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640-68-6,MFCD00064219
Catalog No.:AA00370C

640-68-6 | D-Valine

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Purity
Availability
Price(USD)
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10g
97%
in stock  
$7.00   $5.00
- +
25g
97%
in stock  
$9.00   $7.00
- +
100g
97%
in stock  
$18.00   $13.00
- +
500g
97%
in stock  
$87.00   $61.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00370C
Chemical Name:
D-Valine
CAS Number:
640-68-6
Molecular Formula:
C5H11NO2
Molecular Weight:
117.1463
MDL Number:
MFCD00064219
SMILES:
N[C@@H](C(=O)O)C(C)C
Properties
Properties
 
BP:
213.6 °C at 760 mmHg  
Form:
Solid  
MP:
>295 °C (subl.)(lit.)  
Refractive Index:
-27 ° (C=8, 6mol/L HCl)  
Solubility:
56 g/L (20°C)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
90.4  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
-2.3  

Upstream Synthesis Route

[1]Patent:CN108610358,2018,A,.Locationinpatent:Paragraph0065;0066

[1]JournalofOrganicChemistry,2000,vol.65,#16,p.5037-5042

[2]Tetrahedron,2011,vol.67,#34,p.6227-6232

[3]EuropeanJournalofOrganicChemistry,2016,vol.2016,#4,p.688-692

[4]EuropeanJournalofOrganicChemistry,2017,vol.2017,#1,p.29-33

[5]Journalofmedicinalchemistry,1965,vol.8,#6,p.864-866

[6]Tetrahedron,2006,vol.62,#29,p.6782-6791

[7]AgriculturalandBiologicalChemistry,1987,vol.51,#2,p.537-548

[8]TetrahedronAsymmetry,2008,vol.19,#4,p.459-466

[9]TetrahedronAsymmetry,2008,vol.19,#9,p.1068-1077

[10]CanadianJournalofChemistry,2009,vol.87,#1SPEC.ISS.,p.321-327

[11]JournalofOrganicChemistry,2009,vol.74,#18,p.7013-7022

[12]Chemistry-AEuropeanJournal,2011,vol.17,#51,p.14380-14384

[13]AdvancedSynthesisandCatalysis,2012,vol.354,#11-12,p.2264-2274

[14]BioorganicandMedicinalChemistry,2012,vol.20,#21,p.6305-6312,8

[15]JournalofMolecularCatalysisA:Chemical,2013,vol.379,p.225-233

[16]InorganicaChimicaActa,2014,vol.409,#PARTB,p.244-253

[17]OrganicandBiomolecularChemistry,2014,vol.12,#20,p.3163-3166

[18]LettersinDrugDesignandDiscovery,2014,vol.11,#10,p.1133-1142

[19]JournaloftheAmericanChemicalSociety,2015,vol.137,#28,p.8900-8903

[20]JournalofAgriculturalandFoodChemistry,2016,vol.64,#46,p.8927-8934

[1]ChemistryandBiodiversity,2012,vol.9,#8,p.1567-1578

[1]Patent:US2003/60441,2003,A1,

[1]JournalofNaturalProducts,2009,vol.72,#9,p.1573-1578

Downstream Synthesis Route

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[4]CurrentPatentAssignee:ELILILLY&CO-US2014/235718,2014,A1Locationinpatent:Paragraph0025-0028

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[9]Gisin,B.F.etal.[JournaloftheAmericanChemicalSociety,1969,vol.91,p.2691-2695]

[10]Kogan,TimothyP.;Somers,ToddC.;Venuti,MichaelC.[Tetrahedron,1990,vol.46,#19,p.6623-6632]

[11]James,DavidG.;Moore,ChristopherJ.;Aldrich,JeffreyR.[JournalofChemicalEcology,1994,vol.20,#12,p.3281-3296]

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[1]JournaloftheAmericanChemicalSociety,1956,vol.78,p.4636,4642

[1]Konrad,DavidB.;Kicin,Bilal;Trauner,Dirk[Synlett,2019,vol.30,#4,p.383-386]

[2]Sdira,SofianeBen;Felix,CarolineP.;Giudicelli,Marie-BeatriceA.;Seigle-Ferrand,PascalF.;Perrin,Monique;Lamartine,RogerJ.[JournalofOrganicChemistry,2003,vol.68,#17,p.6632-6638]

[3]Kretschmer,Manuel;Dieckmann,Michael;Li,Pengfei;Rudolph,Sven;Herkommer,Daniel;Troendlin,Johannes;Menche,Dirk[Chemistry-AEuropeanJournal,2013,vol.19,#47,p.15993-16018]

[4]Hinman;Caron;Christensen[JournaloftheAmericanChemicalSociety,1950,vol.72,p.1620]

[5]CurrentPatentAssignee:BAYERAG-US6605726,2003,B1

[6]Rao,Weidong;Kothandaraman,Prasath;Koh,ChiiBoon;Chan,PhilipWaiHong[AdvancedSynthesisandCatalysis,2010,vol.352,#14-15,p.2521-2530]

[7]Chen,Qi-Yin;Liu,Yanxia;Cai,Weijing;Luesch,Hendrik[JournalofMedicinalChemistry,2014,vol.57,#7,p.3011-3029]

[8]Kothandaraman,Prasath;Zhao,Yichao;Lee,BoRa;LeNg,ClarrisaJia;Lee,JunYi;Ayers,BenjaminJames;Chan,PhilipWaiHong[AdvancedSynthesisandCatalysis,2016,vol.358,#9,p.1385-1391]

64-17-5    640-68-6   
(R)-(-)-valineethylester 

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Literature

Title: Helical water chain mediated proton conductivity in homochiral metal-organic frameworks with unprecedented zeolitic unh-topology.

Journal: Journal of the American Chemical Society 20111109

Title: Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20091026

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