Home Fluorides 900515-16-4
900515-16-4,MFCD12024675
Catalog No.:AA0036X0

900515-16-4 | (5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione

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1mg
≥95%
in stock  
$56.00   $39.00
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5mg
≥95%
in stock  
$152.00   $106.00
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10mg
≥95%
in stock  
$270.00   $189.00
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25mg
98% by HPLC
in stock  
$582.00   $408.00
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50mg
98% by HPLC
in stock  
$947.00   $663.00
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100mg
98% by HPLC
in stock  
$1,592.00   $1,114.00
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500mg
98% by HPLC
in stock  
$4,996.00   $3,498.00
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1000mg
98% by HPLC
in stock  
$7,957.00   $5,570.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0036X0
Chemical Name:
(5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
CAS Number:
900515-16-4
Molecular Formula:
C14H8FNO4S
Molecular Weight:
305.2810
MDL Number:
MFCD12024675
SMILES:
O=C1S/C(=C\c2ccc(o2)c2ccc(cc2O)F)/C(=O)N1
Properties
Properties
 
Form:
Solid  
MP:
>235ºC (dec.)  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
484  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
2.7  

Literature

Title: Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A) receptor-operated native TRPC channels in rabbit coronary artery myocytes.

Journal: British journal of pharmacology 20120801

Title: A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.

Journal: Nature chemical biology 20120429

Title: Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.

Journal: Cancer research 20120201

Title: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes.

Journal: Journal of biomedical science 20120101

Title: A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

Journal: Molecular cancer research : MCR 20110701

Title: Key role of phosphoinositide 3-kinase class IB in pancreatic cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20101015

Title: Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.

Journal: Journal of medicinal chemistry 20060629

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Pomel V, et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem. 2006 Jun 29;49(13):3857-71.

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SDS
Tags:900515-16-4 Molecular Formula|900515-16-4 MDL|900515-16-4 SMILES|900515-16-4 (5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione