Home Amines 1211441-98-3
1211441-98-3,MFCD27976795
Catalog No.:AA003A9C

1211441-98-3 | 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

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1mg
98%
in stock  
$12.00   $8.00
- +
5mg
98%
in stock  
$15.00   $11.00
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10mg
98%
in stock  
$19.00   $14.00
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250mg
98%
in stock  
$42.00   $29.00
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1g
98%
in stock  
$99.00   $69.00
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5g
98%
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$338.00   $237.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003A9C
Chemical Name:
7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS Number:
1211441-98-3
Molecular Formula:
C23H30N8O
Molecular Weight:
434.5373
MDL Number:
MFCD27976795
SMILES:
CN(C(=O)c1cc2c(n1C1CCCC1)nc(nc2)Nc1ccc(cn1)N1CCNCC1)C
Properties
Computed Properties
 
Complexity:
636  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Downstream Synthesis Route

[1]Patent:WO2010/20675,2010,A1.Locationinpatent:Page/Pagecolumn107;108

[1]Patent:WO2010/20675,2010,A1.Locationinpatent:Page/Pagecolumn108

[1]Patent:WO2010/20675,2010,A1.Locationinpatent:Page/Pagecolumn93

[1]Patent:WO2010/20675,2010,A1.Locationinpatent:Page/Pagecolumn95;96

Literature

Title: Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes.

Journal: Toxicology letters 20180701

Title: Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial.

Journal: The Lancet. Oncology 20180701

Title: A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and Lymphomas.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20161201

Title: Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer.

Journal: The New England journal of medicine 20161103

Title: Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20131115

Title: A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS.

Journal: Cancer biology & therapy 20130701

Title: The requirement for cyclin D function in tumor maintenance.

Journal: Cancer cell 20121016

Title: Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.

Journal: Cancer cell 20121016

Title: Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.

Journal: Cell cycle (Georgetown, Tex.) 20120715

Title: Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.

Journal: Biochimica et biophysica acta 20110801

Title: A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

Journal: Cancer cell 20100713

Title: The landscape of somatic copy-number alteration across human cancers.

Journal: Nature 20100218

Title: Requirement for CDK4 kinase function in breast cancer.

Journal: Cancer cell 20060101

Title: VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

Title: Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

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SDS
Tags:1211441-98-3 Molecular Formula|1211441-98-3 MDL|1211441-98-3 SMILES|1211441-98-3 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide