucleoside transport.
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Title: Toyocamycin specifically inhibits auxin signaling mediated by SCFTIR1 pathway.
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Title: ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.
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Title: Deazaadenosine prevents leukozyte evasion during acute cardiac allograft rejection by suppression of adhesion molecule expression.
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Title: Conformational change of adenosine deaminase during ligand-exchange in a crystal.
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Title: Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
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Title: 7-Fluorotubercidin: a halogenated derivative of a naturally occurring nucleoside antimetabolite.
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Title: 7-deazainosine derivatives: synthesis and characterization of 7- and 7,8-substituted pyrrolo [2,3-d]pyrimidine ribonucleosides.
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Title: Biochemical and biological properties of 5-bromotubercidin: differential effects on cellular DNA-directed and viral RNA-directed RNA synthesis.
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Title: Complexes of Cu(II) ions and noncovalent interactions in systems with L-aspartic acid and cytidine-5'-monophosphate.
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Title: Cholesterol-linked pyrene excimer molecular beacon with enhanced cell permeability.
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Title: DNA conjugation by Staudinger ligation.
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Title: Synthesis and biological activity of 7-deaza-7-ethynyl-2'-deoxy-2'-fluoro-2'-C-methyladenosine and its 2'-C-methyl-ribo analogue.
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Title: Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells.
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Title: Synthesis and antimicrobial activity of some novel nucleoside analogues of adenosine and 1,3-dideazaadenosine.
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Title: The 7-bromo derivative of 2-amino-2'-deoxytubercidin fluorinated at the sugar moiety.
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Title: Long-term administration of 3-deazaadenosine does not alter progression of advanced atherosclerotic lesions in apolipoprotein E-deficient mice.
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Title: Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei.
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Title: Extended storage of whole blood with 3-deazaadenosine for homocysteine assay.
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Title: Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.
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Title: TOR-induced resistance to toxic adenosine analogs in Leishmania brought about by the internalization and degradation of the adenosine permease.
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Title: A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.
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Title: Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells.
Journal: American journal of physiology. Renal physiology 20070201
Title: Threonine phosphorylation of integrin beta3 in calyculin A-treated platelets is selectively sensitive to 5'-iodotubercidin.
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Title: Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.
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Title: Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth.
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Title: Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy.
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Title: Characterization of copper(II) interactions with sinefungin, a nucleoside antibiotic: combined potentiometric, spectroscopic and DFT studies.
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Title: Functional characterization of nucleoside transporter gene replacements in Leishmania donovani.
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Title: Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
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Title: 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice.
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Title: 2-Amino-7-chloro-2'-deoxytubercidin.
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Title: AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma.
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Title: Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
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Title: 4-Amino-7-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine: a bis-fluorinated analogue of 2'-deoxytubercidin.
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Title: A pull-down assay for 5' AMP-activated protein kinase activity using the GST-fused protein.
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Title: Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues.
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Title: Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
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Title: Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited.
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Title: Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis.
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Title: Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes.
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Title: Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism.
Journal: Osteoarthritis and cartilage 20050301
Title: Synthesis and biological evaluation of 2- and 7-substituted 9-deazaadenosine analogues.
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Title: A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.
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Title: 3-Deazaadenosine, a stabilizer of whole-blood homocysteine content, does not interfere with the single-enzyme homocysteine assay while totally inhibiting the enzyme conversion homocysteine immunoassay.
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Title: 1,N6-Etheno derivative of 7-deaza-2,8-diazaadenosine.
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Title: 3-Deazaadenosine prevents leukocyte invasion by suppression of adhesion molecule expression during acute cardiac allograft rejection: involvement of apoptotic cell death.
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Title: 3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L.
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Title: S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).
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Title: Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.
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Title: New agents active against Mycobacterium avium complex selected by molecular topology: a virtual screening method.
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Title: Synthesis and biological activity of 5-fluorotubercidin.
Journal: Nucleosides, nucleotides & nucleic acids 20040101
Title: The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration.
