Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Journal: Chemical research in toxicology 20170515
Title: Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
Journal: Toxicology and applied pharmacology 20170301
Title: High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160601
Title: Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.
Journal: Toxicology letters 20150702
Title: Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure.
Journal: Toxicology 20141003
Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity.
Journal: Toxicology 20131206
Title: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131101
Title: Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130301
Title: Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes.
Journal: Biopharmaceutics & drug disposition 20121101
Title: Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats.
Journal: Life sciences 20121005
Title: In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.
Journal: Chemical research in toxicology 20120820
Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Journal: Journal of medicinal chemistry 20120524
Title: [Stage-based treatment of integrative medicine on the quality of life in patients with gout].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120501
Title: Gout and organ transplantation.
Journal: Current rheumatology reports 20120401
Title: Relationship between serum allantoin and urate in healthy subjects and effects of benzbromarone in gout patients.
Journal: International journal of clinical pharmacology and therapeutics 20120401
Title: Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms.
Journal: Journal of chemical information and modeling 20120326
Title: Use of uric acid-lowering agents limits experimental cyclosporine nephropathy.
Journal: Nephron. Experimental nephrology 20120301
Title: A high throughput in vitro mrp2 assay to predict in vivo biliary excretion.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120201
Title: Structure-based discovery of anti-influenza virus A compounds among medicines.
Journal: Biochimica et biophysica acta 20120201
Title: Corrector-mediated rescue of misprocessed CFTR mutants can be reduced by the P-glycoprotein drug pump.
Journal: Biochemical pharmacology 20120201
Title: Giant tophi in the calf.
Journal: Internal medicine (Tokyo, Japan) 20120101
Title: Can racial disparities in optimal gout treatment be reduced? Evidence from a randomized trial.
Journal: BMC medicine 20120101
Title: Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2.
Journal: PloS one 20120101
Title: The efficacy and safety of febuxostat for urate lowering in gout patients ≥65 years of age.
Journal: BMC geriatrics 20120101
Title: High plasma uric acid concentration: causes and consequences.
Journal: Diabetology & metabolic syndrome 20120101
Title: The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone.
Journal: PloS one 20120101
Title: Benzofuran derivatives inhibit 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose tissue.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Efficacy of benzbromarone in hyperuricemic patients associated with chronic kidney disease.
Journal: Nucleosides, nucleotides & nucleic acids 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: [Drug-induced hepatic injury, the challenge for cause investigation].
Journal: Rinsho byori. The Japanese journal of clinical pathology 20111201
Title: [Clinical strategies for prevention of drug-induced urinary calculi].
Journal: Clinical calcium 20111001
Title: Validation of membrane vesicle-based breast cancer resistance protein and multidrug resistance protein 2 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110901
Title: Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia.
Journal: American journal of physiology. Heart and circulatory physiology 20110901
Title: [Assessment on the clinical efficacy and safety of xiezhuo chubi recipe in treating hyperuricemia].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110901
Title: The challenges of gout management in the elderly.
Journal: Drugs & aging 20110801
Title: [Gout - regardless of therapeutic options a 'forgotten' disease].
Journal: Deutsche medizinische Wochenschrift (1946) 20110801
Title: Management of asymptomatic hyperuricaemia in patients with chronic kidney disease by Japanese nephrologists: a questionnaire survey.
Journal: Nephrology (Carlton, Vic.) 20110701
Title: Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701
Title: Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
Journal: Biochimica et biophysica acta 20110601
Title: Benzbromarone stabilizes ΔF508 CFTR at the cell surface.
Journal: Biochemistry 20110531
Title: Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors.
Journal: Bioorganic & medicinal chemistry 20110515
Title: CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110501
Title: Human urate transporter 1 (hURAT1) mediates the transport of orotate.
Journal: The journal of physiological sciences : JPS 20110501
Title: Developing potent human uric acid transporter 1 (hURAT1) inhibitors.
Journal: Journal of medicinal chemistry 20110428
Title: Impact of allopurinol use on urate concentration and cardiovascular outcome.
