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66701-25-5,MFCD07366493
Catalog No.:AA0036QT

66701-25-5 | E-64

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1mg
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$17.00   $12.00
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5mg
99+%
in stock  
$42.00   $29.00
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10mg
99+%
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0036QT
Chemical Name:
E-64
CAS Number:
66701-25-5
Molecular Formula:
C15H27N5O5
Molecular Weight:
357.4054
MDL Number:
MFCD07366493
SMILES:
CC(CC(C(=O)NCCCCN=C(N)N)NC(=O)C1OC1C(=O)O)C
Properties
Properties
 
Form:
Solid  
MP:
>170°C (dec.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
518  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
11  
XLogP3:
-0.9  

Literature

Title: Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.

Journal: European journal of medicinal chemistry 20131101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Protease inhibitors decrease the resistance of Vitaceae to Plasmopara viticola.

Journal: Plant physiology and biochemistry : PPB 20121101

Title: Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors.

Journal: Bioorganic & medicinal chemistry 20121101

Title: Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents.

Journal: European journal of medicinal chemistry 20120901

Title: M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues.

Journal: Journal of hepatology 20120801

Title: Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates.

Journal: Molecular and biochemical parasitology 20120801

Title: Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials.

Journal: European journal of medicinal chemistry 20120801

Title: Chlorhexidine inhibits the activity of dental cysteine cathepsins.

Journal: Journal of dental research 20120401

Title: First-time report of metalloproteinases in fish bile and their potential as bioindicators regarding environmental contamination.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20120401

Title: Prolonged signalling and trafficking of the bradykinin B2 receptor stimulated with the amphibian peptide maximakinin: insight into the endosomal inactivation of kinins.

Journal: Pharmacological research 20120201

Title: Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.

Journal: The American journal of pathology 20120101

Title: Cysteine peptidases, secreted by Trichomonas gallinae, are involved in the cytopathogenic effects on a permanent chicken liver cell culture.

Journal: PloS one 20120101

Title: Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents.

Journal: Bioorganic & medicinal chemistry 20111215

Title: Cysteine proteases in differentiation of embryonic stem cells into neural cells.

Journal: Stem cells and development 20111101

Title: Partial purification and characterisation of cysteine protease in wheat germ.

Journal: Journal of the science of food and agriculture 20111001

Title: Identification and characterization of cysteine proteinases of Trypanosoma evansi.

Journal: Parasitology research 20110901

Title: C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism.

Journal: The FEBS journal 20110901

Title: Insecticidal effect of Canavalia ensiformis major urease on nymphs of the milkweed bug Oncopeltus fasciatus and characterization of digestive peptidases.

Journal: Insect biochemistry and molecular biology 20110601

Title: Design and synthesis of protein-protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors.

Journal: European journal of medicinal chemistry 20110601

Title: Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

Journal: Journal of medicinal chemistry 20110526

Title: Fluoride does not inhibit enamel protease activity.

Journal: Journal of dental research 20110401

Title: Cysteine cathepsins in human carious dentin.

Journal: Journal of dental research 20110401

Title: Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.

Journal: Bioorganic & medicinal chemistry letters 20110401

Title: Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.

Journal: European journal of medicinal chemistry 20110301

Title: Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

Journal: Oncogene 20110217

Title: Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.

Journal: Bioorganic & medicinal chemistry 20110201

Title: Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity.

Journal: Experimental parasitology 20110101

Title: Protease-mediated house dust mite allergen-induced reactive oxygen species production by neutrophils.

Journal: International archives of allergy and immunology 20110101

Title: Microarray analysis reveals strategies of Tribolium castaneum larvae to compensate for cysteine and serine protease inhibitors.

Journal: Comparative biochemistry and physiology. Part D, Genomics & proteomics 20101201

Title: Intracellular cathepsin B activity is inversely correlated with the quality and developmental competence of bovine preimplantation embryos.

Journal: Molecular reproduction and development 20101201

Title: Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis.

Journal: Clinical and experimental immunology 20101101

Title: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.

Journal: The FEBS journal 20101101

Title: The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles.

Journal: FEBS letters 20101022

Title: Dentipain, a Streptococcus pyogenes IdeS protease homolog, is a novel virulence factor of Treponema denticola.

Journal: Biological chemistry 20100901

Title: Collagenolytic activity in sonic extracts of Tannerella forsythia.

Journal: Archives of oral biology 20100801

Title: A novel Ca2+-activated protease from germinating Vigna radiata seeds and its role in storage protein mobilization.

Journal: Journal of plant physiology 20100715

Title: Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.