Journal: Neuromolecular medicine 20040101
Title: Protein methylation activates reconstituted ryanodine receptor-ca release channels from coronary artery myocytes.
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Title: Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.
Journal: Nucleosides, nucleotides & nucleic acids 20040101
Title: Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration.
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Title: Effects of 3-deazaadenosine on homocysteine and atherosclerosis in apolipoprotein E-deficient mice.
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Title: Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase.
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Title: The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library.
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Title: Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides.
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Title: Quantitative structure-activity relationship study of 5-iodo- and diaryl-analogues of tubercidin: inhibitors of adenosine kinase.
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Title: Structure, evolution, and inhibitor interaction of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum.
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Title: Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners.
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Title: Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2.
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Title: Effects of temperature on stability of blood homocysteine in collection tubes containing 3-deazaadenosine.
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Title: Effects of an adenosine kinase inhibitor and an adenosine deaminase inhibitor on accumulation of extracellular adenosine by equine articular chondrocytes.
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Title: Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function.
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Title: Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1.
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Title: Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping.
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Title: Interaction of S-adenosylhomocysteine hydrolase of Xenopus laevis with mRNA(guanine-7-)methyltransferase: implication on its nuclear compartmentalisation and on cap methylation of hnRNA.
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Title: Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase.
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Title: Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells.
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Title: Enhancement of cellular adenosine triphosphate levels in PC12 cells by extracellular adenosine.
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Title: Kinetics of apoptotic markers in exogeneously induced apoptosis of EL4 cells.
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Title: Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction.
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Title: Syntheses of puromycin from adenosine and 7-deazapuromycin from tubercidin, and biological comparisons of the 7-aza/deaza pair.
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Title: Methionine depletion induces transcription of the mRNA (N6-adenosine)methyltransferase.
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Title: Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors.
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Title: Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart.
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Title: Stabilization of blood homocysteine in an epidemiological setting.
Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20011001
Title: S-adenosyl-L-homocysteine hydrolase is necessary for aldosterone-induced activity of epithelial Na(+) channels.
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Title: Pre-analytical conditions affecting the determination of the plasma homocysteine concentration.
Journal: Clinical chemistry and laboratory medicine 20010801
Title: Intracellular phosphorylation of carbocyclic 3-deazaadenosine, an anti-Ebola virus agent.
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Title: Selective growth inhibition by sangivamycin of human umbilical vein endothelial cells.
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Title: Fluorescent DNA: the development of 7-deazapurine nucleoside triphosphates applicable for sequencing at the single molecule level.
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Title: Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.
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Title: Synthesis of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides. Isosteres of sangivamycin, tubercidin, and toyocamycin.
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Title: Analysis of increased leukocyte ratio induced by tumor necrosis factor-alpha using several inhibitors in the undisturbed microcirculation of the rat mesentery.
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Title: Renal interstitial adenosine metabolism during ischemia in dogs.
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Title: Binding thermodynamics of the transition state analogue coformycin and of the ground state analogue 1-deazaadenosine to bovine adenosine deaminase.
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Title: Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity.
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Title: Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor.
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Title: The role of phosphatidylethanolamine methylation in the secretion of very low density lipoproteins by cultured rat hepatocytes: rapid inhibition of phosphatidylethanolamine methylation by bezafibrate increases the density of apolipoprotein B48-containing lipoproteins.
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Title: Syntheses of 5'-substituted analogues of carbocyclic 3-deazaadenosine as potential antivirals.
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Title: Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues.
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Title: Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro.
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Title: Antiviral activity of C-5 substituted tubercidin analogues.
Journal: Journal of medicinal chemistry 19840301
Title: Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine.
Journal: Antiviral research 19830301
Title: Metabolism of tubercidin and formycin to their 3':5'-cyclic nucleotides in mammalian cells.
Journal: The Journal of biological chemistry 19781225
Title: Studies on cytochrome oxidase. Partial resolution of enzymes containing seven or six subunits, from yeast and beef heart, respectively.
Journal: The Journal of biological chemistry 19760125
