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120964-45-6,MFCD18782644
Catalog No.:AA003B83

120964-45-6 | 3-Deazaneplanocin A hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$249.00   $174.00
- +
5mg
≥98%
in stock  
$682.00   $477.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003B83
Chemical Name:
3-Deazaneplanocin A hydrochloride
CAS Number:
120964-45-6
Molecular Formula:
C12H15ClN4O3
Molecular Weight:
298.7255
MDL Number:
MFCD18782644
SMILES:
Nc1nccc2c1ncn2C1C=C(C(C1O)O)CO.Cl
Properties
Properties
 
Form:
Solid  
MP:
>185°C (dec.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
378  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route
CASUnavailable 
  120964-45-6 

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

2770-01-6   
(1s,2r,5R)-5-(4-amino-1H-imidazo4,5-cpyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diolmonohydrochloride 

[1]JournalofMedicinalChemistry,1989,vol.32,p.1442-1446

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

Literature

Title: [Role of adrenergic mechanisms in origin of arrhythmias following administration of tricyclic antidepressive agents].

Journal: Deutsche medizinische Wochenschrift (1946) 19760116

Title: Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor LBH589 against human AML cells. Blood, 2009, 114(13), 2733-2743.

Title: Avan A, et al. Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with LY 188011 in pancreatic cancer cells. Mol Cancer Ther. 2012 Aug;11(8):1735-46.

Title: Kikuchi J, et al. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer. 2012 Nov;78(2):138-43.

Title: Sun F, et al. Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus?. Eur J Pharm Sci. 2015 Sep 18;77:290-302.

Title: Noriko Uchiyama, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146.

Title: Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23.

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SDS
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Tags:120964-45-6 Molecular Formula|120964-45-6 MDL|120964-45-6 SMILES|120964-45-6 3-Deazaneplanocin A hydrochloride
Catalog No.: AA003B83
120964-45-6,MFCD18782644
120964-45-6 | 3-Deazaneplanocin A hydrochloride
Pack Size： 1mg
Purity： ≥98%
in stock
$249.00 $174.00
Pack Size： 5mg
Purity： ≥98%
in stock
$682.00 $477.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003B83
Chemical Name: 3-Deazaneplanocin A hydrochloride
CAS Number: 120964-45-6
Molecular Formula: C12H15ClN4O3
Molecular Weight: 298.7255
MDL Number: MFCD18782644
SMILES: Nc1nccc2c1ncn2C1C=C(C(C1O)O)CO.Cl
Properties
Form: Solid  
MP: >185°C (dec.)  
Storage: Inert atmosphere;-20 ℃;  
Complexity: 378  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
CASUnavailable 
  120964-45-6 

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

89291-77-0    120964-45-6 

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

2770-01-6   
(1s,2r,5R)-5-(4-amino-1H-imidazo4,5-cpyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diolmonohydrochloride 

[1]JournalofMedicinalChemistry,1989,vol.32,p.1442-1446

105522-08-5    120964-45-6 

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

105522-07-4    120964-45-6 

[1]Tseng,ChristopherK.H.;Marquez,VictorE.;Fuller,RichardW.;Goldstein,BarryM.;Haines,DavidR.;etal.[JournalofMedicinalChemistry,1989,vol.32,#7,p.1442-1446]

Literature fold

Title: [Role of adrenergic mechanisms in origin of arrhythmias following administration of tricyclic antidepressive agents].

Journal: Deutsche medizinische Wochenschrift (1946)19760116

Title: Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor LBH589 against human AML cells. Blood, 2009, 114(13), 2733-2743.

Title: Avan A, et al. Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with LY 188011 in pancreatic cancer cells. Mol Cancer Ther. 2012 Aug;11(8):1735-46.

Title: Kikuchi J, et al. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer. 2012 Nov;78(2):138-43.

Title: Sun F, et al. Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus?. Eur J Pharm Sci. 2015 Sep 18;77:290-302.

Title: Noriko Uchiyama, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146.

Title: Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23.

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