Journal: Bioorganic & medicinal chemistry 20100715

Title: Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.

Journal: European journal of medicinal chemistry 20100701

Title: Hydrogen peroxide-induced apoptosis-like cell death in Entamoeba histolytica.

Journal: Parasitology international 20100601

Title: Treatment development for systemic Tetrahymena sp. infection in guppies, Poecilia reticulata Peters.

Journal: Journal of fish diseases 20100601

Title: Cathepsin B activity is related to the quality of bovine cumulus oocyte complexes and its inhibition can improve their developmental competence.

Journal: Molecular reproduction and development 20100501

Title: Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.

Journal: Journal of neurochemistry 20100501

Title: Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.

Journal: International journal of oncology 20100401

Title: Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.

Journal: Journal of medicinal chemistry 20100311

Title: Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste.

Journal: Journal of the science of food and agriculture 20100201

Title: Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality.

Journal: BMC musculoskeletal disorders 20100101

Title: Stimulation of fibroblast proliferation by the plant cysteine protease CMS2MS2 is independent of its proteolytic activity and requires ERK activation.

Journal: Biological chemistry 20091201

Title: Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis.

Journal: Parasitology research 20091201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.

Journal: Journal of medicinal chemistry 20090924

Title: Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

Journal: Bioorganic & medicinal chemistry 20090915

Title: Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model.

Journal: Journal of neurochemistry 20090901

Title: Dissimilar peptidase production by avirulent and virulent promastigotes of Leishmania braziliensis: inference on the parasite proliferation and interaction with macrophages.

Journal: Parasitology 20090901

Title: Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Journal: Journal of medicinal chemistry 20090813

Title: House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity.

Journal: FEBS letters 20090618

Title: Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

Journal: Journal of medicinal chemistry 20090409

Title: The comparison of parathyroid hormone degradation effect by various protease inhibitors in blood specimen.

Journal: The Korean journal of laboratory medicine 20090401

Title: Antiparasitic activity of cystine protease inhibitor E-64 against Giardia lamblia excystation in vitro and in vivo.

Journal: Journal of the Egyptian Society of Parasitology 20090401

Title: Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.

Journal: European journal of medicinal chemistry 20090301

Title: Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.

Journal: International immunopharmacology 20090301

Title: Cathepsin K regulates adipocyte differentiation: possible involvement of type I collagen degradation.

Journal: Endocrine journal 20090101

Title: Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment.

Journal: Experimental parasitology 20081201

Title: Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant.

Journal: Bioorganic & medicinal chemistry 20081101

Title: Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

Journal: Nature chemical biology 20080901

Title: A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development.

Journal: Journal of medicinal chemistry 20080612

Title: Activity-based selection of a proteolytic species using ribosome display.

Journal: Biochemical and biophysical research communications 20080523

Title: Plasmodium food vacuole plasmepsins are activated by falcipains.

Journal: The Journal of biological chemistry 20080509

Title: Studies on synchronous egress of coccidian parasites (Neospora caninum, Toxoplasma gondii, Eimeria bovis) from bovine endothelial host cells mediated by calcium ionophore A23187.

Journal: Veterinary research communications 20080401

Title: Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20080301

Title: Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

Journal: Journal of medicinal chemistry 20080227

Title: Molecular determination of laminin-5 degradation: a biomarker for mustard gas exposure diagnosis and its mechanism of action.

Journal: Experimental dermatology 20080101

Title: [Flu virion as a substrate for proteolytic enzymes].

Journal: Bioorganicheskaia khimiia 20080101

Title: Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.

Journal: The Journal of biological chemistry 20071207

Title: Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida).

Journal: Molecular and biochemical parasitology 20071201

Title: In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.

Journal: Journal of medicinal chemistry 20071129

Title: Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes.

Journal: Parasitology 20071101

Title: Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.

Journal: Experimental parasitology 20071001

Title: In vitro activity of the nonsteroidal anti-inflammatory drug indomethacin on a scuticociliate parasite of farmed turbot.

Journal: Veterinary parasitology 20070930

Title: Sperm proteasomes are responsible for the acrosome reaction and sperm penetration of the vitelline envelope during fertilization of the sea urchin Pseudocentrotus depressus.

Journal: Developmental biology 20070801

Title: Development of tier-I toxicity assays for Orius insidiosus (Heteroptera: Anthocoridae) for assessing the risk of plant-incorporated protectants to nontarget heteropterans.

Journal: Environmental entomology 20070801

Title: Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.

Journal: The Journal of biological chemistry 20070720

Title: Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster, that generate sodefrin from its biosynthetic precursor.

Journal: Zoological science 20070501

Title: Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.

Journal: Cell death and differentiation 20070301

Title: Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

Journal: Antimicrobial agents and chemotherapy 20070201

Title: Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion.

Journal: Antimicrobial agents and chemotherapy 20070201

Title: [Hepatic amebiasis].

Journal: Revista de gastroenterologia de Mexico 20061101

Title: Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.

Journal: The Journal of clinical investigation 20061002

Title: Characterization of HC58cDNA, a putative cysteine protease from the parasite Haemonchus contortus.

Journal: Journal of veterinary science 20060901

Title: Aspartic proteinases in the digestive tract of marine decapod crustaceans.

Journal: Journal of experimental zoology. Part A, Comparative experimental biology 20060801

Title: Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060801

Title: Critical roles for excretory-secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae.

Journal: Cellular microbiology 20060601

Title: Microinjection of an antibody against the cysteine-protease involved in male chromatin remodeling blocks the development of sea urchin embryos at the initial cell cycle.

Journal: Journal of cellular biochemistry 20060515

Title: Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis.

Journal: Parasitology research 20060401

Title: Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.

Journal: Journal of medicinal chemistry 20060309

Title: Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.

Journal: International journal for parasitology 20060101

Title: Protein aggregates are transported to vacuoles by a macroautophagic mechanism in nutrient-starved plant cells.

Journal: Autophagy 20060101

Title: High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.

Journal: Analytical chemistry 20051215

Title: Characterization of cathepsin L secreted by Sf21 insect cells.

Journal: Archives of biochemistry and biophysics 20051201

Title: Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes.

Journal: The Korean journal of parasitology 20051201

Title: Pathogenicity of Vibrio penaeicida for white shrimp Litopenaeus vannamei: a cysteine protease-like exotoxin as a virulence factor.

Journal: Diseases of aquatic organisms 20051128

Title: Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.

Journal: FEBS letters 20050815

Title: [Effects of MG132 , an inhibitor of proteasome , on the pollen germination and tube growth of Pecea wilsonii].

Journal: Shi yan sheng wu xue bao 20050801

Title: The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20050726

Title: Fasciola hepatica proteolytic activity in liver revealed by in situ zymography.

Journal: Parasitology research 20050701

Title: Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance.

Journal: Science (New York, N.Y.) 20050617

Title: Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.

Journal: Journal of medicinal chemistry 20050519

Title: Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.

Journal: Experimental cell research 20050515

Title: Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury.

Journal: Biochemical pharmacology 20050401

Title: Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides.

Journal: Bioorganic & medicinal chemistry 20050301

Title: Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.

Journal: Parasitology 20050201

Title: The role of Plasmodium falciparum food vacuole plasmepsins.

Journal: The Journal of biological chemistry 20050114

Title: Candida guilliermondii isolated from HIV-infected human secretes a 50 kDa serine proteinase that cleaves a broad spectrum of proteinaceous substrates.

Journal: FEMS immunology and medical microbiology 20050101

Title: Coordinate involvement of cysteine protease and nuclease in the executive phase of plant apoptosis.

Journal: FEBS letters 20041217

Title: Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.

Journal: Journal of medicinal chemistry 20041216

Title: Proteasome proteolytic activity in hematopoietic cells from patients with chronic myeloid leukemia and multiple myeloma.

Journal: Haematologica 20041201

Title: Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis.

Journal: The Journal of veterinary medical science 20041001

Title: Role of cysteine proteinase of Entamoeba histolytica in target cell death.

Journal: Parasitology 20040801

Title: Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.

Journal: The Biochemical journal 20040715

Title: The Leishmania chagasi proteasome: role in promastigotes growth and amastigotes survival within murine macrophages.

Journal: Acta tropica 20040701

Title: Cysteine proteinase activity is required for survival of the parasite in experimental acute amoebic liver abscesses in hamsters.

Journal: Parasitology 20040701

Title: Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide.

Journal: The Journal of biological chemistry 20040625

Title: Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cells.

Journal: International immunology 20040501

Title: Colorado potato beetles show differential digestive compensatory responses to host plants expressing distinct sets of defense proteins.

Journal: Archives of insect biochemistry and physiology 20040301

Title: A cysteine protease from Taenia solium metacestodes induce apoptosis in human CD4+ T-cells.

Journal: Parasitology research 20040201

Title: In vitro activation of the hemolysin in Prevotella nigrescens ATCC 33563 and Prevotella intermedia ATCC 25611.

