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1038915-60-4,MFCD17779309
Catalog No.:AA0038X2

1038915-60-4 | (S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
2mg
98%
in stock  
$8.00   $6.00
- +
5mg
98%
in stock  
$12.00   $8.00
- +
100mg
98%
in stock  
$54.00   $38.00
- +
250mg
98%
in stock  
$105.00   $74.00
- +
1g
98%
in stock  
$261.00   $183.00
- +
5g
98%
in stock  
$902.00   $632.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0038X2
Chemical Name:
(S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide
CAS Number:
1038915-60-4
Molecular Formula:
C19H20N4O
Molecular Weight:
320.3883
MDL Number:
MFCD17779309
SMILES:
NC(=O)c1cccc2c1nn(c2)c1ccc(cc1)[C@@H]1CCCNC1
Properties
Computed Properties
 
Complexity:
449  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.2  

Downstream Synthesis Route

[1]Patent:WO2009/87381,2009,A1.Locationinpatent:Page/Pagecolumn37-38

[2]JournalofMedicinalChemistry,2009,vol.52,p.7170-7185

[1]JournalofMedicinalChemistry,2009,vol.52,p.7170-7185

[1]Patent:CN106467513,2017,A

[1]Patent:CN106467513,2017,A

[2]Patent:CN106831708,2017,A

2-4-(3-piperidinyl)phenyl-2H-indazole-7-carboxamide 
  1038915-60-4 

[1]Patent:CN106467513,2017,A.Locationinpatent:Paragraph0009;0058;0059;0060;0061;0062

Literature

Title: The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies.

Journal: Frontiers in oncology 20130101

Title: Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.

Journal: Cancer research 20121101

Title: PARP inhibitors: its role in treatment of cancer.

Journal: Chinese journal of cancer 20110701

Title: Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.

Journal: Journal of hematology & oncology 20110101

Title: Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Journal: Journal of medicinal chemistry 20091126

Title: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Journal: The New England journal of medicine 20090709

Title: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

Journal: Nature 20050414

Title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.

Journal: Nature 20050414

Title: Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-ylphenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.

Title: Bridges KA, et al. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86.

Title: Wang L, et al. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec;30(6):2113-20.

Title: Mirza MR, et al. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164.

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Tags:1038915-60-4 Molecular Formula|1038915-60-4 MDL|1038915-60-4 SMILES|1038915-60-4 (S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide
Catalog No.: AA0038X2
1038915-60-4,MFCD17779309
1038915-60-4 | (S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide
Pack Size： 1mg
Purity： 98%
in stock
$6.00 $4.00
Pack Size： 2mg
Purity： 98%
in stock
$8.00 $6.00
Pack Size： 5mg
Purity： 98%
in stock
$12.00 $8.00
Pack Size： 100mg
Purity： 98%
in stock
$54.00 $38.00
Pack Size： 250mg
Purity： 98%
in stock
$105.00 $74.00
Pack Size： 1g
Purity： 98%
in stock
$261.00 $183.00
Pack Size： 5g
Purity： 98%
in stock
$902.00 $632.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA0038X2
Chemical Name: (S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide
CAS Number: 1038915-60-4
Molecular Formula: C19H20N4O
Molecular Weight: 320.3883
MDL Number: MFCD17779309
SMILES: NC(=O)c1cccc2c1nn(c2)c1ccc(cc1)[C@@H]1CCCNC1
Properties
Complexity: 449  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 3  
XLogP3: 2.2  
Downstream Synthesis Route
1038915-56-8    1038915-60-4    1038915-58-0 

[1]Patent:WO2009/87381,2009,A1.Locationinpatent:Page/Pagecolumn37-38

[2]JournalofMedicinalChemistry,2009,vol.52,p.7170-7185

1038915-60-4    1038915-64-8 

[1]JournalofMedicinalChemistry,2009,vol.52,p.7170-7185

1038915-99-9    1038915-60-4 

[1]Patent:CN106467513,2017,A

1038915-90-0    1038915-60-4 

[1]Patent:CN106467513,2017,A

[2]Patent:CN106831708,2017,A

2-4-(3-piperidinyl)phenyl-2H-indazole-7-carboxamide 
  1038915-60-4 

[1]Patent:CN106467513,2017,A.Locationinpatent:Paragraph0009;0058;0059;0060;0061;0062

Literature fold

Title: The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies.

Journal: Frontiers in oncology20130101

Title: Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.

Journal: Cancer research20121101

Title: PARP inhibitors: its role in treatment of cancer.

Journal: Chinese journal of cancer20110701

Title: Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.

Journal: Journal of hematology & oncology20110101

Title: Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Journal: Journal of medicinal chemistry20091126

Title: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Journal: The New England journal of medicine20090709

Title: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

Journal: Nature20050414

Title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.

Journal: Nature20050414

Title: Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-ylphenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.

Title: Bridges KA, et al. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86.

Title: Wang L, et al. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec;30(6):2113-20.

Title: Mirza MR, et al. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164.

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