Name: Name:Amg-837
Brand: AABLOCKS
SKU: AA003CIN
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA003CIN

Chemical Name: Amg-837

CAS Number: 865231-46-5

Molecular Formula: C26H21F3O3

Molecular Weight: 438.4383

MDL Number: MFCD23703041

SMILES: CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O

Properties

Storage: Keep in dry area;2-8℃;

Complexity: 661

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 32

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 6.2

Literature fold

Title: Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.

Journal: Journal of medicinal chemistry20160526

Title: Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.

Journal: Molecular pharmacology20121101

Title: AMG 837: a potent, orally bioavailable GPR40 agonist.

Journal: Bioorganic & medicinal chemistry letters20120115

Title: Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

Journal: Journal of medicinal chemistry20111013

Title: Enantioselective synthesis of a GPR40 agonist AMG 837 via catalytic asymmetric conjugate addition of terminal alkyne to α,β-unsaturated thioamide.

Journal: Organic letters20110304

Title: AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents.

Journal: PloS one20110101

Title: Houze JB, et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70.

Title: Lin DC, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6(11):e27270.

865231-46-5 | Amg-837