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3605-01-4,MFCD00868264
Catalog No.:AA0039VM

3605-01-4 | 2-[4-(2H-1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

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50mg
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100mg
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250mg
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1g
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5g
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25g
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0039VM
Chemical Name:
2-[4-(2H-1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
CAS Number:
3605-01-4
Molecular Formula:
C16H18N4O2
Molecular Weight:
298.3397
MDL Number:
MFCD00868264
SMILES:
c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2
Properties
Computed Properties
 
Complexity:
356  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
3  
XLogP3:
1.8  

Literature

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Title: Dose-dependent impulse control disorders in piribedil overdose.

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Title: Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of unilateral 6-hydroxydopamine induced Parkinson's rats: effect of 5-HT, GABA and bone marrow cell supplementation.

Journal: Journal of biomedical science 20110101

Title: Piribedil-induced sleep attacks in patients without Parkinson disease: a case series.

Journal: Clinical neuropharmacology 20110101

Title: Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands.

Journal: Neuropharmacology 20110101

Title: Case control polysomnographic studies of sleep disorders in Parkinson's disease.

Journal: PloS one 20110101

Title: Pre-treatment with dopamine agonists influence L-dopa mediated rotations without affecting abnormal involuntary movements in the 6-OHDA lesioned rat.

Journal: Behavioural brain research 20101112

Title: From the cell to the clinic: a comparative review of the partial D₂/D₃receptor agonist and α2-adrenoceptor antagonist, piribedil, in the treatment of Parkinson's disease.

Journal: Pharmacology & therapeutics 20101101

Title: Delusional infestation induced by piribedil add-on in Parkinson's disease.

Journal: Pharmacopsychiatry 20100801

Title: Orodispersible sublingual piribedil to abort OFF episodes: a single dose placebo-controlled, randomized, double-blind, cross-over study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20100215

Title: Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition.

Journal: Neuroscience and biobehavioral reviews 20100101

Title: Impulse control disorder and piribedil: report of 5 cases.

Journal: Clinical neuropharmacology 20100101

Title: Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome.

Journal: Behavioral and brain functions : BBF 20100101

Title: Cognitive psychiatry in India.

Journal: Indian journal of psychiatry 20100101

Title: Parkinson's disease sleep scale, sleep logs, and actigraphy in the evaluation of sleep in parkinsonian patients.

Journal: Journal of neurology 20090901

Title: Tinnitus treatment with piribedil guided by electrocochleography and acoustic otoemissions.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20090801

Title: Ruthenium-catalyzed N-alkylation of amines and sulfonamides using borrowing hydrogen methodology.

Journal: Journal of the American Chemical Society 20090211

Title: Dopamine Agonists and their risk to induce psychotic episodes in Parkinson's disease: a case-control study.

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Title: Hallucinations: Etiology and clinical implications.

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Title: Mild cognitive impairment: The dilemma.

Journal: Indian journal of psychiatry 20090101

Title: Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans.

Journal: Current neuropharmacology 20080901

Title: Current management of the cognitive dysfunction in Parkinson's disease: how far have we come?

Journal: Experimental biology and medicine (Maywood, N.J.) 20080801

Title: Comparative effects of the dopaminergic agonists piribedil and bromocriptine in three different memory paradigms in rodents.

Journal: Journal of psychopharmacology (Oxford, England) 20080701

Title: Blockage of dopaminergic D(2) receptors produces decrease of REM but not of slow wave sleep in rats after REM sleep deprivation.

Journal: Behavioural brain research 20080409

Title: Impact of newer pharmacological treatments on quality of life in patients with Parkinson's disease.

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Title: [Implication of piribedil (pronoran) in the treatment of Parkinson's disease; a clinical and pharmacoeconomic analysis].

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Title: Peripheral edema and dopamine agonists in Parkinson disease.

Journal: Archives of neurology 20071001

Title: Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives.

Journal: International journal of nanomedicine 20070901

Title: Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura.

Journal: Journal of clinical neurology (Seoul, Korea) 20070301

Title: Impaired cognition and attention in adults: pharmacological management strategies.

Journal: Neuropsychiatric disease and treatment 20070201

Title: Effects of the dopamine agonist piribedil on prefrontal temporal cortical network function in normal aging as assessed by verbal fluency.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070130

Title: About the anti-Parkinson equivalency of levodopa and dopamine agonists.

