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14907-98-3,MFCD01746220
Catalog No.:AA003ADL

14907-98-3 | Brusatol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$39.00   $28.00
- +
5mg
98%
in stock  
$99.00   $69.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003ADL
Chemical Name:
Brusatol
CAS Number:
14907-98-3
Molecular Formula:
C26H32O11
Molecular Weight:
520.5257
MDL Number:
MFCD01746220
SMILES:
COC(=O)[C@@]12OC[C@]34[C@H]2[C@@H](OC(=O)C=C(C)C)C(=O)O[C@@H]4C[C@@H]2[C@]([C@H]3[C@H]([C@@H]1O)O)(C)CC(=O)C(=C2C)O
Properties
Computed Properties
 
Complexity:
1150  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
0.9  

Literature

Title: T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180401

Title: Gypenosides protect retinal pigment epithelium cells from oxidative stress.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180201

Title: Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells.

Journal: Toxicology and applied pharmacology 20161101

Title: One new pregnane glycoside from the seeds of cultivated Brucea javanica.

Journal: Archives of pharmacal research 20110801

Title: Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20110125

Title: Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc.

Journal: Leukemia 20021101

Title: Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.

Journal: Journal of natural products 20011201

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