Journal: British journal of clinical pharmacology 20110401
Title: Serum CRP in patients with gout and effects of benzbromarone.
Journal: International journal of clinical pharmacology and therapeutics 20110301
Title: Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
Journal: Nephrology (Carlton, Vic.) 20110201
Title: Clinical images: Divergent patterns of joint remodeling following effective urate-lowering therapy in tophaceous gout.
Journal: Arthritis and rheumatism 20110101
Title: Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.
Journal: Journal of vascular research 20110101
Title: MicroRNA expression patterns of the kidney in hyperuricemia mice treated with Xiezhuo Chubi Decoction.
Journal: Chinese journal of integrative medicine 20110101
Title: Tophaceous gout and renal insufficiency: a new solution for an old therapeutic dilemma.
Journal: Case reports in medicine 20110101
Title: Renal co-morbidity in patients with rheumatic diseases.
Journal: Arthritis research & therapy 20110101
Title: Clinical therapeutics in pregnancy.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.
Journal: BMC biology 20110101
Title: Gout, genetics and ABC transporters.
Journal: F1000 biology reports 20110101
Title: Imaging in gout--what can we learn from MRI, CT, DECT and US?
Journal: Arthritis research & therapy 20110101
Title: Hyperuricemia is independently associated with coronary heart disease and renal dysfunction in patients with type 2 diabetes mellitus.
Journal: PloS one 20110101
Title: Quantitative estimation of urate transport in nephrons in relation to urinary excretion employing benzbromarone-loading urate clearance tests in cases of hyperuricemia.
Journal: Nephron extra 20110101
Title: Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: [Impact of serum uric acid level on the cardiovascular system as a risk factor].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20101201
Title: [Treatment of hyperuricemia and gout based on the guideline for the management of hyperuricemia and gout].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Risk factors associated with renal lithiasis during uricosuric treatment of hyperuricemia in patients with gout.
Journal: Arthritis care & research 20100901
Title: The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9) insect cells.
Journal: Talanta 20100615
Title: High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up.
Journal: Diabetes care 20100601
Title: Letter by George regarding article, 'Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled cross-over preliminary study'.
Journal: Circulation. Heart failure 20100501
Title: High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100401
Title: MRP transporters as membrane machinery in the bradykinin-inducible export of ATP.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100401
Title: Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100301
Title: Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting.
Journal: Journal of Korean medical science 20100301
Title: Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study.
Journal: Circulation. Heart failure 20100101
Title: Serum cystatin C is a potential endogenous marker for the estimation of renal function in male gout patients with renal impairment.
Journal: Journal of Korean medical science 20100101
Title: Effect of fenofibrate on uric acid metabolism and urate transporter 1.
Journal: Internal medicine (Tokyo, Japan) 20100101
Title: Management of hyperuricemia in gout: focus on febuxostat.
Journal: Clinical interventions in aging 20100101
Title: Drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone.
Journal: Internal medicine (Tokyo, Japan) 20100101
Title: The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial.
Journal: Arthritis research & therapy 20100101
Title: Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA.
Journal: Arzneimittel-Forschung 20100101
Title: [Human renal urate transpoter URAT1 mediates the transport of salicylate].
Journal: Nihon Jinzo Gakkai shi 20100101
Title: High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study.
Journal: PloS one 20100101
Title: Multidrug resistance protein transporter and Ins(1,4,5)P₃-sensitive Ca²+-signaling involved in adenosine triphosphate export via Gq protein-coupled NK₂-receptor stimulation with neurokinin A.
Journal: Journal of pharmacological sciences 20100101
Title: Advances in gout: some answers, more questions.
Journal: Arthritis research & therapy 20100101
Title: Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: New advances in the treatment of gout: review of pegloticase.
Journal: Therapeutics and clinical risk management 20100101
Title: Epidemiology of gout.
Journal: Arthritis research & therapy 20100101
Title: Compliance in gout patients.
Journal: Acta reumatologica portuguesa 20100101
Title: Advances in the management of gout: critical appraisal of febuxostat in the control of hyperuricemia.