Journal: Research in microbiology 20040101

Title: Monocytes stimulated with group B streptococci or interferons release tumour necrosis factor-related apoptosis-inducing ligand.

Journal: Scandinavian journal of immunology 20040101

Title: A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature.

Journal: Connective tissue research 20040101

Title: Effects of supplemental L-methionine on E-64 [trans-epoxysuccinyl-1-leucyl-amido (4-guanido) butane]-induced dysmorphology in rat embryos cultured in vitro.

Journal: Congenital anomalies 20031201

Title: Invasion of melanoma cells into dermal connective tissue in vitro: evidence for an important role of cysteine proteases.

Journal: International journal of cancer 20030901

Title: Excretory-secretory products secreted by Paragonimus westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-CSF.

Journal: International archives of allergy and immunology 20030901

Title: Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.

Journal: Cell death and differentiation 20030801

Title: Impact of cysteine proteinase inhibition in midgut fluid and oral secretion on fecundity and pollen consumption of western corn rootworm (Diabrotica virgifera virgifera).

Journal: Archives of insect biochemistry and physiology 20030301

Title: Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187.

Journal: Journal of helminthology 20030301

Title: Specific biological functions of vacuolar-type H(+)-ATPase and lysosomal cysteine proteinase, cathepsin K, in osteoclasts.

Journal: The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20030201

Title: Selective modulation of superantigen-induced responses by streptococcal cysteine protease.

Journal: The Journal of infectious diseases 20030201

Title: Thiol-activated serine proteinases from nymphal hemolymph of the African migratory locust, Locusta migratoria migratorioides.

Journal: Archives of biochemistry and biophysics 20030201

Title: Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis.

Journal: American journal of respiratory cell and molecular biology 20030101

Title: The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

Title: Calpain inhibitors, a treatment for Alzheimer's disease: position paper.

Journal: Journal of molecular neuroscience : MN 20030101

Title: Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases.

Journal: American journal of physiology. Lung cellular and molecular physiology 20021001

Title: Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.

Journal: Planta 20020901

Title: pH Dependence of inhibitors targeting the occluding loop of cathepsin B.

Journal: Bioorganic chemistry 20020801

Title: A noninvasive cell-based assay for monitoring proteolytic activity within a specific subcellular compartment.

Journal: Analytical biochemistry 20020715

Title: Stage-specific antimalarial activity of cysteine protease inhibitors.

Journal: Biological chemistry 20020501

Title: A tomato cysteine protease required for Cf-2-dependent disease resistance and suppression of autonecrosis.

Journal: Science (New York, N.Y.) 20020426

Title: Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas.

Journal: International journal of cancer 20020220

Title: A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes.

Journal: Journal of bone and mineral metabolism 20020101

Title: Differential activity of cathepsin L in human placenta at two different stages of gestation.

Journal: Placenta 20020101

Title: E 64.

Journal: Drugs in R&D 20020101

Title: Elevated levels of cathepsin B in human glioblastoma cell lines.

Journal: International journal of oncology 20010901

Title: Biochemical alteration of membrane-associated IL-6 RI (80-kDa) in adherent macrophages and vascular endothelium.

Journal: Molecular immunology 20010901

Title: Defining a link between gap junction communication, proteolysis, and cataract formation.

Journal: The Journal of biological chemistry 20010803

Title: Therapeutic effects of cysteine protease inhibition in allergic lung inflammation: inhibition of allergen-specific T lymphocyte migration.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010801

Title: The role of calpain in caspase activation during etoposide induced apoptosis in T cells.

Journal: European journal of immunology 20010701

Title: Enhancement of protease activity involved in modulation of cell mutability by microgravity stress in UVC-irradiated human cells.

Journal: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 20010701

Title: Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010501

Title: Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.

Journal: Cancer research 20010501

Title: Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501

Title: Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design.

Journal: Biological chemistry 20010501

Title: Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.

Journal: The Journal of biological chemistry 20010427

Title: Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.

Journal: BioTechniques 20010401

Title: 3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum.

Journal: Archives of biochemistry and biophysics 20010215

Title: Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR.

Journal: Calcified tissue international 20010201

Title: Protease inhibitors: current status and future prospects.

Journal: Journal of medicinal chemistry 20000210

Title: Matsumoto K, et al. Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. Biopolymers. 1999;51(1):99-107.

Title: Wadhawan M, et al. Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite. PLoS One. 2014 Mar 25;9(3):e93161.

Title: Baldzizhar R, et al. Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem. 2013 Jan 18;288(3):1612-9.

Title: Blass G, et al. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiol Rep. 2016 Sep;4(17). pii: e12950.

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