Journal: Clinical neuropharmacology 20070101

Title: [Cognitive disturbances and dysfunction of neuromediator systems in cerebral vascular insufficiency after treatment with pronoran].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

Title: Early piribedil monotherapy of Parkinson's disease: A planned seven-month report of the REGAIN study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20061201

Title: The dopamine agonist piribedil with L-DOPA improves attentional dysfunction: relevance for Parkinson's disease.

Journal: The Journal of pharmacology and experimental therapeutics 20061101

Title: Antidepressant-like properties of the anti-Parkinson agent, piribedil, in rodents: mediation by dopamine D2 receptors.

Journal: Behavioural pharmacology 20061101

Title: Activation of D2-like receptors induces sympathetic climactic-like responses in male and female anaesthetised rats.

Journal: British journal of pharmacology 20060601

Title: Restless legs syndrome: diagnosis and review of management options.

Journal: Neuropsychiatric disease and treatment 20060601

Title: The Parkinson-Control study: a 1-year randomized, double-blind trial comparing piribedil (150 mg/day) with bromocriptine (25 mg/day) in early combination with levodopa in Parkinson's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society 20060401

Title: Enhancement in dissolution pattern of piribedil by molecular encapsulation with beta-cyclodextrin.

Journal: Methods and findings in experimental and clinical pharmacology 20060301

Title: Pharmacokinetic optimisation in the treatment of Parkinson's disease : an update.

Journal: Clinical pharmacokinetics 20060101

Title: Proposed dose equivalence for rapid switch between dopamine receptor agonists in Parkinson's disease: a review of the literature.

Journal: Clinical therapeutics 20060101

Title: [The role of pronoran in the therapy of late stage of Parkinson's disease].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: Switching from levodopa to the long-acting dopamine D2/D3 agonist piribedil reduces the expression of dyskinesia while maintaining effective motor activity in MPTP-treated primates.

Journal: Clinical neuropharmacology 20060101

Title: Prevalence and costs of parkinsonian syndromes associated with orthostatic hypotension.

Journal: Therapie 20060101

Title: [Dopaminergic and noradrenergic therapy of cognitive impairment].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: Pathophysiology and management of syncope in Kearns-Sayre syndrome.

Journal: The American heart hospital journal 20060101

Title: [Effect of dopamine deficiency on the preparation of visually guided saccadic eye movements].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20060101

Title: A reversed-phase high-performance liquid chromatographic method for the determination of zafirlukast in pharmaceutical formulations and human plasma.

Journal: Journal of AOAC International 20060101

Title: Chemically modified carbon paste electrode for the potentiometric flow injection analysis of piribedil in pharmaceutical preparation and urine.

Journal: Journal of pharmaceutical and biomedical analysis 20050715

Title: End-of-dose akinesia after a single intravenous infusion of the dopaminergic agonist piribedil in Parkinson's disease patients: a pharmacokinetic/pharmacodynamic, randomized, double-blind study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20050701

Title: Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004.

Journal: Movement disorders : official journal of the Movement Disorder Society 20050501

Title: The effects of dopaminergic agonists on genital reflexes in paradoxical sleep-deprived male rats.

Journal: Physiology & behavior 20050215

Title: [Efficacy of pronoran in age-related memory impairment].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [An impact of pronoran on cognitive and affective disorders in Parkinson's disease].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Modern aproaches to the treatment of early stages of Parkinson disease].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: Cognitive skill learning in healthy older adults after 2 months of double-blind treatment with piribedil.

Journal: Psychopharmacology 20041101

Title: Efficacy and safety of piribedil in early combination with L-dopa in the treatment of Parkinson's disease: a 6-month open study.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20041101

Title: Drug treatment of Parkinson's disease.

Journal: Dialogues in clinical neuroscience 20040901

Title: Drugs in development for Parkinson's disease.

Journal: Current opinion in investigational drugs (London, England : 2000) 20040701

Title: Determination of piribedil in pharmaceutical formulations by micellar electrokinetic capillary chromatography.

Journal: Analytical and bioanalytical chemistry 20040501

Title: [The effectiveness and tolerance of piribedil as adjunct therapy to levodopa in patients with Parkinson's disease: a nine month follow up].

Journal: Revista de neurologia 20040401

Title: Adsorptive stripping voltammetric behaviour of azomethine group in pyrimidine-containing drugs.

Journal: Journal of pharmaceutical and biomedical analysis 20040218

Title: [Clinical and stabilometric analysis of postural instability in Parkinson's disease].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: [Treatment of Parkinson's disease: use of piribedil].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: Acute treatment of migraine. Breaking the paradigm of monotherapy.