Journal: International journal of nephrology and renovascular disease 20100101
Title: New and improved strategies for the treatment of gout.
Journal: International journal of nephrology and renovascular disease 20100101
Title: Multiple testing for bioequivalence with pharmacokinetic data in 2 x 2 crossover designs.
Journal: Statistics in medicine 20091210
Title: [Effects of serial gout granules on insulin-resistance in primary gout patients].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20091201
Title: Influence of luminal monosaccharides on secretion of glutathione conjugates from rat small intestine in vitro.
Journal: International journal of pharmaceutics 20091103
Title: Metabolomics in drug intolerance.
Journal: Current drug metabolism 20091101
Title: The role of transporters in the pharmacokinetics of orally administered drugs.
Journal: Pharmaceutical research 20090901
Title: Mouse GLUT9: evidences for a urate uniporter.
Journal: American journal of physiology. Renal physiology 20090901
Title: Gout--current diagnosis and treatment.
Journal: Deutsches Arzteblatt international 20090801
Title: Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
Journal: Toxicology and applied pharmacology 20090615
Title: A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300-600 mg/day versus benzbromarone 100-200 mg/day in patients with gout.
Journal: Annals of the rheumatic diseases 20090601
Title: Gout--what are the treatment options?
Journal: Expert opinion on pharmacotherapy 20090601
Title: Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.
Journal: The Journal of toxicological sciences 20090601
Title: Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).
Journal: Journal of medicinal chemistry 20090528
Title: Effects of benzbromarone and allopurinol on adiponectin in vivo and in vitro.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090401
Title: Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress.
Journal: Chemico-biological interactions 20090316
Title: Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol.
Journal: Annals of the rheumatic diseases 20090101
Title: Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090101
Title: Gout. Novel therapies for treatment of gout and hyperuricemia.
Journal: Arthritis research & therapy 20090101
Title: What lies behind serum urate concentration? Insights from genetic and genomic studies.
Journal: Genome medicine 20090101
Title: Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout.
Journal: Core evidence 20090101
Title: Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4.
Journal: British journal of pharmacology 20081201
Title: Febuxostat in the management of hyperuricemia and chronic gout: a review.
Journal: Therapeutics and clinical risk management 20081201
Title: Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients.
Journal: American journal of hypertension 20081001
Title: SLC2A9 is a high-capacity urate transporter in humans.
Journal: PLoS medicine 20081001
Title: Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005.
Journal: Annals of the rheumatic diseases 20080701
Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Journal: Journal of medicinal chemistry 20080612
Title: [Stage-based treatment of gouty arthritis by combination therapy of traditional Chinese and Western medicines: a randomized controlled trial].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080601
Title: Modeling and synthesis of novel tight-binding inhibitors of cytochrome P450 2C9.
Journal: Bioorganic & medicinal chemistry 20080401
Title: [Establishment of therapeutic goal and plan of gout and asymptomatic hyperuricemia].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20080401
Title: [Uricosuric agent].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20080401
Title: [New antihyperuricemic medicine: febuxostat, Puricase, etc].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20080401
Title: Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes.
Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20080301
Title: [Usefulness of combination treatment using allopurinol and benzbromarone for gout and hyperuricemia accompanying renal dysfunction: kinetic analysis of oxypurinol].
Journal: Nihon Jinzo Gakkai shi 20080101
Title: A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients?
Journal: Drug safety 20080101
Title: Developments in the scientific and clinical understanding of gout.
Journal: Arthritis research & therapy 20080101
Title: Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol intermediate.
Journal: Chemical research in toxicology 20071201
Title: Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein.
Journal: The Journal of biological chemistry 20071116
Title: Gene expression profiling of rat liver treated with serum triglyceride-decreasing compounds.
Journal: The Journal of toxicological sciences 20071001
Title: Excellent response to the clinical treatment of tophaceous gout.
Journal: Clinical rheumatology 20070901
Title: Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-treated gout patients.
Journal: Clinical rheumatology 20070901
Title: Time required for disappearance of urate crystals from synovial fluid after successful hypouricaemic treatment relates to the duration of gout.
