Home Other Building Blocks 1477-19-6
1477-19-6,MFCD00867417
Catalog No.:AA001F1G

1477-19-6 | Benzarone

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Purity
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Price(USD)
Quantity
  
1g
>98.0%(GC)
in stock  
$42.00   $29.00
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10g
97%
in stock  
$249.00   $174.00
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001F1G
Chemical Name:
Benzarone
CAS Number:
1477-19-6
Molecular Formula:
C17H14O3
Molecular Weight:
266.2913
MDL Number:
MFCD00867417
SMILES:
CCc1oc2c(c1C(=O)c1ccc(cc1)O)cccc2
NSC Number:
82134
Properties
Properties
 
BP:
473.6°C at 760 mmHg  
Form:
Solid  
MP:
124.3°  
Refractive Index:
1.5490 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
346  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
4.3  

Literature

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology 20170515

Title: Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120601

Title: The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone.

Journal: PloS one 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: [Drug-induced hepatic injury, the challenge for cause investigation].

Journal: Rinsho byori. The Japanese journal of clinical pathology 20111201

Title: Developing potent human uric acid transporter 1 (hURAT1) inhibitors.

Journal: Journal of medicinal chemistry 20110428

Title: Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.

Journal: Nephrology (Carlton, Vic.) 20110201

Title: Current concepts of mechanisms in drug-induced hepatotoxicity.

Journal: Current medicinal chemistry 20090801

Title: Mechanisms of benzarone and benzbromarone-induced hepatic toxicity.

Journal: Hepatology (Baltimore, Md.) 20050401

Title: Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.

Journal: Liver 19950201

Title: Subfulminant hepatitis requiring liver transplantation after benzarone administration.

Journal: Journal of hepatology 19940601

Title: [Drug-induced hepatitis due to benzarone (Fragivix): apropos of a clinical case report].

Journal: Acta gastro-enterologica Belgica 19900101

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Tags:1477-19-6 Molecular Formula|1477-19-6 MDL|1477-19-6 SMILES|1477-19-6 Benzarone