Home Other Building Blocks 1038915-73-9
1038915-73-9,MFCD28167748
Catalog No.:AA008TFC

1038915-73-9 | Mk-4827 (tosylate)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$66.00   $46.00
- +
10mg
≥98%
in stock  
$119.00   $83.00
- +
25mg
≥98%
in stock  
$213.00   $149.00
- +
50mg
≥98%
in stock  
$362.00   $253.00
- +
100mg
99%
in stock  
$600.00   $420.00
- +
250mg
99%
in stock  
$1,281.00   $897.00
- +
1g
99%
in stock  
$4,456.00   $3,119.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TFC
Chemical Name:
Mk-4827 (tosylate)
CAS Number:
1038915-73-9
Molecular Formula:
C26H28N4O4S
Molecular Weight:
492.5899
MDL Number:
MFCD28167748
SMILES:
NC(=O)c1cccc2c1nn(c2)c1ccc(cc1)[C@@H]1CCCNC1.Cc1ccc(cc1)S(=O)(=O)O
Properties
Computed Properties
 
Complexity:
655  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  

Literature

Title: Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-ylphenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.

Title: Bridges KA, et al. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86.

Title: Wang L, et al. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec;30(6):2113-20.

Title: Mirza MR, et al. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:1038915-73-9 Molecular Formula|1038915-73-9 MDL|1038915-73-9 SMILES|1038915-73-9 Mk-4827 (tosylate)