Journal: Annals of the rheumatic diseases 20070801
Title: Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070601
Title: Pseudotumor of gout in the patella of a kidney transplant recipient.
Journal: Nature clinical practice. Nephrology 20070601
Title: Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.
Journal: European journal of pharmacology 20070410
Title: Emerging therapies in the long-term management of hyperuricaemia and gout.
Journal: Internal medicine journal 20070401
Title: Human renal organic anion transporter 4 operates as an asymmetric urate transporter.
Journal: Journal of the American Society of Nephrology : JASN 20070201
Title: Flow cytometric monitoring of multidrug drug resistance protein 1 (MRP1/ABCC1) -mediated transport of 2',7'-bis-(3-carboxypropyl)-5-(and-6)- carboxyfluorescein (BCPCF) into human erythrocyte membrane inside-out vesicles.
Journal: Molecular membrane biology 20070101
Title: Activating effect of benzbromarone, a uricosuric drug, on peroxisome proliferator-activated receptors.
Journal: PPAR research 20070101
Title: Utilization of a one-dimensional score for surveying chemical-induced changes in expression levels of multiple biomarker gene sets using a large-scale toxicogenomics database.
Journal: The Journal of toxicological sciences 20061201
Title: Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators.
Journal: The Journal of toxicological sciences 20061201
Title: Antihyperuricemic lignans from the leaves of Phyllanthus niruri.
Journal: Planta medica 20061101
Title: Using serum urate levels to determine the period free of gouty symptoms after withdrawal of long-term urate-lowering therapy: a prospective study.
Journal: Arthritis and rheumatism 20061015
Title: EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).
Journal: Annals of the rheumatic diseases 20061001
Title: Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20061001
Title: [The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061001
Title: Micellar electrokinetic capillary chromatographic method for the quantitative analysis of uricosuric and antigout drugs in pharmaceutical preparations.
Journal: Electrophoresis 20060601
Title: A convergent synthetic study of biologically active benzofuran derivatives.
Journal: Archives of pharmacal research 20060601
Title: Effect of fenofibrate in combination with urate lowering agents in patients with gout.
Journal: The Korean journal of internal medicine 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Ciprofloxacin permeability and its active secretion through rat small intestine in vitro.
Journal: International journal of pharmaceutics 20060426
Title: A causal role for uric acid in fructose-induced metabolic syndrome.
Journal: American journal of physiology. Renal physiology 20060301
Title: The evaluation of some pharmaceutically acceptable excipients as permeation enhancers for amoxicillin.
Journal: International journal of pharmaceutics 20060203
Title: [Molecular mechanism in biological transport in the kidney: Urate transporter URAT1].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060201
Title: A concise history of gout and hyperuricemia and their treatment.
Journal: Arthritis research & therapy 20060101
Title: Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics.
Journal: Arthritis research & therapy 20060101
Title: Phenothiazine maleates stimulate MRP1 transport activity in human erythrocytes.
Journal: Biochimica et biophysica acta 20051230
Title: Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201
Title: Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts.
Journal: The Journal of pharmacy and pharmacology 20051201
Title: Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101
Title: [Clinical observation on electroacupuncture combined with medicine for treatment of acute gouty arthritis].
Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20051001
Title: CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant.
Journal: Molecular pharmacology 20050901
Title: Benzbromarone therapy in management of refractory gout.
Journal: The New Zealand medical journal 20050624
Title: Optimal management of chronic gout: attempting to render the (t)issues crystal-clear.
Journal: The New Zealand medical journal 20050624
Title: Mechanisms of benzarone and benzbromarone-induced hepatic toxicity.
Journal: Hepatology (Baltimore, Md.) 20050401
Title: Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts.
Journal: Anticancer research 20050101
Title: Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter.
Journal: American journal of nephrology 20050101
Title: Gout in solid organ transplantation: a challenging clinical problem.
Journal: Drugs 20050101
Title: Charge and substituent effects on affinity and metabolism of benzbromarone-based CYP2C19 inhibitors.
Journal: Journal of medicinal chemistry 20041230
Title: Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells.