Journal: BMC neurology 20040101

Title: [Pronoran in the treatment of mental organic syndrome in the elderly].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: Piribedil as an adjunct to levodopa in advanced Parkinson's disease: the Asian experience.

Journal: Parkinsonism & related disorders 20031201

Title: Quantitative determination of some pharmaceutical piperazine derivatives through complexation with iron(III) chloride.

Journal: Farmaco (Societa chimica italiana : 1989) 20030801

Title: Treatment of memory impairment, vertigo and tinnitus in the elderly with piribedil in an Indian general practice setting.

Journal: Journal of the Indian Medical Association 20030801

Title: Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20030401

Title: Efficacy of piribedil as early combination to levodopa in patients with stable Parkinson's disease: a 6-month, randomized, placebo-controlled study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20030401

Title: Electroanalytical characteristics of piribedil and its differential pulse and square wave voltammetric determination in pharmaceuticals and human serum.

Journal: Journal of pharmaceutical and biomedical analysis 20030310

Title: Piribedil and bromocriptine in Parkinson's disease: a single-blind crossover study.

Journal: Acta neurologica Scandinavica 20030301

Title: Age-related mild cognitive deficit: a ready-to-use concept?

Journal: Dialogues in clinical neuroscience 20030301

Title: Piribedil-induced sleep attacks in Parkinson's disease.

Journal: Fundamental & clinical pharmacology 20030201

Title: [The use of pronoran (piribedil) in Parkinson's disease].

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Title: [Use of pronoran (piribedil) in Parkinson's disease: the results of a multicenter study].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation.

Journal: Movement disorders : official journal of the Movement Disorder Society 20020901

Title: [Alpha-2 adrenergic receptors and Parkinson's disease].

Journal: Presse medicale (Paris, France : 1983) 20020727

Title: Sleep attacks in patients taking dopamine agonists: review.

Journal: BMJ (Clinical research ed.) 20020622

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Psychomotor and cognitive effects of piribedil, a dopamine agonist, in young healthy volunteers.

Journal: Fundamental & clinical pharmacology 20020201

Title: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease.

Journal: Clinical pharmacokinetics 20020101

Title: Choosing the right dopamine agonist for patients with Parkinson's disease.

Journal: Current medical research and opinion 20020101

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Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020101

Title: [Use of dopamine agonists in the treatment of Parkinson's disease].

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Title: Randomized study of the dopamine receptor agonist piribedil in the treatment of mild cognitive impairment.

Journal: The American journal of psychiatry 20010901

Title: Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization.

Journal: The Journal of pharmacology and experimental therapeutics 20010601

Title: Piribedil for restless legs syndrome: a pilot study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20010501

Title: [Parkinson disease: diagnostic and therapeutic criteria].

Journal: Presse medicale (Paris, France : 1983) 20010303

Title: Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey.

Journal: Brain : a journal of neurology 20010301

Title: Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles.

Journal: Journal of microencapsulation 20010101

Title: Pharmacological treatment for aphasia following stroke.

Journal: The Cochrane database of systematic reviews 20010101

Title: Sleep attacks and Parkinson's disease treatment.

Journal: Lancet (London, England) 20000415

Title: Discriminative stimulus properties of the dopamine D3 receptor agonists, PD128,907 and 7-OH-DPAT: a comparative characterization with novel ligands at D3 versus D2 receptors.

Journal: Neuropharmacology 20000214

Title: [Electrophysiological and pharmacological analysis of L-dopa-induced dyskinesia and tardive dyskinesia (author's transl)].

Journal: Journal de physiologie 19810401

Title: Parkinsonism by haloperidol and piribedil.

Journal: Psychopharmacology 19781031

Title: Dopamine receptor stimulation in the treatment of depression: piribedil (ET-495).

Journal: Neuropsychobiology 19780101

Title: A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism.

Journal: The British journal of psychiatry : the journal of mental science 19770601

Title: Piribedil: its synergistic effect in multidrug regimens for parkinsonism.

Journal: Neurology 19760501

Title: Clinical and pharmacological evaluation of the effects of piribedil in patients with parkinsonism.

Journal: Acta neurologica Scandinavica 19750101

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Tags:3605-01-4 Molecular Formula|3605-01-4 MDL|3605-01-4 SMILES|3605-01-4 2-[4-(2H-1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine |Heterocyclic_Building_Blocks