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Home Other Building Blocks 1374639-75-4
1374639-75-4,MFCD28167747
Catalog No.:AA00137U

1374639-75-4 | Lee011 succinate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
98%
in stock  
$7.00   $5.00
- +
25mg
98%
in stock  
$11.00   $8.00
- +
50mg
98%
in stock  
$15.00   $11.00
- +
100mg
98%
in stock  
$24.00   $17.00
- +
1g
98%
in stock  
$120.00   $84.00
- +
5g
98%
in stock  
$369.00   $259.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00137U
Chemical Name:
Lee011 succinate
CAS Number:
1374639-75-4
Molecular Formula:
C27H36N8O5
Molecular Weight:
552.6253
MDL Number:
MFCD28167747
SMILES:
CN(C(=O)c1cc2c(n1C1CCCC1)nc(nc2)Nc1ccc(cn1)N1CCNCC1)C.OC(=O)CCC(=O)O
Properties
Computed Properties
 
Complexity:
728  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-US2012/115878,2012,A1

110-15-6    1211441-98-3   
7-cyclopentyl-N,N-dimethyl-2-5-(piperazin-1-yl)pyridin-2-ylamino}-7H-pyrrolo2,3-dpyrimidine-6-carboxamidesuccinate 

[1]Patent:US2012/115878,2012,A1.Locationinpatent:Page/Pagecolumn12

[2]Patent:WO2019/40567,2019,A1.Locationinpatent:Page/Pagecolumn20-23;26-27

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-US2012/115878,2012,A1

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-US2012/115878,2012,A1

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-US2012/115878,2012,A1

Literature

Title: VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

Title: Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

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SDS
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Tags:1374639-75-4 Molecular Formula|1374639-75-4 MDL|1374639-75-4 SMILES|1374639-75-4 Lee011 succinate