Journal: The Journal of pharmacology and experimental therapeutics 20041101
Title: Current management of gout in patients unresponsive or allergic to allopurinol.
Journal: Joint, bone, spine : revue du rhumatisme 20041101
Title: [Life-threatening adverse effects of pharmacologic antihyperuricemic therapy].
Journal: Therapeutische Umschau. Revue therapeutique 20040901
Title: The efficacy of combined low dose of Allopurinol and benzbromarone compared to standard dose of Allopurinol in hyperuricemia.
Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040901
Title: Spinal tophaceous gout mimicking a spinal tumor.
Journal: The Journal of rheumatology 20040701
Title: Quantitative binding models for CYP2C9 based on benzbromarone analogues.
Journal: Biochemistry 20040608
Title: Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).
Journal: Biochemical pharmacology 20040415
Title: Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9.
Journal: Molecular pharmacology 20040401
Title: D-glucose triggers multidrug resistance-associated protein (MRP)-mediated secretion of fluorescein across rat jejunum in vitro.
Journal: Pharmaceutical research 20040401
Title: Uric acid: role in cardiovascular disease and effects of losartan.
Journal: Current medical research and opinion 20040301
Title: Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione.
Journal: The international journal of biochemistry & cell biology 20040201
Title: Function and localization of urate transporter 1 in mouse kidney.
Journal: Journal of the American Society of Nephrology : JASN 20040201
Title: Oxidized low-density lipoprotein autoantibodies in patients with primary gout: effect of urate-lowering therapy.
Journal: Clinica chimica acta; international journal of clinical chemistry 20040101
Title: Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion.
Journal: Journal of the American Society of Nephrology : JASN 20040101
Title: Management of acute and chronic gouty arthritis: present state-of-the-art.
Journal: Drugs 20040101
Title: Benzbromarone withdrawn from the European market: another case of 'absence of evidence is evidence of absence'?
Journal: Clinical and experimental rheumatology 20040101
Title: Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20031201
Title: [Chronic gout. Case report of a severe course of disease].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20031115
Title: Stopping progression in familial juvenile hyperuricemic nephropathy with benzbromarone?
Journal: Kidney international 20031101
Title: Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients.
Journal: Matrix biology : journal of the International Society for Matrix Biology 20031101
Title: A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701
Title: Effects of combination treatment using anti-hyperuricaemic agents with fenofibrate and/or losartan on uric acid metabolism.
Journal: Annals of the rheumatic diseases 20030601
Title: A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030601
Title: Effects of aspirin and/or salicylate on hydrolysis and glucuronidation of indomethacin in rat erythrocytes and hepatocytes.
Journal: Biological & pharmaceutical bulletin 20030501
Title: Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
Journal: Chemico-biological interactions 20030201
Title: Urate transport via human PAH transporter hOAT1 and its gene structure.
Journal: Kidney international 20030101
Title: [Anti hyperuricemic agents].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030101
Title: [Drug therapy for idiopathic hyperuricemia--introduction, dose, and side effects].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030101
Title: [Essential hypertension].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030101
Title: [Molecular mechanism for urinary excretion of hypoxanthine and xanthine].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030101
Title: Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes. A structure-activity relationship study.
Journal: Oncology research 20030101
Title: Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout.
Journal: Arthritis and rheumatism 20020801
Title: Efficacy of benzbromarone compared to allopurinol in lowering serum uric acid level in hyperuricemic patients.
Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020601
Title: Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6).
Journal: The Journal of biological chemistry 20020510
Title: Fulminant hepatic failure associated with benzbromarone treatment: a case report.
Journal: Journal of gastroenterology and hepatology 20020501
Title: [Summary of the Dutch College of General Practitioners' 'Gout' Standard].
Journal: Nederlands tijdschrift voor geneeskunde 20020216
Title: [Hyperuricemia and gout--treatment].
Journal: Deutsche medizinische Wochenschrift (1946) 20020201
Title: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).
Journal: The Journal of biological chemistry 20011207
Title: [Vesical uric acid lithiasis in a child with renal hypouricemia].
