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602-41-5,MFCD07995056
Catalog No.:AA00371F

602-41-5 | Thiocolchicoside

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5mg
98%(HPLC)
in stock  
$80.00   $56.00
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10mg
≥98%
in stock  
$143.00   $100.00
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20mg
>98.0%(HPLC)
in stock  
$255.00   $179.00
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250mg
95%
in stock  
$273.00   $191.00
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1g
95%
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$608.00   $425.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00371F
Chemical Name:
Thiocolchicoside
CAS Number:
602-41-5
Molecular Formula:
C27H33NO10S
Molecular Weight:
563.6166
MDL Number:
MFCD07995056
SMILES:
OC[C@H]1O[C@@H](Oc2cc3CC[C@@H](c4c(c3c(c2OC)OC)ccc(c(=O)c4)SC)NC(=O)C)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Properties
 
BP:
929.624°C at 760 mmHg  
Form:
Solid  
MP:
>197°C (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
1010  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
7  
XLogP3:
-0.4  

Literature

Title: Chemotherapy drugs form ion pores in membranes due to physical interactions with lipids.

Journal: Chemical biology & drug design 20121201

Title: The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit.

Journal: Acta neurochirurgica 20120801

Title: Clinical comparative study: efficacy and tolerability of tolperisone and thiocolchicoside in acute low back pain and spinal muscle spasticity.

Journal: Asian spine journal 20120601

Title: Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug.

Journal: British journal of pharmacology 20120401

Title: Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption?

Journal: British journal of pharmacology 20120401

Title: Forced degradation study of thiocolchicoside: characterization of its degradation products.

Journal: Journal of pharmaceutical and biomedical analysis 20120305

Title: Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II.

Journal: Journal of enzyme inhibition and medicinal chemistry 20120201

Title: Iontophoresis: a potential emergence of a transdermal drug delivery system.

Journal: Scientia pharmaceutica 20120101

Title: New Stability-Indicating RP-HPLC Method for Determination of Diclofenac Potassium and Metaxalone from their Combined Dosage Form.

Journal: Scientia pharmaceutica 20120101

Title: An IgE immediate reaction to thiocolchicoside.

Journal: International journal of immunopathology and pharmacology 20120101

Title: Drug Eruptions: An 8-year Study Including 106 Inpatients at a Dermatology Clinic in Turkey.

Journal: Indian journal of dermatology 20120101

Title: Therapeutic intervention for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a systematic review and meta-analysis.

Journal: PloS one 20120101

Title: To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain.

Journal: Journal of the Indian Medical Association 20120101

Title: Combined occlusal and pharmacological therapy in the treatment of temporo-mandibular disorders.

Journal: European review for medical and pharmacological sciences 20111101

Title: Benefit of using muscle relaxants in the routine treatment protocol of oral submucosal fibrosis: a pilot study.

Journal: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20111001

Title: Safety of subcutaneous microinjections (mesotherapy) in musicians.

Journal: Medical problems of performing artists 20110601

Title: Critical review on medicinally potent plant species: Gloriosa superba.

Journal: Fitoterapia 20110401

Title: Thiocolchicoside-induced liver injury.

Journal: Clinics (Sao Paulo, Brazil) 20110301

Title: Simultaneous HPLC determination of thiocolchicoside and glafenine as well as thiocolchicoside and floctafenine in their combined dosage forms.

Journal: Journal of chromatographic science 20110201

Title: Simultaneous estimation of etoricoxib and thiocolchicoside by RP-HPLC method in combined dosage forms.

Journal: Acta poloniae pharmaceutica 20110101

Title: Effectiveness of lumbar zygapophysial joint blockage for low back pain.

Journal: Turkish neurosurgery 20110101

Title: Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study.

Journal: Journal of enzyme inhibition and medicinal chemistry 20101201

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.

Journal: Cancer prevention research (Philadelphia, Pa.) 20101101

Title: [Usefulness of botulinum toxin injections in the treatment of postoperative pain after cervical spine surgery: Preliminary results].

Journal: Neuro-Chirurgie 20101001

Title: [A rare cause of cyanosis: Sulphaemoglobinaemia related to thiocolchicoside (Miorel)].

Journal: Revue des maladies respiratoires 20100101

Title: High-performance thin-layer chromatographic determination of etoricoxib and thiocolchicoside in combined tablet dosage form.

Journal: Journal of AOAC International 20100101

Title: The efficacy of topical thiocolchicoside (Muscoril) in the treatment of acute cervical myofascial pain syndrome: a single-blind, randomized, prospective, phase IV clinical study.

Journal: Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20090701

Title: Epileptic seizure after treatment with thiocolchicoside.

Journal: Therapeutics and clinical risk management 20090101

Title: Effect of interlaminar epidural steroid injection in acute and subacute pain due to lumbar disk herniation: a randomized comparison of 2 different protocols.

Journal: The open orthopaedics journal 20090101

Title: Penetration and distribution of thiocolchicoside through human skin: comparison between a commercial foam (Miotens) and a drug solution.

Journal: AAPS PharmSciTech 20081201

Title: Embolia cutis medicamentosa following thiocolchicoside injection.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20080801

Title: Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm.

Journal: Journal of the Indian Medical Association 20080501

Title: Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study.

Journal: European review for medical and pharmacological sciences 20080101

Title: Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for glycine and gamma-aminobutyric acid receptors.

Journal: Journal of medicinal chemistry 20070503

Title: A placebo-controlled comparison of the efficiency of triple- and monotherapy in category III B chronic pelvic pain syndrome (CPPS).

Journal: European urology 20070401

Title: Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes.

Journal: European journal of pharmacology 20070308

Title: UV-Vis spectrophotometrical and analytical methodology for the determination of singlet oxygen in new antibacterials drugs.

Journal: Analytical chemistry insights 20070101

Title: Skin atrophy caused by thiocolchicoside injections.

Journal: International journal of dermatology 20061201

Title: The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system.

Journal: Neuropharmacology 20060901

Title: Ultraviolet absorbance detection of colchicine and related alkaloids on a capillary electrophoresis microchip.

Journal: Analytica chimica acta 20060721

Title: Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain.

Journal: International journal of clinical practice 20050701

Title: Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report.

Journal: Brain tumor pathology 20050101

Title: Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro.

Journal: Journal of pharmaceutical sciences 20041001

Title: New metabolic and pharmacokinetic characteristics of thiocolchicoside and its active metabolite in healthy humans.

Journal: Fundamental & clinical pharmacology 20040801

Title: Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat.

Journal: Seizure 20031001

Title: Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain.

Journal: Joint, bone, spine : revue du rhumatisme 20030901

Title: Determination of thiocolchicoside in its binary mixtures (thiocolchicoside-glafenine and thiocolchicoside-floctafenine) by TLC-densitometry.

Journal: Farmaco (Societa chimica italiana : 1989) 20030601

Title: Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies.

Journal: International journal of pharmaceutics 20030102

Title: Physicochemical compatibility between thiocolchicoside injections (Miotens) and pharmaceutical products frequently used for combined therapy.

Journal: Farmaco (Societa chimica italiana : 1989) 20021101

Title: Vehicle effects on in vitro skin permeation of thiocolchicoside.

Journal: Die Pharmazie 20021101

Title: Highly specific and sensitive liquid chromatography-tandem mass spectrometry method for the determination of 3-desmethylthiocolchicine in human plasma as analyte for the assessment of bioequivalence after oral administration of thiocolchicoside.

Journal: Journal of chromatography. A 20020308

Title: In vitro permeation screening of a new formulation of thiocolchicoside containing various enhancers.

Journal: Drug delivery 20020101

Title: Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

Journal: Immunopharmacology and immunotoxicology 20011101

Title: Epileptic seizures after treatment with thiocolchicoside.

Journal: Epilepsia 20010801

Title: Autoradiographic localization of [3H]thiocolchicoside binding sites in the rat brain and spinal cord.

Journal: Neuropharmacology 20010601

Title: Photosensitizing activity of thiocolchicoside: photochemical and in vitro phototoxicity studies.

Journal: Die Pharmazie 20010101

Title: Comparative bioavailability and tolerability study of two intramuscular formulations of thiocolchicoside in healthy volunteers.

Journal: European journal of drug metabolism and pharmacokinetics 20010101

Title: Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers.

Journal: European journal of drug metabolism and pharmacokinetics 19950101

Title: Binding of colchicine and thiocolchicoside to human serum proteins and blood cells.

Journal: International journal of clinical pharmacology and therapeutics 19940801

Title: Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers.

Journal: Biopharmaceutics & drug disposition 19940101

Title: Carta M, et al. The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system. Neuropharmacology. 2006 Sep;51(4):805-15.

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Tags:602-41-5 Molecular Formula|602-41-5 MDL|602-41-5 SMILES|602-41-5 Thiocolchicoside