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606143-89-9,MFCD22124525
Catalog No.:AA0039B3

606143-89-9 | Mek162

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%(HPLC)
in stock  
$43.00   $30.00
- +
25mg
98%(HPLC)
in stock  
$86.00   $60.00
- +
100mg
98%(HPLC)
in stock  
$256.00   $179.00
- +
1g
98%
in stock  
$1,636.00   $1,145.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0039B3
Chemical Name:
Mek162
CAS Number:
606143-89-9
Molecular Formula:
C17H15BrF2N4O3
Molecular Weight:
441.2268
MDL Number:
MFCD22124525
SMILES:
OCCONC(=O)c1cc2n(C)cnc2c(c1Nc1ccc(cc1F)Br)F
Properties
Computed Properties
 
Complexity:
521  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.1  

Literature

Title: Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.

Journal: The Lancet. Oncology 20180501

Title: MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.

Journal: The Lancet. Oncology 20130301

Title: J Pheneger, et al. 2006, ACR Annual Scientific Meeting. Abst 794.

Title: Serra V, et al. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. J Clin Invest, 2013, 123(6), 2551-2563.

Title: Kiessling MK, et al. Mutant HRAS as novel target for MEK and mTOR inhibitors. Oncotarget. 2015 Dec 8;6(39):42183-96.

Title: Cheng H, et al. PIK3CA(H1047R)- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling. Oncogene. 2016 Jun 9;35(23):2961-70.

Title: Seip K, et al. Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors. Oncotarget. 2016 Apr 12;7(15):19997-20015.

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SDS
Tags:606143-89-9 Molecular Formula|606143-89-9 MDL|606143-89-9 SMILES|606143-89-9 Mek162