Journal: Anales espanoles de pediatria 20010901
Title: [A case of fulminant hepatitis, possibly caused by benzbromarone].
Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20010401
Title: Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient.
Journal: Current rheumatology reports 20010201
Title: Improvement of renal function in patients with chronic gout after proper control of hyperuricemia and gouty bouts.
Journal: Nephron 20001101
Title: Thoracic cord compression due to gout: a case report and literature review.
Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20000701
Title: Subjective sensation of heaviness in gout patients.
Journal: Hiroshima journal of medical sciences 20000601
Title: Fatal fulminant hepatic failure associated with benzbromarone.
Journal: Journal of hepatology 20000501
Title: Potentiation of anticoagulant effect of warfarin caused by enantioselective metabolic inhibition by the uricosuric agent benzbromarone.
Journal: Clinical pharmacology and therapeutics 19991201
Title: Restoration of the uricosuric effect of probenecid after triglycylvasopressine administration in a gouty patient.
Journal: Clinical nephrology 19981001
Title: Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. A pathogenic approach to the treatment of primary chronic gout.
Journal: Annals of the rheumatic diseases 19980901
Title: Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout.
Journal: Metabolism: clinical and experimental 19980301
Title: Effect of allopurinol and benzbromarone on the concentration of uridine in plasma.
Journal: Metabolism: clinical and experimental 19971201
Title: Expression of the multidrug resistance-associated protein (MRP) and chemoresistance of human non-small-cell lung cancer cells.
Journal: International journal of cancer 19970926
Title: Possible role of the multidrug resistance-associated protein (MRP) in chemoresistance of human melanoma cells.
Journal: International journal of cancer 19970328
Title: Renal handling of urate in a patient with familial juvenile gouty nephropathy.
Journal: Internal medicine (Tokyo, Japan) 19960701
Title: Biotransformation and uric acid lowering effect of benzbromarone in patients with liver cirrhosis - evidence for active benzbromarone metabolites?
Journal: European journal of medical research 19951016
Title: Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.
Journal: Liver 19950201
Title: Subfulminant hepatitis requiring liver transplantation after benzarone administration.
Journal: Journal of hepatology 19940601
Title: Hepatic injury caused by benzbromarone.
Journal: Journal of hepatology 19940301
Title: [The correction of hyperuricemia in patients with different forms of nephrolithiasis using allopurinol and Allomaron].
Journal: Urologiia i nefrologiia 19940101
Title: Hyperuricemia in an infant with Taussig-Bing anomaly and interruption of the aortic arch.
Journal: Pediatric cardiology 19940101
Title: Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.
Journal: Nephron 19930101
Title: The effect of benzbromarone on allopurinol/oxypurinol kinetics in patients with gout.
Journal: European journal of clinical pharmacology 19930101
Title: [Long lasting normalization of uric acid after combination therapy with 300 mg allopurinol and 60 mg benzbromarone in patients with gout and hyperuricemia].
Journal: Medizinische Klinik (Munich, Germany : 1983) 19920915
Title: Toxicological studies on a benzofurane derivative. I. A comparative study with phenobarbital on rat liver.
Journal: Toxicology and applied pharmacology 19901201
Title: [Effectiveness and tolerance of long-term uricosuric treatment].
Journal: Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete 19901201
Title: Toxicological studies on a benzofurane derivative. II. Demonstration of peroxisome proliferation in rat liver.
Journal: Toxicology and applied pharmacology 19901201
Title: [Clinical studies on hyperuricemia and gout after transplantation].
Journal: Hinyokika kiyo. Acta urologica Japonica 19900801
Title: [The effect of benzbromarone on hyperlipidemia in gout].
Journal: Vutreshni bolesti 19900101
Title: [Drug-induced hepatitis due to benzarone (Fragivix): apropos of a clinical case report].
Journal: Acta gastro-enterologica Belgica 19900101
Title: [Effects and side effects of benzbromaron in the initial treatment of hyperuricemia and gout. Results of a field study on 3899 patients].
Journal: Fortschritte der Medizin 19780824
